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| 1 | Development of Cementitious Materials Utilizing Alkali-activated Yellow River Silt显示文摘The possibility of preparing cementitious materials by the alkali-activated method using Yellow River sediment(The second largest river in China)as raw material and the modification effect on different slag addition were investigated.Sodium silicate and calcium hydroxide were used as the activator,and the specimens were prepared by the press molding method.The hydration process,hydration products,pore characteristics,and mechanical properties were investigated using SEM/EDS,FTIR,TG/DTG,XRD,MIP,and uniaxial compressive strength experiments,respectively.The results showed that the compressive strength of the modified yellow river silt-based cementitious material was significantly increased when the water glass dosage was 12 wt%(Ms=1.8)and the slag dosage was 40%,and its 90-day maximum compressive strength could reach 53 MPa. | 王宝民 WANG Wanli 梁晓霞 刘慧 HAN Junnan ZHAO Lu YANG Xingxing YAN Jifei | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，3： | 5 |
| 2 | NaV6O15:A promising cathode material for insertion/extraction of Mg^2+with excellent cycling performance显示文摘The rechargeable magnesium batteries(RMBs)are getting more and more attention because of their high-energy density,high-security and low-cost.Nevertheless,the high charge density of Mg^2+makes the diffusion of Mg2+in the conventional cathodes very slow,resulting in a lack of appropriate electrode materials for RMBs.In this work,we enlarge the layer spacing of V2Os by introducing Na^2+in the crystal structure to promote the diffusion kinetics of Mg^2+.The NaVeO15(NVO)synthesized by a facile method is studied as a cathode material for RMBs with the anhydrous pure Mg^2+electrolyte.As a result,the NVO not only exhibits high discharge capacity(119.2 mAh:g^-1 after 100 cycles at the current density of 20 mA:g^-1)and working voltage(above 1.6 V vs.Mg^2+/Mg),but also expresses good rate capability.Besides,the eX-situ characterizations results reveal that the Mg^2+storage mechanism in NVO is based on the intercalation and deintercalation.The density functional theory(DFT)calculation results further indicate that Mg^2+tends to occupy the semi-occupied sites of Na^+in the NVO.Moreover,the galvanostatic intermittent titration technique(GITT)demonstrates that NVO electrode has the fast diffusion kinetics of Mg^2+during discharge process ranging from 7.55×10^-13 to2.41×10^-11 cm^2·s^-1.Our work proves that the NVO is a potential cathode material for RMBs. | Dongzheng Wu Jing Zeng Haiming Hua Junnan Wu Yang Yang Jinbao Zhao | 2020 | Nano Research2020，13，2： | 2 |
| 3 | Tacit Knowledge Mining:The Key Traditional Chinese Medical Inheritance显示文摘Traditional Chinese medicine(TCM)is a treasure of traditional Chinese culture and a gift to the world.TCM tacit knowledge refers to the knowledge and experiences formed in the process of learning and practice of TCM.The objective of this study is to discuss the importance of TCM tacit knowledge in the inheritance and education of TCM.As the essence of the TCM,TCM tacit knowledge has the characteristics of massive,complicated,relativistic,highly individualized,constantly innovative,the dependence of cultural background and the regional environment,as well as difficult to explicate.It exists in every aspect of the TCM theory and the process of dialectical treatment.Besides the traditional master‑apprentice,family‑based,school‑based,and inheritance and education methods,together with the inheritance based on the books,images,and network platforms,in the process of TCM modernization,a variety of modern theoretical models and computing techniques have also been used in the mining of the TCM tacit knowledge.In this study,we introduced the usage of SECI model,complexity adaptive system,latent variable model,and some of the data mining technologies in the TCM tacit knowledge mining.An accurate and efficient inheritance of TCM tacit knowledge is the key to maintain the vitality and innovative development of TCM.Under the reasonable application and combination of the traditional education methods,modern mining methods,and further the artificial intelligence,the explicit and inheritance of TCM tacit knowledge will get tremendous development,and it could extremely improve the efficiency and accuracy of the TCM inheritance and the TCM modernization. | Xu Lan Junnan Zhao Ying Zhang Yao Chen Yaru Yan Yue Liu Fengqin Xu | 2020 | Chinese Medicine and Culture2020，3，1： | 1 |
