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| 1 | Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer显示文摘渗入肿瘤的 Tregs 的起源,肿瘤免疫力的抑制的批评调停人,是不清楚的。这里,,我们证明在人的乳癌的渗入肿瘤的天真的 CD4 + T 房间和 Tregs 有重叠 TCR 全部剧目几乎别与传播 Tregs 重叠,建议 intratumoral Tregs 主要在 situ 而非从招募的 Tregs 从天真的 T 房间发展。而且,许多天真的 CD4 + T 房间和 Tregs 密切被相关,两个显示的穷人为乳癌病人的预后。天真的 CD4 + T 房间与许多生产 CCL18 巨噬细胞成比例遵守肿瘤片。而且,采纳地转移的人的天真的 CD4 + T 房间以一种 CCL18 依赖的方式渗入人的乳癌 orthotopic 异种皮移植。在在人性化的鼠标的人的乳癌异种皮移植,由将 PITPNM3 的表达式击倒堵住天真的 CD4 + T 房间的招募进肿瘤, CCL18 受体,显著地减少 intratumoral Tregs 并且禁止肿瘤前进。这些调查结果建议那个乳房渗入肿瘤的 Tregs 从在 situ 区分进 Tregs 的传播天真的 CD4 + T 房间的趋化性产生。由防碍 CCL18 的 PITPNM3 识别禁止天真的 CD4 + T 房间招募进肿瘤可以是为 anticancer 免疫疗法的吸引人的策略。 | Shicheng Su Jianyou Liao Jiang Liu Di Huang Chonghua He Fei Chen LinBing Yang Wei Wu Jianing Chen Ling Lin Yunjie Zeng Nengtai Ouyang Xiuying Cui Herui Yao Fengxi Su Jian-dong Huang Judy Lieberman Qiang Liu Erwei Song | 2017 | Cell Research2017，27，4： | 19 |
| 2 | Human CD39hi regulatory T cells present stronger stability and function under inflammatory conditions显示文摘 | Jian Gu Xuhao Ni Xiongxiong Pan Hao Lu Yunjie Lu Jie Zhao Song Guo Zheng Keli L Hippen Xuehao Wang Ling Lu | 2017 | Cellular & Molecular Immunology2017，14，6： | 6 |
| 3 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 4 | Catalytic transfer hydrogenation of levulinate ester intoγ-valerolactone over ternary Cu/ZnO/Al2O3 catalyst显示文摘An effective catalytic transfer hydrogenation (CTH) process of bio-based levulinate esters into γ-valerolactone (GVL) was explored over ternary Cu/ZnO/Al2O3 catalyst which was prepared by coprecipitation method and could be sustainably used. As a result, quantitative conversion of ethyl levulinate (EL) and 99.0% yield of GVL were obtained in the CTH process using i-PrOH as hydrogen donor. The Cu/ZnO/Al2O3 catalyst with high-surface-area could be reused at least four times without the loss of catalytic activity. Furthermore, the structure and properties of Cu/ZnO/Al2O3 catalyst was characterized through XRD, BET, SEM, TEM and H2-TPR. Also, the influence of different support oxides and calcination temperatures was investigated. | Chuntao Zhang Zhibao Huo Dezhang Ren Zhiyuan Song Yunjie Liu Fangming Jin Wanning Zhou | 2019 | Journal of Energy Chemistry2019，28，5： | 2 |
| 5 | Interface-directed epitaxially growing nickle ensembles as efficient catalysts in dry reforming of methane显示文摘Supported nickel catalysts are promising candidates for dry reforming of methane, but agglomeration of Ni^(0) and coke deposition hinder the industrial applications. Herein, we report a novel interface-directed synthetic approach to construct distinct metal ensembles by carefully tuning the compositions of the carriers. A Zr-Mn-Zn ternary oxide-supported Ni catalyst, together with the respective binary oxide-supported analogues, was synthesized by adopting a sequential co-precipitation and wetness impregnation method. Combined characterization techniques identify distinct catalyst models, including (i) conventional NiO nanoparticles with different sizes on Zr-Mn and Zr-Zn, and (ii) epitaxially growing NiO ensembles of a few nanometers thickness at the periphery of ZnO_(x) particles. These catalysts exhibit divergent responses in the catalytic testing, with the ternary oxide system significantly outperforming the binary analogues. The strong electronic interactions between Mn-Ni increase Ni dispersion and the activity while the stability is strengthened upon Zn addition. Both high activity, high selectivity, and remarkable stability are attained upon co-adding Mn and Zn. The interfaces between Ni and Zr-Mn-Zn rather than the physical contacts of individual oxide-supported analogues through mechanical mixing are keys for the outstanding performance. | Ping Wang Song Wei Shiyi Wang Ronghe Lin Xiaoling Mou Yunjie Ding | 2022 | Journal of Energy Chemistry2022，31，3： | 1 |
| 6 | Use of Chiropractic Spinal Manipulation in Older Adults Is Strongly Correlated With Supply显示文摘 | James M. Whedon Yunjie Song Matthew A. Davis Jonathan D. Lurie | 2012 | Spine2012，，： | 1 |
| 7 | Identifying and annotating human bifunctional RNAs reveals their versatile functions显示文摘Bifunctional RNAs that possess both protein-coding and noncoding functional properties were less explored and poorly understood. Here we systematically explored the characteristics and functions of such human bifunctional RNAs by integrating tandem mass spectrometry and RNA-seq data. We first constructed a pipeline to identify and annotate bifunctional RNAs,leading to the characterization of 132 high-confidence bifunctional RNAs. Our analyses indicate that bifunctional RNAs may be involved in human embryonic development and can be functional in diverse tissues. Moreover, bifunctional RNAs could interact with multiple miRNAs and RNA-binding proteins to exert their corresponding roles. Bifunctional RNAs may also function as competing endogenous RNAs to regulate the expression of many genes by competing for common targeting miRNAs. Finally,somatic mutations of diverse carcinomas may generate harmful effect on corresponding bifunctional RNAs. Collectively,our study not only provides the pipeline for identifying and annotating bifunctional RNAs but also reveals their important gene-regulatory functions. | Geng Chen Juan Yang Jiwei Chen Yunjie Song Ruifang Cao Tieliu Shi Leming Shi | 2016 | Science China(Life Sciences)2016，59，10： | 1 |
