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| 1 | Anthropogenic emission inventories in China:a review显示文摘The development of reliable anthropogenic emission inventories is essential for both understanding the sources of air pollution and designing effective air-pollution-control measures in China. However, it is challenging to quantify emissions in China accurately, given the variety of contributing sources, the complexity of the technology mix and the lack of reliable measurements. Over the last two decades,tremendous efforts have been made to improve the accuracy of emission inventories, and significant improvements have been realized. More reliable statistics and survey-based data have been used to reduce the uncertainties in activity rates and technology distributions. Local emission factors and source profiles covering various sources have been measured and reported. Based on these local databases, improved emission inventory models have been developed for power plants, large industrial plants and the residential,transportation and agricultural sectors. In this paper, we review the progress that has been made in developing inventories of anthropogenic emissions in China. We first highlight the major updates that have been made to emission inventory models and the underlying data by source category. We then summarize the sector-based estimates of emissions of different species contained in current inventories. The progress that has been made in the development of model-ready emissions is also presented. Finally, we suggest future directions for further improving the accuracy of emission inventories in China. | Meng Li Huan Liu Guannan Geng Chaopeng Hong Fei Liu Yu Song Dan Tong Bo Zheng Hongyang Cui Hanyang Man Qiang Zhang Kebin He | 2017 | National Science Review2017，4，6： | 100 |
| 2 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 3 | Opening and evolution of the South China Sea constrained by studies on volcanic rocks:Preliminary results and a research design显示文摘The South China Sea (SCS) is characterized by abundant seamounts, which provide important information about the evolution of the SCS and related deep processes. Cenozoic volcanism in the SCS and its surroundings comprises three stages relative to the spreading of the SCS:prespreading (>32 Ma), syn-spreading (32-16 Ma), and post-spreading (<16 Ma). The pre-spreading magmatism predominantly occurs on the northern margin of the SCS and in South China coastal areas and shows a bi-modal affinity. The syn-spreading magmatic activity was very limited on the periphery of the SCS, but may be concentrated in the SCS. However, seafloor samples of this stage are not available yet because of overlying thick sedimentary deposits. Post-spreading magmatism is widespread in the central and southwest sub-basins of the SCS, Hainan Island, Leizhou Peninsula, Thailand, and Vietnam. These are mainly alkali basalts with subordinate tholeiites, and display OIB-type geochemical characteristics. The Dupal isotope anomaly and presence of high-magnesian olivine phenocrysts suggests their possible derivation from the Hainan mantle plume. The temporal and spatial distribution of Cenozoic volcanism in the SCS and its surroundings may be accounted for either by plate stress re-organization before and after SCS spreading, or by ridge suction of plume flow during opening of the SCS. If the latter is the case, the volcanic rocks within the SCS basin may not be typical mid-ocean ridge basalts (MORB). It remains puz-zling, however, that the transition between the South China continental margin and the SCS basin does not have features typical of a volcanic rifted margin. Clearly, the relationship between mantle plume and SCS opening needs further evaluation. A better un-derstanding of the link between deep processes and opening of the SCS not only requires enhanced studies on igneous petrogene-sis, but also is heavily dependent on systematic sampling of seafloor rocks. | XU YiGang WEI JingXian QIU HuaNing ZHANG HuiHuang HUANG XiaoLong | 2012 | Chinese Science Bulletin2012，57，24： | 43 |