| 4 | Atomic scale visualizations of low-angle grain boundary mediated plasticity by coupled dislocation climb and glide in nanoporous gold显示文摘Grain boundaries(GBs),as a prevalent structural characteristic,play a crucial role in the deformation of nanoporous metals with nanosized grains and ligaments.However,the fundamental understanding of GB-mediated deformation is still lacking because the plastic behavior of discrete ligaments involving GBs remains to be unknown.Here,we report atomic scale visualizations of coupled GB dislocation climb and glide in nanoporous gold ligaments with low-angle GBs via in situ tensile straining inside a Cs-corrected transmission electron microscope.The zig-zag motion paths of GB dislocations are precisely determined by real-time tracking of the movements of dislocation cores.The concurrent climb and glide of the dislocation arrays are confined to a narrow GB region,greatly enhancing GB diffusion in the bicrystal ligament.Our findings of coupled dislocation climb and glide shine a light on the room-temperature deformation of nanoporous metals and provide a time-dependent atomic-level physical image for GB engineering. | Shufen Chu Junnan Jiang Xiaoran Zhao Baode Sun Pan Liu | 2023 | Nano Research2023，16，2： | 1 |
| 5 | Co-overexpression of genes for nitrogen transport, assimilation, and utilization boosts rice grain yield and nitrogen use efficiency显示文摘Nitrogen(N)fertilization is necessary for obtaining high rice yield.But excessive N fertilizer reduces rice plant N efficiency and causes negative effects such as environmental pollution.In this study,we assembled key genes involved in different nodes of N pathways to boost nitrate and ammonium uptake and assimilation,and to strengthen amino acid utilization to increase grain yield and nitrogen use efficiency(NUE)in rice.The combinations OsNPF8.9a×OsNR2,OsAMT1;2×OsGS1;2×OsAS1,and OsGS2×OsAS2×OsANT3 optimized nitrate assimilation,ammonium conversion,and N reutilization,respectively.In co-overexpressing rice lines obtained by co-transformation,the tiller number,biomass,and grain yield per plant of the OsAMT1;2×OsGS1;2×OsAS1-overexpressing line exceeded those of wild-type ZH11,the OsNPF8.9a×OsNR2×OsGS1;2×OsAS1-overexpressing line,and the OsGS2×OsAS2×OsANT3-overexpressing line.The glutamine synthase activity,free amino acids,and nitrogen utilization efficiency(NUt E)of the OsAMT1;2×OsGS1;2×OsAS1-overexpressing line exceeded those of ZH11 and other lines that combined key genes.N influx efficiency was increased in the OsAMT1;2×OsGS1;2×OsAS1-overexpressing line and OsNPF8.9a×OsNR2×OsGS1;2×OsAS1-overexpressing line under a low ammonium and a low nitrate treatment,respectively.We propose that combining overexpression of OsAMT1;2,OsGS1;2,and OsAS1 is a promising breeding strategy for systematically increasing rice grain yield and NUE by focusing on key nodes in the N pathway. | Jie Luo Junnan Hang Bilong Wu Xilin Wei Quanzhi Zhao Zhongming Fang | 2023 | The Crop Journal2023，11，3： | 1 |
