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| 1 | Calcium ion as cellular messenger显示文摘The prominent role Ca2+ion plays as a major small biological messenger is fascinating.There are many physiologically important ions,such as Na+,K+,H+,Cl?,Ca2+,Mg2+,Fe3+,and PO43?that participate in cell signaling.Among them,monovalent ions primarily contribute to rapid electrical signaling,while multivalent ions generally act as a co-factor for chemical reactions by associating with the host molecule through electrostatic or covalent interactions.Ca2+plays both roles.Its transmembrane influx supports the plateau phase of cardiac action potential and helps set the speed of pacemaker potential.Inside the cell。 | ZHENG Jie ZENG XuHui WANG ShiQiang | 2015 | Science China(Life Sciences)2015，58，1： | 8 |
| 2 | Diatom-based reconstruction of Holocene environmental changes in Angren Lake,Southern Tibet显示文摘Based on the diatom analysis the climatic sequence between 11 000 and 6 000 aBP in Angren, southern Tibet is established, i.e. cold period (11 095-9 970 aBP)→temperate period (9 970-9 870 aBP)→Anathermal (9 870-9 770 aBP)→cool-dry period (9 770-8 740 aBP) →super-megathermal (8 740-8 590 aBP)→Megathermal (8 590-5 970 aBP). And the opinion that the reaction of diatom to temperature change is more sensitive than to other ecological factors has been pointed out and certified. | Shengfeng Li Fubao Wang Jie Zhang Xuhui Shen Zhaoqi Zeng | 1999 | Chinese Science Bulletin1999，44，12： | 3 |
| 3 | Cross-calibration on the electromagnetic field detection payloads of the China Seismo-Electromagnetic Satellite显示文摘The China Seismo-Electromagnetic Satellite(CSES)deploys three payloads to detect the electromagnetic environment in the ionosphere.The tri-axial fluxgate magnetometers(FGM),as part of the high precision magnetometer(HPM),measures the Earth magnetic vector field in a frequency range from direct current(DC)to 15 Hz.The tri-axial search coil magnetometer(SCM)detects the alternating current(AC)related magnetic field in a frequency range from several Hz to 20 k Hz,and the electric field detector(EFD)measures the spatial electric field in a broad frequency band from DC to 3.5 MHz.This work mainly crosscalibrates the consistency of these three payloads in their overlapped detection frequency range and firstly evaluates CSES’s timing system and the sampling time differences between EFD and SCM.A sampling time synchronization method for EFD and SCM waveform data is put forward.The consistency between FGM and SCM in the ultra-low-frequency(ULF)range is validated by using the magnetic torque(MT)signal as a reference.A natural quasiperiodic electromagnetic wave event verifies SCM and EFD’s consistency in extremely low-frequency and very low-frequency(ELF/VLF)bands.This cross-calibration work is helpful to upgrade the data quality of CSES and brings valuable insights to similar electromagnetic detection solutions by low earth orbit satellites. | ZHIMA Zeren ZHOU Bin ZHAO ShuFan WANG Qiao HUANG JianPing ZENG Li LEI JunGang CHEN Yu LI Cheng YANG DeHe SUN XiaoYing MIAO YuanQing ZHU XingHong SHEN XuHui | 2022 | Science China(Technological Sciences)2022，65，6： | 3 |
| 4 | Recent developments and progress of inorganic photo-stimulated phosphors显示文摘Photo-stimulated luminescence(PSL) is the process in which trapped charges are released by photons and produce luminescence through recombination. The variegated optical characteristics of photostimulated phosphors(PSPs) have drawn increasing attention and a large body of work encompassing mechanism and application of PSPs has been addressed. The optical data storage capacity resulting from abundant defect states enables PSPs to be applied to information storage. Moreover, PSPs provide potential application for anti-counterfeiting, as color changes due to the tunneling process. Recently, near infrared(NIR) light PSPs have been developed, exhibiting enormous potential for in vivo bio-imaging, as the stable and high noise-signal ratio characteristic of PSL. In this review, we devote to introducing the development and process of PSPs, and the challenge and future advance have also been demonstrated. | Xiaotong Fan Zhichao Liu Xiuxia Yang Wenbo Chen Wei Zeng Shuyu Tian Xue Yu Jianbei Qiu Xuhui Xu | 2019 | Journal of Rare Earths2019，37，7： | 2 |