| 8 | SIMULATION RESEARCH OF ACTIVE VIBRATION CONTROL FOR ELASTIC MISSILE WITH SWING NOZZLE THRUST VECTOR CONTROL显示文摘Aiming at the deficiencies of notch filters on the aspect of vibration suppression for elastic missile with swing nozzle thrust vector control(SNTVC),an active vibration controller(AVC)is proposed.It is composed of an optimal state feedback controller(OSFC)and an optimal minimal order state observer(OMOSO),which can be respectively designed based on the separation principle.The design rules of these two elements are successively given.Computer simulation results present that AVC can realize strong vibration suppression and good convergence property after disturbing.Moreover,it has simple design and then it is easily implemented in engineering.In addition,the AVC scheme can also resolve the poor system stability to a great extent,which is resulted from the bad static stability of missile body. | XIAODONG LIU YUNJIE WU YONG DENG SEN WANG JIAYUN SONG | 2013 | International Journal of Modeling, Simulation, and Scientific Computing2013，4，4： | 1 |
| 9 | Erratum to“3D collagen matrices modulate the transcriptional trajectory of bone marrow hematopoietic progenitors into macrophage lineage commitment”[Bioact.Mater.10C(April 2022)255-268]显示文摘The publisher regrets the omission of the below footnote for the author Dr.Nu Zhang.The publisher would like to apologise for any inconvenience caused. | Pan Zhang Linmu Xu Jingsong Gao Guangkui Xu Yanping Song Guang Li Jingjing Ren Yunjie Zhang Cheng Yang Yu Zhang Ruiheng Xie Nu Zhang Hui Yang | 2023 | Bioactive Materials2023，，4： | 1 |
| 10 | A general method for growth of perovskite single-crystal arrays for high performance photodetectors显示文摘Perovskite single-crystal arrays have attracted intensive attention because of their great potentials for integrated optoelectronic devices.However,the traditional top-down lithography strategy requires complex processing and is detrimental to perovskite crystal structures,which is incompatible to directly pattern perovskite single crystals.Herein,we report a lithography-free method to realize the controllable growth of perovskite single-crystal arrays.Through introducing a printed hydrophilic-hydrophobic substrate into the crystallization system,the MAPbCl_(3) single-crystal arrays with precise location and uniform size are effectively fabricated.This method can be applied to prepare diverse perovskite single-crystal arrays,including MAPbBr_(3),CsPbCl_(3),CsPbBr_(3),Cs_(3)Cu_(2)I_(5),Cs_(3)Bi_(2)I_(9),and(BA)_(2)(MA)_(3)Pb_(4)I_(11).The perovskite single crystals can be selectively grown on the electrodes to fabricate ultraviolet photodetectors.The strategy demonstrates a facile approach to fabricate large-scale perovskite single-crystal arrays and opens a pathway to produce diverse perovskite optoelectronic devices. | Shiheng Wang Zhenkun Gu Rudai Zhao Ting Zhang Yunjie Lou Lutong Guo Meng Su Lihong Li Yiqiang Zhang Yanlin Song | 2022 | Nano Research2022，15，7： | 0 |
| 11 | 3D collagen matrices modulate the transcriptional trajectory of bone marrow hematopoietic progenitors into macrophage lineage commitment显示文摘Physical signals provided by the extracellular matrix(ECM)are key microenvironmental parameters for the fate decision of hematopoietic stem and progenitor cells(HSPC)in bone marrow.Insights into cell-ECM interactions are critical for advancing HSC-based tissue engineering.Herein,we employed collagen hydrogels and collagen-alginate hydrogels of defined stiffness to study the behaviors of hematopoietic progenitor cells(HPCs).Three-dimensional(3D)collagen hydrogels with a stiffness of 45 Pa were found to promote HPC maintenance and colony formation of monocyte/macrophage progenitors.Using single-cell RNA sequencing(scRNA-seq),we also characterized the comprehensive transcriptional profiles of cells randomly selected from two-dimensional(2D)and 3D hydrogels.A distinct maturation trajectory from HPCs into macrophages within the 3D microenvironment was revealed by these results.3D-derived macrophages expressed high levels of various cytokines and chemokines,such as Saa3,Cxcl2,Socs3 and Tnf.Furthermore,enhanced communication between 3D-macrophages and other hematopoietic clusters based on ligand-repair interactions was demonstrated through bioinformatic analyses.Our research underlines the regulatory role of matrix-dimensionality in HPC differentiation and therefore probably be applied to the generation of specialized macrophages. | Pan Zhang Linmu Xu Jingsong Gao Guangkui Xu Yanping Song Guang Li Jingjing Ren Yunjie Zhang Cheng Yang Yu Zhang Ruiheng Xie Nu Zhang Hui Yang | 2022 | Bioactive Materials2022，7，4： | 0 |
