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| 1 | Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients显示文摘B 房间对再感染在肝炎 B 病毒(HBV ) 和保护的清理起一个重要作用。然而,与长期的 HBV 感染的结果被联系的这些房间的功能的特征仍然保持未知。我们包括地在不同阶段从 CHB 病人调查了外部 B 房间子集的频率,显型,和功能:有免疫力的忍耐(信息技术) ,有免疫力的激活(IA ) ,有免疫力的清理(IC ) ,有 HBsAg seroconversion 的应答者(解决的病人, RP ) ,并且健康控制(HC ) 。IA 病人与另外的组相比显示了外部血记忆 B 房间的更低的百分比。B 房间的全面 polyclonal 激活,由激活标记和 IgG 和 IgM 的分泌物的高水平显示了,在 IA 病人被观察。这 B 房间 hyperactivation 能被增加的 IFN-α 导致;并且在 IA 病人的可溶的 CD40 ligands。尤其是,合作激发器分子 CD80 和浆液 HBsAb 的表示和 HBsAg 特定的 B 房间的频率显著地与 HC 题目相比在信息技术, IA,和 IC 病人被减少。更重要地, B 房间 hyperactivation, co-stimulatory 分子 downregulation 和 HBsAg 特定的 B 房间缺陷在 RP 病人被颠倒。B 房间 hyperactivation 和功能的缺陷的颠倒在长期的肝炎 B 病人与 HBsAg seroconversion 被联系。 | Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang | 2015 | Cellular & Molecular Immunology2015，12，3： | 15 |
| 2 | Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China显示文摘 | Baoli Cheng Guohao Xie ShangLong Yao Xinmin Wu Qulian Guo Miaoning Gu Qiang Fang Qiuping Xu Dongxin Wang Yuhong Jin ShiYing Yuan Junlu Wang Zhaohui Du Yunbo Sun XiangMing Fang | 2007 | Critical Care Medicine2007，，11： | 2 |
| 3 | Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-β production by interfering with the RIG-I signaling pathway显示文摘 | Rui Luo Shaobo Xiao Yunbo Jiang Hui Jin Dang Wang Manli Liu Huanchun Chen Liurong Fang | 2008 | Molecular Immunology2008，，10： | 2 |
| 4 | Antiviral activity of type I and type III interferons against porcine reproductive and respiratory syndrome virus (PRRSV)显示文摘 | Rui Luo Liurong Fang Hui Jin Yunbo Jiang Dang Wang Huanchun Chen Shaobo Xiao | 2011 | Antiviral Research2011，，2： | 1 |
| 5 | Patients with intralesional hemorrhage in venous malforma- tions: Diagnosis and embolosclerotherapy显示文摘 | Hui Chen MD Xiaoxi Lin MD Yunbo Jin MD Wei Li MD | 2009 | Journal of Vascular Surgery2009，2，： | 1 |
| 6 | Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China显示文摘 | Baoli Cheng Guohao Xie ShangLong Yao Xinmin Wu Qulian Guo Miaoning Gu Qiang Fang Qiuping Xu Dongxin Wang Yuhong Jin ShiYing Yuan Junlu Wang Zhaohui Du Yunbo Sun XiangMing Fang | 2007 | Critical Care Medicine2007，，11： | 1 |
| 7 | Intralesional Interstitial Injection of Bleomycin for Management of Extracranial Arteriovenous Malformations in Children显示文摘Background Despite many advances in the treatment for extracranial arteriovenous malformations(AVMs),they still result in tedious dissection and potential unacceptable complications,particularly in children.Therefore,this study aimed to investigate the efficacy and safety of intralesional interstitial injection of bleomycin for the treatment of children with AVMs.Methods A total of 10 children(6 boys and 4 girls)with AVMs were treated with serial interstitial bleomycin injections between May 2014 and January 2017.Maximum single doses of 15 U and 1 U/kg per session were administered for six sessions at a 1-month interval.Therapeutic effectiveness was evaluated and classified into four categories:complete response(CR),partial response(PR),no response,and worsening at 3 months after the last session.Further clinical follow-up outcomes were classified as improved,stable,or aggravated.Adverse events were recorded according to the Society of Interventional Radiology classification.Results All 10 children completed the sessions and follow-ups.CR occurred in 3(30%)patients,PR in 6(60%),and no response in 1(20%).Minor complications(class A)included maculopapular rash,bulla,vomiting,and hyperpigmentation,whereas no major complications occurred.Conclusion Intralesional interstitial injection of bleomycin is a feasible approach for the treatment of AVMs in children and provides safe and effective outcomes.This method may be an earlier treatment alternative in children to prevent potential destructive progression,considering the serious complications of currently available therapeutic methods. | Yun ZOU Congzhen QIAO Chen HUA Xi YANG Tianyou WANG Yunbo JIN Xiaoxi LIN | 2021 | Chinese Journal Of Plastic and Reconstructive Surgery2021，3，2： | 0 |
