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| 1 | Effects of Bacillus coagulans supplementation on the growth performance and gut health of broiler chickens with Clostridium perfringens-induced necrotic enteritis显示文摘Background: The poultry industry is in need of effective antibiotic alternatives to control outbreaks of necrotic enteritis(NE) due to Clostridium perfringens.Methods: This study was conducted to investigate the effects of feeding Bacil us coagulans on the growth performance and gut health of broiler chickens with C. perfringens-induced NE. Two hundred and forty 1-day-old broiler chicks were randomly assigned to a 2 × 2 factorial arrangement with two dietary B. coagulans levels(0 or 4 × 109 CFU/kg of diet) and two disease chal enge statuses(control or NE chal enged).Results: NE-induced reduction in body weight gain was relieved by the addition of B. coagulans into broiler diets compared with the NE-infected birds. NE infection damaged intestinal morphological structure, promoted intestinal C.perfringens growth and liver invasion, and enhanced anti-C. perfringens specific sI gA concentrations in the gut and specific IgG levels in serum compared with the uninfected birds. NE infection significantly(P < 0.05) decreased mucin-2(at 14 d post-infection(DPI), tol-like receptor 2(TLR2, at 7 and 14 DPI), TLR4(at 7 and 14 DPI), tumor necrosis factor super family15(TNFSF15, at 7 and 14 DPI), lysozyme(LYZ, at 14 DPI) and fowlicidin-2(at 7 and 14 DPI) mR NA levels, whereas it dramatical y(P = 0.001) increased IFN-γ mR NA levels at 7 DPI. However, chal enged birds fed diets supplemented with B.coagulans showed a significant(P < 0.01) decrease in gut lesion scores, decreased C. perfringens numbers in the cecum and liver, and an increase in fowlicidin-2 mR NA levels in compared with the uninfected birds. In addition, compared with the non-supplemented group, dietary inclusion of B. coagulans improved intestinal barrier structure, further increased specific sI gA levels and alkaline phosphatase(IAP) activity in the jejunum, enhanced the expression of jejunum lysozyme mR NA, and inhibited the growth, colonization, and invasion of C. perfringens; in contrast, it reduced serum-specific IgG concentrations and jejunum IFN-γ mR NA levels.Conclusion: These results indicated that dietary B. coagulans supplementation appeared to be effective in preventing the occurrence and reducing the severity of C. perfringens-induced NE in broiler chickens. | Yuanyuan Wu Yujing Shao Bochen Song Wenrui Zhen Zhong Wang Yuming Guo Muhammad Suhaib Shahid Wei Nie | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 31 |
| 2 | Oxidative capacities of size-segregated haze particles in a residential area of Beijing显示文摘The frequent haze days around the Chinese capital of Beijing in recent years have aroused great attention owing to the detrimental efects on visibility and public health. To discover the potential health efects of the haze, oxidative capacities of airborne particles collected in Beijing during haze and clear days were comparably assessed by a plasmid scission assay. Eleven water-soluble trace elements(As, Cd, Cr, Cu, Mn, Ni, Pb, V, Se, Tl, and Zn) in the size-segregated airborne particles were quantitatively analyzed by inductively coupled plasma mass spectrometry, and most of the watersoluble trace elements were found to mainly concentrate in the fine particle size of 0.56–1.0 μm. In comparison with clear days, the mass concentrations of 11 analyzed water-soluble trace elements remarkably increased during haze days, and the oxidative capacities determined by the plasmid scission assay were markedly elevated accordingly during the haze days under the same dosage of particles as for those during clear days. Water-soluble trace elements in airborne particles, such as Cu, V, and particularly Zn, were found to have significantly positive correlations with the plasmid DNA damage rates. Because Cu, V, and Zn have been considered as bioavailable elements, the evident increase of these elements during haze days may be greatly harmful to human health. | Zhenquan Sun Longyi Shao Yujing Mu Ying Hu | 2014 | Journal of Environmental Sciences2014，26，1： | 5 |
