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| 1 | Numerical and experimental research on different inlet configurations of high speed centrifugal compressor显示文摘Three different inlet configurations,including a original straight pipe and two bend pipes with different axial length,for a high speed low mass flow centrifugal compressor were modeled with whole blade passages and simulated unsteadily by 3D viscous Navier-Stokes equations.The performance disparities of compressor stage were tested and verified by experiments in which dynamic pressure data acquisition of internal flow field was performed.As the result shows,the choke point decreases to lower mass flow rate due to the distortion caused by bend-pipe inlet and is aggravated as the rotation speed increases.The distortion effect spreads circumferentially in impeller and makes the flow structure varied.The longer axial distance bent inlet leads to larger radial distortion and heavy blockage at mid-span under large mass flow mainly causes compressor choke margin nar-rowed.Bend pipe distortion brings an impact up to diffuser on unsteady pressure pulsation caused by blades sweep and the impact appears more powerful when it is closer to volute tongue. | LI Du YANG Ce ZHOU Mi ZHU ZhiFu WANG Hang | 2012 | Science China(Technological Sciences)2012，55，1： | 9 |
| 2 | Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia显示文摘Hepatic cholesterol accumulation is an important contributor to hypercholesterolemia,which results in atherosclerosis and cardiovascular disease(CVD).ATP-citrate lyase(ACLY)is a key lipogenic enzyme that converts cytosolic citrate derived from tricarboxylic acid cycle(TCA cycle)to acetyl-CoA in the cytoplasm.Therefore,ACLY represents a link between mitochondria oxidative phosphorylation and cytosolic de novo lipogenesis.In this study,we developed the small molecule 326E with an enedioic acid structural moiety as a novel ACLY inhibitor,and its CoA-conjugated form 326E-CoA inhibited ACLY activity with an IC_(50)=5.31±1.2μmol/L in vitro.326E treatment reduced de novo lipogenesis,and increased cholesterol efflux in vitro and in vivo.326E was rapidly absorbed after oral administration,exhibited a higher blood exposure than that of the approved ACLY inhibitor bempedoic acid(BA)used for hypercholesterolemia.Chronic 326E treatment in hamsters and rhesus monkeys resulted in remarkable improvement of hyperlipidemia.Once daily oral administration of 326E for 24 weeks prevented the occurrence of atherosclerosis in ApoE^(-/-)mice to a greater extent than that of BA treatment.Taken together,our data suggest that inhibition of ACLY by 326E represents a promising strategy for the treatment of hypercholesterolemia. | Zhifu Xie Mei Zhang Qian Song Long Cheng Xinwen Zhang Gaolei Song Xinyu Sun Min Gu Chendong Zhou Yangming Zhang Kexin Zhu Jianpeng Yin Xiaoyan Chen Jingya Li Fajun Nan | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 3 | A study of luminescence properties of (Gd 3+ , Dy 3+ , Nb 5+ )-doped lead tungstate single crystals显示文摘 | Yanlin Huang Wenliang Zhu Xiqi Feng Zhifu Liu Zhenyong Man Zhiwen Yin | 2003 | Optical Materials2003，，1： | 1 |
| 4 | Experimental studies on thermal performance and flow resistance of heat exchangers with helical baffles 显示文摘 | Wang Chen Zhu Jiagui Sang Zhifu | 2009 | Heat Transfer Engineering2009，30，5： | 1 |
| 5 | Multi-attribute decision making with Pythagorean fuzzy sets via conversions to intuitionistic fuzzy sets and ORESTE method显示文摘The aim of this paper is to study the conversions between Pythagorean fuzzy sets and Atanassov’s intuitionistic fuzzy sets.Besides,an ORESTE method based on multi-attribute decision making with Pythagorean fuzzy sets is developed by utilising the developed conversions.In this paper,according to the geometric representations of Pythagorean fuzzy sets and Atanassov’s intuitionistic fuzzy sets,two types of conversions between the two fuzzy sets are constructed,which are further used to derive information measures include entropy and cross-entropy measures of Pythagorean fuzzy sets.Then,by combining with the ORESTE method,a direct decision procedure for multi-attribute decision making with Pythagorean fuzzy information is developed.Finally,a numerical example of the evaluation of regional energy efficiency is shown to illustrate the feasibility and validity of the developed decision procedure. | Zhifu Tao Jiaming Zhu Ligang Zhou Jinpei Liu Huayou Chen | 2021 | Journal of Control and Decision2021，8，3： | 1 |
