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| 1 | MiR-29a/b/c regulate human circadian gene hPER1 expression by targeting its 3/UTR显示文摘在哺乳动物的几必要生物进步被生理节奏的节奏调整。不过分子的机制 ofoscillating 这些生理节奏的节奏被揭开了,生理节奏的基因的特定的功能不是很, clear.It 被报导了那由 microRNA 将生理节奏的基因击倒是有用策略探索 circadianrhythms 的功能。在这研究,通过屏蔽途径的前面的生物信息学,我们作为有势力 inhibitorsfor 识别了 miR-29a/b/c 人的生理节奏的基因 hPER1。我们进一步发现 miR-29a/b/c 能直接在人的 A549 房间在 mRNA 和蛋白质表示层次指向 hPER1 3untranslated 区域(UTR ) 和下面调整 hPER1。因此,我们的调查结果建议 hPER1 的表示被 miR-29a/b/c 调整,它可以也为 hPER1 的功能提供新线索。 | Xiyan Zhao Xueqiang Zhu Shuting Cheng Yizhou Xie Zhengrong Wang Yanyou Liu Zhou Jiang Jing Xiao Huiling Guo Yuhui Wang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，4： | 7 |
| 2 | Deformation behavior of Cu-12wt%Al alloy wires with continuous columnar crystals in dieless drawing process显示文摘The microstructure and mechanical properties of Cu-12wt%Al alloy wires which are composed of continuous columnar crystals after dieless drawing forming at drawing speed of 1.0―1.4 mm/s and deformation temperature of 600―900℃ were analyzed, and deformation behavior of the alloy during dieless drawing forming was experimentally investigated. The results showed that in the abovemen-tioned conditions, recrystallization phenomenon was not found during dieless drawing forming. When a drawing speed of 1.0 mm/s was used, the grain boundaries were out of straight gradually with increasing deformation temperature from 600℃ to 900℃, and tensile strength of the dieless drawn Cu-12wt%Al alloy wires increased while elongations decreased with increasing deformation temperature. At drawing speed of 1.1―1.2 mm/s and deformation temperature of 600℃, the effect of dieless drawing forming process on the microstructure of the alloy was inconspicuous, and when drawing speed was up to 1.3―1.4 mm/s, the grain boundaries of continuous columnar crystals became zigzag while there was little effect of drawing speed of 1.1―1.4 mm/s on the elongation and tensile strength of the alloy wires. | LIU XueFeng WU YuHui XIE JianXin | 2009 | Science China(Technological Sciences)2009，52，8： | 6 |
| 3 | Composition optimized trimetallic PtNiRu dendritic nanostructures as I versatile and active electrocatalysts for alcohol oxidation显示文摘Platinum-based nano crystals are the most effective electrocatalysts for accelerati ng the chemical tran sformatio ns on the anode in direct alcohol fuel cells. To facilitate practical applications and overcome the drawbacks of diverse alcohols, it is significant to develop electrocatalysts with high activities and a wide fuel flexibility. Here, we demonstrate a practicable solution method for fabricating composition tun able trimetallic PtNiRu den dritic nano structures (DNSs) which can serve as versatile and active catalysts for electrooxidatio n of a variety of liquid alcohols. A series of trimetallic DNSs with tun able Pt/Ni/Ru atomic ratios were successfully syn thesized by simply adjusti ng the feeding of precursors. Detailed electrochemical test indicates that, among other compositions, the Pt66Ni27Ru7 DNSs present much superior electroactivity in catalyzing electrooxidation of liquid alcohols in acidic mediums. Specifically, the mass activity and specific activity on the Pt66Ni27Ru7 DNSs, for electrooxidation of methanol, ethanol, and ethylene glycol, are 4.57 and 4.34 times, 3.55 and 3.42 times, and 2.37 and 2.28 times that of the commercial Pt black, respectively. X-ray photoelectron spectroscopy and CO stripping studies reveal the adsorption of CO on these PtNiRu DNSs is much weaker than on pure Pt. Meanwhile, the surface Ru sites can provide neighbouring -OH groups to facilitate the oxidati on and removal of the adsorbed in termediates (-CO) on the surface Pt sites, effectively improvi ng the CO tolera nee of the catalysts. The PtNiRu DNSs also show effectively boosted capacity for breaking the C-C bond in C2-alcohols, showing great potential for fuel-flexible fuel cell applications. | Yan Lu Wei Wang Xiaowei Chen Yuhui Zhang Yanchen Han Yong Cheng Xue-Jiao Chen Kai Liu Yuanyuan Wang Qiaobao Zhang Shuifen Xie | 2019 | Nano Research2019，12，3： | 6 |
