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| 1 | Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells显示文摘人的导致的 pluripotent 茎(iPS ) 房间类似于胚胎的茎(ES ) 房间,和罐头强烈地增殖并且区分进许多房间类型。然而,人的 iPS 房间的肝的区别还没被报导了。在这份报告,人的 iPS 房间被导致由一个逐步的协议区分进肝的房间。肝房间标记的表达式和人的 iPS 的肝相关的函数导出房间的房间被监视并且与区分的人的 ES 房间和主要人的 hepatocytes 的相比。在白天 7 点的约 60% 区分的人的 iPS 房间表示了肝的标记 alpha fetoprotein 和白长袍的。在白天 21 点的区分的房间包括白朊 Asecretion,肝糖合成,脲生产和可诱导的细胞色素 P450 活动展出了肝房间功能。肝的标记的表示和 iPS 的肝相关的功能导出房间的肝的房间比得上人的 ES 导出房间的肝的房间的。这些结果证明人的 iPS 房间,类似于人的 ES 房间,能高效地被导致区分房间进象 hepatocyte 一样。 | Zhihua Song Jun Cai Yanxia Liu Dongxin Zhao Jun Yong Shuguang Duo Xijun Song Yushan Guo Yang Zhao Han Qin Xiaolei Yin Chen Wu Jie Che Shichun Lu Mingxiao Ding Hongkui Deng | 2009 | Cell Research2009，19，11： | 63 |
| 2 | Evaluation of clinical application of ESICM acute gastrointestinal injury grading system: a single-center observational study显示文摘 | Zhang Dong Li Nan Dong Lihua Fu Yao Liu Zhongmin Wang Yushan | 2014 | Chinese Medical Journal2014，，10： | 26 |
| 3 | Prognostic value of clinical and pathological factors for surgically treated localized clear cell renal cell carcinoma显示文摘 | Teng Jingfei Gao Yi Chen Ming Wang Kai Cui Xingang Liu Yushan Xu Danfeng | 2014 | Chinese Medical Journal2014，，9： | 23 |
| 4 | Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis显示文摘Autophagy and apoptosis are both highly regulated biological processes that play essential roles in tissue homeostasis,development and diseases.Autophagy is also described as a mechanism of death pathways,however,the precise mechanism of how autophagy links to cell death remains to be fully understood.Beclin 1 is a dual regulator for both autophagy and apoptosis.In this study we found that Beclin 1 was a substrate of caspase-3 with two cleavage sites at positions 124 and 149,respectively.Furthermore,the autophagosome formation occurred,followed by the appearance of morphological hallmarks of apoptosis after staurosporine treatment.The cleavage products of Beclin 1 reduced autophagy and promoted apoptosis in HeLa cells and the cells in which Beclin 1 was stably knocked down by specific shRNA.In addition,the cleavage of Beclin 1 resulted in abrogating the interaction between Bcl-2 with Beclin 1,which could be blocked by z-VAD-fmk.Thus,our results suggest that the cleavage of Beclin 1 by caspase-3 may contribute to inactivate autophagy leading towards augmented apoptosis. | Yushan Zhu Lixia Zhao Lei Liu Ping Gao Weili Tian Xiaohui Wang Haijing Jin Haidong Xu Quan Chen | 2010 | Protein & Cell2010，1，5： | 17 |
| 5 | Interface electron collaborative migration of Co–Co3O4/carbon dots:Boosting the hydrolytic dehydrogenation of ammonia borane显示文摘Ammonia borane(AB)is an excellent candidate for the chemical storage of hydrogen.However,its practical utilization for hydrogen production is hindered by the need for expensive noble-metal-based catalysts.Herein,we report Co-Co3O4 nanoparticles(NPs)facilely deposited on carbon dots(CDs)as a highly efficient,robust,and noble-metal-free catalyst for the hydrolysis of AB.The incorporation of the multiinterfaces between Co,Co3O4 NPs,and CDs endows this hybrid material with excellent catalytic activity(rB=6816 mLH2 min^-1 gCo^-1)exceeding that of previous non-noble-metal NP systems and even that of some noble-metal NP systems.A further mechanistic study suggests that these interfacial interactions can affect the electronic structures of interfacial atoms and provide abundant adsorption sites for AB and water molecules,resulting in a low energy barrier for the activation of reactive molecules and thus substantial improvement of the catalytic rate. | Han Wu Min Wu Boyang Wang Xue Yong Yushan Liu Baojun Li Baozhong Liu Siyu Lu | 2020 | Journal of Energy Chemistry2020，29，9： | 7 |