| 4 | Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K/Akt/FOXO3A/Bim pathway显示文摘 | Mei-qi ZHANG Yue-liang ZHENG Huan CHEN Jian-feng TU Ye SHEN Jun-ping GUO Xiang-hong YANG Shu-ren YUAN Liang-zhong CHEN Jing-jie CHAI Jian-hong LU Chang-lin ZHAI | 2013 | Acta Pharmacologica Sinica2013，34，11： | 30 |
| 5 | Morphological study on colonic pathology in ulcerative colitis treated by moxibustion显示文摘AIM To observe the therapeutic effect ofmoxibustion on ulcerative colitis and itsinfluence on the colonic mucosal morphology.METHODS Forty-six patients with ulcerativecolitis were randomly divided into themoxibustion with herbal medicine underneathgroup and the western medicine group.Thirtypatients were treated with the abovemoxibustion and 16 patients with Salicylayefapyridine(SASP).The colonic mucosa of 13patients in the moxibustion group was observedby colonoscopy before and after the treatment.Mucin was also analyzed by H.E and AB-PASstaining.RESULTS Seventeen patients were clinicallycured,12 were improved and 1 unchanged in themoxibustion group.In the control group,5patients were clinically cured,7 improved and 4unchanged.Thirteen patients with active UCwere taken as the subjects for histopathologicanalysis in this study.The colonic mucosallesions were remarkably improved and thecharacteristic of the mucin also changed.Inmost sections,the chronic inflammation ofmucosa was geatly ameliorated(P<0.01).Theinflammatory cell infiltratation much decreased and neutrophils,disapeared in most sections(P<0.001).The goblet cells significantlyincreased(P<0.001);crypt paracrypt abscessor mucosal ulceration was seen(P<0.001).CONCLUSION The rate of cure of ulcerative colitis by moxibustion with herbal medicine beneath is superior to that by SASP. This sort of moxibustion can effectively improve the colonic mucosal lesions and restore the proportion of mucoprotein to near normal. | Huan Gan Wu Li Bin Zhou Da Ren Shi Shi Min Liu Hui Rong Liu Bi Meng Zhang Han Ping Chen Lin Shan Zhang | 2000 | World Journal of Gastroenterology2000，6，6： | 28 |
| 6 | Hemorrhagic cystitis following hematopoietic stem cell transplantation:incidence,risk factors and association with CMV reactivation and graft-versus-host disease显示文摘背景在 allogenic 以后的出血性的膀胱炎(HC ) 的明确的致病造血的干细胞移植(allo-HSCT ) 一直不好阐明。在 HC 遗体的发展的复活和 graft-versus-host 疾病(GVHD ) 遮住的 cytomegalovirus (CMV ) 的角色。这研究在 allo-HSCT 以后为 HC 决定了发生和风险因素并且与 CMV 复活和 GVHD 分析了它的协会。我们回顾地在高度学习了 250 个病人的方法为 CMV 冒险疾病都基于 busulfan/cyclophosphamide (BU/CY ) 经历了 allo-HSCT myloablative 政体。发生,病原学,风险因素和 HC 的临床的管理是在 180 天以内开发的 investigated.Results HC 在 72 移植病人与28.8%的全面发生和在有 匹配HLA 的相关施主( MRD )的病人的12.6%的发生,34.38%在那些与 匹配HLA 的无关的施主(泥),49.45%在那些与错配的相关施主( MMRD )。CMV-viremia 显著地增加了以后的发作 HC (LOHC ) 的发生;然而,仅仅, 9 实际上从有 CMV viruria 的 15 个病人开发了 LOHC。多重回归分析识别了等级 - 尖锐 GVHD (RR=2.75;95% CI 1.63-4.66;P0.01 ) 并且从泥或 MMRD 的接枝(RR=2.60;95% CI 1.52-5.20;P0.01 ) 为 HC 的同样独立的风险因素。事件顺序分析显示事件在 GVHD initiation.Conclusions CMV-viremia 附近开始了的 HC 的一个多数是为 LOHC 的一个高风险因素。我们的数据也显示出在尖锐 GVHD 和 HC 之间的关联,它建议 alloimmunity 可以涉及 HC 的致病。 | XU Lan-ping ZHANG Hong-yu HUANG Xiao-jun LIU Kai-yan LIU Dai-hong HAN Wei CHEN Huan CHEN Yu-hong GAO Zhi-yong ZHANG Yao-chen LU Dao-pei | 2007 | Chinese Medical Journal2007，，19： | 22 |