| 4 | Severity of early allograft dysfunction following donation after circulatory death liver transplantation:a multicentre study显示文摘Background:Early allograft dysfunction(EAD)is associated with decreased graft and patient survival rates.This study aimed to identify the severity of EAD and develop a predictive model for EAD after donation after circulatory death(DCD)liver transplantation(LT).Furthermore,the influence of operative time on EAD incidence was also evaluated.Methods:In this retrospective,multicentre cohort study,nomograms were established based on a single-centre training cohort(n=321)and validated in a 3-center validation cohort(n=501).Results:The incidence rate of EAD was 46.4%(149/321)in the training cohort and 40.5%(203/501)in the validation cohort.Of the 149 EAD patients in the training cohort,77 patients with either elevated alanine aminotransferase(ALT)or aspartate aminotransferase(AST)were classified as having EAD type A,and the rest of the EAD patients were classified as having EAD type B.Recipients with EAD type B had lower graft and patient survival rates than recipients with EAD type A(P=0.043 and 0.044,respectively).We further developed a nomogram to predict EAD(graft weight,cold ischemia time,donor age,model for end-stage liver disease(MELD)score)and another nomogram to predict EAD type B(graft weight,cold ischemia time,MELD score).The nomograms for the prediction of EAD and EAD type B had good discrimination[concordance index(C-index)=0.712(0.666-0.758),0.707(0.641-0.773)]and calibration[Hosmer-Lemeshow(HL)P=0.384,P=0.425]in the validation cohort.An increased operative time(>6 h)was associated with increased EAD and EAD type B incidence in the high-risk group(P=0.005,P=0.020,respectively).Conclusions:EAD type B was associated with decreased graft and patient survival rates.The novel nomograms effectively predicted the incidence of EAD and EAD type B in DCD LT patients. | Kun Wang Di Lu Yuhui Liu Wangyao Li Li Zhuang Zhenyu Ma Qinfen Xie Binhua Pan Yichao Wu Junli Chen Lidan Lin Xiaowen Feng Qiang Wei Xuyong Wei Haiyang Xie Zhengxin Wang Shusen Zheng Xiao Xu | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 4 |
| 5 | Revealing the crystallization process and realizing uniform 1.8 eV MA-based wide-bandgap mixed-halide perovskites via solution engineering显示文摘Wide-bandgap perovskites are recently drawing tremendous attention in the community for high-efficiency all-perovskite tandem solar cells.However,the formamidinium (FA^+) and methylammonium (MA^+) based wide-bandgap mixed halide perovskites suffered from high density of traps and pin-holes,respectively.Fundamental understanding on the crystallization and film formation processes are keys to overcome those challenges but not yet clearly understood.In this study,an in-situ photoluminescence technique was used to investigate the perovskite crystallization during the thermal annealing process.It is found that the crystallization of a mixed halide perovskite with bromide (Br^-) and iodine (I^-) ions following the Ostward ripening crystal growth.Interestingly,it is found that the initial nucleation reaction is quickly completed in the first few seconds,however,leaving the small crystals with inhomogeneous composition.The different aggregation affinities of such inhomogeneous small crystals provoke the formation of pin-holes during the thermal annealing process.By engineering the precursor solution to control the nucleation rate,the chemical composition of the small crystals has become homogenous.Uniform pin-hole free high Br-composited wide-bandgap MA0.9Cs0.1Pb(I0.6Br0.4)3 perovskite films with bandgap energy of 1.8 eV have been realized.The corresponding photovoltaic devices have achieved an encouraging device efficiency of 15.1% with superb photostability. | Yue-Min Xie Chunqing Ma Xiuwen Xu Menglin Li Yuhui Ma Jing Wang Hrisheekesh Thachoth Chandran Chun-Sing Lee Sai-Wing Tsang | 2019 | Nano Research2019，12，5： | 2 |