| 6 | Seasonal Variation of Biochemical Components in Clam (Saxidomuspurpuratus Sowerby 1852) in Relation to Its Reproductive Cycle and the Environmental Condition of Sanggou Bay, China显示文摘Seasonal variation of biochemical components in clam(Saxidomus purpuratus Sowerby 1852) was investigated from March 2012 to February 2013 in relation to environmental condition of Sanggou Bay and the reproductive cycle of clam.According to the histological analysis,the reproductive cycle of S.purpuratus includes two distinctive phases:a total spent and inactive stage from November to January,and a gametogenesis stage,including ripeness and spawning,during the rest of the year.Gametes were generated at a low temperature(2.1℃) in February.Spawning took place once a year from June to October.The massive spawning occurred in August when the highest water temperature and chlorophyll a level could be observed.The key biochemical components(glycogen,protein and lipid) in five tissues(gonad,foot,mantle,siphon and adductor muscle) were analyzed.The glycogen content was high before gametogenesis,and decreased significantly during the gonad development in the gonad,mantle and foot of both females and males,suggesting that glycogen was an important energy source for gonad development.The protein and lipid contents increased in the ovary during the gonad development,demonstrating that they are the major organic components of oocytes.The lipid and protein contents decreased in the testis,implying that they can provide energy and material for spermatogenesis.The results also showed that protein stored in the mantle and foot could support the reproduction after the glycogen was depleted. | BI Jinhong LI Qi ZHANG Xinjun ZHANG Zhixin TIAN Jinling XU Yushan LIU Wenguang | 2016 | Journal of Ocean University of China2016，15，2： | 6 |
| 7 | Caspase cleavage of cytochrome cl disrupts mitochondrial function and enhances cytochrome c release显示文摘 | Yushan Zhu Min Li Xiaohui Wang Haijing Jin Shusen Liu Jianxin Xu Quan Chen | 2012 | Cell Research2012，22，1： | 6 |
| 8 | Extraction and back-extraction behaviors of 14 rare earth elements from sulfuric acid medium by TODGA显示文摘The unique physical and chemical properties of rare earth elements lay the foundation for their extensive application. N,N,N',N' Tetra-octyl-3-oxopentanediamide(TODGA) is excellent in its ability of extracting rare earth elements and it is favored for green initiative. In this paper, the extraction and back-extraction of14 rare earth elements by TODGA were studied. Experiments show that in conditions of 6 mol/L sulfuric acid, the extraction temperature of 25 ℃,the phase ratio of 1:1 and 0.04 mol/LTODGA(aviation kerosene as the diluent), the extraction rates of 14 rare earth elements including lanthanum, cerium, praseodymium,neodymium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, and yttrium were 99.00%-99.73%. Mixed with hydrochloric acid and nitric acid(HCl 3.5 mol/L, HNO_30.5 mol/L), the recoveries of the 14 rare earth elements are 91.52%-99.91% when the extraction temperature is 25 ℃ and the ratio is 1:1. The following application is based on the optimum conditions above with practical samples(from the roasting production line of China North Rare Earth High-tech Company Limited) for extraction and back-extraction experiments. Experiments show that TODGA has excellent enrichment effect on 14 rare earth elements, the extraction rates are 91.36%-99.80%, the back-extraction rates are 87.29%-99.64% and the total recoveries are 81.19%-99.44%. | Huiting Yuan Weixiang Hong Yushan Zhou Baisong Pu Aijun Gong Tao Xu Qishan Yang Fukai Li Lina Qiu Weiwei Zhang Yuning Liu | 2018 | Journal of Rare Earths2018，36，6： | 4 |
| 9 | Dual-periodic-microstructure-induced color tunable white organic Ught-emitting devices显示文摘 | Yangang BI Jinhai JI Yang CHEN Yushan LIU Xulin ZHANG Yunfei LI Ming XU Yuefeng LIU Xiaochi HAN Qiang GAO Hongbo SUN | 2016 | Frontiers of Optoelectronics2016，9，2： | 2 |