| 7 | Early kidney injury during long-term adefovir dipivoxil therapy for chronic hepatitis B显示文摘AIM: To evaluate urine β2-microglobulin(β2-M), retinol-binding protein(RBP) excretion, and renal impairment with adefovir dipivoxil(ADV) for chronic hepatitis B. METHODS: We enrolled 165 patients with chronic hepatitis B infection who were treated with ADV monotherapy(n = 90) or ADV plus lamivudine combination therapy(n = 75). An additional 165 chronic hepatitis B patients treated with entecavir were recruited as controls. We detected serum creatinine, urine β2-M, and RBP levels, and estimated the glomerular filtration rate(e GFR) at the initiation of antiviral therapy and every 6 mo for a period of five years. RESULTS: Urine β2-M abnormalities were observed in patients during the first(n = 3), second(n = 7), third(n = 11), fourth(n = 16), and fifth(n = 21) year of ADV treatment. Urinary RBP abnormalities were observed in patients during the first(n = 2), second(n = 8), third(n = 12), fourth(n = 15), and fifth(n = 22) year of ADV treatment. e GFR decreased 20%-30% from baseline in 20 patients, 30%-50% in 12 patients, and > 50% in 3 patients during the five years of treatment. Further analysis indicated that decreases in e GFR of ≥ 30% relative to the baseline level correlated significantly with urine RBP and β2-M abnormalities. In contrast, both serum creatinine and e GFR remained stable in patients treated with entecavir, and only one of these patients developed a urine β2-M abnormality, and two developed urine RBP abnormalities during the five years of treatment. CONCLUSION: Urine RBP and β2-M are biomarkers of renal injury during long-term ADV treatment for chronic hepatitis B, and indicate when treatment should be switched to entecavir. | Hong-Yu Jia Feng Ding Jian-Yang Chen Jiang-Shan Lian Yi-Min Zhang Lin-Yan Zeng Dai-Rong Xiang Liang Yu Jian-Hua Hu Guo-Dong Yu Huan Cai Ying-Feng Lu Lin Zheng Lan-Juan Li Yi-Da Yang | 2015 | World Journal of Gastroenterology2015，21，12： | 22 |
| 8 | Epidemiological characteristics of thyroid nodules and risk factors for malignant nodules: a retrospective study from 6 304 surgical cases显示文摘 | Huan Qin Wang Kun Lou Fuchen Zhang Li Huang Qingxian Han Yunfeng Sun Hancheng Zhu Lei Lin Peng Song Jun Liu Fuqiang Wang Qian Hou Weikai | 2014 | Chinese Medical Journal2014，，12： | 20 |
| 9 | Lower limits of evaluation parameters for the lower Paleozoic Longmaxi shale gas in southern Sichuan Province显示文摘Here we present six key parameters that have been applied to evaluate the Silurian Longmaxi shale gas accumulations of southern Sichuan Province.These parameters include richness of organic matter,single layer shale thickness,burial depth of the shale,maturity,shale properties,and brittle mineral content.In combination with drilling data,the lower limits of these six parameters for marine shale gas have been evaluated and the following conclusions are drawn:(1)Organic carbon recovery, gas content inversion,and production tests have been applied for the first time to measure the lower limit of TOC,which is determined to be 1.0%.(2)Based on the hydrocarbon generation and expulsion theory for source rocks and the characteristics of Longmaxi shale,the lower limit of the single-layer thickness is estimated to be 30 m,of which a thickness of at least 15 m should contain high-quality shale.(3)Based on the correlation of TOC and porosity,the lower limit of gas-filled porosity is 1.2%.(4)Other parameters,such as maturity,burial depth,and brittle mineral content have also been studied with regard to the geologic conditions of southern Sichuan.Based on the study results,an evaluation index system has been established for highly evolved marine shale gas,and the system has been applied successfully to geologically screened shale gas occurrences in southern Sichuan Province. | LI YanJun LIU Huan ZHANG LieHui LU ZongGang LI QiRong HUANG YongBin | 2013 | Science China Earth Sciences2013，56，5： | 20 |
| 10 | Intestinal Microbial Community Differs between Acute Pancreatitis Patients and Healthy Volunteers显示文摘包括 45 尖锐胰腺炎和 44 个健康志愿者的案例控制研究被执行调查在肠的微生物引起的社区和尖锐胰腺炎之间的协会。定序的高产量的 16S rRNA 基因 amplicon 被用来介绍样品的 microbiological 作文。总共, 27 微生物引起的数被检测,胰腺炎病人的样品包含了更少数。从尖锐胰腺炎病人的样品从健康志愿者比那些包含了更多的 Bacteroidetes 和 Proteobacteria 和更少 Firmicutes 和 Actinobacteria。PCoA 分析健康志愿者把尖锐胰腺炎病人的烘便的微生物引起的社区与那些区分开来。尖锐胰腺炎病人的肠的微生物与健康志愿者的那些不同。肠的 microbiome 的调整可以为对待尖锐胰腺炎用作其他的策略。 | ZHANG Xi Mei ZHANG Zheng Yu ZHANG Chen Huan WU Jing WANG You Xin ZHANG Guo Xin | 2018 | Biomedical and Environmental Sciences2018，31，1： | 20 |
