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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | Zircon SHRIMP U-Pb dating on plagiogranite from Kuerti ophiolite in Altay,North Xinjiang显示文摘Field observation, petrological and geochemical characteristics of plagiogranite from Kuerti ophiolite indicate a similar origin to those in shearing zones. It isderived from partial melting of amphibolite that is developed from gabbro within the ocean layer 3 shear zone by the low-angle shearing deformation during the oceanic crustmigrating process. Zircon SHRIMP age of 372±19 Ma for the plagioganite from Kuerti ophiolite indicates that thisophiolite formed in the Devonian period and it alsorepresented the time of extension of the Kuerti backarc basin that is relevant to the northwards subduction of thePaleo-Asian oceanic crust. Therefore, the northwardssubduction of the Paleo-Asian Ocean beneath the Siberian Plate began in the early stage of the Late Paleozoic era. | ZHANG Haixiang NIU Hecai Kentaro Terada YU Xueyuan Hiroaki Sato Jun抜chi Ito | 2003 | Chinese Science Bulletin2003，48，20： | 28 |
| 3 | Bio-reduction of nitrate from groundwater using a hydrogen-based membrane biofilm reactor显示文摘A hydrogen-based membrane biofilm reactor(MBfR) using H2 as electron donor was investigated to remove nitrate from groundwater.When nitrate was first introduced to the MBfR,denitrification took place on the shell side of the membranes immediately,and the effluent concentration of nitrate continuously decreased with 100% removal rate on day 45 under the influent nitrate concentration of 5 mg NO3--N/L,which described the acclimating and enriching process of autohydrogenotrophic denitrification bacteria.A series of short-term experiments were applied to investigate the effects of hydrogen pressures and nitrate loadings on denitrification.The results showed that nitrate reduction rate improved as H2 pressure increasing,and over 97% of total nitrogen removal rate was achieved when the nitrate loading increased from 0.17 to 0.34 g NO3--N/(m2 ·day) without nitrite accumulation.The maximum denitrification rate was 384 g N/(m3 ·day).Partial sulfate reduction,which occurred in parallel to nitrate reduction,was inhibited by denitrififcation due to the competition for H2 .This research showed that MBfR is effective for removing nitrate from the contaminated groundwater. | Siqing Xia Fohua Zhong Yanhao Zhang Haixiang Li Xin Yang | 2010 | Journal of Environmental Sciences2010，22，2： | 23 |
| 4 | Discovery of super-silicic and super-titanic garnets in garnet-pyroxenite in Zhaheba and its geological significance显示文摘Super-silicic garnet which exists stably at more than 5 GPa is a typical ultra-high pressure mineral. The super-silicic garnet and super-titanic garnet were discovered for the first time in garnet-pyroxenite of early Paleozoic Zhaheba-Aermantai orogenic belt in north Xinjiang. Our study indicates that these su- per-silicic garnets as well as super-titanic garnets were formed at a depth of at least 300 km. Their host rock―― garnet-pyroxenite is one kind of ultra-pressure metamorphic rocks which is related to the ul- tra-deep subduction of the oceanic crust. Thus, the early Paleozoic Zhaheba-Aermantai orogenic belt is related to the ultra-deep subduction of the Paleo-Asian oceanic crust. | NIU HeCai ZHANG HaiXiang SHAN Qiang YU XueYuan | 2008 | Chinese Science Bulletin2008，53，14： | 9 |
| 5 | Chance-constrained Coordinated Optimization for Urban Electricity and Heat Networks显示文摘Urban electricity and heat networks(UEHN)consist of the coupling and interactions between electric power systems and district heating systems,in which the geographical and functional features of integrated energy systems are demonstrated.UEHN have been expected to provide an effective way to accommodate the intermittent and unpredictable renewable energy sources,in which the application of stochastic optimization approaches to UEHN analysis is highly desired.In this paper,we propose a chance-constrained coordinated optimization approach for UEHN considering the uncertainties in electricity loads,heat loads,and photovoltaic outputs,as well as the correlations between these uncertain sources.A solution strategy,which combines the Latin Hypercube Sampling Monte Carlo Simulation(LHSMCS)approach and a heuristic algorithm,is specifically designed to deal with the proposed chance-constrained coordinated optimization.Finally,test results on an UEHN comprised of a modified IEEE 33-bus system and a 32-node district heating system at Barry Island have verified the feasibility and effectiveness of the proposed framework. | Zhinong Wei Juan Sun Zhoujun Ma Guoqiang Sun Haixiang Zang Sheng Chen Side Zhang Kwok W.Cheung | 2018 | CSEE Journal of Power and Energy Systems2018，4，4： | 6 |
