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| 1 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 2 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 3 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 4 | Effect of three interventional bronchoscopic methods on tracheal stenosis and the formation of granulation tissues in dogs显示文摘为繁的使成粒状纸巾的形成引起的气管的狭窄的背景治疗学的途径通常包括 electrocautery,机械膨胀,激光治疗,氩血浆凝结(APC ) ,冷冻疗法和 stent 放置。然而,在 stent 插入以后的狭窄仍然是重要限制。我们检验了三条不同途径的功效,包括机械损害的正式就职, APC 与不同力量或持续时间和冷冻疗法表现了,识别限制了使成粒状织物的形成的方法。12 特殊饲养了研究杂种狗的方法被划分成三个组。在组 1 (四条狗) 温和(过程 1;二条狗) 或中等(过程 2;二条狗) 损坏机械地被导致。(六条狗) 组 2 在不同力量或持续时间收到了 APC (过程 3:30 W, 1 amis;过程 4:30 W, 2 cm/s;过程 5:25 W, 3 cm/s ) 。(二条狗) 组 3 收到了冷冻疗法(过程 6:30 秒的二个结冰融化周期) 。揭开的自我可扩充的金属性的 stents 在所有狗被插入维持连续刺激到气管 mucosa。狗被监视因为在使用的使成粒状织物增长和方法之间的 4 个星期和关系被分析。在组 1 的结果,使成粒状织物生长与更多的严重机械损坏增加了。在组 2 的使成粒状织物的生长比在组 1 更显著,并且因为严重狭窄,在过程 3 的两条狗死了。在这个组,使成粒状织物的形成与减少的力量和持续时间减少了。在组 3,没有明显的使成粒状织物在星期 4 点被发现。从外国身体(stent ) 的结论损害和刺激是导致使成粒状组织的增生的二个重要因素。热损害例如 APC,似乎导致更大的使成粒状织物生长和软骨损坏与相比机械并且冷冻疗法损害。在有机械膨胀的联合的冷冻疗法可以是为管理使成粒状织物的形成引起的气管的狭窄的一个安全、有效的处理方法。 | ZHANG Jie WANG Ting WANG Juan PEI Ying-hua XU Min WANG Yu-ling ZHANG Xia WANG Chen | 2010 | Chinese Medical Journal2010，，5： | 23 |
| 5 | Exogenous bone morphogenetic protein-7 reduces hepatic fibrosis inSchistosoma japonicum-infected micevia transforming growth factor-β/Smad signaling显示文摘AIM: To investigate the antifibrotic effects of bone morphogenetic protein-7 (BMP-7) on Schistosoma japonicum (S. japonicum )-induced hepatic fibrosis in BALB/C mice. METHODS: Sixty BALB/C mice were randomly divided into three groups, including a control group (group A, n = 20), model group (group B, n = 20) and BMP-7 treated group (group C, n = 20). The mice in group B and group C were abdominally infected with S. japonicum cercariae to induce a schistosomal hepatic fibrosis model. The mice in group C were administered human recombinant BMP-7. Liver samples were extracted from mice sacrificed at 9 and 15 wk after modeling. Hepatic histopathological changes were assessed using Masson's staining. Transforming growth factor-beta 1 (TGF-β1), alpha-smooth muscle actin (α-SMA), phosphorylated Smad2/3 (pSmad2/3) and Smad7 protein levels and localization were measured by Western blotting and immunohistochemistry, respectively, and their mRNA expressions were detected by reverse transcriptionpolymerase chain reaction (RT-PCR). RESULTS: The schistosomal hepatic fibrosis mouse model was successfully established, as the livers of mice in group B and group C showed varying degrees of typical schistosomal hepatopathologic changes such as egg granuloma and collagen deposition. The degree of collagen deposition in group C was higher than that in group A (week 9: 22.95±6.66vs 2.02±0.76; week 15: 12.84±4.36 vs 1.74±0.80; P<0.05), but significantly lower than that in group B (week 9: 22.95±6.66 vs 34.43±6.96; week 15: 12.84±4.36 vs 18.90±5.07;P<0.05) at both time points. According to immunohistochemistry data, the expressions of α-SMA, TGF-β1 and pSmad2/3 protein in group C were higher than those in group A (α-SMA: week 9: 21.24±5.73 vs 0.33±0.20; week 15: 12.42±4.88 vs 0.34±0.27; TGF-β1: week 9: 37.00±13.74 vs 3.73±2.14; week 15: 16.71±9.80 vs 3.08±2.35; pSmad2/3: week 9: 12.92±4.81 vs 0.83±0.48; week 15: 7.87±4.09 vs 0.90±0.45; P<0.05), but significantly lower than those in group B (α-SMA: week 9: 21.24±5.73 vs 34.39±5.74; week 15: 12.42±4.88 vs 25.90±7.01; TGF-β1: week 9: 37.00±13.74 vs 55.66±14.88; week 15: 16.71±9.80 vs 37.10±12.51; pSmad2/3: week 9: 12.92±4.81 vs 19.41±6.87; week 15: 7.87±4.09vs 13.00±4.98;P<0.05) at both time points; the expression