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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | Environmental connections of novel avian-origin H7N9 influenza virus infection and virus adaptation to the human显示文摘A novel H7N9 influenza A virus has been discovered as the causative identity of the emerging acute respiratory infection cases in Shanghai,China.This virus has also been identified in cases of infection in the neighboring area Hangzhou City in Zhejiang Province.In this study,epidemiologic,clinical,and virological data from three patients in Hangzhou who were confirmed to be infected by the novel H7N9 influenza A virus were collected and analyzed.Human respiratory specimens and chicken feces from a contacted free market were tested for influenza virus by real-time reverse transcription PCR(RT-PCR) and sequencing.The clinical features of the three cases were similar featured with high fever and severe respiratory symptoms;however,only one of the patients died.A certain degree of diversity was observed among the three Hangzhou viruses sequenced from human samples compared with other reported H7N9 influenza A viruses.The sequences of the novel avian-origin H7N9 influenza viruses from Hangzhou City contained important amino acid substitutions related to human adaptation.One of the Hangzhou viruses had gained a novel amino acid substitution(Q226I) in the receptor binding region of hemagglutinin.More importantly,the virus sequenced from the chicken feces had a 627E substitution in the PB2 protein instead of the mammalian-adapted 627K substitution that was found in the PB2 proteins from the Hangzhou viruses from the three patients.Therefore,the newly-emerging H7N9 virus might be under adaptation pressure that will help it 'jump' from avian to human hosts.The significance of these substitutions needs further exploration,with both laboratory experiments and extensive field surveillance. | LI Jun YU XinFen PU XiaoYing XIE Li SUN YongXiang XIAO HaiXia WANG FenJuan DIN Hua WU Ying LIU Di ZHAO GuoQiu LIU Jun PAN JingCao | 2013 | Science China(Life Sciences)2013，56，6： | 32 |
| 3 | The prognostic and therapeutic implications of circulating tumor cell phenotype detection based on epithelial-mesenchymal transition markers in the first-line chemotherapy of HER2-negative metastatic breast cancer显示文摘Background:Epithelial-mesenchymal transition(EMT)is implicated in the metastatic process and presents a chal-lenge to epithelial cell adhesion molecule-based detection of circulating tumor cells(CTCs),which have been demon-strated to be a prognostic indicator in metastatic breast cancer.Although evidence has indicated that heterogeneity of CTCs based on EMT markers is associated with disease progression,no standard recommendations have been established for clinical practice.This study aimed to evaluate the prognostic significance of dynamic CTC detection based on EMT for metastatic breast cancer patients.Methods:We enrolled 108 human epidermal growth factor receptor 2-negative metastatic breast cancer patients from the prospective phase III CAMELLIA study and applied the CanPatrol CTC enrichment technique to identify CTC phenotypes(including epithelial CTCs,biphenotypic epithelial/mesenchymal CTCs,and mesenchymal CTCs)in peripheral blood samples.Receiver operating characteristic curve analyses of total CTC count and the proportion of mesenchymal CTCs for predicting the 1-year progression-free survival(PFS)rate were conducted to determine the optimal cut-off values,and Kaplan-Meier analysis and Cox proportional hazards regression analysis were performed to investigate the prognostic value of the cut-off values of both total CTC count and the proportion of mesenchymal CTCs in combination.Results:For predicting the 1-year PFS rate,the optimal cut-off value of total CTC count was 9.5(Area under the curve[AUC]=0.538,95%confidence interval[CI]=0.418-0.657),and that of the proportion of mesenchymal CTCs was 10.7%(AUC=0.581,95%CI=0.463-0.699).We used the two cut-off values in combination to forecast PFS in which the total CTC count was equaled to or exceeded 10/5 mL with the