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| 1 | Clinicopathologic features, diagnosis and surgical treatment of intrahepatic cholangiocarcinoma in 104 patients显示文摘BACKGROUND: The outcome of surgical treatment of pa- tients with intrahepatic cholangiocarcinoma (ICC) is poor. This study was designed to analyze the relationship between clinicopathologic features and the survival time after opera- tion. METHODS: The operation was performed in 104 patients with mass-forming type ICC at our hospital between No- vember 1996 and May 2000. Seventy-nine patients (76.0%) were followed up successfully. Sixteen clinicopathological variables including age, sex, history of chronic liver di- sease , HBsAg, operation, adjuvant therapy, ascites, lymph node metastasis, invasion of adjacent organs, tumor size, necrosis of tumor, envelope, intrahepatic metastasis, Inter- national Union Against Cancer (UICC) TNM staging, his- tology, and cirrhosis were selected for univariate and multi- variate analyses to evaluate their influence on the prognosis. RESULTS: The accumulative 1-, 3-, 5-year survival rates of the 79 patients were 49.4%, 17.3%, 9.6% respectively. Univariate analysis revealed that sex (P=0.0221), HBsAg (P=0.0115), operation (P=0.0042), adjuvant therapy (P= 0.0389), ascites (P=0.0001), invasion (P=0.0220), intra- hepatic metastasis (P=0.0000) and TNM stage (P= 0.0001) were related to survival time. Multivariate analysis revealed that HBsAg, ascites and TNM stage were signifi- cantly related to prognosis. CONCLUSION: Early diagnosis and treatment and major hepatectomy are essential to improving the results of surgi- cal treatment of ICC patients. | Xiao-Hui Fu, Zhao-Hui Tang, Ming Zong, Guang-Shun Yang, Xiao-Ping Yao and Meng-Chao Wu Shanghai, China Department of Comprehensive Therapy of Hepatobi- liary Tumors, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 24 |
| 2 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 3 | Numerical study on ULF waves in a dipole field excited by sudden impulse显示文摘A three-dimensional numerical model is employed to investigate ULF waves ex-cited by the sudden impulse (SI) of the solar wind dynamic pressure interacting with a dipole magnetosphere. We focus on the solar wind-magnetosphere energy coupling through ULF waves, and the influences of the SI spectrum on the cavity mode structure and the energy deposition due to field line resonances (FLRs) in the magnetosphere. The numerical results show that for a given SI lasting for 1 min with amplitude of 50 mV/m impinging on the subsolar magnetopause, the total ULF energy transported from the solar wind to the magnetosphere is about the magni-tude of 1014 J. The efficiency of the solar wind energy input is around 1%, which depends little on the location of the magnetopause in the model. It is also found that the energy of the cavity mode is confined in the region near the magnetopause, whereas, the energy of the toroidal mode may be distributed among a few specific L-shells. With a given size of the model magnetosphere and plasma density distri-bution, it is shown that the fundamental eigenfrequency of the cavity mode and the central locations of the FLRs do not vary noticeably with the power spectrum of the SI. It is worth noting that the spectrum of the SI affects the excitation of higher harmonics of the global cavity mode. The broader the bandwidth of the SI is, the higher harmonics of cavity mode could be excited. Meanwhile, the corresponding FLRs regions are broadened at the same time, which implies that the global cavity modes and toroidal modes can resonate on more magnetic L-shells when more harmonics of the global cavity modes appear. | YANG Biao FU SuiYan ZONG QiuGang WANG YongFu ZHOU XuZhi PU ZuYin XIE Lun | 2008 | Science China(Technological Sciences)2008，51，10： | 12 |