| 10 | Influence of Sanao Tang on urine volume and expression of aquaporin 2 in rats with respiratory function impairment induced by passive smoking and lipopolysaccharide显示文摘OBJECTIVE: To investigate the effect of Sanao Tang(SAT) on urine volume and the expression of aquaporin-2(AQP2) in rats with lung dysfunction induced by passive smoking and lipopolysaccharide.METHODS: Totally 45 healthy Specific pathogen Free Wistar Rats were randomized into 3 groups:normal control group, model group and SAT group.A rat model of respiratory dysfunction induced by exposure to cigarette smoking and lipopolysaccharide(LPS). Lavage of decoction of the Chinese medicine was performed for rats in the SAT group. Anires 2005 System was used to analyze the pulmonary function. Urine of rats was collected through metabolism cage method. Enzyme-linked immunosorbent assay(ELISA) was used to determine content of antidiuretic hormone(ADH), angiotensin Ⅱ(AngⅡ), atrial natriuretic factor(ANP), endothelin 1(ET-1), nitric oxide(NO) and prostaglandin E2(PGE2) in serum, lung and kidney. The expression of AQP2 in rat renal tissue was determined with real-time fluorescence quantitative PCR(RT-PCR).RESULTS:(a) In comparison with the normal control, It was found that enforced vital capacity(FVC),1-second forced expiratory volume/forced vital capacity%(FEV1/FVC%), 24 h urine volume content of NO and PGE2 were decreased, while AQP2 m RNA level and content of ADH, Agn Ⅱ, ANP and ET-1were increased in the model group with statistical significance(P < 0.05).(b) In comparison with the model group, It was found that FVC, FEV1, FEV1/FVC%, 24 h urine volume, content of PGE2 and NO decreased, while AQP2 m RNA level, content of ANP,ADH and AngⅡ decreased in the SAT group with statistical significance(P < 0.05).CONCLUSION: SAT might effectively regulate the urine volume in the modeled rats; ADH, Ang Ⅱ,ANP, ET-1, NO and PGE2 might play an important role in the regulation on urine volume by lungs.This might be the mechanisms underpinning the function of lung governing water passage in terms of the theory of Traditional Chinese Medicine. | Zhang Jinchao Sun Yan Zhang Shujing Gao Yushan Wang Zhenyi Liu Xiaolei Yang Jiamin Li Yuhang | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 2 |
| 11 | Retention of trace elements in coal-fired flue gas by a novel heterogeneous agglomeration technology显示文摘Heterogeneous agglomeration (HA) is a very potential technology for coal-fired flue gas treatment.In this paper,the distribution and migration mechanisms of trace elements (TEs such as Se,As and Pb in CFPPs were studied on a 30,000 m^(3)/hr pilot-scale experimental plat form.The influences of HA on the removal efficiency of gaseous and particulate TEs were well analyzed.The results showed that Se,As and Pb were enriched in fly ash,and their sen sitivity to particle size is quite different.The content of Se was the highest in PM1,reaching193.04 mg/kg at the electrostatic precipitator (ESP) outlet.The average particle size of the total dust before ESP increased significantly from 21.686 to 62.612μm after injecting the heterogeneous agglomeration adsorbent,conducive to its further removal by ESP.In addi tion,the concentrations of gaseous Se,As and Pb in the flue gas decreased after adsorben spray,and accordingly,their contents in the hierarchical particles increased,indicating tha the adsorbent could effectively promote the adsorption of gaseous trace elements in fly ash and reduce the possibility of their escape to the atmosphere.Total concentrations of Se,As and Pb emitted by wet flue gas desulfurization (WFGD) are 0.223,0.668 and 0.076μg/m^(3)which decreased by 59.98%,47.69%and 90.71%,respectively.Finally,a possible HA mecha nism model was proposed,where chemical adsorption,physical condensation and collision agglomeration of gaseous TEs and fine particles with adsorbent droplets occurred to form larger agglomerates. | Yushan Ji Xiangzheng Cui Jingchao Liu Tianle Zhang Shuzhou Wei Junfeng Zhang Yongchun Zhao Junying Zhang | 2023 | Journal of Environmental Sciences2023，，3： | 2 |
