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| 1 | Bisphenol A in combination with TNF-a selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity显示文摘Bisphenol A(BPA)is a monomer used in manufacturing a wide range of chemical products,including epoxy resins and polycarbonate.BPA,an important endocrine disrupting chemical that exerts estrogen-like activities,is detectable at nanomolar levels in human serum worldwide.The pregnancy associated doses of 17b-estradiol(E2)plus tumor-necrosis factor-a(TNF-a)induce distorted maturation of human dendritic cells(DCs)that result in an increased capacity to induce T helper(Th)2 responses.The current study demonstrated that the presence of BPA during DC maturation influences the function of human DCs,thereby polarizing the subsequent Th response.In the presence of TNF-a,BPA treatment enhanced the expression of CC chemokine ligand 1(CCL1)in DCs.In addition,DCs exposed to BPA/TNF-a produced higher levels of IL-10 relative to those of IL-12p70 on CD40 ligation,and preferentially induced Th2 deviation.BPA exerts the same effect with E2 at the same dose(0.01–0.1 mM)with regard to DC-mediated Th2 polarization.These findings imply that DCs exposed to BPA will provide one of the initial signals driving the development and perpetuation of Th2-dominated immune response in allergic reactions. | Hongchuan Guo Tianyi Liu Yasushi Uemura Shunchang Jiao Deqing Wang Zilin Lin Yayoi Narita Motoharu Suzuki Narumi Hirosawa Yasuko Ichihara Osamu Ishihara Hirosato Kikuchi Yasushi Sakamoto Satoru Senju Qiuhang Zhang Feng Ling | 2010 | Cellular & Molecular Immunology2010，7，3： | 6 |
| 2 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 3 | Process improvement in laser hot wire cladding for martensitic stainless steel based on the Taguchi method显示文摘与低热输入,高精力效率,和高精确的突出的特征,激光热电线 cladding 广泛地被使用因为重新生产的金属分开。然而, cladding 过程需要被使用一个量的方法改善。在这个工作,容量的缺点比率作为标准被建议描述为 cladding 层形成质量的正直。有 FV520B 的激光免职实验, martensitic 不锈钢之一,被使用 Taguchi 方法设计。四个进程变量,也就是激光力量(P) ,扫描速度(V s ), 电线喂率(V f ), 和电线水流(I) ,基于 signal-to-noise (S/N ) 的分析被优化比率。cladding 层的冶金学的观察被进行比较形成的质量并且验证分析方法。有最佳参数联合的稳定、连续的进程与最小的缺点和裂缝生产了一致微观结构,它导致了一个好冶金的结合接口。 | Zilin HUANG Gang WANG Shaopeng WEI Changhong LI Yiming RONG | 2016 | Frontiers of Mechanical Engineering2016，11，3： | 5 |
| 4 | A transient multiphysics coupling method based on OpenFOAM for heat pipe cooled reactors显示文摘Differing from traditional pressurized water reactors(PWRs),heat pipe cooled reactors have the unique characteristics of fuel thermal expansion,expansion reactivity feedback,and thermal contact conductance.These reactors require a new multiphysics coupling method.In this paper,a transient coupling method based on OpenFOAM is proposed.The method considers power variation,thermal expansion,heat pipe operation,thermal contact conductance,and gap conductance.In particular,the reactivity feedback caused by working medium redistribution in a heat pipe is also preliminarily considered.A typical heat pipe cooled reactor KRUSTY(Kilowatt Reactor Using Stirling TechnologY)is chosen as the research object.Compared with experimental results of load following,the calculated results are in good agreement and show the validity of the proposed method.To discuss the self-adjusting capability of this type of reactor system,a hypothetical accident is simulated.It is assumed that at the beginning of this accident,loss of the heat sink occurs.After 1500 s of the transient process,the reactor system recovers immediately.During this hypothetical accident,the control rod is always out of the reactor core,and the reactor only relies on the reactivity feedback to regulate the fission power.According to the simulation,the peak temperature is only about 1112 K,which is far below the safety limit.As for system recovery,the reactor needs approximately 2500 s to return to a steady state and can realize effective power regulation by reactivity feedback.This study confirms the availability of this coupling method and that it can be an effective tool for the simulation of heat pipe cooled reactors. | GUO YuChuan LI ZeGuang WANG Kan SU ZiLin | 2022 | Science China(Technological Sciences)2022，65，1： | 4 |