proportion of mesenchymal CTCs surpassed 10.7%.Patients who met the combined criteria had significantly shorter median PFS than did those who did not meet the criteria(6.2 vs.9.9 months,P=0.010).A nomogram was constructed based on the criteria and significant clinicopatho-logical characteristics with a C-index of 0.613(P=0.010).Conclusions: The criteria, which combine the total CTC count and the proportion of mesenchymal CTCs, may be used to monitor therapeutic resistance and predict prognosis in patients with metastatic breast cancer. | Xiuwen Guan Fei Ma Chunxiao Li Shiyang Wu Shangying Hu Jiefen Huang Xiaoying Sun Jiayu Wang Yang Luo Ruigang Cai Ying Fan Qiao Li Shanshan Chen Pin Zhang Qing Li Binghe Xu | 2019 | Cancer Communications2019，39，1： | 15 |
| 4 | Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis显示文摘人的大脑开发的细胞的复杂性强烈地被调查了,尽管全部人的服的外皮的地区性的描述没基于单个房间的 transcriptome 分析被报导。这里,我们从人的中间怀孕期的胚胎的 22 个大脑区域在超过 4,000 个单个房间上执行了 RNA-seq。我们识别了 29 房间亚簇,它证明在每个区域和脑桥的不同比例显示出星形细胞的特别高的百分比。胚胎的神经原不象成年神经原一样多样,尽管他们在成年人拥有了他们的命运的重要特征。神经原开发是在服的外皮的 unsynchronized,当背面的区域看起来比在这个阶段的腹的区域更成熟。区域特定的基因包括地在每 neuronal 亚簇被识别,并且这些基因的一个大比例是联系的神经疾病。我们的结果介绍区域化的基因表示的一处系统的风景和人的服的外皮的神经原成熟。 | Xiaoying Fan Ji Dong Suijuan Zhong Yuan Wei Qian Wu Liying Yan Jun Yong Le Sun Xiaoye Wang Yangyu Zhao Wei Wang Jie Yan Xiaoqun Wang Jie Qiao Fuchou Tang | 2018 | Cell Research2018，28，7： | 11 |
| 5 | Cervical Cancer Screening Coverage — China, 2018–2019显示文摘What is already known about this topic?The World Health Organization set a 2030 target of 70%cervical cancer screening coverage for women aged 35–45 years.Coverage stood at 37%in China in 2015.What is added by this report?In 2018–2019,China’s cervical cancer screening coverage reached 43.4%in women aged 35–44 years and 36.8%in women aged 35–64 years.Screening coverage was still lower in rural areas as well as central and western regions;large variations existed across provincial-level administrative divisions.What are the implications for public health practice?National and local policy and financial support should be maintained for cervical cancer screening,along with more targeted health education and outreach efforts and strengthened accessibility of health services in the rural areas and central and western regions. | Mei Zhang Yijing Zhong Limin Wang Heling Bao Zhengjing Huang Zhenping Zhao Xiao Zhang Chun Li Kelly Liang Sun Jing Wu Xiaoying Zheng Linhong Wang | 2022 | China CDC weekly2022，4，48： | 11 |
| 6 | Waste oyster shell as a kind of active filler to treat the combined wastewater at an estuary显示文摘Estuaries have been described as one of the most difcult environments on Earth. It is difcult to know how to treat the combined wastewater in tidal rivers at the estuary, where the situation is very diferent from ordinary fresh water rivers. Waste oyster shell was used as the active filler in this study in a bio-contact oxidation tank to treat the combined wastewater at the Fengtang Tidal River. With a middle-experimental scale of 360 m3/day, the average removal efciency of COD, BOD, NH3-N, TP and TSS was 80.05%, 85.02%,86.59%, 50.58% and 85.32%, respectively, in this bio-contact oxidation process. The living microbes in the biofilms on the waste oyster shell in this bio-contact oxidation tank, which were mainly composed of zoogloea, protozoa and micro-metazoa species, revealed that waste oyster shell as the filler was suitable material for combined wastewater degradation. This treatment method using waste oyster shell as active filler was then applied in a mangrove demonstration area for water quality improvement near the experiment area, with a treatment volume of 5 × 103m3/day. Another project was also successfully applied in a constructed wetland, with a wastewater treatment volume of 1 × 103m3/day. This technology is therefore feasible and can easily be applied on a larger scale. | Hongbing Luo Gu Huang Xiaoying Fu Xiaoling Liu Daocai Zheng Jian Peng Ke Zhang Bo Huang Liangqian Fan Fenghui Chen Xiubo Sun | 2013 | Journal of Environmental Sciences2013，25，10： | 11 |