| 6 | Experimental studies on thermal performance and flow resistance of heat exchangers with helical baffles 显示文摘 | WANG Chen ZHU Jiaqui SANG Zhifu | 2009 | Heat Transfer Engineering2009，30，5： | 1 |
| 7 | MEMOIR: A Novel System for Neural Lineage Tracing显示文摘Memory by Engineered Mutagenesis with Optical In situ Readout(MEMOIR)is a novel strategy for lineage tracing that combines Cas9/g RNA and sequential multiplexed single-molecule RNA fluorescence hybridization(seqFISH)[1],which was created by Cai Long et al.at the California Institute of Technology[2].In MEMOIR,dynamic cellular event histories are recorded,then read out in single cells using seq FISH.Here,we introduce | Zhifu Wang Jianhong Zhu | 2017 | Neuroscience Bulletin2017，33，6： | 1 |
| 8 | Zeolite-mediated hybrid Cu^(+)/Cu~0 interface for electrochemical nitrate reduction to ammonia显示文摘The electrocatalytic conversion of reactive nitrogen species to ammonia is a promising strategy for efficient NH_(3) synthesis.In this study,we reveal that the hybrid Cu^(+)/Cu~0 interface is catalytically active for electrochemical ammonia synthesis from nitrate reduction.To maintain the hybrid Cu^(+)/Cu~0 state at negative reaction potentials,hydrophilic zeolite is used to modify Cu/Cu_(2)O electrocatalyst,which demonstrates an impressive NH_(3) production rate of 41.65 mg h^(-1) cm^(-2)with ~100% Faradaic efficiency of ammonia synthesis at-0.6 V vs.RHE.In-situ Raman spectroscopy unveil the high activity originates from the zeolite reconstruction at the electrode–electrolyte interface,which protects the valence state of Cu~0/Cu^(+) site under negative potential and promotes electrochemical activity towards NH_(3) synthesis. | Jiabao Lv Angjian Wu Liang Wang Yunhao Zhong Zhihao Zeng Qunxing Huang Xiaoqing Lin Hao Zhang Shaojun Liu Qian Liu Songqiang Zhu Xiaodong Li Jianhua Yan Zhifu Qi Hao Bin Wu | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 9 | Evaluation of the Bioavailability of Metals in Sediment from the Southern Coastal Wetland of the Qiantang Estuary by Using Diffusive Gradients in Thin Films Technique显示文摘Metal pollution has become an major issue governing the wetland ecosystem health.The southern coastal wetland of the Qiangtang Estuary are facing unusual perturbation due to rapid development along the embayment in recent decades.This study evaluated the bioavailability of metals(Cu,Pb,Cd,Cr and Zn)in the sediment of the southern coastal wetland of the Qiangtang Es-tuary using diffusive gradients in thin films(DGT)techniques and compared with several methods based on total metal content.The results showed that the contents of Cr,Pb,Cd and Cu in sediment,as detected using DGT,were considerably correlated with the exchangeable fraction and the content in Phragmites australis roots,while a weak correlation was observed for Zn.Therefore,DGT analysis could be used to evaluate the bioavailability and potential risk of Cr,Cd,Pb and Cu for P.australis.Quantitative indices,such as DGT concentration,bioaccumulation in P.australis,geoaccumulation index(Igeo)and potential ecological risk index(RI),revealed that Cd was a major potential ecological risk factor along the southern coast wetland of the Qiantang Estuary,especially in the upstream region,which is potentially more vulnerable to the anthropogenic pollution. | FENG Weihua WANG Zhifu ZHU Wenzhuo ZHENG Fangqin ZHANG Dongrong XU Hengtao | 2022 | Journal of Ocean University of China2022，21，2： | 0 |
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