| 12 | Mechanism of improving skin barrier function in a mouse model of atopic dermatitis using Mahuang Lianqiao Chixiaodou decoction and its disassembled formula显示文摘Objective: To reveal the mechanism of Mahuang Lianqiao Chixiaodou decoction and its disassembled formula for improving the skin barrier function in a mouse model of atopic dermatitis(AD).Methods: Sixty specific-pathogen free male BALB/c mice were randomly divided into the control group,model group, whole formula group(WF), exterior-releasing formula group(ERF), interior-clearing formula group(ICF), and positive control group(PC). A mouse model of AD was established using the semiantigen 2,4-dinitrofluorobenzene induction method. The lesion scores, transepidermal water loss and p H, and skin histopathology of mice in each group were observed. The expressions of filaggrin, loricrin,and involucrin were detected by the streptavidin peroxidase immunohistochemical method and western blotting, and their mRNA expressions were detected by quantitative polymerase chain reaction.Results: Mice in the WF, ERF, ICF, and PC groups showed reduced skin lesion performance, improved histopathology, decreased skin lesion score, transepidermal water loss and pH, and upregulated expressions of proteins including filaggrin, loricrin, and involucrin, and their mRNAs. The most obvious regulatory effect was observed in the WF group, followed by the ICF, ERF, and PC groups, accordingly.Conclusions: Mahuang Lianqiao Chixiaodou decoction and its disassembled formula can improve the skin barrier function in a mouse model of AD by upregulating filaggrin, loricrin, and involucrin, and their mRNA expressions, and the most optimal effect was noted in the WF group, followed by the ICF and ERF groups, which suggests that the effect of clearing heat and resolving dampness in improving the skin barrier function of AD is more obvious and is one of the key treatments for AD. | Jingang Liu Yan Sun Huimin Yuan Yuda Li Jing Feng Yushan Gao Yang Tang Shujing Zhang Hang Wang Fengjie Zheng | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，4： | 2 |
| 13 | A chromosome-level genome assembly of rugged rose (Rosa rugosa) provides insights into its evolution, ecology, and floral characteristics显示文摘Rosa rugosa,commonly known as rugged rose,is a perennial ornamental shrub.It produces beautiful flowers with a mild fragrance and colorful seed pods.Unlike many other cultivated roses,R.rugosa adapts to a wide range of habitat types and harsh environmental conditions such as salinity,alkaline,shade,drought,high humidity,and frigid temperatures.Here,we produced and analyzed a high-quality genome sequence for R.rugosa to understand its ecology,floral characteristics and evolution.PacBio HiFi reads were initially used to construct the draft genome of R.rugosa,and then Hi-C sequencing was applied to assemble the contigs into 7 chromosomes.We obtained a 382.6Mb genome encoding 39,704 protein-coding genes.The genome of R.rugosa appears to be conserved with no additional whole-genome duplication after the gamma whole-genome triplication(WGT),which occurred~100 million years ago in the ancestor of core eudicots.Based on a comparative analysis of the high-quality genome assembly of R.rugosa and other high-quality Rosaceae genomes,we found a unique large inverted segment in the Chinese rose R.chinensis and a retroposition in strawberry caused by post-WGT events.We also found that floral development-and stress response signaling-related gene modules were retained after the WGT.Two MADS-box genes involved in floral development and the stress-related transcription factors DREB2A-INTERACTING PROTEIN 2(DRIP2)and PEPTIDE TRANSPORTER 3(PTR3)were found to be positively selected in evolution,which may have contributed to the unique ability of this plant to adapt to harsh environments.In summary,the high-quality genome sequence of R.rugosa provides a map for genetic studies and molecular breeding of this plant and enables comparative genomic studies of Rosa in the near future. | Fei Chen Liyao Su Shuaiya Hu Jia-Yu Xue Hui Liu Guanhua Liu Yifan Jiang Jianke Du Yushan Qiao Yannan Fan Huan Liu Qi Yang Wenjie Lu Zhu-Qing Shao Jian Zhang Liangsheng Zhang Feng Chen Zong-Ming(Max)Cheng | 2021 | Horticulture Research2021，8，1： | 2 |
