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| 1 | Higher intratumor than peritumor expression of DUSP6/MKP-3 is associated with recurrence after curative resection of hepatocellular carcinoma显示文摘 | Yang Bo Tan Yunshan Sun Huichuan Fan Jia Tang Zhaoyou Ji Yuan | 2014 | Chinese Medical Journal2014，，7： | 4 |
| 2 | Study of severe and rare complications of transarterial chemoembolization (TACE) for liver cancer显示文摘 | Jinglin Xia Zhenggang Ren Shenglong Ye Dilip Sharma Zhiying Lin Yuhong Gan Yi Chen Ninglin Ge Zengchen Ma Zhiquan Wu Jia Fan Lunxiu Qin Xinda Zhou Zhaoyou Tang Binghui Yang | 2006 | European Journal of Radiology2006，，3： | 2 |
| 3 | Conversion of surgically verified unresectable to resectable hepatocellular carcinoma显示文摘 | Zhaoyou Tang Yeqin Yu Zengchen Ma Rong Yang Xinda Zhou Kangda Liu Jizhen Lu Yanming Bao Zhiying Lin Binghui Yang | 1989 | Chinese Journal of Cancer Research1989，，3： | 1 |
| 4 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 5 | Transcatheter arterial embolization-salvaged ALPPS, a novel ALPPS procedure especially for patients with hepatocellular carcinoma and severe fibrosis/cirrhosis显示文摘Background:The associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)for hepatocellular carcinoma(HCC)with fibrosis/cirrhosis is often associated with limited growth of future liver remnant(FLR).We introduced a new procedure named transcatheter arterial embolization-salvaged ALPPS(TAE-salvaged ALPPS)which was shown to be especially suitable for HCC patients with cirrhosis or fibrosis who failed adequately to respond to conventional ALPPS.The short-term efficacy and safety for the TAE-salvaged ALPPS on patients with HCC and fibrosis/cirrhosis were studied.Methods:Consecutive HCC patients who underwent TAE-salvaged ALPPS in our hospital between November 2016 and June 2020 were retrospectively studied.The new ALPPS procedure included conventional ALPPS stage-1 using associating liver partition and portal vein ligation.When FLR failed to reach sufficient hypertrophy,TAE was carried out 2 weeks later followed by liver resection 3 weeks after ALPPS stage-1.Results:Nine of 10 patients had a single tumor(median diameter 14.0 cm,range,5.2-17 cm).The remaining patient had multiple tumors(diameter of one tumor 14.0 cm,and two satellite foci 2.0 and 3.0 cm).R0 resection was achieved in all patients(100%)after a median of 21 days.Six patients had cirrhosis,1 had METAVIR grade-3 fibrosis,and 3 had METAVIR grade-2 fibrosis.The median increase in FLR volume after TAE-salvaged ALPPS was 69.7%(34.4-143.9%).The absolute and relative kinetic growth rates(KGRs)were 9.9(7.1-17.3)mL/day and 3.4%(1.9-7.2%)/day,respectively.The median absolute KGRs were 15.7,2.6,and 19.5 mL/day in the first,second,and third postoperative weeks after ALPPS stage-1,respectively.The rapid increase in KGR on the third week was induced by TAE.The overall postoperative morbidity rates were 50,0%(5/10),20.0%(2/10)and 70.0%(7/10)after ALPPS stage-1,TAE and ALPPS stage-2,respectively.The 90-day mortality rate was 10.0%(1/10).The median overall survival was 40 months.Conclusions:The new TAE-salvaged ALPPS induced significant increases in FLR volumes within 3 weeks in patients with HCC and fibrosis/cirrhosis.The procedure is promising in treating patients with HCC and fibrosis/cirrhosis who fail to achieve sufficient FLR hypertrophy after conventional ALPPS stage-1. | Yuanfei Peng Zheng Wang Xudong Qu Feiyu Chen Huichuan Sun Xiaoying Wang Zhenbing Ding Min Tang Lei Yu Xinrong Yang Qiang Gao Zhaoyou Tang Wan Yee Lau Jia Fan Jian Zhou | 2022 | Hepatobiliary Surgery and Nutrition2022，11，4： | 1 |
| 6 | Mutation and overexpression of the β-catenin gene may play an important role in primary hepatocellular carcinoma among Chinese people显示文摘 | Jian Cui Xinda Zhou Yinkun Liu Zhaoyou Tang | 2001 | Journal of Cancer Research and Clinical Oncology2001，，9： | 1 |
| 7 | Prediction of chronic hepatitis B, liver cirrhosis and hepatocellular carcinoma by SELDI-based serum decision tree classification显示文摘 | Jiefeng Cui Xiaonan Kang Zhi Dai Cheng Huang Haijun Zhou Kun Guo Yan Li Yu Zhang Ruixia Sun Jie Chen Yang Li Zhaoyou Tang Toshimasa Uemura Yinkun Liu | 2007 | Journal of Cancer Research and Clinical Oncology2007，，11： | 1 |
| 8 | The Predictive Value of Chromosome 8p Deletion for Metastasis of Hepatocellular Carcinoma:A Summary of 10 Years' Works显示文摘Hepatocellular carcinoma (HCC) represents an extremely poor prognostic cancer, which is mainly due to the high frequency of metastasis/recurrence after surgical operation. To detect the specific chromosome | Lunxiu QIN Zhaoyou TANG Xinyuan GUAN Huliang JIA Ning REN | 2009 | 中国肺癌杂志2009，12，6： | 0 |