| 12 | Chip design with machine learning:a survey from algorithm perspective显示文摘Chip design with machine learning(ML)has been widely explored to achieve better designs,lower runtime costs,and no human-in-the-loop process.However,with tons of work,there is a lack of clear links between the ML algorithms and the target problems,causing a huge gap in understanding the potential and possibility of ML in future chip design.This paper comprehensively surveys existing studies in chip design with ML from an algorithm perspective.To achieve this goal,we first propose a novel and systematical taxonomy that divides target problems in chip design into three categories.Then,to solve the target problems with ML algorithms,we formulate the three categories as three ML problems correspondingly.Based on the taxonomy,we conduct a comprehensive survey in terms of target problems based on different ML algorithms.Finally,we conclude three key challenges for existing studies and highlight several insights for the future development of chip design with machine learning.By constructing a clear link between chip design problems and ML solutions,we hope the survey can shed light on the road to chip design intelligence from previous chip design automation. | Wenkai HE Xiaqing LI Xinkai SONG Yifan HAO Rui ZHANG Zidong DU Yunji CHEN | 2023 | Science China(Information Sciences)2023，66，11： | 0 |
| 13 | Accelerated Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydride via Inorganic Nano-initiators显示文摘While the accelerated polymerization of N-carboxyanhydrides (NCAs) has been utilized to synthesize versatile polypeptide materials in an efficient manner with minimized side reactions, the preparation of polypeptide-based inorganic/organic hybrid materials with the acceleration strategy remained largely unexplored. Herein, we report the accelerated ring-opening polymerization (ROP) of NCAs mediated by amine-modified inorganic nano-initiators, such as mesoporous silica nanoparticles (MSN-NH2), which is driven by the cooperative effect of the neighboring α-helical polypeptide chains in a dichloromethane (DCM)/water biphasic system. Well-defined nano-hybrids were prepared within 15 min from non-purified NCA monomers, through in situ purification and subsequent ultrafast polymerization process. NCAs can be rapidly initiated by amino groups of MSN uniformly dispersed at the interface of DCM and water, and subsequently formed the well-defined polypeptides within 15 min. The prepared inorganic/organic nano-hybrid with MSN as the core and polypeptide as the shell adopted spherical morphology and uniform size distribution due to the excellent controllability of ROP. Besides, this system is also suitable for a variety of NCAs and inorganic nano-initiators. This research allows efficient and rapid preparation of inorganic/organic nano-hybrids, and further promotes the extensive application of this material in the biomedical fields. | Junliang Zhu Yunjie He Chenglong Ge Wenting Si Ziyuan Song Lichen Yin | 2023 | Chinese Journal of Chemistry2023，41，19： | 0 |
| 14 | Identification and modulation of expression of a TNF receptor superfamily member 25 homologue in grass carp (Ctenopharyngodon idella)显示文摘The TNF receptor superfamily member 25(TNFRSF25)is part of the tumor necrosis factor receptor superfamily and contains a typical death domain.It is also known as DR3,TRAMP,LARD,WSL-1,Apo-3 and TR3,and has a vital role in regulating cell proliferation,differentiation and apoptosis.In this study,a homologue of the TNFRSF25 gene was identified in grass carp(Ctenopharyngodon idella).It encodes a transmembrane protein with an extracellular domain containing a cysteine-rich domain and an intracellular domain containing a death domain.It is an orthologue of fish TNFRSF1ALs and shares conserved gene synteny with human TNFRSF25.Expression studies showed that CiTNFRSF25 was constitutively expressed in the majority of fish tissues and can be modulated by interleukin 4/13B and infection by F.columnare.To our knowledge,this is the first report describing the existence of a TNFRSF25 homologue in teleost fish. | Xingxing Cheng Xinyu Jiang Yunjie Song Jingduo Gao Yujie Xue Zeinab Hassan Qian Gao Jun Zou | 2020 | Aquaculture and Fisheries2020，5，1： | 0 |
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