| 14 | Regulation of mATG9 trafficking by Src- and ULK1mediated phosphorylation in basal and starvation-induced autophagy显示文摘Autophagy 要求多样的膜来源并且包含 mATG9 的膜 trafficking,在 ATG 家庭的唯一的膜蛋白质。然而,为 autophagy 开始的 mATG9 trafficking 的分子的规定仍然保持不清楚。这里,我们识别了在 mATG9 的 cytosolic N 终点以内排序信号的二保存经典适配器蛋白质,它调停从经由和 AP1/2 建筑群的相互作用的血浆膜和 trans-Golgi 网络(TGN ) 的 mATG9 的 trafficking。在 Tyr8 到的 Src phosphorylates mATG9 处于不着重的条件维持它的 endocytic 和组成的 trafficking。响应饥饿,在由 Src 的 Tyr8 并且在由 ULK1 的 Ser14 的 mATG9 的 phosphorylation 机能上地合作支持在 mATG9 和 AP1/2 建筑群之间的相互作用,为 autophagy 从血浆膜和 juxta 原子的区域导致 mATG9 的再分配到外部水池开始。我们的调查结果揭开 mATG9 trafficking 的新奇机制并且建议基础、导致压力的 autophagy 的协作。 | Changqian Zhou Kaili Ma Ruize Gao Chenglong Mu Linbo Chen Qiangqiang Liu Qian Luo Du Feng Yushan Zhu Quan Chen | 2017 | Cell Research2017，27，2： | 2 |
| 15 | Study on the Physiological,Cellular,and Morphological Aspects of the Postharvest Development of Cut Lily Flowers显示文摘It is of great practical significance to study the development process of cut lily for regulating flowering and preservation.In this study,the developmental process of lily cut flower was explored from cellular,morphological,and physiological aspects.Froma morphological aspect,the tepal edge grows faster than the midrib.The midrib groove of the flowering stage is wider than that of bud stage.The fast-growing edge of the petals results in the midrib bending outward.Moreover,the rapid growth of the stamens and stigmas also contributes to bud cracking.From the cellular aspect,in the bud stage there were more wrinkles in the outer epidermal cell wall of the tepal than those in the inner epidermal cell wall,indicating that asymmetric structural differences exist from the beginning of lily development.From a physiological aspect,from the bud cracking stage to the senescence stage,a variety of substances in the tepal cells gradually decreased,including total nitrogen,total phosphorus,total potassium,total calcium,starch,soluble sugar,and soluble protein,but not malondialdehyde.These results indicate that the asymmetric growth caused by this structural difference is responsible for flowering.The wrinkles in the cell wall can be regarded as indicators of senescent cells and are caused by the degradation of the cell wall and the loss of intracellular turgor pressure.The differences in the epidermal cells between the inner and outer tepal indicated ultrastructural changes in the tepal cells.The bud and flowering stages are maintained by the tepals acting as a sink.After flowering,the tepals gradually change from a sink to a source organ.Senescence of the cut lily flowers was caused by the decomposition of intracellular compounds in the tepals and the remobilization of nutrients from the tepals to the developing organs. | Yushan Zhang Dexin Zhong Zhanfei Liu Jiawei Gao | 2021 | Horticultural Plant Journal2021，7，2： | 2 |