| 6 | Pullulan Acetate Coated Magnetite Nanoparticles for Hyper-Thermia:Preparation,Characterization and In Vitro Experiments显示文摘Amphipathic polymer pullulan acetate (PA)-coated magnetic nanoparticles were prepared and characterized by various physicochemical means. The cytotoxicity and cellular uptake of the magnetic nanoparticles were examined. The hyperthermic effect of the magnetic nanoparticles on tumor cells was evaluated. Transmission electron microscopy (TEM) showed that the PA coated magnetic nanoparticles (PAMNs) had spherical morphology. Dynamic light scattering (DLS) showed that the size distribution of PAMNs was unimodal,with an average diameter of 25.8 nm ± 6.1 nm. The presence of the adsorbed layer of PA on the magnetite surface was confirmed by Fourier transform infrared (FTIR) spectroscopy. Magnetic measurements revealed that the saturation magnetization of the PAMNs reached 51.9 emu/g and the nanoparticles were superparamagnetic. Thermogravimetric analysis (TGA) showed that the Fe_(3)O_(4) particles constituted 75 wt% of the PAMNs. The PAMNs had good heating properties in an alternating magnetic field. Cytotoxicity assay showed that PAMNs exhibited no significant cytotoxicity against L929 cells. TEM results showed that a large number of PAMNs were internalized into KB cells. PAMNs have good hyperthermia effect on KB cells in vitro by magnetic field induced hyperthermia. These novel magnetic nanoparticles have great potential as magnetic hyperthermia mediators. | Fuping Gao Yuanyuan Cai Jing Zhou Xiaoxue Xie Weiwei Ouyang Yuhui Zhang Xufei Wang Xiaodong Zhang Xiaowen Wang Lingyun Zhao Jintian Tang | 2010 | Nano Research2010，3，1： | 2 |
| 7 | A low-density polyethylene composite with phosphorus-nitrogen based flame retardant and multi-walled carbon nanotubes for enhanced electrical conductivity and acceptable flame retardancy显示文摘Design and exploitation of flame retardant polymers with high electrical conductivity are desired for polymer applications in electronics.Herein,a novel phosphorus-nitrogen intumescent flame retardant was synthesized from pentaerythritol octahydrogen tetraphosphate,phenylphosphonyl dichloride,and aniline.Low-density polyethylene was combined with the flame retardant and multi-walled carbon nanotubes to form a nanocomposite material via a ball-milling and hot-pressing method.The electrical conductivity,mechanical properties,thermal performance,and flame retardancy of the composites were investigated using a four-point probe instrument,universal tensile machine,thermogravimetric analysis,and cone calorimeter tests,respectively.It was found that the addition of multi-walled carbon nanotubes can significantly improve the electrical conductivity and mechanical properties of the low-density polyethylene composites.Furthermore,the combination of multi-walled carbon nanotubes and phosphorus–nitrogen flame retardant remarkably enhances the flame retardancy of matrixes with an observed decrease of the peak heat release rate and total heat release of 49.8%and 51.9%,respectively.This study provides a new and effective methodology to substantially enhance the electrical conductivity and flame retardancy of polymers with an attractive prospect for polymer applications in electrical equipment. | Yong Luo Yuhui Xie Renjie Chen Ruizhi Zheng Hua Wu Xinxin Sheng Delong Xie Yi Mei | 2021 | Frontiers of Chemical Science and Engineering2021，15，5： | 2 |