| 6 | Removing Endotoxin from Protein Solution by Chitosan Modified Affinity Membrane显示文摘Affinity membrane was prepared with chitosan immobilized on the hydrophile- modified poly(vinylidene fluoride) (PVDF) membrane. Fourier transform infrared spectroscopy (FTIR.) analysis indicated that the contents of —NH2 and —OH groups increased and fluoride decreased on the membrane surface after modification. Using this kind of affinity membrane, the effects of operation parameters such as pH, ionic strength and flow rate, on the amount of endotoxin removed were investigated. The results showed that the equilibrium adsorption capacity and the dissociation constant of the affinity membrane to endotoxin were 21.4 EU·mg-1 membrane and 0.50EU·ml-1, respectively, at pH 7.0 and ionic strength 0.2 mol·L-1. Adsorption appeared to follow a typical Langmuir adsorption isotherm. At pH 5.0, ionic strength of 0.2 mol·L-1, the removal rate of endotoxin from BSA solution with the chitosan affinity membrane was up to 88.6% (11.50 EU·mg-1 membrane), and the recovery of BSA was 93.4% (0.187mg·mg-1 membrane), while at pH 11.0, ionic strength of 0.2mol·L-1, the removal rate of endotoxin from lysozyme solution was 72.4% (9.92EU·mg-1 membrane), and the recovery of lysozyme was 92.3% (0.104 mg·mg-1 membrane). | SUN Haixiang(孙海翔) ZHANG Lin(张林) CHAI Hong(柴红) CHEN Huanlin(陈欢林) | 2005 | Chinese Journal of Chemical Engineering2005，13，4： | 5 |
| 7 | Optimization of corn-stalk skin flake-wood shaving composite technology显示文摘We focused on the optimization of corn-stalk skin flake-wood shaving composite technology. We studied the effects of material-mixture ratio, glue content, hotpressing temperature, and hot-pressing time on the appearance, physical, and mechanical properties of the composite by the orthogonal experiment method. Our findings yielded highly significant results in all three cases: the effects of the material-mixture ratio on 2 h of thickness swelling(2h TS)and the modulus of rupture(MOR); the effects of glue content on 2h TS, internal bond strength, and modulus of elasticity(MOE); and the effects of hot-pressing temperature on MOR and MOE. Product optimization is achieved when the ratio of corn stalk skin flake to wood shaving is 3:7, the glue content is 12 %, the hot-pressing temperature is 150 °C, and the hot-pressing time is 4.5 min. | Haixiang L Xianquan Zhang Bo Yu | 2015 | Journal of Forestry Research2015，26，3： | 3 |
| 8 | Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair显示文摘Over 300 billion of cells die every day in the human body,producing a large number of endogenous apoptotic extracellular vesicles(apoEVs).Also,allogenic stem cell transplantation,a commonly used therapeutic approach in current clinical practice,generates exogenous apoEVs.It is well known that phagocytic cells engulf and digest apoEVs to maintain the body’s homeostasis.In this study,we show that a fraction of exogenous apoEVs is metabolized in the integumentary skin and hair follicles.Mechanistically,apoEVs activate the Wnt/β-catenin pathway to facilitate their metabolism in a wave-like pattern.The migration of apoEVs is enhanced by treadmill exercise and inhibited by tail suspension,which is associated with the mechanical force-regulated expression of DKK1 in circulation.Furthermore,we show that exogenous apoEVs promote wound healing and hair growth via activation of Wnt/β-catenin pathway in skin and hair follicle mesenchymal stem cells.This study reveals a previously unrecognized metabolic pathway of apoEVs and opens a new avenue for exploring apoEV-based therapy for skin and hair disorders. | Lan Ma Chider Chen Dawei Liu Zhiqing Huang Jiaqi Li Haixiang Liu Ryan Tsz Kin Kwok Benzhong Tang Bingdong Sui Xiao Zhang Jianxia Tang Xueli Mao Weiying Huang Songtao Shi Xiaoxing Kou | 2023 | Bioactive Materials2023，，1： | 3 |