| 5 | China Seismo-Electromagnetic Satellite search coil magnetometerdata and initial results显示文摘Four levels of the data from the search coil magnetometer(SCM) onboard the China Seismo-Electromagnetic Satellite(CSES)are defined and described. The data in different levels all contain three components of the waveform and/or spectrum of the induced magnetic field around the orbit in the frequency range of 10 Hz to 20 kHz; these are divided into an ultra-low-frequency band(ULF,10–200 Hz), an extremely low frequency band(ELF, 200–2200 Hz), and a very low frequency band(VLF, 1.8–20 kHz). Examples of data products for Level-2, Level-3, and Level-4 are presented. The initial results obtained in the commission test phase demonstrated that the SCM was in a normal operational status and that the data are of high enough quality to reliably capture most space weather events related to low-frequency geomagnetic disturbances. | Qiao Wang JianPing Huang XueMin Zhang XuHui Shen ShiGeng Yuan Li Zeng JinBin Cao | 2018 | Earth and Planetary Physics2018，2，6： | 2 |
| 6 | Ca^(2+) signals induced from calcium stores in pancreatic islet β cells显示文摘In single rat pancreatic βcells, using fura-2 microfluorometry to measure [Ca2+] response upon different stimuli, the ways of calcium regulation have been studied. When the extracellular calcium concentration was 2.5 mmol/L, either 60 mmol/L KCI, 20 mmol/L D-glucose or 0.1 mmol/L tolbutamide induced increase in [Ca2+]. Such increase in [Ca2+] was absent when the same stimuli were applied under zero extracellular calcium. These results indicate that the increase of [Ca2+] is induced by the activation of voltage-dependent calcium channels in p celis. The manifold forms of [Ca2+] change induced by glucose imply that the effects of glucose are complex. 5 mmol/L caffeine or 5 mmol/L MCh increase the [Ca2+], which is independent of the external calcium, suggesting that [Ca2+] can be regulated by Ca2+ release from not only the IP3-sensitive but also the ryanodine sensitive calcium stores in p celis. The latency of Ca responses for IP3 pathway (5 s) is faster than that for ryanodine pathway (30 s), it is | ZENG Xuhui, QU Anlian, LOU Xuelin, XU Jianhua, WANG Junjian, WU Hongxiu & ZHOU Zhuan1. Institute of Biochemistry and Biophysics, Huazhong University of Science and Technology, Wuhan 430074, China 2. Pharmacology, Huazhong University of Science and Technology, Wuhan 430074, China 3. School of Life Sciences, University of Science and Technology of China, Hefei 230027, China Correspondence should be addressed to Zhou Zhuan. | 2000 | Chinese Science Bulletin2000，45，1： | 2 |
| 7 | Predictive Decision and Reliable Accessing for UAV Communication in Space-Air-Ground Integrated Networks显示文摘The cooperation of multiple Unmanned Aerial Vehicles(UAVs) has become a promising scenario in Space-Air-Ground Integrated Networks(SAGINs) recently due to their widespread applications,where wireless communication is a basic necessity and is normally categorized into control and nonpayload communication(CNPC) as well as payload communication. In this paper, we attempt to tackle two challenges of UAV communication respectively on establishing reliable CNPC links against the high mobility of UAVs as well as changeable communication conditions, and on offering dynamic resource optimization for Quality-of-Service(QoS) guaranteed payload communication with variable link connectivity. Firstly, we propose the concept of air controlling center(ACC), a virtual application equipped on the infrastructure in SAGINs, which can collect global information for estimating UAV trajectory and communication channels. We then introduce the knapsack problem for modelling resource optimization of UAV communication in order to provide optimal access points for both CNPC and payload communication. Meanwhile, using the air controlling information, predictive decision algorithm and handover strategy are introduced for the reliable connection with multiple access points. Simulation results demonstrate that our proposal ensures an approximate always-on reliable accessing of communication links and outperforms the existing methods against high mobility,sparse distribution, and physical obstacles. | Bowen Zeng Zhongshan Zhang Xuhui Ding Xiangyuan Bu Jianping An | 2022 | China Communications2022，19，1： | 1 |