| 5 | Tomato SlPUB24 enhances resistance to Xanthomonas euvesicatoria pv. perforans race T3显示文摘Solanum lycopersicum var.cerasiforme accession PI 114490 has broad-spectrum resistance to bacterial spot caused by several species of Xanthomonas.Resistance is quantitatively inherited,and a common quantitative trait locus QTL-11B on chromosome 11 has been identified previously.In this study,the SlPub24 gene was characterized in QTL-11B.SlPub24 in PI 114490 was upregulated by infection with X.euvesicatoria pv.perforans race T3,but its transcription was low in the susceptible line OH 88119 whether or not it was infected by the pathogen.The differential expression of SlPub24 between PI 114490 and OH 88119 was due to great sequence variation in the promoter region.The promoter of SlPub24 in OH 88119 had very low activity and did not respond to pathogen infection.Transgenic lines of OH 88119 overexpressing SlPub24 isolated from PI 114490 showed significantly enhanced resistance,while mutants of Slpub24 generated by CRISPR/Cas9 editing showed more susceptibility to race T3 and to other races.The mutants also showed spontaneous cell death in leaves.The expression of the salicylic acid(SA)pathway gene phenylalanine ammonia-lyase(PAL)and signaling-related genes pathogenesis-related(PR1)and nonexpresser of PR1(NPR1)were influenced by SlPub24.The content of SA in tomato plants was consistent with the level of SlPub24 expression.Furthermore,SlPUB24 interacted with the cell wall protein SlCWP and could regulate the degradation of SlCWP.The expression levels of SlCWP and SlCWINV1,a cell wall invertase gene,showed opposite patterns during pathogen infection.The activity of SlCWINV1 was lower in mutants than in PI 114490.The results are discussed in terms of the roles of the abovementioned genes,and a potential model for SlPUB24-mediated resistance to bacterial spot is proposed. | Xin Liu Ge Meng Mengrui Wang Zilin Qian Yaxian Zhang Wencai Yang | 2021 | Horticulture Research2021，8，1： | 4 |
| 6 | Simultaneous determination of three curcuminoids in Curcuma longa L.by high performance liquid chromatography coupled with electrochemical detection显示文摘A novel method for analysis of three active components curcumin,demethoxycurcumin and bisdemethoxycurcumin in Curcuma longa L.was developed by HPLC coupled with electrochemical detection.Three curcuminoids were well separated on a C_(18) column and detected with high sensitivity.A mobile phase containing acetonilrile and 10 mM Na_2HPO_4-H_3PO_4(pH 5.0)(50:50.v/v) was used.Good linearity was obtained in the range of 0.208-41.6,0.197-39.4,and 0.227-114 μM for curcumin.demethoxycurcumin and bisdemethoxycurcumin respectively.The limit of detection reached up to 10^(-8) M.which was lower than that by UV detection.The relative standard deviations(RSDs) ranged from 1.06% to 1.88% for intra-day precision and from 4.30% to 5.79% for inter-day precision,respectively.The proposed method has been applied in real herb sample and recoveries ranging from 86.3% to 111% were obtained. | Yuling Long Wenpeng Zhang Fang Wang Zilin Chen | 2014 | Journal of Pharmaceutical Analysis2014，4，5： | 4 |
| 7 | Electrochemical behavior and the determination of methyl jasmonate显示文摘In this work,the electrochemical behavior of methyl jasmonate(MeJA)on a glassy carbon electrode was investigated in 0.1 mol/L H2SO4 by voltammetry.MeJA exhibited enhanced oxidation behavior in the presence of sodium dodecyl sulfate(SDS). The electrochemical reaction of MeJA on the electrode was carried out with SDS micelles to improve the solubility of MeJA by hydrophobic interaction.Consequently,the oxidation peak current was sensitively enhanced.The effect of experimental parameters on the oxidative peak current was investigated including the surfactant concentration,supporting electrolyte,accumulation potential and time,and scan rate. | LIAO YaQian WANG Fang CHEN ZiLin | 2010 | Chinese Science Bulletin2010，55，21： | 3 |
