|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Relevance of α-defensins(HNP1-3) and defensin β-1 in diabetes显示文摘AIM: To investigate the genetic background of human defensin expression in type 1 and 2 diabetes.METHODS: Associations between DEFA1/DEFA3 gene copy number polymorphism and diabetes as well as between the promoter polymorphisms of DEFB1 and diabetes were studied. The copy number variation of the DEFA1/DEFA3 genes was determined in 257 diabetic patients(117 patients with type 1 and 140 with type 2 diabetes). The control group consisted of 221 age- and gender-matched healthy blood donors. The cumulative copy numbers of the DEFA1/DEFA3 genes were detected by using quantitative PCR analysis. To evaluate the HNP 1-3(human neutrophil peptide 1-3 or α-defensin) levels in the circulation, plasma HNP 1-3 concentrations were measured by ELISA. The expression of DEFA1/A3 in peripheral leukocytes of the diabetic patients was measured by quantitative RT PCR analysis. Three SNPs of the human DEFB1(human defensin β-1) gene: DEFB1 G-20A(rs11362), DEFB1 C-44G(rs1800972) and DEFB1 G-52A(rs1799946) were genotyped by Custom TaqMan? Real Time PCR assay.RESULTS: Significant differences were observed in HNP1-3 levels between the healthy subjects and both groups of diabetic patients. The mean ± SE was 28.78 ± 4.2 ng/mL in type 1 diabetes, and 29.82 ± 5.36 ng/mL in type 2 diabetes, vs 11.94 ± 2.96 ng/mL in controls; P < 0.01 respectively. There was no significant difference between patients with type 1 and type 2 diabetes in the high plasma concentrations of HNP1-3. The highest concentrations of α-defensin were found in diabetic patients with nephropathy(49.4 ± 4.8 ng/mL), neuropathy(38.7 ± 4.8 ng/mL) or cardiovascular complications(45.6 ± 1.45 ng/L). There was no significant difference in the cumulative copy numbers of DEFA1/DEFA3 genes between controls and patients, or between patients with the two types of diabetes. Comparisons of HNP 1-3 plasma level and DEFA1/A3 copy number of the same patient did not reveal significant relationship between defensin-α levels and the gene copy numbers(r2 = 0.01). Similarly, no positive correlation was observed between the copy numbers and the mRNA expression levels of DEFA1/A3. Regarding the C-44G polymorphism of DEFB1, the GG 'protective' genotype was much less frequent(1%-2%) among both groups of patients than among controls(9%).CONCLUSION: Elevated HNP1-3 levels in diabetes are independent of DEFA1/DEFA3 copy numbers, but GG genotype of C-44G SNP in DEFB1 gene may result in decreased defensin β-1 production. | Balázs Csaba Németh Tamás Várkonyi Ferenc Somogyvári Csaba Lengyel Katalin Fehértemplomi Szabolcs Nyiraty Péter Kempler Yvette Mándi | 2014 | World Journal of Gastroenterology2014，20，27： | 4 |
| 2 | Glucagon-like peptide 2:A nutrientresponsive gut growth factor显示文摘 | Douglas G B Yvette P Barbara S | 2001 | The Journal of Nutrition Bethesda2001，131，3： | 1 |
| 3 | Duration Dependence Testing For Speculative Bubbles显示文摘 | Yvette S Harman Thomas W Zuehlke | 2004 | Journal of Economics and Finance2004，28，2： | 1 |
| 4 | Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression 显示文摘 | Yvette I Sheline Milan S | 1999 | J Neurosci1999，19，12： | 1 |
| 5 | Depression duration but not age predicts hippocampal volume loss in medically healthy woman with recurrent major depression 显示文摘 | Yvette I Sheline Milan S | 1999 | J Neurosci1999，19，12： | 1 |
| 6 | Pulmonary function following high dose radiotherapy of non small cell lung cancer 显示文摘 | Katrien D J Yvette S Lieshen J B | 2003 | Int J Radiat Oncol Biol Phys2003，55，5： | 1 |
| 7 | Pulmonary function following high dose radiotherapy of non-small-cell lung cancer显示文摘 | Katrien DJ Yvette S Liesbeth JB | 2003 | Int J Radiat Oncol Biol Phys2003，55，： | 1 |
| 8 | Fatty acid composition of French butters, with special emphasis on conjugated linoleic acid (CLA) isomers显示文摘 | Martial Ledoux Jean-Michel Chardigny Mariannick Darbois Yvette Soustre Jean-Louis Sébédio Laurent Laloux | 2004 | Journal of Food Composition and Analysis2004，，5： | 1 |
| 9 | Isolation of Alicyclobacillus and the influence of different growth parameters显示文摘 | CORLI W R YVETTE S M | 2011 | International Journal of Food Microbiology2011，146，1： | 1 |
| 10 | Laparoscopic resection is safe and feasible for large(≥6 cm)pheochromocytomas without suspicion of malignancy显示文摘 | Yvette M Haggi Mazeh Rebecca S | 2012 | Endocr Pract2012，18，5： | 1 |
| 11 | Food depriva-tion induces chronic stress and affects thyroid hormone metabolism in Senegalese sole (Solea senegalensis) post-larvae显示文摘 | Yvette S W Gonzalo M R Manuel Y | 2012 | Comparative Biochemistry and Physi-ology A-Molecular and Integrative Physiology2012，162，4： | 1 |
| 12 | Glucagon - Like Peptide 2: ANutrient - Responsive Gut Growth Faetor显示文摘 | Douglas GB Yvette P Barbara S | 2001 | Recent Advances in Nutritional Science2001，131，： | 1 |
| 13 | Plasma levels of IL-6 correlate with hemodynamic abnormalities in acute pancreatitis in rabbits显示文摘 | Zoltán Jambrik Mariann Gy?ngy?si Péter Hegyi László Czakó Tamás Takács András Farkas Yvette Mándy Csaba Góg Dietmar Glogar Miklós Csanády | 2002 | Intensive Care Medicine2002，，12： | 1 |
| 14 | Steroid synthesis and metabolism in the nervous system: trophic and protective effects 显示文摘 | Michael S Yvette A Rachida G | 2000 | J Neurocytologv2000，29，： | 1 |
| 15 | Food deprivation induces chronic stress and affects thyroid hormone metabolism in Senegalese sole (Solea senegalensis) post-larvae显示文摘 | Yvette S W Gonzalo M R Manuel Y | | 0，，： | 1 |
| 16 | Elevated n-terminal pro-b- type natriuretie peptide levels : the effect of chronic obstructive pulmonary disease显示文摘 | Yvette R B van Gestel M Don D S | 2009 | JACC2009，53，5： | 1 |
| 17 | NF-κB activation is detrimental in arginine-induced acute pancreatitis显示文摘 | Zoltán Rakonczay Katalin Jármay József Kaszaki Yvette Mándi Ern? Duda Péter Hegyi Imre Boros János Lonovics Tamás Takács | 2003 | Free Radical Biology and Medicine2003，，6： | 1 |
| 18 | Depression duration but not age predicts hippocampal volume loss in medically healthy woman with recurrent major depression显示文摘 | Sheline Milan S | 1999 | J Neurosci1999，19，12： | 1 |
| 19 | Understanding existential authenticity显示文摘 | Carol J S Yvette R | 2006 | Annals of Tourism Research2006，33，2： | 1 |
| 20 | Reconceptualing object authenticity显示文摘 | Yvette R Carol J S | 2006 | Annals of Tourism Research2006，33，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员