| 7 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 8 | Occurrence of mycotoxins in feed ingredients and complete feeds obtained from the Beijing region of China显示文摘Background:The current study was carried out to provide a reference for the control of mycotoxin contamination in feed ingredients and complete feeds for swine.Methods:A total of 55 feed ingredients,including 14 corn,13 wheat bran,11 soybean meal and 17 dried distillers grains with solubles(DDGS) as well as 76 complete swine feeds including 7 creep feeds,14 starter feeds,14 grower feeds,18 grower-finisher feeds,10 gestating sow feeds,and 13 lactating sow feeds were randomly collected from15 swine farms located in the Beijing region of China from July to August 2011.Immunoaffinity clean-up,using High-Performance Liquid Chromatography(HPLC) in combination with UV or Fluorescence Detection,was used for quantitative analysis of aflatoxin B,(AFB,),deoxynivalenol(DON),zearalenone(ZEA) and ochratoxin A(OTA) in the ingredients and complete feeds.Results:DON and ZEA were the most prevalent mycotoxins found.DON was detected at percentages of 93,92,54,100 and 97%with a mean level of 1.01,0.44,0.05,1.36 and 0.65 ppm in the samples of corn,wheat bran,soybean meal,DDGS and complete feeds,respectively.The detected percentages of ZEA were 100,100,54,100 and 100 with mean levels of 109.1,14.9,9.2,882.7 and 58.9 ppb in the same samples.In the wheat bran and soybean meal samples,the content of all four mycotoxins were below the maximum limits set by Chinese regulations while the percentage of samples that exceeded regulatory limits were 7,57 and 7%for corn,and 7,14 and 3%for the complete feeds for AFB,,DON and OTA respectively.DDGS showed the most serious mycotoxin contamination and the percentage of samples that exceeded regulatory limits were 6,88 and 41%,for AFB,,DON and ZEA,respectively.Conclusions:This paper is the first to present data on the natural occurrence of AFB,,DON,ZEA and OTA in ingredients and complete feeds obtained from swine farms in China's Beijing region.The data shows that feed ingredients and complete swine feeds obtained from these farms are most often contaminated with DON followed by contamination with AFB,and ZEA. | Xiaoying Li Lihong Zhao Yu Fan Yaxiong Jia Lei Sun Shanshan Ma Cheng Ji Qiugang Ma Jianyun Zhang | 2014 | Journal of Animal Science and Biotechnology2014，5，4： | 7 |
| 9 | An antiretroviral regimen containing 6 months of stavudine followed by long-term zidovudine for first-fine HIV therapy is optimal in resource-limited settings: a prospective, multicenter study in China显示文摘 | Li Taisheng Guo Fuping Li Yijia Zhang Chengda Han Yang Lye Wei He Yun Lu Hongzhou Xie Jing Huang Aiqiong Li Yanling Tang Xiaoping Wang Hui Zhang Tong Gao Guiju Lei Junkang Zhang Xiaoying Wu Xinhua Sun Yongtao Bai Jinsong Luo Ling Wang Huanlmg | 2014 | Chinese Medical Journal2014，，1： | 6 |
| 10 | Standardized Operational Protocol for Human Brain Banking in China显示文摘With the progress of society, there is an increasing need to tackle disorders of the central nervous system. Human brain tissue, unlike animal tissues, is an irreplaceable resource for the study of neurological diseases (1)Aimed at scientific research and education, the roles of human brain tissue repositories are to acquire brain tissue from donors, prepare, process, and preserve collected samples,provide tissue to specific eligible facilities, and determine the characteristics of each tissue sample. | Wenying Qiu Hanlin Zhang Aimin Bao Keqing Zhu Yue Huang Xiaoxin Yan Jing Zhang Chunjiu Zhong Yong Shen Jiangning Zhou Xiaoying Zheng Liwei Zhang Yousheng Shu Beisha Tang Zhenxin Zhang Gang Wang Ren Zhou Bing Sun Changlin Gong Shumin Duan Chao Ma | 2019 | Neuroscience Bulletin2019，35，2： | 6 |