| 16 | Maximal methane potential of different animal manures collected in northwest region of China显示文摘Maximum methane potential(B0)is an important parameter used in assessing suitability of a substrate for biogas production.This study examined maximum methane potential of different manures generated from three major Chinese livestock,namely chicken,hog and cattle,and evaluated the important factors that affect the maximum methane potential of a substrate.The livestock manures collected from the local farms were incubated under a thermophilic anaerobic condition(55℃).The results showed that the maximum methane potential(B0)of cattle,hog and chicken manures were 292.0 mL/g VS,272.0 mL/g VS and 266.4 mL/g VS,respectively.The B0 value decreases with increasing contents of crude protein and crude fat,while increases with increasing the contents of carbohydrates and crude fiber in manures.The content of NH4+-N in chicken manure was significantly higher during the digestion period,reached as high as 1962.5 mg/L by the end of incubation period.Heavy metals of Cu and Zn in the manure also affect the B0.Empirical relationships that describe the B0 decrease in response to increase of Zn and Cu contents in manure were developed and used as a simple tool to assess the effects of these metals on the B0.It was concluded that the protein,Cu and Zn contents of manure are most important chemical compositions that negatively affect maximum methane potential.Based on the three experimental manures,the maximum methane potential was limited by either ammonium content or Cu and Zn content in the manure.For a commercial biogas production facility using these manures as main feedstock,one should consider to add co-substrate or co-substrates to reduce concentration of these chemicals to maximize biogas production. | Chen Fen Yu Gao Li Wei Liu Fenwu Zhang Wuping Bu Yushan Li Xiaomei | 2017 | International Journal of Agricultural and Biological Engineering2017，10，1： | 2 |
| 17 | Effect of the Inclination Angle on Slippage Loss in Gas-Liquid Two-Phase Flow显示文摘The lifting efficiency and stability of gas lift well are affected by the socalled slippage-loss effect in gas-liquid two-phase flow.The existing studies on this subject have generally been based on vertical and horizontal wells.Only a few of them have considered inclined pipes.In the present work a new focused study is presented along these lines.More specifically,we use the non-slip pressure drop model with Flanigan’s fluctuation correction coefficient formula(together with the parameters of slippage density,slippage pressure drop and slippage ratio)to analyze the influence of the inclination angle on slippage loss for different conditions(different gas-liquid superficial velocity and pipe diameters).Moreover,the“standard regression coefficient method”is used for multi-factor sensitivity analysis.The experimental results indicate that slippage loss is affected by multiple factors,and the influence of the inclination angle on slippage loss is less significant than other factors.The change of the slippage pressure drop with the superficial velocity of gas-liquid is similar to that of the total pressure drop.The inclination angles of 45°and 60°have the greatest influence on slippage loss.The correlation between slippage density and slippage ratio is not obvious.Using the so-called slippage ratio seems to be a more accurate option to evaluate the degree of slippage loss. | Yushan Liu Yubin Su Zhenhua Wu Wei Luo Ruiquan Liao | 2020 | Fluid Dynamics & Materials Processing2020，16，3： | 2 |
| 18 | Four rice QTL controlling number of spikelets per panicle expressed the characteristics of single Mendelian gene in near isogenic backgrounds显示文摘 | Yushan Zhang Lijun Luo Touming Liu Caiguo Xu Yongzhong Xing | 2009 | Theoretical and Applied Genetics2009，，6： | 1 |
| 19 | 显示文摘 | Liu Yushan Liu Peng Su Zhixing | 2007 | Synthetic Metals2007，157，： | 1 |
| 20 | Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation显示文摘 | Maria E. Figueroa Omar Abdel-Wahab Chao Lu Patrick S. Ward Jay Patel Alan Shih Yushan Li Neha Bhagwat Aparna Vasanthakumar Hugo F. Fernandez Martin S. Tallman Zhuoxin Sun Kristy Wolniak Justine K. Peeters Wei Liu Sung E. Choe Valeria R. Fantin Elisabeth P | 2010 | Cancer Cell2010，，6： | 1 |
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