| 3 | Feasibility of C_(3)F_(7)CN/CO_(2)gas mixtures in high-voltage DC GIL:a review on recent advances显示文摘With the rise of renewable energy resources,especially offshore wind power plant,the DC transmission concept has attracted more and more attention.The selection of eco-friendly insulating gas,as most critical insulating part of gas-insulated equipment is top priority for developing highly reliable system.Moreover,it is acknowledged that eco-friendly C_(3)F_(7)CN/CO_(2) gas mixtures have become a potential alternative to SF_(6) gas due to its excellent performance.This study reviews the basic physical properties of C_(3)F_(7)CN gas/gas mixtures and insulation properties including the gas gap breakdown and surface flashover performance at DC,as well as lightning impulse voltage.Investigation about the gas stability is presented,including the compatibility of gas with solid materials in gas-insulated transmission line(GIL),and the decomposition characteristics under long-term electrical and thermal stresses.The important progress on the charge accumulation characteristics of gas-solid interface in the novel gas environment under DC voltage stress is analysed.Finally,the key issues that need to be paid attention to and further followed through regarding the application of this novel gas in GIL are summarised and put forward.This study hopefully can provide a complete reference for the development of eco-friendly DC gas insulation equipment with C_(3)F_(7)CN/CO_(2) gas mixtures. | Youping Tu Geng Chen Cong Wang Yuming Shao Yujing Tong Chuanyang Li Guoming Ma Tohid Shahsavarian | 2020 | High Voltage2020，5，4： | 2 |
| 4 | Human cytomegalovirus miR-US5-1 inhibits viral replication by targeting Geminin mRNA显示文摘Viruses commonly create favorable cellular conditions for their survival through multiple mechanisms. Micro RNAs(mi RNAs), which function as post-transcriptional regulators, are utilized by human cytomegalovirus(HCMV) in its infection and pathogenesis. In the present study, the DNA replication inhibitor Geminin(GMNN) was identified to be a direct target of hcmv-mi R-US5-1. Overexpression of hcmv-mi R-US5-1 could block the accumulation of GMNN during HCMV infection, and the decrease of GMNN expression caused by hcmv-mi R-US5-1 or GMNN specific si RNA reduced HCMV DNA copies in U373 cells. Meanwhile, ectopic expression of hcmv-mi R-US5-1 and consequent lower expression of GMNN influenced host cell cycle and proliferation. These results imply that hcmv-mi R-US5-1 may affect viral replication and host cellular environment by regulating expression kinetics of GMNN during HCMV infection. | Shujuan Jiang Yujing Huang Ying Qi Rong He Zhongyang Liu Yanping Ma Xin Guo Yaozhong Shao Zhengrong Sun Qiang Ruan | 2017 | Virologica Sinica2017，32，5： | 1 |
| 5 | Pretreatment with probiotics Enterococcus faecium NCIMB 11181 attenuated Salmonella Typhimurium-induced gut injury through modulating intestinal microbiome and immune responses with barrier function in broiler chickens显示文摘Background:Preventing Salmonella infection and colonization in young birds is key to improving poultry gut health and reducing Salmonella contamination of poultry products and decreasing salmonellosis for human consumption(poultry meat and eggs).Probiotics can improve poultry health.The present study was conducted to investigate the impact of a probiotics,Enterococcus faecium NCIMB 11181(E.faecium NCIMB 11181)on the intestinal mucosal immune responses,microbiome and barrier function in the presence or absence of Salmonella Typhimurium(S.Typh-imurium,ST)infection.Methods:Two hundred and forty 1-day-old Salmonella-free male broiler chickens(Arbor Acres AA+)were randomly allocated to four groups with 6 replicate cages of 10 birds each.The four experimental groups were follows:(1)nega-tive control(NC),(2)S.Typhimurium,challenged positive control(PC),(3)the E.faecium NCIMB 11181-treated group(EF),(4)the E.faecium NCIMB 11181-treated and S.Typhimurium-challenged group(PEF).Results:Results indicated that,although continuous feeding E.faecium NCIMB 11181 did not obviously alleviate growth depression caused by S.Typhimurium challenge(P>0.05),E.faecium NCIMB 11181 addition significantly blocked Salmonella intestinal colonization and translocation(P<0.05).Moreover,supplemental E.faecium NCIMB 11181 to the infected chickens remarkably attenuated gut morphological structure damage and intestinal cell apoptosis induced by S.Typhimurium infection,as evidenced by increasing gut villous height and reducing intes-tinal TUNEL-positive cell numbers(P<0.05).Also,E.faecium NCIMB 11181 administration notably promoting the production of anti-Salmonella antibodies in intestinal mucosa and serum of the infected birds(P<0.05).Addition-ally,16S rRNA sequencing analysis revealed that E.faecium NCIMB 11181 supplementation ameliorated S.Typhimu-rium infection-induced gut microbial dysbiosis by enriching Lachnospiracease and Alistipes levels,and suppressing Barnesiella abundance.Predicted function analysis indicated that the functional genes of cecal microbiome involved in C5-branched dibasic acid metabolism;valine,leucine and isoleucine biosynthesis;glycerolipid metabolism and lysine biosynthesis were enriched in the infected chickens given E.faecium NCIMB 11181.While alanine,asparate and glutamate metabolism;MAPK signal pathway-yeast;ubiquine and other terpenoid-quinore biosynthesis,protein processing in endoplasmic reticulum;as well as glutathione metabolism were suppressed by E.faecium NCIMB 11181 addition.Conclusion:Collectively,our data suggested that dietary E.faecium NCIBM 11181 supplementation could ameliorate S.Typhimurium infection-induced gut injury in broiler chickens.Our findings also suggest that E.faecium NCIMB 11181 may serve as an effective non-antibiotic feed additive for improving gut health and controlling Salmonella infection in broiler chickens. | Yujing Shao Wenrui Zhen Fangshen Guo Zeqiong Hu Kaichen Zhang Linhua Kong Yuming Guo Zhong Wang | 2023 | Journal of Animal Science and Biotechnology2023，14，2： | 1 |