| 11 | XingNaoJing injections protect against cerebral ischemia/reperfusion injury and alleviate blood-brain barrier disruption in rats, through an underlying mechanism of NLRP3 inflammasomes suppression显示文摘The aim of this study was to explore the neuroprotective effect and mechanism of XingNaoJing injections(XNJ) on cerebral ischemia injury and blood-brain barrier(BBB) disruption. Middle cerebral artery occlusion(MCAO) method was applicated to establish the model of cerebral ischemia/reperfusion(I/R) injury in rats. BBB permeability after I/R injury was assessed with the leaking amount of Evans Blue and the expression of occludin and ZO-1. The expression of NOD-like receptor family, pyrin domain containing(NLRP3) was checked to explore the inhibition of inflammation by XNJ. The results showed that XNJ could significantly increase the survival percent, decrease the infarct area and ameliorate neurological deficits and brain damage after I/R injury. Leaking amount of Evans Blue was reduced by XNJ, and the expression of tight junction protein, occludin and ZO-1 was also up-regulated by XNJ, which showed a role of protection on BBB disruption. The expression of NLRP3 was inhibited after exposure of XNJ, which was associated with inhibition of the inflammatory response. In summary, XNJ could suppress NLRP3 inflammasomes and improve BBB disruption and brain damage in rats after cerebral I/R injury, which provided a beneficial insight to further explore XNJ. | QU Xiao-Yu ZHANG Yue-Ming TAO Li-Na GAO Huan ZHAI Jing-Hui SUN Jing-Meng SONG Yan-Qing ZHANG Si-Xi | 2019 | Chinese Journal of Natural Medicines2019，17，7： | 20 |
| 12 | Soil Erosion Changes over the Past Five Decades in the Red Soil Region of Southern China显示文摘This paper reports the dynamic changes of soil and water loss in the red soil region of Southern China since the 1950s. The red soil region covers eight provinces: Jiangxi, Zhejiang, Fujian, Anhui, Hubei, Hunan, Guangdong and Hainan. From the 1950s to 1986, the annual rate of soil erosion increased by 3.4%. From 1986 to 1996 and from 1996 to 2000, the annual rates of soil erosion decreased by 2.0% and 0.32%, respectively. Field surveys showed that from 2000 to 2005, the area of soil and water loss decreased annually by 1.2%. This decrease was a result of large-scale erosion control activities across China. Although the eroded soil has been restored, the restoration process is very slow and full restoration will take a long time. Our report suggests that controlling soil and water loss is a challenging task, and additional measures must be taken to effectively control the soil erosion in the red soil region. | LIANG Yin LI Decheng LU Xixi YANG Xuan PAN Xianzhang MU Huan SHI Deming ZHANG Bin | 2010 | Journal of Mountain Science2010，7，1： | 18 |
| 13 | A general end-to-end diagnosis framework for manufacturing systems显示文摘The manufacturing sector is envisioned to be heavily influenced by artificial-intelligence-based technologies with the extraordinary increases in computational power and data volumes. A central challenge in the manufacturing sector lies in the requirement of a general framework to ensure satisfied diagnosis and monitoring performances in different manufacturing applications. Here, we propose a general data-driven,end-to-end framework for the monitoring of manufacturing systems. This framework, derived from deep-learning techniques, evaluates fused sensory measurements to detect and even predict faults and wearing conditions. This work exploits the predictive power of deep learning to automatically extract hidden degradation features from noisy, time-course data. We have experimented the proposed framework on 10 representative data sets drawn from a wide variety of manufacturing applications. Results reveal that the framework performs well in examined benchmark applications and can be applied in diverse contexts,indicating its potential use as a critical cornerstone in smart manufacturing. | Ye Yuan Guijun Ma Cheng Cheng Beitong Zhou Huan Zhao Hai-Tao Zhang Han Ding | 2020 | National Science Review2020，7，2： | 18 |