| 11 | Validity of distress thermometer for screening of anxiety and depression in family caregivers of Chinese breast cancer patients receiving postoperative chemotherapy显示文摘Objective:Family caregivers(FCs)of breast cancer patients play a vital role throughout the treatment process.Psychological distress of FCs is common and often ignored.A simple and effective instrument for screening psychological distress would help in selecting those FCs requiring special attention and intervention.Here,the validity of distress thermometer(DT)in FCs of Chinese breast cancer patients receiving postoperative chemotherapy was assessed,and the prevalence of anxiety and depression was evaluated.Methods:We recruited 200 FCs of hospitalized breast cancer patients in this cross-sectional descriptive study.Before the first cycle of adjuvant chemotherapy,the levels of anxiety and depression among FCs were assessed using DT and Hospital Anxiety and Depression Scale(HADS).In total,191 valid cases were analyzed.HADS was used as the diagnostic standard to assess the effectiveness of DT as a screening tool for anxiety and depression as well as to analyze the diagnostic efficiency of DT at various cutoff points.Results:The definitive prevalence of both anxiety and depression was 8.90%.The mean level of anxiety and depression among FCs was 5.64±3.69 and 5.09±3.85,respectively,both of which were significantly higher than corresponding Chinese norms(P<0.01).The areas under receiver operating characteristic curves of DT for the diagnoses of FCs'anxiety and depression were 0.904 and 0.885,respectively.A cutoff value of 5 produced the best diagnostic effects of DT for anxiety and depression.Conclusions:The levels of both anxiety and depression were higher in the FCs of Chinese breast cancer patients receiving postoperative chemotherapy than the national norm.DT might be an effective tool to initially screen psychological distress among FCs.This process could be integrated into the palliative care of breast cancer patients and warrant further research. | Min Yang Fei Ma Bo Lan Jianqiang Cai Xiaoying Sun Binghe Xu | 2020 | Chinese Journal of Cancer Research2020，32，4： | 5 |
| 12 | The association between early-onset cardiac events caused by neoadjuvant or adjuvant chemotherapy in triple-negative breast cancer patients and some novel autophagy-related polymorphisms in their genomic DNA: a real-world study显示文摘Background:An increasing number of cancer patients die of cardiovascular diseases.The cardiotoxicity of chemo-therapy is particularly important in triple-negative breast cancer(TNBC)with limited therapeutic options.Cardiac autophagy is an important mechanism of cardiotoxicity.This research was aimed to investigate the cardiotoxicity of chemotherapy in TNBC,screen the susceptible population,and determine the relationship between cardiotoxicity and autophagy-related polymorphisms.Methods:From a total of 2450 stage I-III TNBC patients,147 met the inclusion criteria and finally recruited.Electro-cardiography(ECG)was performed before most chemotherapy cycles,and echocardiography(UCG)was performed according to clinical needs.All ECG and UCG records were re-interpreted by cardiologists at the National Center for Cardiovascular Disease,Fuwai Hospital.According to the National Center for Biotechnology Information and the Catalog of Somatic Mutations in Cancer database,we selected 25 single nucleotide polymorphisms(SNPs)related to autophagy and genotyped the 147 TNBC patients.Paired-sample T tests,Chi squared tests,and logistic regression models were employed for the analysis.Results:Only 46(31.3%)patients had normal ECG records after every chemotherapy cycle.Among the 16 patients who underwent UCG,2(12.5%)had a reversible decrease of left ventricular ejection fraction.The use of anthracyclines and excessive alcohol consumption were risk factors of ECG abnormalities.With the continuation of chemotherapy,heart rate gradually increased.Anthracyclines were associated with QRS duration abnormalities(P=0.043).After genotyping for 25 autophagy-related SNPs,we found that the G allele of autophagy-related 13(ATG13)rs10838611 was significantly associated with ECG abnormalities(odds ratio=2.258,95%confidence interval=1.318-3.869;P=0.003).Conclusion:ECG abnormalities caused by chemotherapy are common in the real world.Autophagy-related SNPs are associated with chemotherapy-induced cardiotoxicity,thereby providing new evidence for autophagy as a cause of chemotherapy-induced cardiac damage. | Binliang Liu Tao An Meiying Li Zongbi Yi Chunxiao Li Xiaoying Sun Xiuwen Guan Lixi Li Yanfeng Wang Yuhui Zhang Binghe Xu Fei Ma Yixin Zeng | 2018 | Cancer Communications2018，38，1： | 5 |