| 8 | 无人机遥感在植物生态学中的应用与挑战显示文摘无人机为获取高时空分辨率的遥感数据提供了经济灵活的工具,为植物生态学家开展从个体到区域尺度的生态学研究提供了新的机遇和手段。但作为一种新兴的技术手段,当前无人机遥感在植物生态学中的应用仍充满了挑战,植物生态学的科研需求与无人机遥感的生态应用需要更为深入的融合。本文综述了无人机遥感技术在植物生态学中的应用,展望了无人机在植物生态学研究中的应用前景。在所综述的400篇文献中,59%的文章发表于非植物生态学领域的遥感类期刊,遥感学者与生态学者的关注点存在较大差异。当前的研究集中在无人机遥感的技术层面,如数据处理和遥感反演方法等,对生态学问题本身的关注较少。综述的文献中,61%的研究案例集中在群落尺度,可见光(RGB)相机和多光谱相机是最常用的传感器类型(75%)。无人机遥感数据中蕴藏着诸多待挖掘的、有重要意义的生态参数,这些参数有助于我们识别林窗的几何特征,构建林冠的化学组合,更好地了解林冠表面的不规则性和群落的异质性。无人机遥感技术在植物生态学研究中的深入应用,需要集植物生态学家和遥感专家之合力共同推进。 | Zhongyu Sun Xiaonian Wang Zhihui Wang Long Yang Yichun Xie Yuhui Huang | 2021 | Journal of Plant Ecology2021，14，6： | 1 |
| 9 | Molecular proper- ties of R-phycocyanin subunits from Polysiphonia urceolata in po- tassium phosphate buffer 显示文摘 | Ma Yuhui Xie Jie Zhang Rui | 2008 | Photochem Photobiol Sci2008，7，2： | 1 |
| 10 | Upgrading CO_(2) into acetate on Bi_(2)O_(3)@carbon felt integrated electrode via coupling electrocatalysis with microbial synthesis显示文摘Upgrading of atmospheric CO_(2) into high-value-added acetate using renewable electricity via electrocatalysis solely remains a great challenge.Here,inspired by microbial synthesis via biocatalysts,we present a coupled system to produce acetate from CO_(2) by bridging inorganic electrocatalysis with microbial synthesis through formate intermediates.A 3D Bi_(2)O_(3)@CF integrated electrode with an ice-sugar gourd shape was fabricated via a straightforward hydrothermal synthesis strategy,wherein Bi_(2)O_(3) microspheres were decorated on carbon fibers.This ice-sugar gourd-shaped architecture endows electrodes with multiple structural advantages,including synergistic contribution,high mass transport capability,high structural stability,and large surface area.Consequently,the resultant Bi_(2)O_(3)@CF exhibited a maximum Faradic efficiency of 92.4%at−1.23 V versus Ag/AgCl for formate generation in 0.5 M KHCO_(3),exceeding that of Bi_(2)O_(3)/CF prepared using a conventional electrode preparation strategy.Benefiting from the high formate selectivity,unique architecture,and good biocompatibility,the Bi_(2)O_(3)@CF electrode attached with enriched CO_(2)-fixing electroautotrophs served as a biocathode.As a result,a considerable acetate yield rate of 0.269±0.009 g L^(−1) day^(−1)(a total acetate yield of 3.77±0.12 g L^(−1) during 14-day operation)was achieved in the electrochemical–microbial system equipped with Bi_(2)O_(3)@CF. | Xiaojing Liu Kang Zhang Yidan Sun Shukang Zhang Zhenyu Qiu Tianshun Song Jingjing Xie Yuping Wu Yuhui Chen | 2023 | SusMat2023，3，2： | 1 |
| 11 | Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse显示文摘 | XIE Xiaoduo ZHANG Yixuan JIANG Yuhui | 2008 | Carcinogenesis2008，29，8： | 1 |
| 12 | Dual stacked partial least squares for analysis of near-infrared spectra显示文摘 | Yiming Bi Qiong Xie Silong Peng Liang Tang Yong Hu Jie Tan Yuhui Zhao Changwen Li | 2013 | Analytica Chimica Acta2013，，： | 1 |
| 13 | Intra-host Ebola viral adaption during human infection显示文摘The onsite next generation sequencing(NGS)of Ebola virus(EBOV)genomes during the 2013–2016 Ebola epidemic in Western Africa provides an opportunity to trace the origin,transmission,and evolution of this virus.Herein,we have diagnosed a cohort of EBOV patients in Sierra Leone in 2015,during the late phase of the outbreak.The surviving EBOV patients had a recovery process characterized by decreasing viremia,fever,and biochemical parameters.EBOV genomes sequenced through the longitudinal blood samples of these patients showed dynamic intra-host substitutions of the virus during acute infection,including the previously described short stretches of 13 serial TNC mutations.Remarkably,within individual patients,samples collected during the early phase of infection possessed Ts at these nucleotide sites,whereas they were replaced by Cs in samples collected in the later phase,suggesting that these short stretches of TNC mutations could emerge independently.In addition,up to a total of 35 nucleotide sites spanning the EBOV genome were mutated coincidently.Our study showed the dynamic intra-host adaptation of EBOV during patient recovery and gave more insight into the complex EBOV-host interactions. | William JLiu Weifeng Shi Wuyang Zhu Cong Jin Shumei Zou Ji Wang Yuehua Ke Xiaofeng Li Mi Liu Tao Hu Hang Fan Yigang Tong Xiang Zhao Wenbin Chen Yuhui Zhao Di Liu Gary Wong Chengchao Chen Chunyu Geng Weiwei Xie Hui Jiang Idrissa Laybor Kamara Abdul Kamara Matt Lebby Brima Kargbo Xiangguo Qiu Yu Wang Xiaofeng Liang Mifang Liang Xiaoping Dong Guizhen Wu George F.Gao Yuelong Shu | 2019 | Biosafety and Health2019，1，1： | 1 |