| 6 | Efficient catalytic hydrogen generation by intermetallic platinum-lead nanostructures with highly tunable porous feature显示文摘The water-gas shift(WGS) reaction is an essential industrial reaction for upgrading hydrogen(H2) by removing carbon monoxide(CO), while highly efficient platinum(Pt)-based catalysts for WGS with simultaneously high activity and stability are still yet to be developed due to the poisoning issue during the reaction. Herein, we report on the porous PtPb peanut nanocrystals(porous PtPb PNCs) and porous PtPb octahedron nanocrystals(porous PtPb ONCs) with controllable ratios of Pt/Pb as extremely active and stable catalysts towards WGS reaction. It exhibits the composition-dependent activity with porous PtPb PNCs-40/ZnO being the most active for WGS to H_2, 16.9 times higher than that of the commercial Pt/C. The porous PtPb PNCs-40/ZnO also display outstanding durability with barely activity decay and negligible structure and composition changes after ten successive reaction cycles. X-ray photoelectron spectroscopy(XPS) results reveal that the suitable binding energy of Pt 4f_(7/2) and the high ratio of Pt(0)to Pt(II) in porous PtPb PNCs/ZnO and porous PtPb ONCs/ZnO are crucial for the enhanced WGS activity.The CO stripping results indicate the optimized CO adsorption strength on the Pt surface ensure the excellent WGS activity and the outstanding durability. The present work demonstrates an important advance in tuning the porous metal nanomaterials as highly efficient and durable catalysts for catalysis,energy conversion and beyond. | Bin E Lingzheng Bu Qi Shao Yujing Li Xiaoqing Huang | 2019 | Science Bulletin2019，64，1： | 1 |
| 7 | A com- parison study on airborne particles during haze days and non- haze days in Beijing 显示文摘 | Zhenquan Sun Yujing Mu Yanju Liu Longyi Shao | 2013 | Science of the Total Envi- ronment2013，1，08： | 1 |
| 8 | Facile spray-drying/pyrolysis synthesis of core–shell structure graphite/silicon-porous carbon composite as a superior anode for Li-ion batteries显示文摘 | Min Li Xianhua Hou Yujing Sha Jie Wang Shejun Hu Xiang Liu Zongping Shao | 2014 | Journal of Power Sources2014，，： | 1 |
| 9 | A comparison study on airborne particles during haze days and non-haze days in Beijing显示文摘 | Zhenquan Sun Yujing Mu Yanju Liu Longyi Shao | 2013 | Science of the Total Environment2013，，： | 1 |
| 10 | Enhancing catalytic H2 generation by surface electronic tuning of systematically controlled Pt-Pb nanocrystals显示文摘Although many previous studies have show n that the shape-c ontrol of nano crystal(NCs)is an efficient strategy to improve the catalytic performance,these syntheses were conducted under very different conditions,which are not suitable for the shape-dependent properties studies as well as catalysis optimization.Herein,we demonstrate an effective method for the selective synthesis of well-defined PtPb NCs in a highly con trollable mariner.Four disti net PtPb NCs,n amely PtPb pea nut nano crystals,PtPb hexag onal nan opiates,PtPb octahedra nano crystals(ONCs)and PtPb nan oparticles have been selectively prepared in the prese nee of differe nt phe nols.Sign ifica ntly,we found that the created PtPb NCs/C shows the shape-dependent activity with the optimized PtPb ONCs/C being the most active for the ethanol reforming to H2,22.4 times higher than the commercial Pt/C.The high performance of PtPb ONCs/C has been also successfully expanded into other polyhydric alcohols reformings.X-ray photoelectron spectroscopy(XPS)reveals that the high Pt(O)/Pt(ll)ratio in PtPb NCs/C enhances the alcohols reforming.The density functional theory(DFT)studies show the PtPb ONCs possess the highest surface averaged electronic occu patio n for unit Pt-atom,matchi ng well with XPS results.The PtPb ONCs/C also displays excelle nt durability with limited activity decay and negligible structure/composition changes after ten cycles.This work demonstrates an important advance in the high-level control of metallic nanostructures to tune the catalytic activities. | Bin E Bolong Huang Nan Zhang Qi Shao Yujing Li Xiaoqing Huang | 2019 | Nano Research2019，12，9： | 1 |