| 4 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 5 | Fast acceleration of “killer” electrons and energetic ions by interplanetary shock stimulated ULF waves in the inner magnetosphere显示文摘Energetic electrons and ions in the Van Allen radiation belt are the number one space weather threat. Understanding how these energetic particles are accelerated within the Van Allen radiation belt is one of the major challenges in space physics. This paper reviews the recent progress on the fast acceleration of 'killer' electrons and energetic ions by ultralow frequency (ULF) waves stimulated by the interplanetary shock in the inner magnetosphere. Very low frequency (VLF) wave-particle interaction is considered to be one of the primary electron acceleration mechanisms because electron cyclotron resonances can easily occur in the VLF frequency range. Recently, using four Cluster spacecraft observations, we have found that, after interplanetary shocks impact the Earth’s magnetosphere, energetic electrons in the radiation belt are accelerated almost immediately and continue to accelerate for a few hours. The time scale (a few days) for traditional acceleration mechanisms, based on VLF wave-particle interactions to accelerate electrons to relativistic energies, is too long to explain our observations. Furthermore, we have found that interplanetary shocks or solar wind pressure pulses, with even small dynamic pressure changes, can play a non-negligible role in radiation belt dynamics. Interplanetary shocks interaction with the Earth’s magnetosphere manifests many fundamental space physics phenomena including energetic particle acceleration. The mechanism of fast acceleration of energetic electrons in the radiation belt responding to interplanetary shock impacts consists of three contributing parts: (1) the initial adiabatic acceleration due to strong shock-related magnetic field compression; (2) followed by the drift-resonant acceleration with poloidal ULF waves excited at different L-shells; and (3) particle acceleration due to the quickly damping electric fields associated with ULF waves. Particles end up with a net acceleration because they gain more energy in the first half of this cycle than they lose in the second. The results reported in this paper cast a new light on understanding the acceleration of energetic particles in the Earth’s Van Allen radiation belt. The results of this study can likewise be applied to interplanetary shock interaction with other planets such as Mercury, Jupiter, Saturn, Uranus and Neptune, and other astrophysical objects with magnetic fields. | ZONG QiuGang WANG YongFu YUAN ChongJing YANG Biao WANG ChenRui ZHANG XiangYun | 2011 | Chinese Science Bulletin2011，56，12： | 11 |
| 6 | Multi-spacecraft observations of ULF waves during the recovery phase of magnetic storm on October 30, 2003显示文摘Based on observations obtained by Cluster C1, GOES 10, 12, and Polar, the global ULF wave properties are studied during the recovery phase of a very intense magnetic storm-Halloween storm (October 31, 2003, 21:00-23:00 UT). The results indicate that the ULF waves’ properties observed by different satellites, such as amplitude, period, etc. show large variations. This can be interpreted as that Field Line Resonance (FLR) might take place in the region where Cluster C1 passed. The compressional wave of the cavity mode coupled with FLR’s shear Alfven wave and fed energy to the latter, forming a large-amplitude toroidal mode. From the point of period, Cluster C1 observed the shortest period, GOES 10, 12 observed the middle, while Polar observed the longest. The wave period of toroidal mode observed by Cluster C1 kept almost unchanging when Cluster C1 passed L range from 11.7 to 5.3. Using the Squared Wavelet Coherence analysis method, we estimated that the FLR region in the dayside magnetosphere could expand to at least 4 local time widths. The toroidal mode observed by Polar was a standing wave, while the pol-oidal mode was a propagating wave, the observation results could be well ex-plained by the waveguide mode theory. Since the solarwind speed Vx was -800 km/s and the dynamic pressure varied little, we speculated that the source of the ULF wave was the Kelvin-Helmholtz instability at the magnetopause triggered by high speed solarwind. | YongFu Wang SuiYan Fu QiuGang Zong Biao Yang ZuYin Pu Lun Xie XuZhi Zhou | 2008 | Science China(Technological Sciences)2008，51，10： | 11 |
| 7 | Computed morphometric analysis and expression of alpha fetoprotein in hepatocellular carcinoma and its related lesion显示文摘INTRODUCTION Hepatocellular carcinoma(HCC)is closely relatedwith hepatitis and cirrhosis.In order to investigatethe pathogenesis and early pathologic diagnosis ofHCC,HCC and related lesions were analyzedqualitively and quantitively by automatic imageanalysor and immunohistochemical assay. | Li Juan Shen Zong Ji Zhang Yang Ming Ou Hua Xian Zhang Run Huang Yun He Min Jie Wang Guo Shu Xu | 2000 | World Journal of Gastroenterology2000，6，3： | 11 |