| 14 | Towards ultrastrong and ductile medium-entropy alloy through dual-phase ultrafine-grained architecture显示文摘Advanced materials with superior comprehensive mechanical properties are strongly desired,but it has long been a challenge to achieve high ductility in high-strength materials.Here,we proposed a new V 0.5 Cr 0.5 CoNi medium-entropy alloy(MEA)with a face-centered cubic/hexagonal close-packed(FCC/HCP)dual-phase ultrafine-grained(UFG)architecture containing stacking faults(SFs)and local chemical order(LCO)in HCP solid solution,to obtain an ultrahigh yield strength of 1476 MPa and uniform elongation of 13.2%at ambient temperature.The ultrahigh yield strength originates mainly from fine grain strength-ening of the UFG FCC matrix and HCP second-phase strengthening assisted by the SFs and LCO inside,whereas the large ductility correlates to the superior ability of the UFG FCC matrix to storage disloca-tions and the function of deformation-induced SFs in the vicinity of the FCC/HCP boundary to eliminate the stress concentration.This work provides new guidance by engineering novel composition and stable UFG structure for upgrading the mechanical properties of metallic materials. | Zhen Chen Hongbo Xie Haile Yan Xueyong Pang Yuhui Wang Guilin Wu Lijun Zhang Hu Tang Bo Gao Bo Yang Yanzhong Tian Huiyang Gou Gaowu Qin | 2022 | Journal of Materials Science & Technology2022，，31： | 1 |
| 15 | Preparation of cinnamic hydroxamic acid collector and study on flotation characteristics and mechanism of scheelite显示文摘In this paper,using methyl cinnamate as raw material,the new cinnamic hydroxamic acid collector(CIHA)was synthesized by the hydroxylamine method.The collector performance of hydroxamic acid was investigated for scheelite and gangue calcite,and the flotation separation test of scheelite and calcite was carried out with CIHA as the collector.The interaction mechanism between hydroxamic acid and scheelite minerals has also been investigated through zeta potential,Fourier transform infrared spectroscopy(FTIR)experiments,X-ray photoelectron spectroscopy(XPS)experiments,and density functional theory(DFT)calculation.The single mineral flotation test and artificially mixed ore showed that CIHA had an excellent collection effect and selectivity.Zeta potential,FTIR,and XPS showed that CIHA was adsorbed on the scheelite surface by strong chemical adsorption.The active group of CIHA was analyzed through quantum chemical calculation.It was speculated that C=O and N-O bonds could synthesize a five-membered chelated hydroxamic acid group with Ca element chelate on scheelite surface,changing hydrophobicity and making it more likely to emerge from the pulp. | Xiang Yao Xinyang Yu Liping Wang Yuhui Zeng Linghan Mao Shanming Liu Honghui Xie Guichun He Zhiqiang Huang Zhilin Liu | 2023 | International Journal of Mining Science and Technology2023，33，6： | 1 |