| 11 | Co-thermal in-situ reduction of inorganic carbonates to reduce carbon-dioxide emission显示文摘Thermal decomposition of inorganic metal carbonates is the main path to prepare metal oxides;nonetheless,it is always accompanied by the emission of large amounts of CO_(2) as one of the gas products.This study reports a concept of co-thermal insitu reduction of inorganic carbonates by using the energy released by carbonate decomposition under pure hydrogen atmosphere,which reduces the decarboxylation temperature and significantly inhibits the CO_(2) emissions.A combination of hydrogen–deuterium exchange,isotope experiment,and density functional theory calculations demonstrates that the CO results from the selective cleavage of Ca–O bonds at the surface of CaCO_(3) via the direct hydrogenation mechanism at relatively low temperature.However,it undergoes the reverse water–gas shift reaction path at high temperature,i.e.,CO being produced by the reduction of CO_(2) released by the decomposition of carbonates.This study sheds light on the potential of green hydrogen technology for inorganic carbonate valorization toward high value-added products,which can facilitate the large-scale industrial applications. | Zhen Xue Jingyi Guo Shasha Wu Wenfu Xie Yujing Fu Xiaojie Zhao Kui Fan Ming Xu Hong Yan Mingfei Shao Xue Duan | 2023 | Science China Chemistry2023，66，4： | 0 |
| 12 | 3D amorphous carbon and graphene co-modified LiFePO_4 composite derived from polyol process as electrode for high power lithium-ion batteries显示文摘Amorphous carbon and graphene co-modified LiFePO_4 nanocomposite has been synthesized via a facile polyol process in connection with a following thermal treatment.Various characterization techniques,including XRD.Mossbauer spectra,Raman spectra,SEM,TEM,BET,O_2-TPO,galvano charge-discharge,CV and EIS were applied to investigate the phase composition,carbon content,morphological structure and electrochemical performance of the synthesized samples.The effect of introducing way of carbon sources on the properties and performance of LiFePO_4/C/graphene composite was paid special attention.Under optimized synthetic conditions,highly crystalized olivine-type LiFePO_4was successfully obtained with electron conductive Fe_2P and FeP as the main impurity phases.SEM and TEM analyses demonstrated the graphene sheets were randomly distributed inside the sample to create an open structured LiFePO_4 with respect to graphene,while the glucosederived carbon mainly coated over LiFeP04 particles which effectively connected the graphene sheets and LiFePO_4 particles to result in a more efficient charge transfer process.As a result,favorable electrochemical performance was achieved.The performance of the amorphous carbon-graphene co-modified LiFePO_4 was further progressively improved upon cycling in the first 200 cycles to reach a reversible specificcapacity as high as 97 mAh·g^(-1) at 10 C rate. | Guan Wu Ran Ran Bote Zhao Yujing Sha Chao Su Yingke Zhou Zongping Shao | 2014 | Journal of Energy Chemistry2014，23，3： | 0 |
| 13 | Efficient light-driven reductive amination of furfural to furfurylamine over ruthenium-cluster catalyst显示文摘Selective reductive amination of carbonyl compounds with high activity is very essential for the chemical and pharmaceutical industry,but scarcely successful paradigm was reported via efficient photocatalytic reactions.Herein,the ultrasmall Ru nanoclusters(~0.9 nm)were successfully fabricated over P25 support with positive charged Ru^(δ+)species at the interface.A new route was developed to achieve the furfural(FAL)to furfurylamine(FAM)by coupling the light-driven reductive amination and hydrogen transfer of ethanol over this type catalyst.Strikingly,the photocatalytic activity and selectivity are strongly dependent on the particle size and electronic structure of Ruthenium.The Ru^(δ+)species at the interface promote the formation of active imine intermediates;moreover,the Ru nanoclusters facilitate the separation efficiency of electrons and holes as well as accelerate the further hydrogenation of imine intermediates to product primary amines.In contrast Ru particles in larger nanometer size facilitate the formation of the furfuryl alcohol and excessive hydrogenation products.In addition,the coupling byproducts can be effectively inhibited via the construction of sub-nanocluster.This study offers a new path to produce the primary amines from biomass-derived carbonyl compounds over hybrid semiconductor/metal-clusters photocatalyst via light-driven tandem catalytic process. | Zhen Xue Shasha Wu Yujing Fu Lan Luo Min Li Zhenhua Li Mingfei Shao Lirong Zheng Ming Xu Haohong Duan | 2023 | Journal of Energy Chemistry2023，，1： | 0 |
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