| 14 | Coinfection with influenza A virus enhances SARS-CoV-2 infectivity显示文摘The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health.Through experimental coinfection with influenza A virus(IAV)and either pseudotyped or live SARS-CoV-2 virus,we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types.Remarkably,in vivo,increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV.Moreover,such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses,likely due to a unique feature of IAV to elevate ACE2 expression.This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection,and thus,prevention of IAV infection is of great significance during the COVID-19 pandemic. | Lei Bai Yongliang Zhao Jiazhen Dong Simeng Liang Ming Guo Xinjin Liu Xin Wang Zhixiang Huang Xiaoyi Sun Zhen Zhang Lianghui Dong Qianyun Liu Yucheng Zheng Danping Niu Min Xiang Kun Song Jiajie Ye Wenchao Zheng Zhidong Tang Mingliang Tang Yu Zhou Chao Shen Li Zhou Yu Chen Huan Yan Ke Lan Ke Xu | 2021 | Cell Research2021，31，4： | 16 |
| 15 | Evidence for a mouse origin of the SARS-CoV-2 Omicron variant显示文摘The rapid accumulation of mutations in the SARS-CoV-2 Omicron variant that enabled its outbreak raises questions as to whether its proximal origin occurred in humans or another mammalian host. Here, we identified 45 point mutations that Omicron acquired since divergence from the B.1.1 lineage. We found that the Omicron spike protein sequence was subjected to stronger positive selection than that of any reported SARS-CoV-2 variants known to evolve persistently in human hosts, suggesting a possibility of hostjumping. The molecular spectrum of mutations(i.e., the relative frequency of the 12 types of base substitutions) acquired by the progenitor of Omicron was significantly different from the spectrum for viruses that evolved in human patients but resembled the spectra associated with virus evolution in a mouse cellular environment. Furthermore, mutations in the Omicron spike protein significantly overlapped with SARS-CoV-2 mutations known to promote adaptation to mouse hosts, particularly through enhanced spike protein binding affinity for the mouse cell entry receptor. Collectively, our results suggest that the progenitor of Omicron jumped from humans to mice, rapidly accumulated mutations conducive to infecting that host,then jumped back into humans, indicating an inter-species evolutionary trajectory for the Omicron outbreak. | Changshuo Wei Ke-Jia Shan Weiguang Wang Shuya Zhang Qing Huan Wenfeng Qian | 2021 | Journal of Genetics and Genomics2021，48，12： | 16 |
| 16 | Plasmacytoid Dendritic Cells Act as the Most Competent Cell Type in Linking Antiviral Innate and Adaptive Immune Responses显示文摘Appropriate in vivo control of plasmacytoid dendritic cell (pDC) recruitment and activation is a fundamental requirement for defense against viral infection. During this process, a pivotal event that influences the outcome of viral infection is the production of high levels of type I interferon by pDCs. In particular, recent research findings showed that pDCs not only shape the nature of innate resistance, but are also responsible for the successful transition from innate to adaptive immunity for viral resistance. In addition, pDCs can differentiate into antigen presenting cells that may regulate tolerance to a given pathogen. Importantly, in a series of recent clinical studies,pDCs appeared