| 8 | Super Na^(+)Half/Full Batteries and Ultrafast Na+Diffusion Kinetics of Cobalt-Nickel Selenide from Assembling Co_(0.5)Ni_(0.5)Se_(2)@NC Nanosheets into Cross-Stacked Architecture显示文摘Explorati on of adva need an ode materials for sodium-i on batteries(SIBs)is still a big challe nge due to the large radius of sodium.In this work,the hierarchical architectures assembled from N-doped carbon-coated Co_(0.5)Ni_(0.5)Se_(2)(Co_(0.5)Ni_(0.5)Se_(2)@NC)nanoparticles encapsulated into cross-stacked nano sheets have been successfully prepared from the cobalt-nickel bin ary-metal organic frameworks(CoNi-MOF)by two steps of the solid-state sele nizati on and carb on coating processes.Imports ntly,the resulta nt hierarchical Co0.5Nio:5Se2@NC architecture can achieve a satisfactory electrochemical performance,maintaining a high-rate capacity of 330 mA-h-g^(-1)1 at 3 A·g^(-1) and a stable cyclability of 100 cycles without obvious capacity decay at 0.2 A·g^(-1).The design of distinct superstructure can not only be applied to other electrode materials but also boost the forward development of energy storage systems. | Zhiyong Li Zilin Peng Rui Sun Zhaoxia Qin Xinlong Liu Caihong Wang Haosen Fan Shengjun Lu | 2021 | Chinese Journal of Chemistry2021，39，9： | 3 |
| 9 | Sex disparity of lung cancer risk in non-smokers:a multicenter population-based prospective study based on China National Lung Cancer Screening Program显示文摘Background: Non-smokers account for a large proportion of lung cancer patients, especially in Asia, but the attention paid to them is limited compared with smokers. In non-smokers, males display a risk for lung cancer incidence distinct from the females-even after excluding the influence of smoking;but the knowledge regarding the factors causing the difference is sparse. Based on a large multicenter prospective cancer screening cohort in China, we aimed to elucidate the interpretable sex differences caused by known factors and provide clues for primary and secondary prevention.Methods: Risk factors including demographic characteristics, lifestyle factors, family history of cancer, and baseline comorbidity were obtained from 796,283 Chinese non-smoking participants by the baseline risk assessment completed in 2013 to 2018. Cox regression analysis was performed to assess the sex difference in the risk of lung cancer, and the hazard ratios (HRs) that were adjusted for different known factors were calculated and compared to determine the proportion of excess risk and to explain the existing risk factors.Results: With a median follow-up of 4.80 years, 3351 subjects who were diagnosed with lung cancer were selected in the analysis. The lung cancer risk of males was significantly higher than that of females;the HRs in all male non-smokers were 1.29 (95% confidence interval [CI]: 1.20-1.38) after adjusting for the age and 1.38 (95% CI: 1.28-1.50) after adjusting for all factors, which suggested that known factors could not explain the sex difference in the risk of lung cancer in non-smokers. Known factors were 7% (|1.29-1.38|/1.29) more harmful in women than in men. For adenocarcinoma, women showed excess risk higher than men, contrary to squamous cell carcinoma;after adjusting for all factors, 47% ([1.30-1.16]/[1.30-1]) and 4% ([7.02-6.75]/[7.02-1])) of the excess risk was explainable in adenocarcinoma and squamous cell carcinoma. The main causes of gender differences in lung cancer risk were lifestyle factors, baseline comorbidity, and family history.Conclusions: Significant gender differences in the risk of lung cancer were discovered in China non-smokers. Existing risk factors did not explain the excess lung cancer risk of all non-smoking men, and the internal causes for the excess risk still need to be explored;most known risk factors were more harmful to non-smoking women;further exploring the causes of the sex difference would help to improve the prevention and screening programs and protect the non-smoking males from lung cancers. | Zheng Wu Fengwei Tan Zhuoyu Yang Fei Wang Wei Cao Chao Qin Xuesi Dong Yadi Zheng Zilin Luo Liang Zhao Yiwen Yu Yongjie Xu Jiansong Ren Jufang Shi Hongda Chen Jiang Li Wei Tang Sipeng Shen Ning Wu Wanqing Chen Ni Li Jie He | 2022 | Chinese Medical Journal2022，，11： | 3 |