| 6 | Chinese Fetal Growth:A Multicenter Cohort Study Based on Fetal Ultrasound Measurements显示文摘Objective:To build a reference fetal growth chart for the Chinese population based on fetal ultrasound measurements.Methods:This was a multicenter,population-based retrospective cohort study.Longitudinal ultrasound measurement data were collected from 24 hospitals in 18 provinces of China from 1st September through 31st October of 2019.The estimated fetal weight(EFW)was calculated based on head circumference,abdominal circumference,and femur length using Hadlock formula 3.Fetal growth curves were estimated using a two-level linear regression model with cubic splines.All participants were divided into two groups:the northern group(n=5829)and the southern group(n=3246)based on the geographical division of China and male fetus group(n=4775)and female fetus group(n=4300)based on fetal gender.The EFW was compared by fetal gender and geographical group.All statistical models were adjusted for maternal sociodemographic characteristics.Results:A total of 9075 participants with 31,700 ultrasound measurement records were included in this study.Male fetuses demonstrated significantly larger EFW compared to female ones starting at 16 weeks of gestation and extending to delivery(global testP<0.01).The overall geographic difference in EFW was significant(global testP=0.03),and week-specific comparisons showed that the northern group had a greater EFW starting at 15 weeks of gestation and extending to 29 weeks of gestation,although this difference did not extend to the time of delivery.TheZ-score of EFW confirmed that our Chinese fetal growth charts differed from previously published standards.Conclusion:This study provides EFW and ultrasound biometric reference measurements for Chinese fetuses and reveals differences from other fetal growth charts.The chart is worth promoting in more regions of China but should be tested prudently before use. | Xiaoli Gong Tianchen Wu Xiaoli Wang Lizhen Zhang Yiping You Hongwei Wei Xifang Zuo Ying Zhou Xinli Xing Zhaoyan Meng Qi Lyu Zhaodong Liu Jian Zhang Liyan Hu Junnan Li Li Li Chulin Chen Chunyan Liu Guoqiang Sun Aiju Liu Jingsi Chen Yuan Lyu Yuan Wei Yangyu Zhao | 2023 | Maternal-Fetal Medicine2023，5，1： | 0 |
| 7 | Shunxin decoction(顺心组方) improves diastolic function in rats with heart failure with preserved ejection fraction induced by abdominal aorta constriction through cyclic guanosine monophosphate-dependent protein kinase Signaling Pathway显示文摘OBJECTIVE: To determine whether Shunxin decoction(顺心组方) improves diastolic function in rats with heart failure with preserved ejection fraction(HFp EF) by regulating the cyclic guanosine monophosphatedependent protein kinase(c GMP-PKG) signaling pathway. METHODS: Except for control group 8 and sham surgery group 8, the remaining 32 male Sprague-Dawlay rats were developed into HFp EF rat models using the abdominal aorta constriction method. These rats in the HFp EF model were randomly divided into the model group, the Shunxin high-dose group, the Shunxin lowdose group, and the Qiliqiangxin capsule group. The three groups received high-dose Shunxin decoction, lowdose Shunxin decoction, and Qiliqiangxin capsule by gavage, respectively, for 14 d. After the intervention, the diastolic function of each rat was evaluated by testing E/A, heart index, hematoxylin-eosin staining, Masson, myocardial ultrastructure, and N-terminal pro-brain natriuretic peptide(NT-pro BNP). The Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine(BATMAN-TCM) software was used to predict targets for which Shunxin decoction acts on the c GMP-PKG pathway. Natriuretic peptide receptor A(NPRA) and guanylate cyclase(GC) were detected by immunohistochemistry, and e NOS, phosphodiesterase 5A(PDE5A), and c GMP-dependent protein kinase 1(PKG I) were determined by Western blotting. RESULTS: Compared to the model group, the thickness of the interventricular septum at the end of diastole(IVSd) and the thickness of the posterior wall at the end of diastole(PWd) of the Shunxin decoction high-dose group, Shunxin decoction low-dose group, and Qiliqiangxin capsule group were all significantly reduced(P < 0.01). Furthermore, Shunxin decoction high-dose group E/A value was decreased(P < 0.01). Compared to the model group, the expression of NPRA and GC increased in the Shunxin decoction low-dose group and the