|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Geochronology of Baogutu porphyry copper deposit in Western Junggar area, Xinjiang of China显示文摘Baogutu copper deposit in Western Junggar area is a mesoscopic porphyry deposit found in recent years. Study on its geochronology will help further understand ore genesis and regional ore-forming pattern. A series of small quartz-diorite and granodiorite stocks outcrop at Baogutu area, numbered I―X according to their size. A detailed exploration on Number V stock confirmed it as a mesoscopic scale copper deposit, and various exploration work has been carried out on other stocks with ore-forming evidence. This paper studies geochronology of Number V stock using zircon SHRIMP U-Pb and single mineral K-Ar method. Twenty-five SHRIMP ages yield two 206Pb/238U weighed mean ages of 335.6 ± 7.8 Ma and 311.4 ± 3.3 Ma respectively. The older date is considered to be inherited zircon from either surrounding rock tuff or deep granitoid batholith, whereas the younger date is the formation age of ore-bearing intrusion. K-Ar ages of ore-forming biotites, 296.0 ± 3.7 Ma and 297.3 ± 3.8 Ma, in combination with Re-Os age of molybdenite, 310 Ma, confirm the ore-forming age of 310-296 Ma. Granophyre and dioritic porphyrite dikes cut Number V stock and their K-Ar ages range from 278 to 240 Ma, which confine the lower boundary of the mineralization. The framework of Baogutu ore-forming geochrono-logy can be established based on these data. | LIU YuLin GUO LiShuang LIU YuDe SONG HuiXia SONG Biao ZHANG Rui XU FaJun ZHANG YunXiao | 2009 | Science China Earth Sciences2009，52，10： | 33 |
| 2 | Distribution characteristic and geological signiflcance of rare earth elements in Lopingian mudstone of Permian,Panxian county,Guizhou province显示文摘In order to discuss the geochemical characteristic of REEs(rare earth elements) and their geological application,we measured the contents of rare earth elements,trace elements and minerals of 29 Lopingian(Late Permian) mudstone samples in Panxian county,carrying out ICP-MS and XRD analysis.The results show that the amount of REEs(185.56-729.46 10à6) is high.The ratios of w(LREE)/w(HREE)(6.84-13.86) and w(La)N/w(Yb)N(1.01-3.02) show clear differentiation of LREEs and HREEs.RREE has a significantly or critically positive correlation with lithophile elements Th,Nb,Ta,Ti,Ga,Sc,Cs,Zr,Hf,Sr,Be and chalcophile element Zn,a critically negative correlation with siderophile element Fe and a slightly positive correlation with illite,illite smectite mixed layers and siderite.REEs originate mainly from terrigenous minerals,in an inorganic phase.Source rocks of our samples consist of Emeishan basalt and a small part of sedimentary rocks,as suggested by the distribution patterns of REEs and w(PREE)-w(La)/w(Yb) diagram.Moreover,abnormal surfaces near the sequence boundaries(SB2,SB3,SB4) are related with the boundaries,identifled by geochemical characteristics of the REEs,such as PREE,w(LREE)/w(HREE),Eu/Eu and Ceanom. | Shao Yubao Guo Yinghai Qin Yong Shen Yulin Tian Li | 2011 | Mining Science and Technology2011，21，4： | 23 |
| 3 | Biofunctional magnesium coated Ti6Al4V scaffold enhances osteogenesis and angiogenesis in vitro and in vivo for orthopedic application显示文摘The insufficient osteogenesis and osseointegration of porous titanium based scaffold limit its further application.Early angiogenesis is important for scaffold survival.It is necessary to develop a multifunctional surface on titanium scaffold with both osteogenic and angiogenic properties.In this study,a biofunctional magnesium coating is deposited on porous Ti6Al4V scaffold.For osseointegration and osteogenesis analysis,in vitro studies reveal that magnesium-coated Ti6Al4V co-culture with MC3T3-E1 cells can improve cell proliferation,adhesion,extracellular matrix(ECM)mineralization and ALP activity compared with bare Ti6Al4V cocultivation.Additionally,MC3T3-E1 cells cultured