| 9 | Challenges and strategies in high-accuracy manufacturing of the world’s largest SiC aspheric mirror显示文摘In the process of manufacturing the world’s largest silicon carbide(SiC)aspheric mirror,the primary difficulties are mirror blank preparation,asphere fabrication,and testing,as well as cladding and coating.Specifically,the challenges include the homogeneity of the complicated structure casting,accuracy and efficiency of the fabrication process,print-through effect,fidelity and precision of test procedure,stress and denseness of cladding process,the dynamic range of interferometric measurement,and air turbulence error due to the long optical path.To break through such a barrier of difficulties,we proposed the water-soluble room temperature vanishing mold and gel casting technology,homogeneous microstructure reaction-formed joint technology,nano-accuracy efficient compound fabrication,gravity unloading technology,high-denseness low-defect physical vapor deposition(PVD)Si-cladding technology,test data fusion method,and time-domain averaging method,etc.Based on the proposed technologies and methods,we have accomplished the world’s largest SiC aspheric mirror with a size of φ4.03 m.The impressive performance of the SiC aspheric mirror is validated by the characteristics of the fabricated SiC aspheric mirror.The aerial density of the SiC blank is less than 120 kg/m^(2),surface shape test accuracy is better than 6 nm RMS,thickness inhomogeneity of the cladding layer is less than 5%,and the final surface figure error and roughness are 15.2 nm RMS and 0.8 nm RMS,respectively. | Xuejun Zhang Haixiang Hu Xiaokun Wang Xiao Luo Ge Zhang Wenxing Zhao Xiaoyi Wang Zhenyu Liu Ling Xiong Erhui Qi Congcong Cui Yanchao Wang Yingjie Li Xu Wang Longxiang Li Yang Bai Qiang Cheng Zhiyu Zhang Ruigang Li Wa Tang Xuefeng Zeng Weijie Deng Feng Zhang | 2022 | Light(Science & Applications)2022，11，12： | 3 |
| 10 | Single-particle trapping and dynamic manipulation with holographic optical surface-wave tweezers显示文摘Optical surface waves have widely been used in optical tweezers systems for trapping particles sized from the nanoto microscale,with specific importance and needs in applications of super-resolved detection and imaging if a single particle can be trapped and manipulated accurately.However,it is difficult to achieve such trapping with high precision in conventional optical surface-wave tweezers.Here,we propose and experimentally demonstrate a new method to accurately trap and dynamically manipulate a single particle or a desired number of particles in holographic optical surface-wave tweezers.By tailoring the optical potential wells formed by surface waves,we achieved trapping of the targeted single particle while pushing away all surrounding particles and further dynamically controlling the particle by a holographic tweezers beam.We also prove that different particle samples,including gold particles and biological cells,can be applied in our system.This method can be used for different-type optical surface-wave tweezers,with significant potential applications in single-particle spectroscopy,particle sorting,nano-assembly,and others. | XI XIE XIANYOU WANG CHANGJUN MIN HAIXIANG MA YUNQI YUAN ZHANGYU ZHOU YUQUAN ZHANG JING BU XIAOCONG YUAN | 2022 | Photonics Research2022，10，1： | 3 |
| 11 | Economic analysis of freeway town of Yunnan显示文摘Freeway town in Yunnan is driving to promote the economic development ties. The development along the highway in the town will become the central point of the performance the high-intensive economy in space and will increase new economic growth point along highway the vertical and horizontal development of the area around the gradient the proliferation Point and Area. The highway town will develop to speed up the urbanization process and China should accelerate the development of the freeway town. Encouraging farmers will shift the highway town where some good conditions will build to form a regional economic development and growth. This will be the promotion an inevitable choice of progress and rational way of China's rural economic and social prosperity. In particular, freeway town will bring more added value of other social services of accommodation and catering industry of whole-sale and retail of transportation and warehousing. Highway town and agriculture industrialization development will increase agriculture industry chain to improve agricultural products value and will enhance agricultural eff iciency in Yunnan. The concentration of the non-agricultural industries of the speedway town will form pillar industries of highway town and will promote of tertiary industry development of hotels of insurance of f inance of business of sports of culture of education of communications of transportation. Rural areas of Yunnan will adjust to optimize the industrial structure. It is estimated that a total 10 construction of the highway town of Yunnan will increase 0.8-1 billion yuan revenue each year. | Zhao Junquan Zhang Haixiang | 2009 | Ecological Economy2009，5，1： | 2 |