to be defective in number and function in conditions of chronic viral diseases such as infected with HIV-1, HBV or HCV. pDC-associated clinical antiviral therapy is also emerging. This review describes research findings exanining the functional and antiviral properties of in vivo pDC plasticity. | Zheng Zhang~1 Fu-Sheng Wang~(1,2) ~1Research Center of Biological Therapy,Beijing 302 Hospital,Beijing 100039,China ~2Research Centre of Biological Therapy,Beijing Institute of Infectious Diseases,Beijing 302 Hospital,100 Xi Si Huan Middle Road,Beijing 100039,China. | 2005 | Cellular & Molecular Immunology2005，2，6： | 16 |
| 17 | The Prevalence of Nonalcoholic Fatty Liver Disease and its Association with Lifestyle/dietary Habits among University Faculty and Staff in Chengdu显示文摘Objective To investigate the prevalence of nonalcoholic fatty liver disease(NAFLD) in different university categories and its association with lifestyle/dietary habits.Methods A cross-sectional study was carried out on 9 378 faculty members and staff who participated in an annual health checkup at three universities selected by random cluster sampling.Demographic,anthropometric,biochemical indices and abdominal ultrasound measurements were collected.A nested case-control study was conducted with 200 NAFLD cases and 200 controls matched by gender,age(±3 years),and university.Results The overall prevalence of NAFLD was 10.3%(13.7% in males and 6.8% in females).The prevalence was significantly higher in the science and engineering university(22.1%) than in the comprehensive universities with(6.4%) and without(10.9%) medical colleges.Obesity/overweight,hyperlipidemia,diabetes mellitus,and family history of NAFLD were independently associated with higher risk of NAFLD,as were frequent consumption of desserts and salty/spicy foods.Using nutritional supplements was a protective factor against NAFLD.Intake of coarse cereals,potatoes,vegetables,fruits,and milk was significantly lower,and intake of red meat,viscera,candies and pastries,cooking oil,and total energy was significantly higher in participants with NAFLD than in controls.Conclusion Science and engineering university faculty and staff are key targets for NAFLD prevention.NAFLD is closely associated with age,gender,university type,metabolic diseases,and lifestyle/dietary habits. | SHI Lei LIU Zhong Wu LI Yun GONG Cai ZHANG Huan SONG Li Juan HUANG Cheng Yu LI Ming | 2012 | Biomedical and Environmental Sciences2012，25，4： | 16 |
| 18 | Factors Affecting the Performance of Single-Chamber Soil Microbial Fuel Cells for Power Generation显示文摘There is limited information about the factors that affect the power generation of single-chamber microbial fuel cells(MFCs) using soil organic matter as a fuel source. We examined the effect of soil and water depths, and temperature on the performance of soil MFCs with anode being embedded in the flooded soil and cathode in the overlaying water. Results showed that the MFC with 5 cm deep soil and 3 cm overlaying water exhibited the highest open circuit voltage of 562 mV and a power density of 0.72 mW m-2. The ohmic resistance increased with more soil and water. The polarization resistance of cathode increased with more soil while that of anode increased with more water. During the 30 d operation, the cell voltage positively correlated with temperature and reached a maximum of 162 mV with a 500 ? external load. After the operation, the bacterial 16S rRNA gene from the soil and anode was sequenced. The bacteria in the soil were more diverse than those adhere to the anode where the bacteria were mainly affiliated to Escherichia coli and Deltaproteobacteria. In summary, the two bacterial groups may generate electricity and the electrical properties were affected by temperature and the depth of soil and water. | DENG Huan WU Yi-Cheng ZHANG Fan HUANG Zong-Chuan CHEN Zheng XU Hui-Juan ZHAO Feng | 2014 | Pedosphere2014，24，3： | 15 |