with magnesium-coated Ti6Al4V show significantly higher osteogenesisrelated genes expression.In vivo studies including fluorochrome labeling,micro-computerized tomography and histological examination of magnesium-coated Ti6Al4V scaffold reveal that new bone regeneration is significantly increased in rabbits after implantation.For angiogenesis studies,magnesium-coated Ti6Al4V improve HUVECs proliferation,adhesion,tube formation,wound-healing and Transwell abilities.HUVECs cultured with magnesium-coated Ti6Al4V display significantly higher angiogenesis-related genes(HIF-1αand VEGF)expression.Microangiography analysis reveal that magnesium-coated Ti6Al4V scaffold can significantly enhance the blood vessel formation.This study enlarges the application scope of magnesium and provides an optional choice to the conventional porous Ti6Al4V scaffold with enhanced osteogenesis and angiogenesis for further orthopedic applications. | Peng Gao Bo Fan Xiaoming Yu Wenwen Liu Jie Wu Lei Shi Di Yang Lili Tan Peng Wan Yulin Hao Shujun Li Wentao Hou Ke Yang Xiaokang Li Zheng Guo | 2020 | Bioactive Materials2020，5，3： | 15 |
| 4 | Progress and records in the study of endogenetic mineralization during collisional orogenesis显示文摘To develop and perfect the theory of plate tectonics and regional metallogeny, metal-logenesis during collisional orogenesis should be thoroughly studied and will attract increasing at-tention of more and more scientists. This paper presents the main aspects of research and discus-sions on metallogenesis during collisional orogenesis after the development of plate tectonics, and accordingly divides the study history into two stages, i.e. the junior stage during 1971-1990 and the senior stage after 1990. Beginning with the negation of mineralization in the collision regime by Guild (1971), the focus of study was put on whether there occurred any mineralization during collisional orogenesis at the junior stage. At the senior stage, which is initiated by the advance of met-allogenic and petrogenic model for collisional orogenesis, scientists begin to pay their attention to the geodynamic mechanism of metallogenesis, spatial and temporal distribution of ore deposits, ore-forming fluidization, relationship | Yanjing Chen Huayong Chen Yulin Liu Guangjun Guo Yong Lai Shan Qin Baoling Huang Zengjie Zheng Yinghui Sui Chao Li et al. | 2000 | Chinese Science Bulletin2000，45，1： | 13 |
| 5 | Distribution of ground stress on Puhe Coal Mine显示文摘Puhe Coal Mine is a typical Tertiary coal in Shenbei mining area. With an increase in mining depth, tectonic stress field becomes more complex, leading to increased deformation and failure of the soft rock roadway. Stress becomes an important factor of mine safety and stability. This paper analyzes the distribution of the regional tectonic field, and determines the distribution of situ stress measurement through measuring the ground stress field in the main mining area level of Puhe Coal Mine using stress relief method. The acquired in situ stress data at different locations and depths provide a reference for the rational arrangement of the stop and mine roadway supporting design, which are of great significance for the efficient safety production of the mine. | Guo Zhibiao Jiang Yulin Pang Jiewen Liu Jiawei | 2013 | International Journal of Mining Science and Technology2013，23，1： | 10 |
