Effects of Bacillus coagulans supplementation on the growth performance and gut health of broiler chickens with Clostridium perfringens-induced necrotic enteritis

查看全文 作　　者：Yuanyuan [1]Wu;Yujing [2]Shao;Bochen [1]Song;Wenrui [1]Zhen;Zhong [1]Wang;Yuming [1]Guo;Muhammad Suhaib [1]Shahid;Wei [1]Nie

机构地区：[1]State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University;[2]College of Biology,China Agricultural University

出　　处：《Journal of Animal Science and Biotechnology》索引2018年第9卷第2期,共14页

基　　金：The National Special Fund for Agro-Scientific Research in the Public Interest(20140304–07);the National Broiler Industry Technology Project(No.31072049)supported this study 摘　　要：Background: The poultry industry is in need of effective antibiotic alternatives to control outbreaks of necrotic enteritis(NE) due to Clostridium perfringens.Methods: This study was conducted to investigate the effects of feeding Bacil us coagulans on the growth performance and gut health of broiler chickens with C. perfringens-induced NE. Two hundred and forty 1-day-old broiler chicks were randomly assigned to a 2 × 2 factorial arrangement with two dietary B. coagulans levels(0 or 4 × 109 CFU/kg of diet) and two disease chal enge statuses(control or NE chal enged).Results: NE-induced reduction in body weight gain was relieved by the addition of B. coagulans into broiler diets compared with the NE-infected birds. NE infection damaged intestinal morphological structure, promoted intestinal C.perfringens growth and liver invasion, and enhanced anti-C. perfringens specific sI gA concentrations in the gut and specific IgG levels in serum compared with the uninfected birds. NE infection significantly(P < 0.05) decreased mucin-2(at 14 d post-infection(DPI), tol-like receptor 2(TLR2, at 7 and 14 DPI), TLR4(at 7 and 14 DPI), tumor necrosis factor super family15(TNFSF15, at 7 and 14 DPI), lysozyme(LYZ, at 14 DPI) and fowlicidin-2(at 7 and 14 DPI) mR NA levels, whereas it dramatical y(P = 0.001) increased IFN-γ mR NA levels at 7 DPI. However, chal enged birds fed diets supplemented with B.coagulans showed a significant(P < 0.01) decrease in gut lesion scores, decreased C. perfringens numbers in the cecum and liver, and an increase in fowlicidin-2 mR NA levels in compared with the uninfected birds. In addition, compared with the non-supplemented group, dietary inclusion of B. coagulans improved intestinal barrier structure, further increased specific sI gA levels and alkaline phosphatase(IAP) activity in the jejunum, enhanced the expression of jejunum lysozyme mR NA, and inhibited the growth, colonization, and invasion of C. perfringens; in contrast, it reduced serum-specific IgG concentrations and jejunum IFN-γ mR NA levels.Conclusion: These results indicated that dietary B. coagulans supplementation appeared to be effective in preventing the occurrence and reducing the severity of C. perfringens-induced NE in broiler chickens. 关键词：BACILLUS coagulans BROILER CHICKENS CLOSTRIDIUM perfringens GUT HEALTH

相关文献

参考文献（69）
引证文献（39）
耦合文献（11）

参考文献(69)

引证文献(39)

耦合文献(11)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Effects of Bacillus coagulans supplementation on the growth performance and gut health of broiler chickens with Clostridium perfringens-induced necrotic enteritis

参考文献(69)

引证文献(39)

耦合文献(11)

用户提示