| 8 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders:executive summary and 2019 update of the management of high-risk population显示文摘Aim Cerebrovascular disease is the leading cause of death and disability in China,causing a huge burden among patients and their families.Hence,stroke prevention is critical,especially in the high-risk population.Here,we present the evidence-based guideline suitable for the Chinese population.Methods Literature search of PubMed and Cochrane library(from January 1964 to June 2019)was done.After thorough discussion among the writing group members,recommendations were listed and summarised.This guideline was reviewed and discussed by the fellow writing committees of the Chinese Stroke Association’s Stroke.Results This evidence-based guideline was written in three parts:controlling the risk factors of stroke,utilisation of antiplatelet agents and assessing the risks of first-ever stroke.All recommendations were listed along with the recommending classes and levels of evidence.Conclusions This guideline provides recommendations for primary prevention of cerebrovascular disease among high-risk population in China.Controlling related risk factors,appropriately using antiplatelet agents,assessing the risk of developing first-ever stroke should help reduce the rate of cerebrovascular disease in China. | Yilong Wang Shangrong Han Haiqiang Qin Huaguang Zheng Bin Jiang Yong Cao Yuan Gao Ling Guan Qian Jia Yong Jiang Yuming Jiao Shuya Li Yapeng Li Zixiao Li Wei Liu Xiaojuan Ru Dongling Sun Haixin Sun Penglian Wang Tingting Wang Lixia Zong Lei Guo Xuewei Xie Yuming Xu Yuyuan Xu Xiaomeng Yang Yingying Yang Mengyuan Zhou Wenzhi Wang Chinese Stroke Association Stroke Council Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 11 |
| 9 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 10 | Expert consensus on the evaluation and diagnosis of combat injuries of the Chinese People's Liberation Army显示文摘The accurate assessment and diagnosis of combat injuries are the basis for triage and treatment of combat casualties. A consensus on the assessment and diagnosis of combat injuries was made and discussed at the second annual meeting of the Professional Committee on Disaster Medicine of the Chinese People's Liberation Army(PLA). In this consensus agreement, the massive hemorrhage, airway, respiration, circulation and hypothermia(MARCH) algorithm, which is a simple triage and rapid treatment and field triage score, was recommended to assess combat casualties during the first-aid stage, whereas the abbreviated scoring method for combat casualty and the MARCH algorithm were recommended to assess combat casualties in level Ⅱ facilities. In level Ⅲ facilities, combined measures, including a history inquiry, thorough physical examination, laboratory examination, X-ray, and ultrasound examination, were recommended for the diagnosis of combat casualties. In addition, corresponding methods were recommended for the recognition of casualties needing massive transfusions, assessment of firearm wounds, evaluation of mangled extremities, and assessment of injury severity in this consensus. | Zhao-wen Zong Lian-yang Zhang Hao Qin Si-xu Chen Lin Zhang Lei Yang Xiao-xue Li Quan-wei Bao Dao-cheng Liu Si-hao He Yue Shen Rong Zhang Yu-feng Zhao Xiao-zheng Zhong representing the PLA Professional Committee and Youth Committee on Disaster Medicine | 2018 | Military Medical Research2018，5，3： | 10 |
| 11 | Mechanical properties and failure characteristics of fractured sandstone with grouting and anchorage显示文摘Based on uniaxial compression experimental results on fractured sandstone with grouting and anchorage, we studied the strength and deformation properties, the failure model, crack formation and evolution laws of fractured sandstone under different conditions of anchorage. The experimental results show that the strength and elastic modulus of fractured sandstone with different fracture angles are significantly lower than those of intact sandstone. Compared with the fractured samples without anchorage,the peak strength, residual strength, peak and ultimate axial strain