| 8 | Physical modeling and numerical simulation of electromagnetic stirring in a slab continuous casting mold显示文摘Through physical modeling and numerical simulation,the flow field in a slab continuous casting mold with electromagnetic stirring is measured under different casting parameters and stirring currents. To qualitatively evaluate the flow field in the mold,two indexes,i. e.,mold flux entrapment and velocity uniformity,are proposed.Based on these two indexes,some optimized stirring parameters under different casting conditions can be determined. | LI Bin LEI Zuosheng GE Jiangmeng ZHONG Yunbo REN Zhongming ZHOU Yueming WU Cunyou JIN Xiaoli WEI Rujun | 2016 | Baosteel Technical Research2016，10，1： | 0 |
| 9 | Absolute ethanol embolization for treatment of peripheral arteriovenous malformations显示文摘Arteriovenous malformations(AVMs)are aggressive congenital high-flow vascular anomalies,in which the feeding artery and draining vein are connected through fistulas without normal capillary networks.In severe cases,the condition may cause swelling,ulceration,bleeding,and even heart failure.Various treatment options are available for AVMs,including laser,surgical resection,embolization,and targeted drug therapy.With the development of endovascular treatment technology,absolute ethanol embolization of AVMs has become one of the first-line therapies owing to its sustained efficacy and low recurrence rate.However,administration of this therapy is challenging and may lead to serious complications if inappropriately managed.In this article,we reviewed and summarized previous clinical articles,literature reviews,and clinical trial data to comprehensively describe clinical manifestations of AVMs,the mechanism of ethanol embolotherapy,key points in treatment and management of complications,and issues that need to be addressed.We expect to provide a reliable information reference source for clinical physicians and researchers. | Jingwei Zhou Chen Hua Xi Yang Yuxi Chen Yunbo Jin Xiaoxi Lin | 2023 | Chinese Journal Of Plastic and Reconstructive Surgery2023，5，3： | 0 |
| 10 | MEK inhibitors for the treatment of extracranial arteriovenous malformations显示文摘Arteriovenous malformations(AVMs)are serious congenital vascular anomalies in which the arteries connect directly with veins without capillaries.This condition will continue to worsen without proper intervention and cause ulcers,repeated hemorrhages,and even cardiac insufficiency.Primary treatment options for AVMs include surgery and interventional treatment;however,they are associated with high risk and recurrence rates.Recent studies revealed that excessive activation of the Ras/MAPK pathway can induce the formation and development of peripheral AVM,whereas MEK inhibitors can effectively control nidus progression,making them a potential novel treatment for AVM.This review provides an up-to-date overview of correlated laboratory and clinical research to provide information for further research and clinical practice. | Zi’an Xu Jingwei Zhou Yuxi Chen Xi Yang Chen Hua Yunbo Jin Xiaoxi Lin | 2023 | Chinese Journal Of Plastic and Reconstructive Surgery2023，5，3： | 0 |
| 11 | Bleomycin inhibits CLEC14A to attenuate the progression of extracranial arteriovenous malformations显示文摘Background:We previously reported that interstitial injection of bleomycin(BLM)reduces the size of early-stage extracranial arteriovenous malformation(AVM).Here,we sought to investigate the potential mechanism of BLM in treating extracranial AVM.Methods:Samples of human extracranial AVM(n=3)with no pharmacological treatment were harvested.AVM endothelial cells were isolated and cultured in primary cell culture.The transcriptome was examined using RNAsequencing,and differentially expressed C-type lectin domain family 14 member A(CLEC14A)was validated at the transcriptomic and protein levels.Immunocytochemical staining