| 6 | Impending HRT wave precursors to the Wenchuan M_s8.0 earthquake and methods of earthquake impending prediction by using HRT wave显示文摘We deployed four geo-electric monitoring stations in Sichuan and Yunnan provinces from 2004, using the new generation of equipment (PS-100) and technologies to capture the HRT wave earthquake precursor. Before the Wenchuan Ms8.0 earthquake, we recorded the HRT wave precursor at the only operating station in Hongge (HG, Δ=465 km) and found that significant impending signal had been recorded at the station in the early morning ( 0―5 am) of 12th of May, 2008. The precursor for this earthquake is consistent with precursors recorded for other strong earthquakes. The measured physical properties (geo-resistivity and telluric-current) show tidal wave period oscillations from several days to several months before the earthquakes and the amplitude of such HT oscillation increases significantly towards the occurrence of an earthquake. These HT and RT waves from the epicenter have a causal relationship with the earthquakes that happened several days later. The arrival time of two RT waves is proportional to the distance from the station to the epicenter. The estimated natural decay of the amplitude is correlated with the natural period (T0) of the earthquake fault, which is proportional to the fault length. From this relationship, we can predict the earthquake magnitude. For magnitude 6―9 earthquakes, the natural period is about 1―6 hours. Such oscillation comes from the epicenter area and they can propagate several thousand kilometers in the Earth's crust. Before a strong earthquake in the shallow crust, the conductive pore fluid will experience major changes before the fault rapture. Such fluid change will emit an oscillation in the pore fluid pressure. This is the mechanism for the HRT wave generation. Since the China Earthquake Administration funded the HRT wave short-term earth-quake prediction project in 2003, the first record of HRT precursor wave has been recorded from the 2004-12-26 Sumatra Mw9.0 earthquake with the largest epicentre distance Δ=2900 km. Thereafter, we have captured HRT waves from more than twenty strong earthquakes, which are well-matched and show repeatability, consistency and regularity. All our observation with the HRT waves demonstrate that HRT wave precursors to earthquakes indeed exist. Strong earthquakes can be predicted and short-term and impending earthquake prediction is achievable in the very near future. From all the observations, including the ones at HG station from Wenchuan Ms8.0 earthquake, we conclude that using HRT wave to predict earthquakes is feasible. | QIAN FuYe ZHAO BiRu QIAN Wei ZHAO Jian HE ShiGen ZHANG HongKui LI ShiYu LI ShaoKun YAN GuLiang WANG ChengMin SUN ZhenKai ZHANG DongNing LU Jun ZHANG Ping YANG GuoJun SUN JiaLin GUO ChunSheng TANG YuXiong XU JianMing XIA KunTao JU Hang YIN BangHong LI Ming YANG DongSheng QI WeiLuo HE TaiMing GUAN HuaPing ZHAO YuLin | 2009 | Science China Earth Sciences2009，52，10： | 8 |
| 7 | Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression显示文摘OBJECTIVE: To investigate the effects of Sini San and fluoxetine on the levels of central and peripheral 5-HT in a rat model of depression, and provide new insight into the treatment of depression with integrated Chinese-Western Medicine.METHODS: A rat model of depression was established by chronic mild stress(CMS). Model rats received either Sini San, fluoxetine, a combination of the two drugs, or no drug treatment. Healthy naive rats were used as controls. Open field and sucrose preference tests were used to assess depression-like behavior. ELISA and immunohistochemistry were used to determine central and peripheral levels of 5-HT.RESULTS: In the group with no drug treatment,central 5-HT expression decreased while peripheral5-HT concentrations increased as CMS continued.Four weeks after CMS, Sini San alone was less effective in reducing depression-like behavior than fluoxetine alone or in combination with Sini San,but combined use was more effective than fluoxetine alone. Eight weeks after CMS, Sini San alone or in combination with fluoxetine was more effective in reducing depression-like behavior than fluoxetine alone. Furthermore Sini San and fluoxetine used alone or in combination notably increased central 5-HT expression and decreased peripheral 5-HT levels in the rat model.CONCLUSION:The results of the present study indicate that there is a synergistic action between the two medicines in the treatment of depression. Sini San exhibited a relatively long lag before its effects were observed; however, by eight weeks the Traditional Chinese Medicine appeared at least as effective as fluoxetine. We suggest that Sini San can replace fluoxetine in the later stages of depression treatment to minimize side effects observed with long-term fluoxetine administration. | Yubo Li Yuxiu Sun Xueling Ma Xiaoxing Xue Wenting Zhang Zhiqian Wu Yulin Ouyang Jianxin Chen Weiming Wang Shuzhen Guo Wei Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 6 |