| 10 | Reassessment of the Distribution of Mantle CO_(2) in the Bohai Sea,China:The Perspective from the Source and Pathway System显示文摘Research on the distribution of mantle CO_(2)should involve comprehensive analysis from CO_(2)source to accumulation.The crust-mantle pathway system is the key controlling factor of the distribution of mantle CO_(2),but has received little attention.The pathway system and controlling factors of CO_(2)distribution in the Bohai Sea are analyzed using data on fault styles and information on the mantle and lithosphere.The relation between volcanic rocks and the distribution of mantle CO_(2)is reassessed using age data for CO_(2)accumulations.The distribution of mantle CO_(2)is controlled by uplift of the asthenosphere and upper mantle,magma conduits in the mantle and fault systems in the crust.Uplifted regions of the asthenosphere are accumulation areas for CO_(2).The area with uplift of the Moho exhibits accumulation of mantle CO_(2)at depth.CO_(2)was mainly derived from vertical migration through the upper mantle and lower crust.The fault style in the upper crust controls the distance of horizontal migration and the locations of CO_(2)concentrations.The distribution of mantle CO_(2)and volcanic rocks are not the same,but both probably followed the same pathways sometimes.Mantle CO_(2)in the Bohai Sea is concentrated in the Bozhong sag and the surrounding area,particularly in a trap that formed before 5.1 Ma and is connected to crustal faults(the Bozhang faults)and lithospheric faults(the Tanlu faults). | TANG Huafeng GUO Tianchan WU Keqiang LIU Zilin XU Jianyong LU Baoliang WANG Pujun | 2022 | Acta Geologica Sinica(English Edition)2022，96，1： | 2 |
| 11 | Fiber Bragg Grating Strain Sensors for Marine Engineering显示文摘 | Tingting WANG Zilin YUAN Yuan GONG Yu WU Yunjiang RAO Lili WEI Peng GUO Junpu WANG Fu WAN | 2013 | Photonic Sensors2013，3，3： | 2 |
| 12 | Determination of bavachin and isobavachalcone in Fructus Psoraleae by high-performance liquid chromatography with electrochemical detection 显示文摘 | Li Yuan Wang Fang Chen Zilin | 2011 | J Sep Sci2011，34，： | 1 |
| 13 | An electropolymerized Nile Blue sensing film-based nitrite sensor and application in food analysis显示文摘 | CHEN XIAOWEI WANG FANG CHEN ZILIN | 2008 | Anal Chin Acta2008，632，2： | 1 |
| 14 | Aptamer- based electrochemical biosensor for label-free voltam- metric detection of thrombin and adenosine 显示文摘 | YAN Fangfang WANG Fang CHEN Zilin | 2011 | Sensors and Actuators B: Chemical2011，160，1： | 1 |
| 15 | Modem teacher's five scale 显示文摘 | Cui Jie Wang Zilin | 1994 | Journal of Harbin1994，03，： | 1 |
| 16 | Triple-functional bone adhesive with enhanced internal fixation,bacteriostasis and osteoinductive properties for open fracture repair显示文摘At present,effective fixation and anti-infection implant materials represent the mainstay for the treatment of open fractures.However,external fixation can cause nail tract infections and is ineffective for fixing small fracture fragments.Moreover,closed reduction and internal fixation during the early stage of injury can lead to potential bone infection,conducive to bone nonunion and delayed healing.Herein,we designed a bone adhesive with anti-infection,osteogenic and bone adhesion fixation properties to promote reduction and fixation of open fractures and subsequent soft tissue repair.It was prepared by the reaction of gelatin(Gel)and oxidized starch(OS)with vancomycin(VAN)-loaded mesoporous bioactive glass nanoparticles(MBGNs)covalently cross-linked with Schiff bases.Characterization and adhesion experiments were conducted to validate the successful preparation of the Gel-OS/VAN@MBGNs(GOVM-gel)adhesive.Meanwhile,in vitro cell experiments demonstrated its good antibacterial effects with the ability to stimulate bone marrow mesenchymal stem cell(BMSCs)proliferation,upregulate the expression of alkaline phosphatase(ALP)and osteogenic proteins(RunX2 and OPN)and enhance the deposition of calcium nodules.Additionally,we established a rat skull fracture model and a subcutaneous infection model.The histological analysis showed that bone adhesive enhanced osteogenesis,and in vivo experiments demonstrated that the number of inflammatory cells and bacteria was significantly reduced.Overall,the adhesive could promote early reduction of fractures and antibacterial and osteogenic effects,providing the foothold for treatment of this patient population. | Yusheng Yang Shenghui Su Shencai Liu Weilu Liu Qinfeng Yang Liangjie Tian Zilin Tan Lei Fan Bin Yu Jian Wang Yanjun Hu | 2023 | Bioactive Materials2023，，7： | 1 |