Qiliqiangxin capsule group(P < 0.01). Compared to the model group, the expressions of e NOS and PKG I increased(P < 0.05) in the Shunxin decoction high-dose group. The expression of PDE5A expression decreased in the myocardium of the Shunxin decoction high-dose group, Shunxin decoction low-dose group, and Qiliqiangxin capsule group compared to the model group(P < 0.01). CONCLUSIONS: Shunxin decoction can improve diastolic function in rats with HFp EF. It increases the expression of NPRA, GC, and e NOS in the myocardial cell c GMP-PKG signaling pathway, upregulates c GMP expression, decreases PDE5A expression to reduce the c GMP degradation. Thus, the c GMP continually stimulates PKG I, reversing myocardial hypertrophy and improving myocardial compliance in HFp EF rats. | ZHANG Jiaying WEI Xiangxiang LI Xuefeng YUAN Yang DOU Yinghuan SHI Yanbin XIE Ping ZHOU Mengru ZHAO Junnan LI Miao ZHANG Shuwen ZHU Rui TIAN Ying TAN Hao TIAN Feifei | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 0 |
| 8 | Aiphanol, a native compound, suppresses angiogenesis via dual-targeting VEGFR2 and C0X2显示文摘Dear Editor,Pathological neo-vascularization is a hallmark of cancer and several diseases.Accumulating evidence supports the notion that antiangiogenic treatment can abolish tumor angiogenesis to achieve Ion ger disease-free survival.Although growth factors and their receptors function as the main drivers in angiogenesis,the involvement of other regulators,e.g.,Cyclooxygenase-2(COX2),^(1) should also be con sidered,especially for managi ng the resista nee to therapies against receptor tyrosine kinases(RTKs). | Shanmei Chen Junnan Feng Chuanke Zhao Lixin Wang Lin Meng Caiyun Liu Shaoqing Cai Yanxing Jia Like Qu Chengchao Shou | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 9 | Lack of evolutionary convergence in multiple primary lung cancer suggests insufficient specificity of personalized therapy显示文摘Multiple primary lung cancer(MPLC)is an increasingly prevalent subtype of lung cancer.According to recent genomic studies,the different lesions of a single MPLC patient exhibit functional similarities that may reflect evolutionary convergence.We perform whole-exome sequencing for a unique cohort of MPLC patients with multiple samples from each lesion found.Using our own and other relevant public data,evolutionary tree reconstruction reveals that cancer driver gene mutations occurred at the early trunk,indicating evolutionary contingency rather than adaptive convergence.Additionally,tumors from the same MPLC patient are as genetically diverse as those from different patients,while within-tumor genetic heterogeneity is significantly lower.Furthermore,the aberrant molecular functions enriched in mutated genes for a sample show a strong overlap with other samples from the same tumor,but not with samples from other tumors or other patients.Overall,there is no evidence of adaptive convergence during the evolution of MPLC.Most importantly,the similar between-tumor diversity and between-patient diversity suggest that personalized therapies may not adequately account for the genetic diversity among different tumors in an MPLC patient.To fully exploit the strategic value of precision medicine,targeted therapies should be designed and delivered on a per-lesion basis. | Hua Cheng Ziyan Guo Xiaoyu Zhang Xiao-Jin Wang Zizhang Li Wen-Wen Huo Hong-Cheng Zhong Xiao-Jian Li Xiang-Wen Wu Wen-Hao Li Zhuo-Wen Chen Tian-Chi Wu Xiang-Feng Gan Bei-Long Zhong Vassily ALyubetsky Leonid Yu Rusin Junnan Yang Qiyi Zhao Qing-Dong Cao Jian-Rong Yang | 2023 | Journal of Genetics and Genomics2023，50，5： | 0 |