| 8 | Correlation and analysis of well-log sequence with Milankovitch cycles as rulers: A case study of coal-bearing strata of late Permian in western Guizhou显示文摘Based on the well-logging data of typical wells of Zhijin,Panxian and Weining areas in western Guizhou,the well-logging data GR of late Permian coal-bearing strata were processed and wavelet transform technique was used to carry out the sequence stratigraphy division and correlation.The study mainly focuses on the controlling effects which Milankovitch had on high frequency sequence,Milankovitch cycle can be used as a ruler of sequence stratigraphy division and correlation to ensure the scientifcity and the unity of sequence stratigraphy division.According to well-logging signal of the ideal Milankovitch cycle,the corresponding relation between the wavelet scales and the cycles is determined by wavelet analysis.Through analyzing analog signals of subsequence sets to search the corresponding relation between various system tracts and the features of time-frequency,the internal features of wavelet transform scalogram could be made clearly.According to ideal model research,features of Milankovitch curves and wavelet spectrum can be seen clearly and each well can be classifed into four third-order sequences and two system tracts.At the same time Milankovitch cycle can realize the division and correlation of stratigraphic sequence in a quick and convenient way. | Yuan Xuexu Guo Yinghai Yu Jifeng Shen Yulin Shao Yubao | 2013 | International Journal of Mining Science and Technology2013，23，4： | 6 |
| 9 | Phosphate recovery with granular acid-activated neutralized red mud:Fixed-bed column performance and breakthrough curve modelling显示文摘Granular acid-activated neutralized red mud(AaN-RM)has been successfully prepared with good chemical stability and physical strength.However,its potential for industrial application remains unknown.Therefore,the performance of granular AaN-RM for phosphate recovery in a fixed-bed column was investigated.The results demonstrated that the phosphate adsorption performance of granular AaN-RM in a fixed-bed column was affected by various operational parameters,such as the bed depth,flow rate,initial solution pH and initial phosphate concentration.With the optimal empty-bed contact time(EBCT)of 24.27 min,the number of processed bed volumes and the phosphate adsorption capacity reached 496.95 and 84.80 mg/g,respectively.Then,the saturated fixed-bed column could be effectively regenerated with a0.5 mol/L HCl solution.The desorption efficiency remained as high as 83.45%with a low weight loss of 3.57%in the fifth regeneration cycle.In addition,breakthrough curve modelling showed that a 5-9-1 feed-forward artificial neural network(ANN)could be effectively applied for the optimization of the fixed-bed adsorption system;the coefficient of determination(R^2)and the root mean square error(RMSE)evaluated on the validation-testing data were 0.9987 and 0.0183,respectively.Therefore,granular AaN-RM fixed-bed adsorption exhibits promising potential for phosphate removal and recovery from polluted water. | Andong Hu Guoping Ren Jiangang Che Yulin Guo Jie Ye Shungui Zhou | 2020 | Journal of Environmental Sciences2020，32，4： | 4 |