of CLEC14A was performed in samples of human extracranial AVM,with and without BLM treatment.Results:Through second-generation sequencing,we found that the expression of 5689 genes were differentially increased or decreased following 24-h BLM stimulation.We found that CLEC14A may play an important role in the progression of AVM and can be inhibited by BLM treatment.Conclusion:BLM inhibited CLEC14A expression to attenuate the progression of AVM. | Congzhen Qiao Yajing Qiu Yun Zou Chen Hua Yuanbo Li Yunbo Jin Xiaoxi Lin | 2021 | Chinese Journal Of Plastic and Reconstructive Surgery2021，3，4： | 0 |
| 12 | A Fast and Effective Surgical Method for a Painful Skin Lesion显示文摘Background Eccrineangiomatoushamartoma(EAH)is a rare benign disease that comprises vascular and eccrine malformations.Pain is one of the most common symptoms and surgical resection is generally required.Objective To report a novel surgical technique that can alleviate severe pain caused by a large lesion in an EAH patient.Methods On magnetic resonance imaging(MRI),a subcutaneous abnormal signal was detected in the right hip and groin area of an 18-year-old male.The lesion was carefully elevated from the normal tissue above the plane of the deep fascia and was sutured in situ.Additionally,a small sample of the central lesion tissue was collected for histological examination.Results The visual analog scale score of pain decreased from 9 points to 2 points at 1week and to 0 points at 2 weeks after the surgery.The only complication observed was local numbness,which recovered spontaneously.No recurrence of pain was observed after 1 year of surgery.Histological findings demonstrated that the numbers of eccrine sweat glands and abnormal vessels decreased post-surgery.Conclusion The surgical procedure used in our case may represent a novel,easy,safe,and effective option for the treatment of a large,severely painful EAH. | Li HU Hui CHEN Xi YANG Yunbo JIN Gang MA Wei LI Xiaoxi LIN | 2020 | Chinese Journal Of Plastic and Reconstructive Surgery2020，2，1： | 0 |
| 13 | Flame Burn Injury in Yichang of China:the Trends,Complications,and Risk Factor Analysis显示文摘Background A flame burn is an injury of body tissues,including respiratory tract damage,due to exposure to a flame or its dense smoke.Flame burns cause some of the most physically and psychologically devastating forms of trauma.Compared to scald burns,flame burn patients have a higher mortality rate and a higher frequency of multiorgan failure.The purpose of this research was to investigate the trends,complications,and mortality risk factors of flame burns at the Department of Plastic and Burn Surgery(DPBS)of the People’s Hospital of China Three Gorges University(PHCTGU).Methods A retrospective analysis of 48 flame burn patients—accounting for 8.3%of the 576 burn victims admitted for burns at the PHCTGU from February 1,2010,to September 30,2019—was performed after collecting information from the Burns Registry of the said hospital.Results The proportion of patients with flame burns was 8.3%(n=48).The mean total body surface area(TBSA)affected was 27.6%.The mean duration of hospitalization was 32.5 days.The etiologies of the flame burns were as follows:gas explosions(21,43.8%),ethanol(8,16.7%),charcoal fire(7,14.6%),petrol explosions(4,8.3%),wooden houses(4,8.3%),and others,including dust,cigarette lighter,and burning incense,accounting for 8.3%of cases(4).Finally,42(87.5%)patients were treated and discharged,and 6(12.5%)patients died.Complications included scarring in 38(90.5%)patients,severe scar contractures on different parts of the body in 25(60.0%)patients,scar ulcer in 6(14.3%)patients,keloids in 3(7.1%)patients,and scar cancer in 1(2.4%)patient.Multiple complications occurred in the same patient.The only risk factor for mortality that was identified was TBSA(P=0.043).Conclusions Our study revealed that a small population(8.3%)was injured by flame burns,but 6 deaths were recorded.Society must continually enhance safeguard procedures to flames and strengthen education to protect life and avoid severe complications. | Lixia WEN Weimin WU Yunbo JIN Bo ZHOU Lei WU Yapeng LIU Ying HU | 2021 | Chinese Journal Of Plastic and Reconstructive Surgery2021，3，1： | 0 |