of fractured sandstone under different anchorage increase by 64.5–320.0%, 62.8–493.0%, and 31.6–181.4%, respectively. The number of bolts and degree of pre-stress has certain effects on the peak strength and failure model of fractured sandstone. The peak strength of fractured sandstone under different anchorage increases to some extent, and the failure model of fractured sandstone also transforms from tensile failure to tensile–shear mixed failure with the number of bolts. The pre-stress can restrain the formation and evolution process of tensile cracks, delay the failure process of fractured sandstone under anchorage and impel the transformation of failure model from brittle failure to plastic failure. | Zong Yijiang Han Lijun Qu Tao Yang Shengqi | 2014 | International Journal of Mining Science and Technology2014，24，2： | 9 |
| 12 | Green Production Technology of the Monomer of Nylon-6: Caprolactam显示文摘 | Baoning Zong Bin Sun Shibiao Cheng Xuhong Mu Keyong Yang Junqi Zhao Xiaoxin Zhang Wei Wu | 2017 | Engineering2017，3，3： | 9 |
| 13 | Characterization of Prealloyed Ti–6Al–4V Powders from EIGA and PREP Process and Mechanical Properties of HIPed Powder Compacts显示文摘Prealloyed Ti–6Al–4V powders were prepared by electrode induction melting gas atomization(EIGA) and plasma rotating electrode process(PREP) in this work. A comparative study of EIGA and PREP powders for hot isostatic pressing(HIPing) compaction was conducted. Characterization of important technological parameters such as particle size distribution, powder surface morphology and flowability was carried out. Microstructure and mechanical properties of Ti–6Al–4V powder compacts HIPed from EIGA and PREP powders were also investigated. The results showed that the EIGA powder has a finer average particle size and higher tap density, while the PREP powder has better flowability and less pores. Micropores can be observed in heat-treated EIGA powder compacts by X-ray tomography and the porosity was found to be about 0.02%. There are no micropores(C4 μm) to be detected in heat-treated PREP powder compacts.Transgranular fracture mode as well as micropores contributes to the scatter in fatigue property of heat-treated PREP powder compacts. The respective advantages and disadvantages of both EIGA and PREP powders for producing Ti-based complex parts through HIPing were also discussed. | Rui-Peng Guo Lei Xu Bernie Ya-Ping Zong Rui Yang | 2017 | Acta Metallurgica Sinica(English Letters)2017，30，8： | 9 |
| 14 | Tetramethylpyrazine Improves Postoperative Tissue Adhesion: A Drug Repurposing显示文摘Plants are known to possess plenty of pharmacological activities as a result of various phytoconstituents. Tetramethylpyrazine(TMP), one of the most widely used medicinal compound isolated from traditional Chinese herb, is usually employed for anti-oxidation, anti-inflammation, anti-platelet aggregation, antilipid, anti-fibrosis, as well as activating blood, removing stasis, dilating small arteries, improving microcirculation and antagonizing calcium. In the present paper, the anti-adhesion effect of TMP were reviewed. TMP was found to play a multi-target and muti-link role in anti-adhesion by inhibiting hyperplasia of collagen and overexpression of adhesion-related factors and reducing the concentration of white blood cells and fibrin in plasma. Because previous studies mostly focused on in vitro experiments and animal experiments, there is an urgent need for clinical research with abundant indicators to further prove its anti-adhesion potency. Future basic research should concentrate on the development of TMP as a biological material. | YAN Shuai YUE Yin-zi ZONG Yang ZENG Li | 2019 | Chinese Journal of Integrative Medicine2019，25，7： | 9 |