| 10 | Bone metastasis of hepatocellular carcinoma:facts and hopes from clinical and translational perspectives显示文摘Patients with hepatocellular carcinoma(HCC)and bone metastasis(BM)suffer from greatly reduced life quality and a dismal prognosis.However,BM in HCC has long been overlooked possibly due to its relatively low prevalence in previous decades.To date,no consensus or guidelines have been reached or formulated for the prevention and management of HCC BM.Our narrative review manifests the increasing incidence of HCC BM to sound the alarm for additional attention.The risk factors,diagnosis,prognosis,and therapeutic approaches of HCC BM are detailed to provide a panoramic view of this disease to clinicians and specialists.We further delineate an informative cancer bone metastatic cascade based on evidence from recent studies and point out the main factors responsible for the tumor-associated disruption of bone homeostasis and the formation of skeletal cancer lesions.We also present the advances in the pathological and molecular mechanisms of HCC BM to shed light on translational opportunities.Dilemmas and challenges in the treatment and investigation of HCC BM are outlined and discussed to encourage further endeavors in the exploration of underlying pathogenic and molecular mechanisms,as well as the development of novel effective therapies for HCC patients with BM. | Zhao Huang Jingyuan Wen Yufei Wang Shenqi Han Zhen Li Xuemei Hu Dongling Zhu Zhenxiong Wang Junnan Liang Huifang Liang Xiao-ping Chen Bixiang Zhang | 2022 | Frontiers of Medicine2022，16，4： | 0 |
| 11 | Game Theoretic Simulation on the Mimicry Honeypot显示文摘A mimicry honeypot framework based on game theory is presented in our work, which can calculate the equilibrium strategy of the deceptive game using non-cooperative incomplete dynamic game theory, and make decisions for the mimicry framework to deploy the simple service, the honeypot and the fake honeypot. A mimicry prototype is implemented using NS2 platform, and simulation experiments are launched to validate the decision-making result and the deceptive performance of the mimicry honeypot. The empirical study shows that the mimicry honeypot framework based on game theory can be able to influence the equilibrium strategy results by dynamically changing the deployment vector of the mimicry system. It validates that the mimicry honeypot framework has better flexibility, activeness and fraudulence than the traditional honeypot. | SHI Leyi ZHAO Junnan JIANG Lanlan XING Wenjuan GONG Jian LIU Xin | 2016 | Wuhan University Journal of Natural Sciences2016，21，1： | 0 |
| 12 | Studying bona fide SARS-CoV-2 biology in a BSL-2 biosafety environment using a split-virus-genome system显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARSCoV-2)was identified as the pathogen causing the coronavirus disease(COVID-19),which sometimes resulted in fatal pneumonia(Hu et al.,2021).SARS-CoV-2 is a biosafety level 3(BSL-3)pathogen,and the requirement for high containment conditions is a bottleneck for basic research on viral biology.To help general researchers who wish to study SARS-CoV-2 but do not have access to a BSL-3 facility,a system that(1)can mimic the real life cycle of the virus;(2)allows easy genetic manipulation;and(3)shows high biosafety in BSL-2 laboratory is required. | Yingxin Ma Guobin Mao Weishan Yang Guoqiang Wu Guoqiang Li Xiaoying Li Xin Lin Junnan Lu Shijun Zhao Wei Zhao Junbiao Dai Xian-En Zhang | 2022 | Science China(Life Sciences)2022，65，9： | 0 |
| 13 | Correction: Aiphanol, a native compound, suppresses angiogenesis via dual-targeting VEGFR2 and COX2显示文摘Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-021-00739-5,published online 03 December 2021 After online publication of the letter1,the author found two images in the supplement materials were used incorrectly,Additionally,there is an error in the chemical structure of Aiphanol in Figs.1a and 1s that needs to be corrected.The correct data are provided as follows.The key findings of the article are not affected by these corrections.The original article has been corrected. | Shanmei Chen Junnan Feng Chuanke Zhao Lixin Wang Lin Meng Caiyun Liu Shaoqing Cai Yanxing Jia Like Qu Chengchao Shou | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 0 |
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