| 16 | Boosting fire safety and mechanical performance of thermoplastic polyurethane by the face-to-face two-dimensional phosphorene/MXene architecture显示文摘Black phosphorus(BP), as one of the most promising fillers for flame retarding polymer, has been seriously limited in practical application, due to the agglomeration and poor structural stability challenges.Here, the BP was modified by MXene and polydopamine(PDA) via ultrasonication and dopamine modification strategy to improve the structural stability and dispersibility in the matrix. Then, the obtained(BP-MXene@PDA) nanohybrid was employed to promote the mechanical performance, thermal stability,and flame retardancy of thermoplastic polyurethane elastomer(TPU). The resultant TPU composite containing 2 wt.% of BP1-MXene2@PDA showed a 19.2% improvement in the tensile strength and a 13.8%increase in the elongation at break compared to those of the pure TPU. The thermogravimetric analysis suggested that BP-MXene@PDA clearly enhances the thermal stability of TPU composites. Furthermore,the introduction of the BP-MXene@PDA nanohybrids could considerably improve the flame retardancy of TPU composite, i.e., 64.2% and 27.3% decrease in peak heat release rate and total heat release, respectively. The flame-retardant mechanisms of TPU/BP-MXene@PDA in the gas phase and condensed phase were investigated systematically. This work provides a novel strategy to simultaneously enhance the fire safety and mechanical properties of TPU, thus expanding its industrial applications. | Yong Luo Yuhui Xie Wei Geng Junhan Chu Hua Wu Delong Xie Xinxin Sheng Yi Mei | 2022 | Journal of Materials Science & Technology2022，，34： | 1 |
| 17 | Effect of slow-release iron fertilizer on iron-deficiency chlorosis, yield and quality of Lilium davidii var.unicolor in a two-year field experiment显示文摘Iron deficiency chlorosis of Lilium davidii var. unicolor is often the case in practice in alkaline soils of northwest region of China. It is difficult to control iron chlorosis because of high cost and short effective work time of conventional iron fertilizers. In this study, a 2-year field experiment was conducted to evaluate the effects of two slow-release fertilizers on the suppression of iron deficiency chlorosis, soil chemical properties, and the yield and quality of L. davidii var. unicolor. Results show that both coated slow-release iron fertilizers and embedded slow-release iron fertilizer effectively controlled iron-deficiency chlorosis. The application of slow-release iron fertilizers significantly increased plant height and chlorophyll content of L. davidii var. unicolor at different growth stages. Furthermore, coated iron fertilizer application significantly increased starch, protein, soluble sugar and vitamin C content of L. davidii var. unicolor, and it also significantly improved total amino acid content, with increases in essential amino acids(Trp, Leu, Lys, Phe, Val, and Thr contents) and in nonessential amino acids(Asp, Glu, Cit, Ihs, Acc, Ala, Pro, and Cys contents). It was concluded that application of coated slow-release iron fertilizer could be a promising option for suppression of iron deficiency chlorosis and deserves further study. | Yang Qiu ZhongKui Xie XinPing Wang YaJun Wang YuBao Zhang YuHui He WenMei Li WenCong Lv | 2018 | Research in Cold and Arid Regions2018，10，5： | 1 |
| 18 | Leveraging nano-engineered mesenchymal stem cells for intramedullary spinal cord tumor treatment显示文摘Intramedullary spinal cord tumor(IMSCT)is comparatively rare malignant tumor in the central nervous system and is very difficult accessible by conventional chemotherapy regimen.Currently,there are very limited researches for IMSCT treatment using nanomedicine.To fill this gap,we originally reported a targeted strategy by leveraging nano-engineered mesenchymal stem cells(MSCs)for synergistic antiIMSCT treatment.In this study,two mode drugs paclitaxel(PTX)and metformin(MET)were co-loaded in maleimide-modified poly(lactic-co-glycolicacid)(PLGA-MAL)nanoparticles,which were further conjugated onto MSCs surface via the thioether bond formed between PLGA-MAL and MSCs without affecting the migration ability of MSCs.Owing to the excellent tumor tropism and penetrability of MSCs and good biodegradability of PLGA,the designed drug delivery platform could accurately target IMSCT sites to exert long-term synergistic antitumor efficacy,exhibiting promising research value for alternative IMSCT management beyond surgery. | Lu Tang Mengying Xie Jing Li Yijun Mei Yuqi Cao Qiaqia Xiao Haijuan Dong Yuhui Zhang Wei Wang | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