| 15 | Development of genome-wide insertion/deletion markers in rice based on graphic pipeline platform显示文摘DNA markers play important roles in plant breeding and genetics.The Insertion/Deletion(InDel) marker is one kind of co-dominant DNA markers widely used due to its low cost and high precision.However,the canonical way of searching for InDel markers is time-consuming and laborintensive.We developed an end-to-end computational solution(InDel Markers Development Platform,IMDP) to identify genome-wide InDel markers under a graphic pipeline environment.IMDP constitutes assembled genome sequences alignment pipeline(AGA-pipe) and next-generation resequencing data mapping pipeline(NGS-pipe).With AGA-pipe we are able to identify 12,944 markers between the genome of rice cultivars Nipponbare and 93-11.Using NGS-pipe,we reported 34,794 InDels from re-sequencing data of rice cultivars Wu-Yun-Geng7 and Guang-Lu-Ai4.Combining AGApipe and NGS-pipe,we developed 205,659 InDels in eight japonica and nine indica cultivars and 2,681 InDels showed a subgroup-specific pattern.Polymerase chain reaction(PCR)analysis of subgroup-specific markers indicated that the precision reached 90%(86 of 95).Finally,to make them available to the public,we have integrated the InDels/markers information into a website(Rice InDel Marker Database,RIMD,http://202.120.45.71/).The application of IMDP in rice will facilitate efficiency for development of genome-wide InDel markers,in addition it can be used in other species with reference genome sequences and NGS data. | Yang L Xiao Cui Rui Li Piaopiao Huang Jie Zong Danqing Yao Gang Li Dabing Zhang Zheng Yuan | 2015 | Journal of Integrative Plant Biology2015，57，11： | 9 |
| 16 | Strong ozone production at a rural site in the North China Plain: Mixed effects of urban plumes and biogenic emissions显示文摘Regional ozone(O_3) pollution has drawn increasing attention in China over the recent decade, but the contributions from urban pollution and biogenic emissions have not been clearly elucidated. To better understand the formation of the regional O_3 problem in the North China Plain(NCP), intensive field measurements of O_3 and related parameters were conducted at a rural site downwind of Ji'nan, the capital city of Shandong province, in the summer of 2013. Markedly severe O_3 pollution was recorded, with the O_3 mixing ratios exceeding the Chinese national ambient air quality standard on 28 days(a frequency of 78%) and with a maximum hourly value of 198 ppbv. Extensive regional transport of wellprocessed urban plumes to the site was identified. An observation-constrained chemical box model was deployed to evaluate in situ photochemical O_3 production on two episodes.The results show that the in situ formation accounted for approximately 46% of the observed O_3 accumulation, while the remainder(~54%) was contributed by regional transport of the O_3-laden urban plumes. The in situ ozone production was in a mixed controlled regime that reducing either NOx or VOCs would lead to a reduction of ozone formation. Biogenic VOCs played an important role in the local ozone formation. This study demonstrates the significant mixed effects of both anthropogenic pollution from urban zones and biogenic emission in rural areas on the regional O_3 pollution in the NCP region,and may have general applicability in facilitating the understanding of the formation of secondary pollution over China. | Ruihan Zong Xue Yang Liang Wen Caihong Xu Yanhong Zhu Tianshu Chen Lan Yao Liwei Wang Junmei Zhang Lingxiao Yang Xinfeng Wang Min Shao Tong Zhu Likun Xue Wenxing Wang | 2018 | Journal of Environmental Sciences2018，30，9： | 8 |
| 17 | Cadmium Activates Reactive Oxygen Species-dependent AKT/mT OR and Mitochondrial Apoptotic Pathways in Neuronal Cells显示文摘Objective To examine the role of Cd-induced reactive oxygen species(ROS)generation in the apoptosis of neuronal cells.Methods Neuronal cells(primary rat cerebral cortical neurons and PC12 cells)were incubated with or without Cd post-pretreatment with rapamycin(Rap)or N-acetyl-L-cysteine(NAC).Cell viability was determined by MTT assay,apoptosis was examined using flow cytometry and fluorescence microscopy,and the activation of phosphoinositide 3'-kinase/protein kinase B(Akt)/mammalian target of rapamycin(m TOR)and mitochondrial apoptotic pathways were measured by western blotting or immunofluorescence assays.Results Cd-induced activation of Akt/m TOR signaling,including Akt,m TOR,p70 S6 kinase(p70 S6K),and eukaryotic initiation factor 4E binding protein 1(4E-BP1).Rap,an m TOR inhibitor and NAC,a ROS scavenger,blocked Cd-induced activation of Akt/m TOR signaling and apoptosis of neuronal cells.Furthermore,NAC blocked the decrease of B-cell lymphoma 2/Bcl-2 associated X protein(Bcl-2/Bax)ratio,release of cytochrome c,cleavage of caspase-3 and poly(ADP-ribose)polymerase(PARP),and nuclear translocation of apoptosis-inducing factor(AIF)and endonuclease G(Endo G).Conclusion Cd-induced ROS generation activates Akt/m TOR and mitochondrial pathways,leading to apoptosis of neuronal cells.Our findings suggest that m TOR inhibitors or antioxidants have potential for preventing Cd-induced neurodegenerative diseases. | YUAN Yan WANG Yi HU Fei Fei JIANG Chen Yang ZHANG Ya Jing YANG Jin Long ZHAO Shi Wen GU Jian Hong LIU Xue Zhong BIAN Jian Chun LIU Zong Ping | 2016 | Biomedical and Environmental Sciences2016，29，2： | 8 |
