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| 1 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 2 | Starch-based adhesive hydrogel with gel-point viscoelastic behavior and its application in wound sealing and hemostasis显示文摘Hydrogels with tissue adhesiveness have demonstrated great promise for wearable electronics,artificial skin,soft robotics,and tissue repair.Nevertheless,adhesive hydrogels that are capable of sealing and hemostasis of wound with severe hemorrhage still lack.For this purpose,a series of ionically crosslinked starch hydrogels were developed here.The viscoelastic properties and tissue adhesiveness of the starch hydrogels were investigated.It is shown that the starch and cross linkers had significant influence on the viscoelastic properties of the starch hydrogels,which further resulted in varied tissue adhesiveness.Among the starch gels,there was one exhibiting a unique and stable'Gel Point'viscoelastic characteristic and it was named as gel-point adhesive hydrogel(GPAH).GPAH showed electrical conductivity,high tissue adhesiveness,high stretch-ability,self-healing capability,injectability,and degradability.The GPAH also exhibited high cytocompatibility,low hemolysis risk,and strong antibacterial effect.The wound sealing and hemostatic performance of GPAH was further evaluated by a rat femoral artery injury model.The blood loss after the sealing of GPAH(2.4±1.3 g)was significantly decreased compared to the group using gauze for sealing(6.3±1.5 g).Meanwhile,GPAH did not cause pathological changes of the soft tissues surrounding the wound.The above results indicate that GPAH,with high tissue adhesiveness,suitable viscoelastic property,strong antibacterial capacity,as well as electro-conductivity,bears great potential for the applications in smart wound management. | Yuxuan Mao Peng Li Jiewei Yin Yanjie Bai Huan Zhou Xiao Lin Huilin Yang Lei Yang | 2021 | Journal of Materials Science & Technology2021，，4： | 3 |
| 3 | Characteristics of novel Ti-10Mo-xCu alloy by powder metallurgy for potential biomedical implant applications显示文摘When biomaterials are implanted in the human body,the surfaces of the implants become favorable sites for microbial adhesion and biofilm formation,causing peri-implant infection which frequently results in the failure of prosthetics and revision surgery.Ti-Mo alloy is one of the commonly used implant materials for load-bearing bone replacement,and the prevention of infection of Ti-Mo implants is therefore crucial.In this study,bacterial inhibitory copper(Cu)was added to Ti-Mo matrix to develop a novel Ti-Mo-Cu alloy with bacterial inhibitory property.The effects of Cu content on microstructure,tensile properties,cytocompatibility,and bacterial inhibitory ability of Ti-Mo-Cu alloy were systematically investigated.Results revealed that Ti-10Mo-1Cu alloy consisted ofαandβphases,while there were a few Ti2Cu intermetallic compounds existed for Ti-10Mo-3Cu and Ti-10Mo-5Cu alloys,in addition toαandβphases.The tensile strength of Ti-10Mo-xCu alloy increased with Cu content while elongation decreased.Ti-10Mo-3Cu alloy exhibited an optimal tensile strength of 1098.1 MPa and elongation of 5.2%.Cytocompatibility study indicated that none of the Ti-10Mo-xCu alloys had a negative effect on MC3T3-E1 cell proliferation.Bacterial inhibitory rates against S.aureus and E.coli increased with the increase in Cu content of Ti-10Mo-xCu alloy,within the ranges of 20-60%and 15-50%,respectively.Taken together,this study suggests that Ti-10Mo-3Cu alloy with high strength,acceptable elongation,excellent cytocompatibility,and the bacterial inhibitory property is a promising candidate for biomedical implant applications. | Wei Xu Chenjin Hou Yuxuan Mao Lei Yang Maryam Tamaddon Jianliang Zhang Xuanhui Qu Chaozong Liu Bo Su Xin Lu | 2020 | Bioactive Materials2020，5，3： | 2 |