| 19 | Integrating TM and Ancillary Geographical Data with Classification Trees for Land Cover Classification of Marsh Area显示文摘The main objective of this research is to determine the capacity of land cover classification combining spec- tral and textural features of Landsat TM imagery with ancillary geographical data in wetlands of the Sanjiang Plain, Heilongjiang Province, China. Semi-variograms and Z-test value were calculated to assess the separability of grey-level co-occurrence texture measures to maximize the difference between land cover types. The degree of spatial autocorrelation showed that window sizes of 3×3 pixels and 11×11 pixels were most appropriate for Landsat TM im- age texture calculations. The texture analysis showed that co-occurrence entropy, dissimilarity, and variance texture measures, derived from the Landsat TM spectrum bands and vegetation indices provided the most significant statistical differentiation between land cover types. Subsequently, a Classification and Regression Tree (CART) algorithm was applied to three different combinations of predictors: 1) TM imagery alone (TM-only); 2) TM imagery plus image texture (TM+TXT model); and 3) all predictors including TM imagery, image texture and additional ancillary GIS in- formation (TM+TXT+GIS model). Compared with traditional Maximum Likelihood Classification (MLC) supervised classification, three classification trees predictive models reduced the overall error rate significantly. Image texture measures and ancillary geographical variables depressed the speckle noise effectively and reduced classification error rate of marsh obviously. For classification trees model making use of all available predictors, omission error rate was 12.90% and commission error rate was 10.99% for marsh. The developed method is portable, relatively easy to im- plement and should be applicable in other settings and over larger extents. | NA Xiaodong ZHANG Shuqing ZHANG Huaiqing LI Xiaofeng YU Huan LIU Chunyue | 2009 | Chinese Geographical Science2009，19，2： | 14 |
| 20 | Notch signaling pathway:architecture,disease,and therapeutics显示文摘The NOTCH gene was identified approximately 110 years ago.Classical studies have revealed that NOTCH signaling is an evolutionarily conserved pathway.NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription of target genes.NOTCH signaling deeply participates in the development and homeostasis of multiple tissues and organs,the aberration of which results in cancerous and noncancerous diseases.However,recent studies indicate that the outcomes of NOTCH signaling are changeable and highly dependent on context.In terms of cancers,NOTCH signaling can both promote and inhibit tumor development in various types of cancer.The overall performance of NOTCH-targeted therapies in clinical trials has failed to meet expectations.Additionally,NOTCH mutation has been proposed as a predictive biomarker for immune checkpoint blockade therapy in many cancers.Collectively,the NOTCH pathway needs to be integrally assessed with new perspectives to inspire discoveries and applications.In this review,we focus on both classical and the latest findings related to NOTCH signaling to illustrate the history,architecture,regulatory mechanisms,contributions to physiological development,related diseases,and therapeutic applications of the NOTCH pathway.The contributions of NOTCH signaling to the tumor immune microenvironment and cancer immunotherapy are also highlighted.We hope this review will help not only beginners but also experts to systematically and thoroughly understand the NOTCH signaling pathway. | Binghan Zhou Wanling Lin Yaling Long Yunkai Yang Huan Zhang Kongming Wu Qian Chu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 14 |
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