| 8 | Miocene Crustal Anatexis of Paleozoic Orthogneiss in the Zhada Area,Western Himalaya显示文摘Granitic gneiss(orthogneiss)and Himalayan leucogranite are widely distributed in the Himalayan orogen,but whether or not the granitic gneiss made a contribution to the Himalayan leucogranite remains unclear.In this study,we present the petrological,geochronological and geochemical results for orthogneisses and leucogranites from the Zhada area,Western Himalayas.Zhada orthogneiss is composed mainly of quartz,plagioclase,K-feldspar,biotite and muscovite,with accessory zircon and apatite.Orthogneiss zircon cathodoluminescence(CL)images show that most grains contain a core with oscillatory zoning,which indicates an igneous origin.Sensitive high-resolution ion microprobe(SHRIMP)U-Pb dating of the zircon cores in the orthogneiss shows a weighted ^(206)Pb/^(238)U age of 515±4 Ma(early Paleozoic),with sponge-like zircon rims of 17.9±0.5 Ma(Miocene).Zhada leucogranite shows^(206)Pb/^(238)U ages ranging from 19.0±0.4 Ma to 12.4±0.2 Ma,the weighted average age being 16.2±0.4 Ma.The leucogranites have a low Ca content(<1 wt%),FeOt content(<1 wt%),Rb content(67.0-402 ppm),Sr content(<56.6 ppm),Ba content(3.35-238 ppm)and Rb/Sr ratio(0.5-14.7),which are similar to the geochemical characteristics of the Himalayan leucogranite derived from muscovite dehydration partial melting of metasediments and representative of most Himalayan leucogranites.The highly variable Na_(2)O+K_(2)O(4.33 wt%-9.13 wt%),Al_(2)O_(3)(8.44 wt%-13.51 wt%),ΣREE(40.2-191.0 ppm),Rb(67.0-402 ppm)and Nb(8.23-26.4 ppm)contents,^(87)Sr/^(86)Sr(t)ratios(0.7445-0.8605)andεNd(t)values(−3.6 to−8.2)indicate that the leucogranite is derived from a heterogenetic source.The nonradiogenic Nd isotope values of the studied Zhada leucogranite and orthogneiss range from−8.2 to−3.6 and from−8.7 to−4.1,respectively.Therefore,the general mixing equation was used to perform the Sr and Nd isotope mixing calculations.The results indicate that the heterogenetic source was the Tethyan Himalayan Sequence(THS)/Higher Himalayan Crystalline(HHC)metasediments and Zhada orthogneiss.The Zhada area experienced crustal anatexis during the Miocene and the heterogenetic source of the orthogneiss and metasediment may have experienced crustal anatexis controlled by muscovite dehydration.The Zhada leucogranite inherited not only the geochemical characteristics of the Himalayan metasediment(muscovite dehydration melting),but also the trace elements and Sr-Nd isotopic characteristics of the Zhada orthogneiss.These results indicate that the Paleozoic Zhada orthogneiss was involved in crustal anatexis at 17.9±0.5 Ma(Miocene)and that the muscovite dehydration of the metasediments in the heterogenetic source produced fluid,which may have caused the orthogneiss solidus lines to decline,triggering a partial melting of the Zhada orthogneiss.It is therefore proposed that Himalayan leucogranite is a crust-derived granite rather than a S-type granite,as previously hypothesized. | CHEN Han HU Guyue ZENG Lingsen YU Xuhui LI Yike | 2022 | Acta Geologica Sinica(English Edition)2022，96，3： | 1 |