| 17 | Allelopathy of Gaseous Volatiles of Eupatorium adenophorum on Seed Germination and Seedling Growth of Pinus yunanensis显示文摘[Objective] The paper was to understand allelopathy of gaseous volatiles of Eupatorium adenophorum stems and leaves on seed germination and seedling growth of Pinus yunnanensis.[Method] P.yunnanensis seeds were treated by fresh stems and leaves of E.adenophorum in translucent airtight container under high concentration( 0.0694g/cm3),middle concentration( 0.0231g/cm3) and lower concentration( 0.0077g/cm3),respectively.[Result] Gaseous volatiles affected seed germination process;with the increasing processing concentration,the day on which seeds began to germinate and the day reaching germination peak were delayed,and the germination quantity on the day reaching germination peak was decreased;the day on which the germination quantity began to significantly reduce was delayed;the process curve was developed from sudden increase and sudden decrease to gentle change,and nearly became a beeline at high concentration.The effects of gaseous volatiles on seed germination( seed germination rate,germination potential,germination index) and seedling growth( fresh weight,dry weight,radicle length,hypocotyl length) of P.yunnanensis were basically consistent,showing a regularity that high concentration had stronger inhibition effect and the inhibition effect became weaker with the decreasing concentration of E.adenophorum.E.adenophorum was widely distributed under P.yunnanensis forests,and might affect natural regeneration and growth of P.yunnanensis via allelopathy.[Conclusion] The paper provides reference for scientific management of P.yunnanensis forests. | Cao Zilin Wang Xiaoli Li Genqian Li Xiaoting Gao Hui Yuan Sian | 2013 | Plant Diseases and Pests2013，4，4： | 1 |
| 18 | New norlignan enantiomers from the fruit of Crataegus pinnatifida with neuroprotective activities显示文摘(±)-Crataegusnorin A(la/1b) and B(2a/2b),two pairs of rare 8,9’-epoxy-type norlignan enantiomers featuring a y-butyrolactone ring,were isolated from the fruit of Crataegus pinnatifida.Their structures were determined via extensive spectroscopic analyses.Gauge-independent atomic orbital(GIAO) NMR chemical shift calculations,combined with the advanced statistical method DP4+were employed to establish the relative configurations of four compounds.Next,chiral separation was accomplished by chiral chromatographic column and the absolute configurations of the four compounds were unambiguously assigned by comparison between their experimental electronic circular dichroism curves with the quantum-mechanically calculated curves based on time-dependent density functional theory(TDDFT).All the isolates were evaluated fo r their neuroprotective activities against H2O2-induced cell injury in human neuroblastoma SH-SY5Y cells.The results showed that two pairs of enantiomers 1a/1b and 2a/2b displayed diff;erent effect on neuroprotective activity.Among them,compound 2a displayed the most potent neuroprotective effect Further flow cytometry analysis indicated that 2a could protect SH-SY5Y cells from oxidative damage through inhibiting cell apoptosis. | Rui Guo Tianming Lv Fengying Han Zilin Hou Guodong Yao Bin Lin Xiaobo Wang Xiaoxiao Huang Shaojiang Song | 2020 | Chinese Chemical Letters2020，31，5： | 1 |
| 19 | Power distribution and coordinated control for a power split hybrid electric bus显示文摘 | WANG Feng ZHONG Hu MA Zilin | 2008 | Journal of electric Engineering & Technology2008，3，4： | 1 |
| 20 | Using ther- moregulated PEG biphase system to effect the hydro- formylation of p-isobutylstyrene catalyzed by REzOPGPP complex显示文摘 | Feng Cuilan Wang Yanhua Jin Zilin | 2006 | J Mol Catal A :Chem2006，248，： | 1 |
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