|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A quantification model of Traditional Chinese Medicine syndromes in children with idiopathic precocious puberty and early puberty显示文摘OBJECTIVE:To establish a quantification model of Traditional Chinese Medicine(TCM)syndromes by sampling patients undergoing idiopathic precocious puberty(IPP)and early puberty.METHODS:A questionnaire for classifying and quantifying TCM syndromes was designed and administered.All the results were analyzed;the relationship between 3 types of syndrome and 47symptoms were summated.Meanwhile,the frequency distribution of each symptom or sign was aggregated.Fuzzy mathematics was used to develop a quantification model ofTCM syndromes.RESULTS:We found that precocious puberty had 3types of syndrome,including hyperactivity of fire due to Yin deficiency(Syndrome I),depressed liver Qi transforming into fire(Syndrome II),and end retention of damp heat(Syndrome III).In the IPP group,Syndrome I was the most common principal syndrome(100%).Forty-six patients(43.81%)werediagnosed with Syndrome I accompanied by Syndrome II and 11(10.48%)were diagnosed with Syndrome I accompanied by Syndrome III.In the early puberty group,Syndrome I was also the main syndrome(98.39%).The degrees of most symptoms were mild to moderate.Reddened tongue was the most common tongue manifestation(62.86%prevalence)in the IPP group.The most common pulse manifestations were slippery pulse,thread pulse,and taut pulse.The Asymptotic Normalization Coefficient(ANC)method was used to quantify the TCM syndromes in 167 cases.Diagnostic accuracy rate reached 91%,comparable to expert diagnosis.CONCLUSION:We find that there are 3 types of syndrome in the IPP group and in the early puberty group.Syndrome I(hyperactivity of fire due to Yin deficiency)is the main syndrome in the two groups.ANC may be an appropriate for quantification model ofTCM syndromes. | Yanyan Lin Yuanyuan Xue Jian Yu Yonghong Wang Wen Sun Yanyan Sun Yumin Shi Yiqun Zhang Hong Hu | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 9 |
| 2 | Regulatory effects of stage-treatment with established Chinese herbal formulas on inflammatory mediators in pediatric asthma显示文摘OBJECTIVE: To explore the regulatory effects of established Chinese herbal formulas on inflammatory mediators released during asthma attacks, and to elucidate the molecular mechanism of Traditional Chinese Medicine in the treatment of asthma. METHODS: Seventy-five asthmatic children were randomly divided into a Chinese medication group(45 cases) and a Western medication control group(30 cases). Patients in the Chinese medication group were treated with a series of established Chinese herbal formulas, whereas the Western medication control group received a leukotriene receptor antagonist and a bronchial relaxant. Real-time PCR was used to determine the mRNA expression levels of interleukin(IL)-4, cysteinyl leukotriene receptor 1(CysLTR1), and interferon(IFN)-γ in peripheral blood mononuclear cells before and after treatment. Enzyme-linked immunosorbent assay was used to measure the peripheral blood levels of IL-4, leukotriene(LTE)-4, and INF-γ before and after treatment. RESULTS: After treatment, the mRNA expression levels of IL-4 and CysLTR1 were down-regulated(P< 0.01) and the mRNA expression levels of IFN-γ were up-regulated(P<0.05) in the Chinese medication and Western medication groups; no significant difference was found between the two groups. In the Chinese medication group, IL-4 blood level was decreased and it was significantly different from that in the Western medication group(P<0.05); there was also a significant increase in IFN-γ blood levels after treatment with Chinese medication(P<0.05). There were no significant differences in LTE-4 blood levels between the two groups before and after treatment(P>0.05). CONCLUSION: Chinese medication has a regulatory effect on leukotriene receptor gene expression and the imbalance of Th1/Th2 immune cells during asthma attacks in pediatric patients. | Suhuan Li Yonghong Wang Yumin Shi JianYu Wen Sun Hong Hu Yiqun Zhang | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 8 |
| 3 | Prescriptions from Traditional Chinese Medicine compared with salbutamol and montelukast for the treatment of pediatric asthma: a randomized controlled trial显示文摘OBJECTIVE: To compare the effects of a series of Traditional Chinese Medicine(TCM) empirical prescriptions with salbutamol and montelukast(SM) in children with asthma.METHODS: A total of 182 children with asthma were randomized into the TCM group(n = 97) or SM group(n = 85). Patients in the TCM group were treated with a series of TCM prescriptions, whereas those in the SM group received salbutamol and montelukast; both groups received their respective treatment for 12 weeks. Asthma control, changes in scores of TCM symptom patterns, and asthma symptom control(SC) scores after treatment were compared between the two groups.RESULTS: A higher percentage of patients in the TCM group had asthma control compared withthose in the SM group(91.67% and 76.83%, respectively, P = 0.006). Scores for abnormal feces(P <0.001), hyperhidrosis(P < 0.001), and tongue appearance(P = 0.001) in the TCM group were significantly better than those in the SM group. However,the total scores of TCM symptom patterns and SC scores did not differ significantly between the two groups(P > 0.05).CONCLUSION: Compared with salbutamol and montelukast, the TCM prescriptions tested were better for symptom control in children with asthma. | Du Hui Wang Yonghong Yu Jian Shi Yumin Li Suhuan Sun Wen Zhang Yiqun Hu Hong | 2017 | Journal of Traditional Chinese Medicine2017，37，4： | 7 |