of Smad7 protein in group B was higher than that in group A and group C at week 9 (8.46±3.95 vs 1.00±0.40 and 8.46±3.95 vs 0.77±0.42; P<0.05), while there were no differences in Smad7 expression between the three groups at week 15 (1.09±0.38 vs 0.97±0.42 vs 0.89±0.39; P>0.05). Although minor discrepancies were observed, the results of RT-PCR and Western blotting were mainly consistentwith the immunohistochemical results. CONCLUSION: Exogenous BMP-7 significantly decreased the degree of hepatic fibrosis in both the acute and chronic stages of hepato-schistosomiasis, and the regulatory mechanism may involve the TGF-β/Smad signaling pathway. | Bo-Lin Chen Jie Peng Qing-Fu Li Min Yang Yuan Wang Wei Chen | 2013 | World Journal of Gastroenterology2013，19，9： | 21 |
| 6 | Resistin induces insulin resistance, but does not affect glucose output in rat-derived hepatocytes显示文摘目的: 现在的学习的目的是观察效果抵抗在在在导出老鼠的 hepatocytes.Methods 的胰岛素敏感度和葡萄糖输出上: 老鼠肝细胞瘤房间线 H4IIE 与有教养、刺激抵抗在; supernant 葡萄糖和肝糖内容被检测。胰岛素受体底层(红外)-1 和 IRS-2,蛋白质激酶 B/Akt,肝糖 synthase kinase-3 (3 (GSK-3p ) , suppress 或表明 3 的 cytokine (SOCS-3 ) ,蛋白质内容,以及磷酸化地位被西方的弄污估计。对 SOCS-3 指导的特定的反感觉 oligodeoxynucleotides 习惯于击倒的 SOCS-3.Results :抵抗素导致了抗胰岛素性,但是在老鼠肝细胞瘤房间的affect 葡萄糖输出没衬里 H4IIE.Resistin 胰岛素的稀释多重效果包括刺激胰岛素的肝糖合成和红外的磷酸化,蛋白质激酶 B/Akt ,象 GSK-3beta.Resistin 一样,处理显著地导致了基因和 SOCS-3 的蛋白质表示,胰岛素发信号的一个已知的禁止者。而且,对 SOCS-3 处理指导的特定的反感觉 oligodeoxynucleotide 阻止了抵抗在从反对胰岛素 action.Conclusion : 主要功能抵抗在在肝上是导致胰岛素 resistance.SOCS-3 感应的可以贡献胰岛素在 H4HE hepatocytes 发信号的调停 resistin 的抑制。 | Feng LIU Tao YANG Bin WANG Min ZHANG Nan GU Jie QIU Hong-qi FAN Chun-mei ZHANG Li FEI Xiao- qing PAN Mei GUO Rong-hua CHEN Xi-rong GUO | 2008 | Acta Pharmacologica Sinica2008，29，1： | 21 |
| 7 | Free triiodothyronine level indicates the degree of myocardial injury in patients with acute ST-elevation myocardial infarction显示文摘 | Wang Wen-yao Tang Yi-da Yang Min Cui Cheng Mu Mu Qian Jie Yang Yue-jin | 2013 | Chinese Medical Journal2013，，20： | 21 |
| 8 | Nickel-exposed Workers in China: A Cohort Study显示文摘There are more than 50 000 workers in Jinchuan Group Co,Ltd(JNMC).Since all staff in JNMC are eligible for a medical examination every two years,only 23 484 nickel-exposed subjects who participated in medical examination were included in this study.Their data,collected from June 22,2011 to September 28,2012,in a | BAI Ya Na YAGN Ai Min PU Hong Quan HE Jie CHENG Ning ZHENG Tong Zhang DAI Min ZHANG Ya Wei BASSING Bryan WANG Qiu Ying | 2014 | Biomedical and Environmental Sciences2014，27，3： | 20 |
| 9 | Mitochondrial transcription termination factor 2 binds to entire mitochondrial DNA and negatively regulates mitochondrial gene expression显示文摘(mTERF2 ) Mitochondrial 抄写结束因素 2 是绑在 mitochondrial DNA 的 mitochondrial 矩阵蛋白质。以前的研究证明了 mTERF2 的 overexpression 能禁止房间增长,但是机制到目前为止一直不是明确的。这研究试图在 vivo 介绍 mTERF2 的有约束力的模式给 mitochondrial DNA (mtDNA ) ,并且在 mtDNA, mRNA 抄写,和蛋白质翻译的复制上调查了 mTERF2 的生物功能。到全部 mtDNA 的 mTERF2 绑定经由染色质 immunoprecipitation 分析被识别。当 mTERF2 是在 HeLa 房间的 overexpressed 时,线粒体基因的 mtDNA 复制效率和表示层次显著地被禁止。mtDNA 内容的抑制水平是有 mRNA 和 mitochondrial 蛋白质表示的减少的层次的一样。总的来说, mTERF2 可能基于它 mtDNA 复制上的否定效果是一个细胞生长禁止者,它最后下面调整在是必要的为的线粒体的氧化 phosphorylation 部件,细胞是的所有精力新陈代谢。 | Weiwei Huang Min Yu Yang Jiao Jie Ma Mingxing Ma Zehua Wang Hong Wu Deyong Tan | 2011 | Acta Biochimica et Biophysica Sinica2011，43，6： | 17 |