| 10 | Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice显示文摘混乱毛细管扩张变异(ATM ) kinase 在 genomic 的维护起一个必要作用稳定性。ATM 缺乏(ATM/) 老鼠展出造血的干细胞(HSC ) 机能障碍和淋巴瘤的高发生。Gadd45a 控制房间周期拘捕, apoptosis 和 DNA 修理,并且涉及 ATM-p53 调停的 DNA 损坏反应。然而,在调整 ATM/ HSC 的功能的 Gadd45a 的角色是未知的。这里,我们报导那 Gadd45a 删除没在 ATM/ 鼠标救 T 房间和 B 房间开发的缺点。相反, ATM 和 Gadd45a 加倍 HSC 展出了的大美人(ATM/Gadd45a/) 在与在 HSC 移植的 ATM/ HSC 相比的长期的自强能力的一个加重的缺点试验。进一步的实验表明 ATM/Gadd45a/ HSC 的加重的缺点由于房间增长的减小,包括 p53-p21 发信号的一条起来规定与 DNA 损坏的累积和 DNA 损坏反应的随后的激活联系了小径。另外, ATM/Gadd45a/ 老鼠比 ATM/ 老鼠显示出造血的恶意,以及转移的增加的率的增加的发生。在结论, Gadd45a 删除加重了 DNA 损坏累积,它随后在 ATM/ HSC 导致了一个进一步损害的自强能力和增加的恶意的转变。 | Yulin Chen Runan Yang Peng Guo Zhenyu Ju | 2014 | Protein & Cell2014，5，1： | 4 |
| 11 | Geochronology and Geochemistry of the Tinggong Porphyry Copper Ore Deposit, Tibet显示文摘We have determined the ages of the ore-bearing Tinggong porphyries and the Eocene granites using the LA-ICPMS zircon U-Pb method. Zircons from one adamellite porphyry and two diorite porphyries yield ages of 15.54±0.28 Ma, 15.02±0.25 Ma and 14.74±0.22 Ma, respectively. The ages of two granites are 50.48±0.71 Ma and 50.16±0.48 Ma. Light Rare Earth Elements(LREE) are enriched in the ore-bearing adamellite porphyries, which are high-K calc-alkaline and metaluminous, while Heavy Rare Earth Elements(HREE) and Y are strongly depleted, indicating an adakitic affinity. The Large Ion Lithophile Elements(LILE) of the adamellite porphyries are highly enriched, whereas some High Field Strength Elements(HFSE) are depleted. The diorite porphyry in this study is chemically similar to the adamellite porphyries, except that the Mg# of the diorite porphyry is a little higher, demonstrating more mantle contamination. Four samples from different rocks are selected for in situ zircon Hf isotopic analyses. The samples show positive εHf(t) values and young Hf model ages, indicating their derivation from juvenile crust. However, the adamellite porphyry and diorite porphyry formed in the Miocene exhibit more heterogeneous Hf isotopic ratios, with lower εHf(t) values than the granites formed in the Eocene, suggesting the involvement of old Indian continent crust in their petrogenesis. The geochronology and geochemistry of the adamellite porphyries and the diorite porphyries indicate that they formed from the same source region in a post-collisional environment, but contaminated by crust and mantle materials in different ratios. The metallic minerals formed mainly during the older adamellite porphyry stage, but they were recycled and reactivated by the diorite porphyry intrusion. | CHEN Rui LIU Yulin GUO Lishuang WANG Zhenghua LIU Hongfei XU Kaifeng ZHANG Jinshu | 2014 | Acta Geologica Sinica(English Edition)2014，88，3： | 4 |
| 12 | Heteroatom-doped porous carbon from methyl orange dye wastewater for oxygen reduction显示文摘Banana peel-derived porous carbon(BPPC) was prepared from banana peel and used as an adsorbent for methyl orange(MO) wastewater removal. BPPC-MO50 is a N,S-doped BPPC obtained via secondary carbonization. The BPPC-MO50 exhibited a high specific surface area of1774.3 m^2/g. Heteroatom-doped porous carbon(PC) was successfully synthesized from the BPPC absorbed MO at high temperature and used for oxygen reduction. The BPPC-MO50 displayed the highest ORR onset potential among all carbon-based electrocatalysts, i.e., 0.93 V vs.reversible hydrogen electrode(RHE). This is the first report to describe porous carbon-activated materials from agriculture and forestry waste that is used for adsorption of dyes from wastewater via an enhanced heteroatom(N,S) content. These results may contribute to the sustainable development of dye wastewater treatment by transforming saturated PC into an effective material and has potential applications in fuel cells or as energy sources. | Yiqing Wang Mingyuan Zhu Yingchun Li Mengjuan Zhang Xueyan Xue Yulin Shi Bin Dai Xuhong Guo Feng Yu | 2018 | Green Energy & Environment2018，3，2： | 4 |