| 13 | Regulation of microbiota–GLP1 axis by sennoside A in diet-induced obese mice显示文摘Sennoside A(SA) is a bioactive component of Chinese herbal medicines with an activity of irritant laxative, which is often used in the treatment of constipation and obesity. However, its activity remains unknown in the regulation of insulin sensitivity. In this study, the impact of SA on insulin sensitivity was tested in high fat diet(HFD)-induced obese mice through dietary supplementation. At a dosage of 30 mg/kg/day, SA improved insulin sensitivity in the mice after 8-week treatment as indicated by HOMA-IR(homeostatic model assessment for insulin resistance) and glucose tolerance test(GTT). SA restored plasma level of glucagon-like peptide 1(GLP1) by 90% and mRNA expression of Glp1 by 80% in the large intestine of HFD mice. In the mechanism, SA restored the gut microbiota profile, short chain fatty acids(SCFAs), and mucosal structure in the colon. A mitochondrial stress was observed in the enterocytes of HFD mice with ATP elevation, structural damage, and complex dysfunction. The mitochondrial response was induced in enterocytes by the dietary fat as the same responses were induced by palmitic acid in the cell culture. The mitochondrial response was inhibited in HFD mice by SA treatment. These data suggest that SA may restore the function of microbiota–GLP1 axis to improve glucose metabolism in the obese mice. | Jiamei Le Xiaoying Zhang Weiping Jia Yong Zhang Juntao Luo Yongning Sun Jianping Ye | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 5 |
| 14 | A Multiresponsive Hydrophobic Associating Hydrogel Based on Azobenzene and Spiropyran显示文摘Summary of main observation and conclusion Stimuli-responsive hydrogels crosslinked by weak noncovalent bonds such as hydrogen bonds,ionic interactions,host-guest interactions and hydrophobic interactions have been extensively investigated.Herein,azobenzene and spiropyran acting as two hydrophobic pendant groups were introduced into a hydrophilic polyacrylamide (PAM) via free radical copolymerization to construct a hydrophobic interaction based thermo-,light-responsive polymer hydrogel.Its viscosity and color could be reversibly regulated by heating and cooling.Meanwhile,its color could be specifically switched by light without obvious viscosity change.The gel was also capable of being transited to sol by addition of β-cyclodextrin (β-CD),which encaged the hydrophobic groups and then increased the solubility of polymer in water.The hydrogel could be regained after UV irradiation at λ=365 nm,and after irradiation at λ=440 nm,the hydrogel changed into a clear sol again. | Anqi Liu Chenxiao Xiong Xiaoying Ma Wenjing Ma Ruyi Sun | 2019 | Chinese Journal of Chemistry2019，37，8： | 4 |
| 15 | The Rice'NUTRITION RESPONSE AND ROOT GROWTH' (NRR) Gene Regulates Heading Date显示文摘Dear Editor, As one of the most important developmental traits,flowering time has been extensively investigated in the long-day plant Arabidopsis.Multiple factors are involved,including photoperiod and/or temperature (Amasino,2010).Flowering locus T (FT) is known to be an important integrator of different flowering pathways (Taoka et al.,2011).Genes of the CONSTANS (CO) family also play key roles in regulating flowering time.The CO protein consists of a zinc finger and a CCT domain shared by a group of plant-specific transcription factors that regulate photoperiodic flowering response and circadian rhythms in Arabidopsis.In the case of short-day plants such as rice,previous studies have also revealed a number of genes that control heading date,such as the CO ortholog Heading date 1 (Hdl) and,at its downstream,Heading date 3a (Hd3a),an ortholog of FT (Kojima et al.,2002;Komiya et al.,2008).Although the main photoperiodic flowering regulators are highly conserved between Arabidopsis and rice,there are genes that act differently relating to the daylength property of rice,such as Early heading datel (Ehdl),Indeterminate1 (OslD1),the MADS-box gene OsMADS51 (Doiet al.,2004;Kim et al.,2007;Park et al.,2008),and Ghd7 (Xue et al.,2008). | Yuman Zhang Ge Zhang Na Xiao Lina Wang Yaping Fu Zongxiu Sun Rongxiang Fang Xiaoying Chen | 2013 | Molecular Plant2013，6，2： | 3 |