| 19 | The role of autophagy in colitis-associated colorectal cancer显示文摘Autophagy is an evolutionarily conserved catabolic process that eliminates harmful components through lysosomal degradation.In addition to its role in maintaining cellular homeostasis,autophagy is critical to pathological processes,such as inflammation and cancer.Colitis-associated colorectal cancer(CAC)is a specific type of colorectal cancer that develops from long-standing colitis in inflammatory bowel disease(IBD)patients.Accumulating evidence indicates that autophagy of microenvironmental cells plays different but vital roles during tumorigenesis and CAC development.Herein,after summarizing the recent advances in understanding the role of autophagy in regulating the tumor microenvironment during different CAC stages,we draw the following conclusions:autophagy in intestinal epithelial cells inhibits colitis and CAC initiation but promotes CAC progression;autophagy in macrophages inhibits colitis,but its function on CAC is currently unclear;autophagy in neutrophils and cancer-associated fibroblasts(CAFs)promotes both colitis and CAC;autophagy in dendritic cells(DCs)and T cells represses both colitis and CAC;autophagy in natural killer cells(NKs)inhibits colitis,but promotes CAC;and autophagy in endothelial cells plays a controversial role in colitis and CAC.Understanding the role of autophagy in specific compartments of the tumor microenvironment during different stages of CAC may provide insight into malignant transformation,tumor progression,and combination therapy strategies for CAC. | Yuhui Wu Junlin Yao Jiansheng Xie Zhen Liu Yubin Zhou Hongming Pan Weidong Han | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 0 |
| 20 | Neutrophil peptide 1 accelerates the clearance of degenerative axons during Wallerian degeneration by activating macrophages after peripheral nerve crush injury显示文摘Macrophages play an important role in peripheral nerve regeneration,but the specific mechanism of regeneration is still unclear.Our preliminary findings indicated that neutrophil peptide 1 is an innate immune peptide closely involved in peripheral nerve regeneration.However,the mechanism by which neutrophil peptide 1 enhances nerve regeneration remains unclear.This study was designed to investigate the relationship between neutrophil peptide 1 and macrophages in vivo and in vitro in peripheral nerve crush injury.The functions of RAW 264.7 cells we re elucidated by Cell Counting Kit-8 assay,flow cytometry,migration assays,phagocytosis assays,immunohistochemistry and enzyme-linked immunosorbent assay.Axonal debris phagocytosis was observed using the CUBIC(Clear,Unobstructed Brain/Body Imaging Cocktails and Computational analysis)optical clearing technique during Wallerian degeneration.Macrophage inflammatory factor expression in different polarization states was detected using a protein chip.The results showed that neutrophil peptide 1 promoted the prolife ration,migration and phagocytosis of macrophages,and CD206 expression on the surfa ce of macrophages,indicating M2 polarization.The axonal debris clearance rate during Wallerian degeneration was enhanced after neutrophil peptide 1 intervention.Neutrophil peptide 1 also downregulated inflammatory factors interleukin-1α,-6,-12,and tumor necrosis factor-αin invo and in vitro.Thus,the results suggest that neutrophil peptide 1 activates macrophages and accelerates Wallerian degeneration,which may be one mechanism by which neutrophil peptide 1 enhances peripheral nerve regeneration. | Yuhui Kou Yusong Yuan Qicheng Li Wenyong Xie Hailin Xu Na Han | 2024 | Neural Regeneration Research2024，19，8： | 0 |
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