| 4 | Injectable hydrogel wound dressing based on strontium ion cross-linked starch显示文摘Severe skin wounds cause great problems and sufferings to patients.In this study,an injectable wound dressing based on strontium ion cross-linked starch hydrogel(SSH)was developed and evaluated.The good inject-ability of SSH made it easy to be delivered onto the wound surface.The good tissue adhesiveness of SSH ensured a firm protection of the wound.Besides,SSH supported the proliferation of NIH/3T3 fibroblasts and facilitated the migration of human umbilical vein endothelial cells(HUVECs).Importantly,SSH exhibited strong antibacterial effects on Staphylococcus aiireiis(S.ai/rec/s),which could prevent wound infection.These results demonstrate that SSH is a promising wound dressing material for promoting wound healing. | Yuxuan MAO Mingming PAN Huilin YANG Xiao LIN Lei YANG | 2020 | Frontiers of Materials Science2020，14，2： | 2 |
| 5 | Optimization design of fertilizer apparatus owned arc gears based on discrete element method显示文摘To improve the uniformity of the flow when fertilizer apparatus discharges fertilizer,a kind of fertilizer apparatus owned arc gears was designed.Also,the design and working principle of its general structure and key components were analyzed theoretically.Aiming at exploring the influence of arc structural parameters to the performance of arc gears discharging fertilizer,DEM simulation was used in this study.Fertilizer apparatus owned arc gears was taken as the research object to analyze the influence of two key components including the arc radius of gears’concave-grooves and the minimal length between two mutual meshing gears.The variation coefficient of fertilizer discharging amount stability and the linear determined coefficient of fertilizer discharging amount in unit time as evaluation index were selected.Two factors and five levels quadratic rotation orthogonal experiment was applied,and Design-Expert 8.0 software was used to achieve data processing and analysis.The results of experiment indicated that the arc radius of gears’concave-grooves had significant effect on the linear determined coefficient of fertilizer discharging amount in unit time,and the minimal length between two mutual meshing gears had significant effect on the variation coefficient of fertilizer discharging amount stability.The optimum structural parameters were 8.54 mm as the arc radius of gears’concave-grooves and 5.22 mm as the minimal length between two mutual meshing gears.Upon this circumstance,the variation coefficient was 0.28 and determination coefficient was 0.9972.The optimum apparatus was selected to conduct the bench test and field simulation test.The results indicated that the variation coefficient is 0.27,and the linear determined coefficient of is 0.9980.The results of simulation experiment were anastomotic basically with the real result,which showed that DEM simulation technology was usable to the experiment of testing fertilizer discharging.The results of this research can provide a reference to the improving of performance in discharging fertilizer. | Guoqiang Dun Zhiyong Gao Yuxuan Liu Wenyi Ji Ning Mao Xingpeng Wu Wenhui Liu | 2021 | International Journal of Agricultural and Biological Engineering2021，14，2： | 1 |
| 6 | Physical dosimetric reconstruction of a case of large area back skin injury due to overexposure in an interventional procedure显示文摘To estimate the physical dose of skin and key organs in a case of overexposure during a cardiac interventional procedure.Methods The female patient aged 50 suffered from owerexposure during ardiac interventional therapy in a hospital,Xinxiang city,Henan province,China in January 2020.The mesh-type phantom for the patient was constructed based on the adult mesh-type reference computational phantoms(MRCPs)released by the International Comission on Radiological Protection Publication 145 (ICRP145)and phantom deformation technology.Models of exposure scenario were constructed and simulated with particle and heavy ion transport code system(PHTTS)according to exposure conditions.Resuts:The maximum absorbed dose of key organs/tissues under iradiation in posteroanterior(PA)and 30°left anterior oblique directions(LOA)was 632.4 and 305.6 mGy,respectively.The let lung,heart,and left mammary gland received a larger dose under both iradiation conditions.The ratio of the absorbed dose with and without shielding was a lculated,and the relative difference in most organs was<1%between two directions.The iso-dose curve of the back skin revealed the ditribution of the absorbed dose(0.1-5.2 Gy).The dose estimate of key tssues/organs was higher than the conventional level,especially the local skin,up to 5.2 Gy.Concusions The interventional procedure in this ase resulted in a higher dose.Monte Carlo codes combined with the MRCPs can be employed to estimate physical dose to individuals in concrete irradia tion scenarios. | Yuchen Yin Xuan Wang Xianghui Kong Wenyue Zhang Yidi Wang Yuxuan Mao Jianwei Wang Tianhe Jia Yu Tu Bingjie Zhang Liang Sun | 2022 | Radiation Medicine and Protection2022，3，1： | 0 |