| 16 | Catalytic Property and Stability of Subnanometer Pt Cluster on Carbon Nanotube in Direct Propane Dehydrogenation显示文摘Main observation and conclusion The stability of nanosized platinum catalyst in direct propane dehydrogenation reaction is one of most critical challenges,which hin-ders the further improvements of catalytic performance.The cokes from side reaction covering the active site seriously undermine the catalyst stability.In this work,first principles calculations are performed to explore the catalytic properties of supported subna-nometer platinum cluster on carbon nanotube support and focus is put on the inhibition of deep dehydrogenation.The reactivities of metal,interface,and tin promoter are investigated at the same footing.The whole reaction pathway from propane adsorption to propene desorption is revealed for different sites.It turns out that the C-H bond activation in propane is not the catalytic step with the largest barrier.Instead,the desorption of propene is more difficult.The comparison between different sites indicates that the in-terface between metal and support and Sn promoter is helpful to curb the propene deep dehydrogenation.Moreover,a descriptor is proposed to screen the potential effective propane direct dehydrogenation catalyst.The current work provides important insights on the development of new dehydrogenation catalyst. | Xiaoying Sun Jjiahui Xue Yu Ren Xinyu Li Liing Zhou Bo Li Zhen Zhao | 2021 | Chinese Journal of Chemistry2021，39，3： | 3 |
| 17 | Inhibition of temperature-sensitive TRPV3 channel by two natural isochlorogenic acid isomers for alleviation of dermatitis and chronic pruritus显示文摘Genetic gain-of-function mutations of warm temperature-sensitive transient receptor potential vanilloid 3(TRPV3)channel cause Olmsted syndrome characterized by severe itching and keratoderma,indicating that pharmacological inhibition of TRPV3 may hold promise for therapy of chronic pruritus and skin diseases.However,currently available TRPV3 tool inhibitors are either nonselective or less potent,thus impeding the validation of TRPV3 as therapeutic target.Using whole-cell patch-clamp and single-channel recordings,we report the identification of two natural dicaffeoylquinic acid isomers isochlorogenic acid A(IAA)and isochlorogenic acid B(IAB)that selectively inhibit TRPV3 currents with IC50 values of 2.7±1.3 and 0.9±0.3μmol/L,respectively,and reduce the channel open probability to 3.7±1.2%and 3.2±1.1%from 26.9±5.5%,respectively.In vivo evaluation confirms that both IAA and IAB significantly reverse the ear swelling of dermatitis and chronic pruritus.Furthermore,the isomer IAB is able to rescue the keratinocyte death induced by TRPV3 agonist carvacrol.Molecular docking combined with site-directed mutations reveals two residues T636 and F666 critical for the binding of the two isomers.Taken together,our identification of isochlorogenic acids A and B that act as specific TRPV3 channel inhibitors and gating modifiers not only provides an essential pharmacological tool for further investigation of the channel pharmacology and pathology,but also holds developmental potential for treatment of dermatitis and chronic pruritus. | Hang Qi Yuntao Shi Han Wu Canyang Niu Xiaoying Sun KeWei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 3 |
| 18 | Additive Effect of Zfhx3/Atbf1 and Pten Deletion on Mouse Prostatic Tumorigenesis显示文摘The phosphatase and tensin homolog(PTEN) and the zinc finger homeobox 3(ZFHX3)/AT-motif binding factor 1(ATBF1) genes have been established as tumor suppressor genes in prostate cancer by their frequent deletions and mutations in human prostate cancer and by the formation of mouse prostatic intraepithelial neoplasia(mPIN) or tumor by their deletions in mouse prostates.However,whether ZFHX3/ATBF1 deletion together with PTEN deletion facilitates prostatic tumorigenesis is unknown.In this study,we simultaneously deleted both genes in