| 13 | Copy number variations of HLA-DRB5 is associated with systemic lupus erythematosus risk in Chinese Han population显示文摘全身的豺狼座 erythematosus (SLE ) 是复合基因,全身的、自体免疫的疾病。拷贝数字变体(CNVS ) 被发现了与很多复杂混乱被联系。我们拿了当前的学习在中国汉人口探索在 genomic CNVS 和 SLE 之间的潜在的协会。在发现阶段,七个 SLE 病人在屏蔽测试与高密度的比较 genomic 杂交 microarrays 被检查因为 SLE 联系了 CNVS。在确认阶段,然后, 135 个 SLE 病人和 219 个匹配的健康题目被 AccuCopy 技术为基因 HLA-DRB5 的 CNVS 调查。量的聚合酶链反应被执行在 SLE 病人决定拷贝数字(CN ) 和 HLA-DRB5 的 mRNA 水平。尽管在在 SLE 病人的 CN 删除组和 CN 正常的组之间的 HLA-DRB5 的 mRNA 水平不是统计上积极的( P = 0.46 ),我们的结果仍然比在健康控制在 SLE 病人显示出 HLA-DRB5 的更多的 CN ( P = 3.98 業慮瑮愠摮爠'酞棙M敶洠摯汥漠?偔?挠摯湯?′敷敲瀠牥潦浲摥?敲灳'虡N敶祬?剏?ㄠ????‥??ㄠ???劳?倠吗?? | Lijun Wu Shicheng Guo Dongqin Yang Yanyun Ma Hengdong Ji Yulin Chen Jun Zhang Yi Wang Li Jin Jiucun Wang Jie Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，2： | 3 |
| 14 | A vacuum ultraviolet laser with a submicrometer spot for spatially resolved photoemission spectroscopy显示文摘Vacuum ultraviolet(VUV)lasers have demonstrated great potential as the light source for various spectroscopies,which,if they can be focused into a small beam spot,will not only allow investigation of mesoscopic materials and structures but also find application in the manufacture of nano-objects with excellent precision.In this work,we report the construction of a 177 nm VUV laser that can achieve a record-small(〜0.76 μm)focal spot at a long focal length(~45 mm)by using a flat lens without spherical aberration.The size of the beam spot of this VUV laser was tested using a metal grating and exfoliated graphene flakes,and we demonstrated its application in a fluorescence spectroscopy study on pure and Tm3+-doped NaYF4 microcrystals,revealing a new emission band that cannot be observed in the traditional up-conversion process.In addition,this laser system would be an ideal light source for spatially and angleresolved photoemission spectroscopy. | Yuanhao Mao Dong Zhao Shen Yan Hongjia Zhang Juan Li Kai Han Xiaojun Xu Chuan Guo Lexian Yang Chaofan Zhang Kun Huang Yulin Chen | 2021 | Light(Science & Applications)2021，10，3： | 3 |
| 15 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 16 | Existence and uniqueness of smooth solution for the system of ferro-magnetic chain显示文摘 | Zhou Yulin Guo Boling Tan Shaobin | 1991 | Science in China1991，，： | 2 |
| 17 | Plant distribution at the mobile dune scale and its relevance to soil properties and topographic features显示文摘 | Xiaoan Zuo Halin Zhao Xueyong Zhao Yirui Guo Yulin Li Yayong Luo | 2008 | Environmental Geology2008，，5： | 2 |
| 18 | The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway显示文摘Polyphyllin I(PPI)and polyphyllin II(PII)are the main active substances in the Paris polyphylla.However,liver toxicity of these compounds has impeded their clinical application and the potential hepatotoxicity mechanisms remain to be elucidated.In this work,we found that PPI and PII exposure could induce significant hepatotoxicity in human liver cell line L-02 and zebrafish in a dose-dependent manner.The results of the proteomic analysis in L-02 cells and transcriptome in zebrafish indicated that the hepatotoxicity of PPI and PII was associated with the cholesterol biosynthetic pathway disorders,which were alleviated by the cholesterol biosynthesis inhibitor lovastatin.Additionally,3-hydroxy-3-methy-lglutaryl CoA reductase(HMGCR)and squalene epoxidase(SQLE),the two rate-limiting enzymes in the cholesterol synthesis,selected as the potential targets,were confirmed by the molecular docking,the overexpression,and knockdown of HMGCR or SQLE with siRNA.Finally,the pull-down and surface plasmon resonance technology revealed that PPI could directly bind with SQLE but not with HMGCR.Collectively,these data demonstrated that PPI-induced hepatotoxicity resulted from the direct binding with SQLE protein and impaired the sterol-regulatory element binding protein 2/HMGCR/SQLE/lanosterol synthase pathways,thus disturbing the cholesterol biosynthesis pathway.The findings of this research can contribute to a better understanding of the key role of SQLE as a potential target in drug-induced hepatotoxicity and provide a therapeutic strategy for the prevention of drug toxic effects with similar structures in the future. | Zhiqi Li Qiqi Fan Meilin Chen Ying Dong Farong Li Mingshuang Wang Yulin Gu Simin Guo Xianwen Ye Jiarui Wu Shengyun Dai Ruichao Lin Chongjun Zhao | 2023 | Journal of Pharmaceutical Analysis2023，13，1： | 2 |