| 10 | Overexpression of insulin-like growth factor-Ⅰ receptor as a pertinent biomarker for hepatocytes malignant transformation显示文摘AIM:To investigate the dynamic features of insulinlike growth factor-Ⅰreceptor(IGF-ⅠR)expression in rat hepatocarcinogenesis,and the relationship between IGF-ⅠR and hepatocytes malignant transformation at mRNA or protein level.METHODS:Hepatoma models were made by inducing with 2-fluorenylacetamide(2-FAA)on male SpragueDawley rats.Morphological changes of hepatocytes were observed by pathological Hematoxylin and eosin staining,the dynamic expressions of liver and serum IGF-ⅠR were quantitatively analyzed by an enzymelinked immunosorbent assay.The distribution of hepatic IGF-ⅠR was located by immunohistochemistry.The fragments of IGF-ⅠR gene were amplified by reverse transcription-polymerase chain reaction,and confirmed by sequencing.RESULTS:Rat hepatocytes after induced by 2-FAA were changed dynamically from granule-like degeneration,precancerous to hepatoma formation with the progressing increasing of hepatic mRNA or IGF-ⅠR expression.The incidences of liver IGF-ⅠR,IGF-ⅠR mRNA,specific IGF-ⅠR concentration(ng/mg wet liver),and serum IGF-ⅠR level(ng/mL)were 0.0%,0.0%,0.63±0.17,and 1.33±0.47 in the control;50.0%,61.1%,0.65±0.2,and 1.51±0.46 in the degeneration;88.9%,100%,0.66±0.14,and 1.92±0.29 in the precancerosis;and 100%,100%,0.96±0.09,and2.43±0.57 in the cancerous group,respectively.IGF-ⅠR expression in the cancerous group was significantly higher(P<0.01)than that in any of other groups at mRNA or protein level.The closely positive IGF-ⅠR relationship was found between livers and sera(r=0.91,t=14.222,P<0.01),respectively.CONCLUSION:IGF-ⅠR expression may participate in rat hepatocarcinogenesis and its abnormality should be an early marker for hepatocytes malignant transformation. | Xiao-Di Yan Min Yao Li Wang Hai-Jian Zhang Mei-Juan Yan Xing Gu Yun Shi Jie Chen Zhi-Zhen Dong Deng-Fu Yao | 2013 | World Journal of Gastroenterology2013，19，36： | 16 |
| 11 | Duration of untreated psychosis and clinical outcomes of first- episode schizophrenia: a 4-year follow-up study显示文摘 | Honsyun QIN Jie ZHANG Zhenping WANG Haiyin8 MIN Caiying YAN Fuzhen CHEN Weizhong FU Ming ZHANG | 2014 | 上海精神医学2014，26，1： | 15 |
| 12 | CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization显示文摘Despite the diverse etiologies of drug-induced liver injury(DILI),innate immunity activation is a common feature involved in DILI progression.However,the involvement of innate immunity regulation in inflammation resolution and liver regeneration in DILI remains obscure.Herein,we identified the chemokine CCL5 as a central mediator of innate immunity regulation in the pathogenesis of DILI.First,we showed that serum and hepatic CCL5 levels are elevated in both DILI patients and an APAP-induced liver injury(AILI)mouse model.Interestingly,both nonparenchymal cells and stressed hepatocytes are cell sources of CCL5 induction in response to liver injury.Functional experiments showed that CCL5 deficiency has no effect on the early phase of AILI but promotes liver repair in the late phase mainly by promoting inflammation resolution and liver regeneration,which are associated with an increased number of hepatic M2 macrophages.Mechanistically,CCL5 can directly activate M1 polarization and impede M2 polarization through the CCR1-and CCR5-mediated activation of the MAPK and NF-κB pathways.We then showed that CCL5 inhibition mediated by either a CCL5-neutralizing antibody or the antagonist Met-CCL5 can greatly alleviate liver injury and improve survival in an AILI mouse model.Our data demonstrate CCL5 induction during DILI,identify CCL5 as a novel innate immunity regulator in macrophage polarization,and suggest that CCL5 blockage is a promising therapeutic strategy for the treatment of DILI. | Meng Li Xuehua Sun Jie Zhao Lei Xia Jichang Li Min Xu Bingrui Wang Han Guo Chang Yu Yueqiu Gao Hailong Wu Xiaoni Kong Qiang Xia | 2020 | Cellular & Molecular Immunology2020，17，7： | 13 |