| 9 | Associating liver partition and portal vein ligation for staged hepatectomy for colorectal liver metastasis:a single-center experience显示文摘Background:Associated liver partition and portal vein ligation for staged hepatectomy(ALPPS)is increasingly used for the treatment of primarily unresectable colorectal liver metastases(CRLM)because of the insufficient future liver remnant(FLR).The aim of this study was to share our experience with ALPPS for advanced CRLM and review the role of ALPPS in the management of patients with CRLM.Methods:Consecutive patients(n=10)with CRLM who underwent ALPPS at our center between December 2014 and October 2021 were retrospectively studied.Results:The median age of patients was 58 years(range 49–70 years).Five patients had metachronous CRLM and the other 5 patients had synchronous CRLM.Five patients had unilateral CRLM and the other 5 patients had bilateral CRLM.All patients previously underwent neoadjuvant chemotherapy.The FLR volume increased by 45.3%(35.8%–61.6%)over 14 days(range 7–21 days).The absolute and relative kinetic growth rates were 17.9 mL/day(range 7.5–32.1 mL/day)and 4.6%/day(range 2.3%–8.8%/day),respectively.Overall morbidity rates were 20%(2/10)and 40%(4/10)after ALPPS stage 1 and stage 2,respectively.The 30-day and 90-day mortality rates were 0%and 10%,respectively.R0 resection was achieved for all patients,and the median disease-free survival was 18.7 months.Conclusions:ALPPS is an effective treatment option for advanced CRLM.It enables rapid hypertrophy of the FLR and achieves a high R0 resection rate with an acceptable oncological outcome.However,ALPPS should be reserved for selected patients because of its relatively high morbidity and mortality. | Yuanfei Peng Feiyu Chen Zheng Wang Xiaoying Wang Yinghong Shi Zhenbing Ding Yongsheng Xiao Kang Song Lei Yu Jie Hu Min Tang Zhaoyou Tang Jia Fan Jian Zhou | 2022 | iLIVER2022，1，1： | 0 |
| 10 | The predictive value of chromosome 8p deletion for metastasis of hepatocellular carcinoma:a summary of works in 10 years显示文摘Hepatocellular carcinoma(HCC)represents an extremely poor prognostic cancer,which is mainly due to the high frequency of metastasis/recurrence after surgical operation.Exploring the molecular mechanisms involved in HCC metastasis could be helpful in the pre-diction and early diagnosis of HCC recurrence and could also provide new therapeutic targets for HCC metastasis.In the recent decade,we analyzed the genomic aberrations of the clinical specimens,as well as the metastatic models and cell lines of human HCC to identify the genetic mar-kers related to HCC metastasis and to verify their clinical values in the prediction and control of metastasis of HCC.Using the comparative genomic hybridization(CGH)technique,we compared the differences of chromosomal aberrations between primary HCC tumors and their matched metastatic lesions,and found that chromosome 8p deletions might contribute to HCC metastasis.This novel finding was further confirmed by comparison between nude mice models of HCC with different meta-static potentials.By the more sensitive genome-wide microsatellite analysis,8p deletion was defined to 8p23.3 and 8p11.2,which are two likely regions harboring meta-stasis-related genes of HCC.Using‘8p-specific’microar-rays,two novel metastatic suppressors(HTPAP and MRSA)were identified,and were proven to suppress in vitro invasion and in vivo metastasis of HCC.Clinical studies indicate that 8p deletion detected in HCC or cir-culating plasma DNA of patients is a useful predictor for metastatic recurrence and prognosis,even for patients with early stage HCC.These novel findings are regarded as important advances in the study of the molecular mechanisms of HCC metastasis,which provide not only a holistic view on the molecular cytogenetic bases of HCC metastasis,but also candidate regions for further study to identify metastatic suppressor genes. | Lunxiu QIN Zhaoyou TANG Xinyuan GUAN Qinghai YE Huliang JIA Ning REN | 2008 | Frontiers of Medicine2008，2，3： | 0 |
| 11 | Metastasis-related genes in hepatocellular carcinoma cell-lines are clustered on chromosome territories predicted by transcriptome and proteome显示文摘Recently,we have analyzed expressional transcriptome and proteome for a number of cancer cell lines,including 8hepatocellular carcinoma(HCC)ones[1,2].These 8 HCC cell lines consist of 6 metastatic(all with mutant p53)and 2non-metastatic(with a mutant and a lost p53)ones,being all HBV traceable for relatively close genetic-backgrounds.We have analyzed the related dataset and obtained transcriptome(16353 genes)and proteome(7861 proteins)of these 8HCC cell lines,and explored a group of up-regulated | Li Feng Hong Li Yang Zhang Huali Shen Hongxiu Yu Fan Zhong Lunxiu Qin Fuchu He Pengyuan Yang Zhaoyou Tang | 2016 | Science China Chemistry2016，59，3： | 0 |
| 12 | “Three-Grade Criteria” of Radical Resection for Primary Liver Cancer显示文摘 | Zengchen Ma Liwen Huang Zhaoyou Tang Xinda Zhou Zhiying Lin Lunxiu Qin Qinghai Ye Huichuan Sun Zhiquan Wu Jia Fan Zhenggang Ren Jinglin Xia | 2005 | Chinese Journal of Clinical Oncology2005，2，5： | 0 |
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