| 19 | Geochemical Characteristics and Sedimentary Control of Pinghu Formation(Eocene)Coal-bearing Source Rocks in Xihu Depression,East China Sea Basin显示文摘Coal-bearing source rocks of the Pinghu Formation in the Xihu Depression comprise an important material basis of oil and gas resources in the East China Sea Basin.Based on drilling core observation results combined with the analysis and test results of macerals,trace/rare earth elements,and rock pyrolysis,the geochemical characteristics and sedimentary control of coal-bearing source rocks formation are discussed in a high-frequency sequence framework.The results indicate that the macerals composition of the coal-bearing source rocks of the Eocene Pinghu Formation in the Xihu Depression is dominated by vitrinite,with low-medium abundance of exinite and almost no inertinite.The coals and carbonaceous mudstones display higher amounts of total organic carbon(TOC)(14.90%-65.10%),S1+S2(39.24-136.52 mg/g),and IH(191-310 HC/g TOC)respectively,as compared to the mudstones.Organic matter is plotted in typeⅢkerogens and partially in typeⅡ;it is mainly in the low maturity stage.The trace elements results imply that the samples were deposited in a weakly reducing to weakly oxidizing environment and were occasionally affected by seawater.The coal-bearing source rocks were deposited in a relatively oxygen-containing environment.The coal-bearing source rocks development is jointly controlled by the coal accumulation environment,the water conditions affected by ocean currents in offshore basins in China,oxidation-reduction cycles of aqueous media and paleoclimate evolution in a high-frequency sequence framework. | SHEN Yulin QIN Yong CUI Min XIE Guoliang GUO Yinghai QU Zhenghui YANG Tianyang YANG Liu | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 2 |
| 20 | Oxygen vacancies enriched nickel cobalt based nanoflower cathodes: Mechanism and application of the enhanced energy storage显示文摘The rational design of oxygen vacancies and electronic microstructures of electrode materials for energy storage devices still remains a challenge. Herein, we synthesize nickel cobalt-based oxides nanoflower arrays assembled with nanowires grown on Ni foam via the hydrothermal process followed annealing process in air and argon atmospheres respectively. It is found that the annealing atmosphere has a vital influence on the oxygen vacancies and electronic microstructures of resulting NiCo_(2)O_(4) (NCO-Air) and CoNiO_(2) (NCO-Ar) products, which NCO-Ar has more oxygen vacancies and larger specific surface area of 163.48 m^(2)/g. The density functional theory calculation reveals that more oxygen vacancies can provide more electrons to adsorb –OH free anions resulting in superior electrochemical energy storage performance. Therefore, the assembled asymmetric supercapacitor of NCO-Ar//active carbon delivers an excellent energy density of 112.52 Wh/kg at a power density of 558.73 W/kg and the fabricated NCO-Ar//Zn battery presents the specific capacity of 180.20 mAh/g and energy density of 308.14 Wh/kg. The experimental measurement and theoretical calculation not only provide a facile strategy to construct flower-like mesoporous architectures with massive oxygen vacancies, but also demonstrate that NCO-Ar is an ideal electrode material for the next generation of energy storage devices. | Jiahui Ye Xingwu Zhai Long Chen Wen Guo Tiantian Gu Yulin Shi Juan Hou Fei Han Yi Liu Changchun Fan Gang Wang Shanglong Peng Xuhong Guo | 2021 | Journal of Energy Chemistry2021，30，11： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员