| 9 | Artificial intelligence for the development and implementation guidelines for traditional Chinese medicine and integrated traditional Chinese and western medicine显示文摘The translation and implementation of clinical practice guidelines(CPGs)for Traditional Chinese Medicine(TCM)and Integrated Traditional Chinese and Western medicine is crucial to the adoption of medical science and technology,but the low operability and slow update of integrated traditional Chinese and Western Medicine guidelines,and the lack of integration between guidelines and clinical practice,result in the guidelines not having the desired clinical effects in practice.The application of Artificial Intelligence(AI)to the field of CPGs development aims to shorten the development time,optimize and accelerate the whole process of CPG’s development.This article summarized the current research and application status of AI in development and implementation CPGs for TCM and Integrated Traditional Chinese and Western medicine and proposed the method of Combining real world data and AI technology to enrich for TCM and Integrated Traditional Chinese and Western medicine. | Yinghui Jin Xiangying Ren Lina Yu Yongbo Wang Qiao Huang Xuhui Li Xiangge Ren Jiaao Lou Kuang Gao Mukun Chen Wenbin Hu Xiantao Zeng Hongcai Shang | 2021 | TMR Modern Herbal Medicine2021，4，2： | 1 |
| 10 | A novel homozygous splice variant in DNAAF4 is associated with asthenozoospermia显示文摘Primary ciliary dyskinesia(PCD)is an autosomal recessive disorder with a high degree of genetic and phenotypic heterogeneity resulted from defects in the structural characteristics and motility of flagella and cilia[1].To data,over 50 mutations have been identified as harboring PCD-related mutations,and approximately half of the affected patients suffer from infertility as a result of sperm morphological or functional abnormalities[2]. | Xiaobin Zhu Chen Chen Jian Song Shijue Dong Xuhui Zeng Zhihong Niu Yanwei Sha Xiaoning Zhang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，10： | 0 |
| 11 | Clinical management of a rare melanoma case arising from congenital melanocytic nevus显示文摘Congenital melanocytic nevi(CMNs)are skin lesions characterized by benign melanocytic proliferations and present at birth or shortly thereafter.Large and giant CMNs,with a projected adult size≥20 cm and 40 cm in diameter respectively,are more likely to develop into malignant melanoma.In most cases,melanoma arising from congenital melanocytic nevus(CMN)is particularly aggressive. | Ruixin Jiang Yan Wang Xuhui Ma Xinyang Xuanyuan Yanjie Zhang Bin Jiang Weizhen Zhang Hanlin Zeng | 2024 | Genes & Diseases2024，11，3： | 0 |
| 12 | Theasinensin A attenuated diabetic development by restoring glucose homeostasis, improving hepatic steatosis and modulating gut microbiota in high-fat-diet/streptozotocin-induced diabetic mice显示文摘Theasinensin A(TSA),a dimer of epigallocatechin gallate,has been preliminarily demonstrated to have hypoglycemia and anti-inflammatory effects.However,little information is available on its potential mechanisms of anti-diabetes.Therefore,the present study aimed to investigate the influence of TSA on glucose and lipid metabolism and gut microbiota in high-fat-diet/streptozotocin-induced diabetic mice.As result,TSA improved polydipsia,polyphagia and impaired glucose tolerance of diabetic mice,declined the fasting blood glucose and hepatic triglyceride level,and enhanced the expression at mRNA level of insulin receptor substrate,phosphoinositide 3-kinase,protein kinase B and glucagon-like peptide 1 receptor(GLP-1R)in the diabetic liver.Moreover,TSA could restore the disorder of gut microbiota of diabetic mice.High-dose(100 mg/kg)TSA showed better benefi cial effects from the blood biochemical parameters,hepatic function and gut microbiota.In general,high-dose TSA significantly modulated gut microbiota by increasing the relative abundance of Akkermansia and decreasing the relative abundances of Acetatifactor,Anaerotruncus,Pseudofl avonifactor,Oscillibacter and Clostridium clusters.The results indicated that TSA could exert an anti-diabetes effect in diabetic mice through restoring glucose homeostasis,declining hepatic steatosis,activating insulin and GLP-1 signaling pathways,and ameliorating gut microbiota dysbiosis. | Weiqi Xu Yujie Huang Wangting Zhou Yujia Peng Xuhui Kan Wei Dong Guijie Chen Xiaoxiong Zeng Zhonghua Liu | 2023 | Food Science and Human Wellness2023，12，6： | 0 |
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