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| 1 | Modification of a neural network utilizing hybrid filters for the compensation of thermal deformation in machine tools显示文摘 | KANG Yuan CHANG Chuanwei HUANG Yuanrue | 2007 | In- ternational Journal of Machine Tools and Manufacture2007，47，2： | 1 |
| 2 | Research on the fatigue behavior of titanium based biomaterial coated with titanium nitride film by ion beam enhanced deposition显示文摘 | Huang Nan Chen yuanru Cai Guangjun | 1996 | Surf Coat Tech1996，88，： | 1 |
| 3 | Intra-articular drug delivery from an optimized topical patch containing teriflunomide and lornoxicam for rheumatoid arthritis treatment: Does the topical patch really enhance a local treatment?显示文摘 | Honglei Xi Dongmei Cun Rongwu Xiang Yanli Guan Yuxiu Zhang Yuanru Li Liang Fang | 2013 | Journal of Controlled Release . 2013 (1-2)2013，，： | 1 |
| 4 | Research on the fatigue behavior of titanium based biomaterial coated with titanium nitride film by ion beam enhanced deposition显示文摘 | Huang Nan Chen yuanru Cai Guangjun | 1996 | Surface & Coatings Technology1996，88，： | 1 |
| 5 | Research on the fatigue behavior of titanium based biomaterial coated with titanium nitride film by ion beam enhanced deposition显示文摘 | Huang Nan Chen yuanru Cai Guangjun | 1996 | Surf Coat Tech1996，88，： | 1 |
| 6 | Theoretical studies on the electronic and spectroscopic properties of Keggin-structure polyoxometalates α/β-n-(X=Si,P; M=Mo,W)显示文摘 | Guo Yuanru Pan Qingjiang Wei Yongde | 2004 | Journal of Molecular Structure:THEOCHEM2004，676，： | 1 |
| 7 | Synthesis of BhSi3012 powders by a sol-gel method显示文摘 | XIE Hhuidong JIA Caixia JIANG Yuanru | 2012 | Mater Chem Phys2012，133，23： | 1 |
| 8 | Starch phosphorylase 2 is essential for cellular carbohydrate partitioning in maize显示文摘Carbohydrate partitioning is essential for plant growth and development,and its hindrance will result in excess accumulation of carbohydrates in source tissues.Most of the related mutants in maize(Zea mays L.)display impaired whole-plant sucrose transport,but other mechanisms affecting carbohydrate partitioning have seldom been reported.Here,we characterized chlorotic leaf3(chl3),a recessive mutation causing leaf chlorosis with starch accumulation excessively in bundle sheath chloroplasts,suggesting that chl3 is defective in carbohydrate partitioning.Positional cloning revealed that the chl3 phenotype results from a frameshift mutation in ZmPHOH,which encodes starch phosphorylase 2.Two mutants in ZmPHOH exhibited the same phenotype as chl3,and both alleles failed to complement the chl3 mutant phenotype in an allelism test.Inactivation of Zm PHOH in chl3 leaves reduced the efficiency of transitory starch conversion,resulting in increased leaf starch contents and altered carbohydrate metabolism patterns.RNA-seq revealed the transcriptional downregulation of genes related to photosynthesis and carbohydrate metabolism in chl3 leaves compared to the wild type.Our results demonstrate that transitory starch remobilization is very important for cellular carbohydrate partitioning in maize,in which Zm PHOH plays an indispensable role. | Yao Qin Ziyi Xiao Hailiang Zhao Jing Wang Yuanru Wang Fazhan Qiu | 2022 | Journal of Integrative Plant Biology2022，64，9： | 1 |
| 9 | Theo-refical investigation of ground-and excited-state properties of flu-orenone alkynyl Hg(Ⅱ)complexes:The tuning of electronic spec-troseopy显示文摘 | ZHANG YING PAN QINGJIANG GUO YUANRU | 2009 | Joumal of Molecular Structure:THEOCHEM2009，907，： | 1 |
| 10 | Zebrafish facilitates drug screening: potential of 3-deoxy-andrographoside from Chuanxinlian(Herba Andrographitis Paniculatae) as an anti-inflammatory agent显示文摘OBJECTIVE: To systematically evaluate the in vivo antiinflammatory potential of diterpene lactones from Chuanxinlian(Herba Andrographitis Paniculatae)(AP). METHODS: We firstly adopted zebrafish, a novel and ideal animal model for high-throughput drug screening, to investigate the in vivo anti-inflammatory activities of 17 diterpene lactones isolated from AP.RESULTS: The results showed that most of diterpene lactones displayed significant anti-inflammatory effects in lipopolysaccharide microinjection-, copper sulfate exposure-or