| 18 | A prospective study of vertical transmission of hepatitis C virus显示文摘AprospectivestudyofverticaltransmissionofhepatitisCvirusSUNDeGui1,LIUCaiYun1,MENGZongDa2,SUNYongDe2,WANGShuCong1,YANGYu... | SUN De Gui 1, LIU Cai Yun 1, MENG Zong Da 2, SUN Yong De 2, WANG Shu Cong 1, YANG Yu Qi 1, LIANG Zheng Lun 3 and ZHUANG Hui 3 | 1997 | World Journal of Gastroenterology1997，3，2： | 8 |
| 19 | Oscillation analysis of a DFIG-based wind farm interfaced with LCC-HVDC显示文摘With the increasing capacity of wind farm, HVDC technology has become a promising transmission scheme for long distance transportation of large-scale wind power. However oscillation caused by this system will have a great influence on the security and stability of power system operation. In this paper, the oscillation of a doubly-fed induction generator(DFIG)-based wind farm interfaced with line commutated converter(LCC) based HVDC is discussed. Low-frequency oscillation and subsynchronous oscillation(SSO) are studied since these two oscillations are the particularly concerned oscillations in the stability study of power system in recent years. The model of a DFIG-based wind farm interconnected with LCC-HVDC is developed. The impact of drive train model's structure and parameters on the oscillation characteristics is analyzed. Eigenvalue and participation factor analysis are used to identify the three main modes, which include controller mode, electromechanical mode, and shaft mode. The effects of DFIG controller's parameters, wind speed and operating conditions of HVDC on those modes are studied. Electromagnetic transient simulations are performed to verify the results of the eigenvalue analysis. | YANG Lin XIAO Xiang Ning PANG Cheng Zong | 2014 | Science China(Technological Sciences)2014，57，12： | 7 |
| 20 | Food legume production in China显示文摘Food legumes comprise all legumes grown for human food in China as either dry grains or vegetables,except for soybean and groundnut.China has a vast territory with complex ecological conditions.Rotation,intercropping,and mixed cropping involving pulses are normal cropping systems in China.Whether indigenous or introduced crops,pulses have played an important role in Chinese cropping systems and made an important contribution to food resources for humans since ancient times.The six major food legume species(pea,faba bean,common bean,mung bean,adzuki bean,and cowpea) are the most well-known pulses in China,as well as those with more local distributions;runner bean,lima bean,chickpea,lentil,grass pea,lupine,rice bean,black gram,hyacinth bean,pigeon pea,velvet bean,winged bean,guar bean,sword bean,and jack bean.China has remained the world's leading producer of peas,faba beans,mung beans,and adzuki beans in recent decades,as documented by FAO statistics and China Agriculture Statistical Reports.The demand for food legumes as a healthy food will markedly increase with the improvement of living standards in China.Since China officially joined the World Trade Organization(WTO) in2001,imports of pea from Canada and Australia have rapidly increased,resulting in reduced prices for dry pea and other food legumes.With reduced profits for food legume crops,their sowing area and total production has decreased within China.At the same time,the rising consumer demand for vegetable food legumes as a healthy food has led to attractive market prices and sharp production increases in China.Vegetable food legumes have reduced growing duration and enable flexibility in cropping systems.In the future,production of dry food legumes will range from stable to slowly decreasing,while production of vegetable food legumes will continue to increase. | Ling Li Tao Yang Rong Liu Bob Redden Fouad Maalouf Xuxiao Zong | 2017 | The Crop Journal2017，5，2： | 7 |
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