| 12 | MicroRNA-145 suppresses mouse granulosa cell proliferation by targeting activin receptor IB显示文摘 | Guijun Yan Lianxiao Zhang Ting Fang Qun Zhang Shaogen Wu Yue Jiang Haixiang Sun Yali Hu | 2012 | FEBS Letters2012，，19： | 2 |
| 13 | Optimization of supercritical carbon dioxide extraction of silkworm pupal oil applying the response surface methodology显示文摘 | WEI Zhaojun LIAO Aimei ZHANG Haixiang | 2009 | Bioresouree Technology2009，100，18： | 1 |
| 14 | Effect of surfactant headgroups on the oil/water interface: An interfacial tension measurement and simulation study显示文摘 | Jiafang Xu Yang Zhang Haixiang Chen Pan Wang Zhenhua Xie Yongji Yao Youguo Yan Jun Zhang | 2013 | Journal of Molecular Structure2013，，： | 1 |
| 15 | Construction of cytopathic PK-15 cell model of classical swine fever virus显示文摘No cytopathic effect (CPE) can be observed on classical swine fever virus (CSFV) infected cell culture in vitro. This brings an obstacle to the researches on reciprocity between CSFV and host cells. Based on the construction of full-length genomic infectious Cdna clone of Chinese CSFV standard virulent Shimen strain, partial deletion is intro- duced into genomic Cdna to obtain a 7.5 kb subgenomic Cdna. A new subgenomic CSFV is derived from transfection with the subgenomic Cdna on PK-15 cells pre-infected by CSFV Shimen virus. Typical CPE induced by this subgenomic virus is observed on PK-15 cells. Coexistence of wild- type and subgenomic virus in cytopathic cell culture is dem- onstrated by RT-PCR detection in cytopathic cells. For conclusion, the construction of cytopathic cell model exploited a new way for researches on the molecular mechanism of CSFV pathogenesis. | WU Haixiang, ZHANG Chuyu, ZHENG Congyi, WANG Jiafu, PAN Zishu, LI Lei, CAO Shen & Yl GuanghuiInstitute of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, ChinaCorrespondence should be addressed to Zhang Chuyu (e-mail: avlab@ whu.edu.cn) | 2003 | Chinese Science Bulletin2003，48，9： | 1 |
| 16 | Enhanced hydrogen storage properties of NaBH_(4)–Mg(BH_(4))_(2) composites by NdF_(3) addition显示文摘As two important members of complex hydrides,Mg(BH_(4))2 and Na BH_(4) have a high gravimetric capacity(14.9 and10.8 wt%,respectively).In this study,the Mg(BH_(4))2 was synthesized by the ion exchange method.Afterwards,the Mg(BH_(4))_(2) and Na BH_(4) composites with different amounts(30,40 and 50 wt%)of NdF3 were prepared by mechanical milling.Effects of the Nd F3 on the microstructural evolution and hydrogen storage properties were investigated.The results show that Nd F3catalyst can significantly improve the dehydrogenation kinetics of the eutectic composites of Na BH_(4)–Mg(BH_(4))_(2).The onset hydrogen desorption temperature of the composites is about88.6C,which is about 110C lower than that of Mg(BH_(4))_(2)and Na BH_(4)composites.Mg(BH_(4))_(2)–Na BH_(4)-0.5NdF3composites can released 5.2 wt%H_(2)at 250C within 30 min,and the dehydrogenation capacity is significantly higher than that of Mg(BH_(4))_(2)–Na BH_(4)composites.The analysis of the dehydrogenation mechanism reveals that NdF3takes participate in the reaction to generate Na MgF3 to promote the dehydrogenation reaction process of the composites. | Jianguang Yuan Jinting Chen Haixiang Huang Yujie Lv Bogu Liu Zhongyu Li Bao Zhang Wei Lv Ying Wu | 2021 | Progress in Natural Science:Materials International2021，31，4： | 1 |
| 17 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 18 | Optimization of supercritical carbon dioxide extraction of silkworm pupal oil applying the response surface methodology显示文摘 | WEI Zhaojun LIAO Aimei ZHANG Haixiang | 2009 | Bioresource Technology2009，100，18： | 1 |
| 19 | MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2显示文摘 | Anyi Dai Haixiang Sun Ting Fang Qun Zhang Shaogen Wu Yue Jiang Lijun Ding Guijun Yan Yali Hu | 2013 | FEBS Letters2013，，15： | 1 |
| 20 | Optimization of supercritical carbon dioxide extraction of silkworm pupal oil applying the response surface methodology显示文摘 | WEI Zhaojun LIAO Aimei ZHANG Haixiang | 2009 | Bioresource Technology2009，100，18： | 1 |
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