| 7 | Achieving Fine-Grained Microstructure and Superior Mechanical Property in a Plain Low-Carbon Steel Using Heavy Cold Rolling Combined with Short-Time Heat Treatment显示文摘A new thermomechanical process consisting of heavy cold rolling(HCR)and short-time heat treatment(STH)is developed to fabricate fine-grained martensite microstructure in a low-cost plain low-carbon steel.To achieve the optimal mechanical properties after STH,three different ferrite-pearlite(F-P)dual-phase microstructures are prepared via hot rolling(HR),HR and austenitizing,and HR and HCR.The microstructure evolution and the comprehensive mechanical properties of the alloy during STH are then investigated.We find that the volume fractions of transformed martensite after STH increase with decreasing grain sizes of the pre-STH F-P dual phases.The rapid heating and short-time holding of STH promote grain nucleation and inhibit grain growth,resulting in microstructure refinement.The formation of martensites with different morphologies and different carbon concentrations in the HR and HCR+STH alloy is identified,owing to the inhomogeneous carbon distribution by STH.Tensile experiments demonstrate that STH greatly improves the comprehension mechanical properties of the alloy.Excellent mechanical properties,with a yield strength of 1224 MPa,a tensile strength of 1583 MPa,a uniform elongation of 4.0%and a total elongation of 7.3%are achieved in the HR and HCR+STH alloy.These excellent mechanical properties are principally attributed to the microstructure refinement and martensite formation induced by STH,with a yield strength improvement of 134%and a tensile strength improvement of 150%relative to the HR alloy. | Yuxuan Liu Shichang Liu Liming Fu Huanrong Wang Wei Wang Mao Wen Aidang Shan | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，10： | 0 |
| 8 | Portal Fibrotic Cord is Associated with Transjugular Intrahepatic Portosystemic Shunt Failure and Death in Cirrhotic Patients显示文摘Background and Aims:Occlusive portal vein thrombosis(PVT)often causes portal hypertension-related complications in cirrhotic patients.Transjugular intrahepatic portosystemic shunt(TIPS)is an effective treatment for this difficult problem.However,the factors influencing TIPS success and overall survival in patients with occlusive PVT are unknown.This study investigated the factors influencing TIPS success and overall survival in cirrhotic patients with occlusive PVT.Methods:Cirrhotic patients with occlusive PVT were selected from a prospective database of consecutive patients treated with TIPS in Xijing Hospital between January 2015 and May 2021.Baseline characteristics,TIPS success rate,complications,and survival were collected,and the factors associated with the TIPS success rate and transplant-free survival were analyzed.Results:A total of 155 cirrhotic patients with occlusive PVT were enrolled.TIPS succeeded in 126(81.29%)cases.The 1-year survival rate was 74%.Compared with those without,patients with portal fibrotic cord had a lower TIPS success rate(39.02%vs.96.49%,p<0.001),shorter median overall survival(300 vs.1,730 days,p<0.001)and more operation-related complications(12.20%vs.1.75%,p<0.01).Logistic regression analysis found that portal fibrotic cord(odds ratio 0.024)was a risk factor for TIPS failure.Univariate and multivariate analysis showed that portal fibrotic cord was an independent predictor of death(hazard ratio 2.111;95%CI:1.094-4.071,p=0.026).Conclusions:Portal fibrotic cord increased the TIPS failure rate and is a risk factor for poor prognosis in cirrhotic patients. | Yunshu Yang Chuangye He Xulong Yuan Kai Li Wenyuan Jia Jing Niu Na Han Jiao Xu Ying Zhu Li Xu Yuxuan Mao Yuanping Xu Xiaoyuan Gou Jun Tie | 2023 | Journal of Clinical and Translational Hepatology2023，11，4： | 0 |
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