| 14 | Systemic Hemodynamic Changes in Low-Dose Ethanol Embolotherapy for Soft-Tissue Arteriovenous Malformations显示文摘Background Ethanol embolotherapy is considered an optimal choice for the treatment of arteriovenous malformations(AVMs);however,there are some complications associated with this treatment.This study aimed to prospectively investigate systemic hemodynamic changes in high-flow AVMs using ethanol embolotherapy.Methods From September 2012 to September 2014,34 male patients and 26 female patients with AVMs who underwent embolotherapy(100 sessions in total)with absolute ethanol were included in this study.Invasive systolic blood pressure(SBP)and heart rate(HR)were recorded before and after each injection and throughout the procedure.Differences between the initial and highest SBP(ΔmaxSP)and HR values(ΔmaxHR),as well as the initial and final SBP(ΔSP)and HR(ΔHR)values,were analyzed.We aimed to explore the potential association between these values and the amount of ethanol that was used.Results The total ethanol used was variable(0.01–0.40 mL/kg;mean,0.20 mL/kg).SBP and HR increased after ethanol injection in most sessions(91 in 100 sessions).SBP decreased in 9 sessions(9 in 100 sessions),while HR,oxygen saturation,and end-tidal CO2 decreased in one of the 9 sessions.ΔmaxSP andΔmaxHR averaged 38.4 mmHg and 27.8 bpm,respectively(both P<0.05),whileΔSP andΔHR averaged 3.4 mmHg and 4.0 bpm,respectively(both P<0.05).ΔmaxSP andΔmaxHR were positively correlated with the total dose of ethanol injected.Conclusions Elevations in SBP and HR during ethanol embolotherapy are common,temporary,and most likely pain-mediated;these increases tend to be positively correlated with ethanol dose.Hypotension may be regarded as an acute complication of ethanol embolotherapy.Hypotension combined with bradycardia,oxygen desaturation,and decreased end-tidal CO2 may be a potential predictor of cardiovascular collapse. | Xi YANG Chen HUA Hui CHEN Lan LUO Gang MA Xiaojie HU YaJing QIU Wenxin YU Lei CHANG Yunbo JIN Xiaoxi LIN | 2021 | Chinese Journal Of Plastic and Reconstructive Surgery2021，3，1： | 0 |
| 15 | PAK1 is a novel cardiac protective signaling molecule显示文摘我们这里考察多功能的酶的新奇心脏的保护的效果,激活 p21 的 kinase 1 (PAK1 ) ,一个 serine/threonine 蛋白质 kinase 家庭的一个成员。尽管有从在 noncardiac 组织的研究的证据的大身体,显示那项 PAK1 活动在很多细胞的功能的规定是关键的,在心的 PAK1 的角色仅仅在过去几年被揭示了。在这评论,我们在在心发信号的 PAK1 上装配最近的调查结果的概述,特别地它的心脏的保护的效果。我们在场为表明那的 PAK1 的一个模型为明确地影响在哪个蛋白质 phosphorylation 的规定由蛋白质磷酸酶 2A ( PP2A )说 predominates.We 的心脏的细胞的过程提供机制讨论反肾上腺素能并且 antihypertrophic PAK1 的心脏的保护的效果,象它在维持室的 Ca 的角色一样<啜class=“ a-plus-plus ”>2+动态平衡和 electrophysiological 稳定性在下面生理,肾上腺素能并且 hypertrophic 压力条件。 | Yunbo Ke Xin Wang XU YU Jin R. John Solaro Ming Lei | 2014 | Frontiers of Medicine2014，8，4： | 0 |
| 16 | Metal-ligand cooperative iridium complex catalyzed C-alkylation of oxindole and 1,3-dimethylbarbituric acid using alcohols显示文摘A general and high-efficiency C-alkylation of oxindoles and barbituric acids has been developed by a Cp*Ir complex[Cp*Ir(2,20-bpyO)(OH)]Na with a bipyridine-based functional ligand.In particular,H_(2)O was selected as the solvent instead of the organic solvent in this catalytic system.Through mild reaction conditions gave a variety of corresponding alkylated heterocyclic compounds with good to excellent yields.More importantly,the gramscale C-alkylation reaction was successfully carried out with good yield using a common route with only a single purification by column chromatography. | Ao Song Yunbo Liu Xuan Jin Dianrun Su Zhaopeng Li Shengsheng Yu Lingbao Xing Xiangchao Xu Rongzhou Wang Feng Li | 2023 | Green Synthesis and Catalysis2023，4，3： | 0 |
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