tail transection-induced zebrafish inflammation models. Moreover, diterpene lactone 3-deoxy-andrographoside(AP-5) was firstly found to attenuate inflammatory responses, which was closely associated with the myeloid differentiation primary response 88/nuclear factor-kappa B and signal transducer and activator of transcription 3 pathways. CONCLUSION: Our research sheds light on the inestimable roles of zebrafish in high-throughput drug screening, elucidates the potent inhibitory effects of diterpene lactones against inflammation and indicates that AP-5 may serve as a potential alternative agent for the treatment of inflammatory diseases. | HE Xuemei XIAO Junjie FAN Chunlin LU Zibin CAO Huihui YU Linzhong ZHENG Yuanru LIU Junshan | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 0 |
| 11 | Conductivity of (NH4)3[CrMo6O24H6]·7H2O Treated by Nd Chemistry-Heated Diffused Permeation显示文摘Rare earth co-permeation of (NH4)3[CrMo6O24H6]·7H2O was reported and the conductivity of (NH4)3[CrMo6O24H6]was improved by 6.734×109 times. X-ray fluorescence spectrometry (XRF), thermogravimetry-differential thermalanalysis (TG-DTA), X-ray diffraction (XRD) have been used to character (NH4)3[CrMo6 O24H6]·7H2O and permeatedsample. Experimental results showed that Nd could be permeated into the body of this sample and the XRDpatterns showed great difference between (NH4)3[CrMo6O24H6]·7H2O and permeated sample. The structure of(NH4)3[CrMo6O24H6]·7H2O was destroyed and new compound MoN perhaps formed. | Xin LI Zhonghua LI Yuzhi GAO Maomao ZHAO Yuanru GUO Baibin ZHOU | 2005 | Journal of Materials Science & Technology2005，21，5： | 0 |
| 12 | Investigation of the Surface Properties of Titanium Biomaterial with Oxide Layer of Rutile Structure显示文摘InvestigationoftheSurfacePropertiesofTitaniumBiomaterialwithOxideLayerofRutileStructureHuangNan;ChenYuanru(DepartmentofMateri... | Huang Nan Chen Yuanru(Department of Material Engineering),Southwest Jiaotong University, Chengdu 61031, ChinaXiao Jing Xue Zhennan(Biomedical Engineering Institute),West China University of Medical Sciences,Chengdu 610041, ChinaLiu Xianghuai(Shanghai In | 1994 | Journal of Modern Transportation1994，11，2： | 0 |
| 13 | Pharmacodynamics simulation of HOEC by a computational model of arachidonic acid metabolic network显示文摘Backgrounds Arachidonic acid (AA) metabolic network is activated in the most inflammatory related diseases, and small-molecular drugs targeting AA network are increasingly available. However, side effects of above mentioned drugs have always been the biggest obstacle.什)-2-( 1 -hydroxy 1-4-oxocycIohexyl) ethyl caffeate (HOEC), a natural product acted as an inhibitor of 5-Iipoxygenase (5-LOX) and 15-LOX in vitro^ exhibited weaker therapeutic effect in high dose than that in low dose to collagen induced arthritis (CIA) rats. In this study, we tried to elucidate the potential regulatory mechanism by using quantitative pharmacology. Methods: First, we generated an experimental data set by monitoring the dynamics of AA metabolites, concentration in A23187 stimulated and different doses of HOEC co-incubated RAW264.7. Then we constructed a dynamic model of A23187-stimulated AA metabolic model to evaluate how a model-based simulation of AA metabolic data assists to find the most suitable treatment dose by predicting the pharmacodynamics of HOEC? Results: Compared to the experimental data, the model could simulate the inhibitory effect of HOEC on 5-LOX and 15-LOX, and reproduced the increase of the metabolic flux in the cyclooxygenase (COX) pathway. However, a concomitant, early-stage of stimulation-related decrease of prostaglandins (PGs) production in HOEC incubated RAW264.7 cells was not simulated in the model. Conclusion-. Using the model, we predict that higher dose of HOEC disrupts the flux balance in COX and LOX of the AA network, and increased COX flux can interfere the curative effects of LOX inhibitor on resolution of inflammation which is crucial for the efficient and safe drug design. | Wen Yang Xia Wang Kenan Li Yuanru Liu Ying Liu Rui Wang Honglin Li | 2019 | Frontiers of Electrical and Electronic Engineering in China2019，7，1： | 0 |
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