mouse prostatic epithelia and performed histological and molecular analyses.While deletion of one Pten allele alone caused low-grade(LG) mPIN as previously reported,concurrent deletion of 2fla3/Atbf1 promoted the progression to high-grade(HG)mPIN or early carcinoma.Zfhx3/Atbf1 and Pten deletions together increased cell proliferation,disrupted the smooth muscle layer between epithelium and stroma,and increased the number of apoptotic cells.Deletion of both genes also accelerated the activation of Akt and Erk1/2 oncoproteins.These results suggest an additive effect of ZFHX3/ATBF1 and PTEN deletions on the development and progression of prostate neoplasia. | Xiaodong Sun Changsheng Xing Xiaoying Fu Jie Li Baotong Zhang Henry F.Frierson Jr. Jin-Tang Dong | 2015 | Journal of Genetics and Genomics2015，42，7： | 3 |
| 19 | Fiber-shaped organic electrochemical transistors for biochemical detections with high sensitivity and stability显示文摘Precise and continuous monitoring of biochemicals by biosensors assists to understand physiological functions for various diagnostics and therapeutic applications.For implanted biosensors,small size and flexibility are essential for minimizing tissue damage and achieving accurate detection.However,the active surface area of sensor decreases as the sensor becomes smaller,which will increase the impedance and decrease the signal to noise ratio,resulting in a poor detection limit.Taking advantages of local amplification effect,organic electrochemical transistors(OECTs)constitute promising candidates for high-sensitive monitoring.However,their detections in deep tissues are rarely reported.Herein,we report a family of implantable,fiber-shaped all-in-one OECTs based on carbon nanotube fibers for versatile biochemical detection including H2O2,glucose,dopamine and glutamate.These fiber-shaped OECTs demonstrated high sensitivity,dynamical stability in physiological environment and antiinterference capability.After implantation in mouse brain,7-day dopamine monitoring in vivo was realized for the first time.These fiber-shaped OECTs could be great additions to the'life science'tool box and represent promising avenue for biomedical monitoring. | Xiaoying Wu Jianyou Feng Jue Deng Zhichang Cui Liyuan Wang Songlin Xie Chuanrui Chen Chengqiang Tang Zhengqi Han Hongbo Yu Xuemei Sun Huisheng Peng | 2020 | Science China Chemistry2020，63，9： | 3 |
| 20 | Cross-calibration on the electromagnetic field detection payloads of the China Seismo-Electromagnetic Satellite显示文摘The China Seismo-Electromagnetic Satellite(CSES)deploys three payloads to detect the electromagnetic environment in the ionosphere.The tri-axial fluxgate magnetometers(FGM),as part of the high precision magnetometer(HPM),measures the Earth magnetic vector field in a frequency range from direct current(DC)to 15 Hz.The tri-axial search coil magnetometer(SCM)detects the alternating current(AC)related magnetic field in a frequency range from several Hz to 20 k Hz,and the electric field detector(EFD)measures the spatial electric field in a broad frequency band from DC to 3.5 MHz.This work mainly crosscalibrates the consistency of these three payloads in their overlapped detection frequency range and firstly evaluates CSES’s timing system and the sampling time differences between EFD and SCM.A sampling time synchronization method for EFD and SCM waveform data is put forward.The consistency between FGM and SCM in the ultra-low-frequency(ULF)range is validated by using the magnetic torque(MT)signal as a reference.A natural quasiperiodic electromagnetic wave event verifies SCM and EFD’s consistency in extremely low-frequency and very low-frequency(ELF/VLF)bands.This cross-calibration work is helpful to upgrade the data quality of CSES and brings valuable insights to similar electromagnetic detection solutions by low earth orbit satellites. | ZHIMA Zeren ZHOU Bin ZHAO ShuFan WANG Qiao HUANG JianPing ZENG Li LEI JunGang CHEN Yu LI Cheng YANG DeHe SUN XiaoYing MIAO YuanQing ZHU XingHong SHEN XuHui | 2022 | Science China(Technological Sciences)2022，65，6： | 3 |
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