| 4 | The diagnostic value of apolipoprotein E in malignant pleural effusion associated with non-small cell lung cancer显示文摘 | Yumin Wang Zengqiang Chen Jie Chen Jingye Pan Wenhui Zhang Qinshi Pan Hongyan Ding Xiaomei Lin Xiushu Wen Yangyang Li Qing H. Meng | 2013 | Clinica Chimica Acta2013，，： | 1 |
| 5 | Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells:detected by untargeted metabolomics and stable isotope tracing analysis显示文摘Background:Internal tandem duplications(ITD)within the juxtamembrane domain of FMS-like tyrosine kinase 3(FLT3)represent a poor prognostic indicator in acute myeloid leukemia(AML).Therapeutic benefits of tyrosine kinase inhibitors,such as sorafenib,are limited due to the emergence of drug resistance.While investigations have been con-ducted to improve the understanding of the molecular mechanisms underlying the resistance to this FLT3 inhibitor,a profile of cell functioning at the metabolite level and crosstalk between metabolic pathways has yet to be created.This study aimed to elucidate the alteration of metabolomic profile of leukemia cells resistant to the FLT3 inhibitor.Methods:We established two sorafenib-resistant cell lines carrying FLT3/ITD mutations,namely the murine BaF3/ITD-R and the human MV4-11-R cell lines.We performed a global untargeted metabolomics and stable isotope-labe-ling mass spectrometry analysis to identify the metabolic alterations relevant to the therapeutic resistance.Results:The resistant cells displayed fundamentally rewired metabolic profiles,characterized by a higher demand for glucose,accompanied by a reduction in glucose flux into the pentose phosphate pathway(PPP);and by an increase in oxidative stress,accompanied by an enhanced glutathione synthesis.We demonstrated that the highest scoring network of altered metabolites in resistant cells was related to nucleotide degradation.A stable isotope tracing experiment was performed and the results indicated a decrease in the quantity of glucose entering the PPP in resistant cells.Further experiment suggested that the inhibition of major enzymes in the PPP consist of glucose-6-phosphate dehydrogenase deficiency(G6PD)in the oxidative arm and transketolase(TKT)in the non-oxidative arm.In addition,we observed that chronic treatment with sorafenib resulted in an increased oxidative stress in FLT3/ITD-positive leu-kemia cells,which was accompanied by decreased cell proliferation and an enhanced antioxidant response.Conclusions:Our data regarding comparative metabolomics characterized a distinct metabolic and redox adaptation that may contribute to sorafenib resistance in FLT3/ITD-mutated leukemia cells. | Xin You Weiye Jiang Wenhua Lu Hui Zhang Tiantian Yu Jingyu Tian Shijun Wen Guillermo Garcia-Manero Peng Huang Yumin Hu | 2019 | Cancer Communications2019，39，1： | 1 |
| 6 | The diagnostic value of apolipoprotein E in malignant pleural effusion associated with non-small cell lung cancer显示文摘 | Yumin Wang Zengqiang Chen Jie Chen Jingye Pan Wenhui Zhang Qinshi Pan Hongyan Ding Xiaomei Lin Xiushu Wen Yangyang Li Qing H. Meng | 2013 | Clinica Chimica Acta2013，，： | 1 |
| 7 | Experimental study of antimetastatic function of nm23-h1 gene on high metastatic pulmonary cell line ACC-M显示文摘 | Wen LI Yumin WEN Changmei WANG | 2003 | Journal of Chinese Dental Research2003，3，： | 1 |
| 8 | Fabrication and properties of a porous chitin/chitosan conduit for nerve regeneration显示文摘 | Yumin Yang Xiaosong Gu Renxiang Tan Wen Hu Xiaodong Wang Peiyun Zhang Tianyi Zhang | 2004 | Biotechnology Letters2004，，23： | 1 |
| 9 | 显示文摘 | H Li Wen S H Yumin C | 2013 | Journal of Alloys and Com- pounds2013，569，25： | 1 |
| 10 | Sulfation of Chinese lacquer polysaccharides in different solvents显示文摘 | Jianhong Yang Yumin Du Yan Wen Tianyu Li Ling Hu | 2003 | Carbohydrate Polymers2003，，4： | 1 |
| 11 | SustainableDevelopmen--The Chinese People’s Choice显示文摘Since the Chinese government set out to transform the country’s economic development model, China’s economy has grown healthier, more sustainable and better adapted to fast, long-term growth. | ZHANG SHIFU WEN YUMIN LI ZONGPIN QIU JIANGHONG MA YIWEN SUN PENGHAO WANG YING | 2013 | China Today2013，62，5： | 0 |
| 12 | The Choice Is Sustainable development显示文摘‘China, along with the United States, Europe, India and Japan, will become the five engines of world economic development, forging ahead side by side,' said Justin Yifu Lin, a member of the National Committee of the Chinese People’s Political Consultative Conference (CPPCC) and former Chief Economist of the World Bank. On more than one occasion he expressed confidence that China would | Zhang Shifu Wen Yumin Li zongpin Chou Jianghong Ma Yiwen Sun Penghao Wang Ying | 2013 | Beijing Review2013，56，13： | 0 |
| 13 | Sustainable Development,China’s Choice显示文摘CHINA,the United States,Europe,India and Japan, will become the five engines of world economic development, forging ahead side by side,said Justin Lin Yifu, Member of the National Committee of the Chinese People’s Political Consultative Conference(CPPCC).and former Senior Vice President of the World Bank. Although Lin’s prediction is backed by other global economists,some are predicting China’s impending collapse, Western media has even ranked the hard landing | Zhang Shifu Wen Yumin Li Zongpin Chou Jianghong Ma Yiwen Sun Penghao Wang Ying | 2013 | ChinAfrica2013，5，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员