| 13 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 14 | Serum Uric Acid is Associated with the Predicted Risk of Prevalent Cardiovascular Disease in a Community-dwelling Population without Diabetes显示文摘Objective To examine the association between serum uric acid levels and cardiovascular disease risk among individuals without diabetes. Methods We investigated the association between serum uric acid levels and the risk of prevalent cardiometabolic diseases, 10-year Framingham risk for coronary heart disease, and 10-year risk for atherosclerotic cardiovascular diseases(ASCVD) among 8,252 participants aged ≥ 40 years without diabetes from Jiading district, Shanghai, China. Results Body mass index, waist circumference, blood glucose, glycated hemoglobin, blood pressure, and serum lipids increased progressively across the sex-specific quartiles of uric acid(all P trend < 0.05). Compared with individuals in the lowest quartile, those in the higher quartiles had a significantly higher prevalence of obesity, hypertension, and dyslipidemia(all P trend < 0.05). A fully adjusted logistic regression analysis revealed that individuals in the highest quartile had an increased risk of predicted cardiovascular disease compared with those in the lowest quartile of uric acid. The multivariate adjusted odds ratios(ORs) [95% confidence intervals(CIs)] for the highest quartiles for high Framingham risk were 3.00(2.00-4.50) in men and 2.95(1.08-8.43) in women. The multivariate adjusted ORs(95% CIs) for the highest quartile for high ASCVD risk were 1.93(1.17-3.17) in men and 4.53(2.57-7.98) in women. Conclusion Serum uric acid level is associated with an increased risk of prevalent obesity, hypertension, dyslipidemia, 10-year Framingham risk for coronary heart disease, and 10-year risk for ASCVD among Chinese adults without diabetes. | CHENG Di DU Rui WU Xue Yan LIN Lin PENG Kui MA Li Na XU Yu XU Min CHEN Yu Hong BI Yu Fang WANG Wei Qing DAI Meng LU Jie Li | 2018 | Biomedical and Environmental Sciences2018，31，2： | 13 |
| 15 | Irregular surface of carotid atherosclerotic plaque is associated with ischemic stroke: a magnetic resonance imaging study显示文摘Objective To determine the association between the irregularity of carotid plaque surface using multidimensional magnetic resonance imaging(MRI) of ipsilateral acute cerebral infarction(ACI) cases. Methods Patients with recent cerebrovascular symptoms(stroke or transient ischemic attack < 2 weeks) and atherosclerotic plaque in at least one carotid artery were diagnosed by B-mode ultrasound imaging(intima-media thickness ≥ 1.5 mm) and recruited for the present study. Irregular surface was defined when plaque surface was uneven with high and low fluctuation or plaque with surface ulceration. The irregularity of carotid plaque surface was determined on axial or oblique images alone(single-dimension) and on both axial images and oblique images(multidimensions), separately. Univariate and multivariate logistic regression analyses were performed to calculate the odds ratio(OR) and the corresponding 95% CI of the irregular plaque surface in discriminating the presence of ipsilateral ACI. Results A total of 217 included subjects(mean age: 60.7 ± 10.2 years, 149 men) were recruited and 89(41.0%), 88(40.6%) and 118(54.4%) of them exhibited irregular plaque surface on axial, oblique and multidimensional MR images, respectively. The OR of irregularity of the plaque surface was determined by multidimensional MRI to be 5.88(95% CI: 3.16–10.96, P < 0.001) in discriminating the presence of ipsilateral ACI. Following adjustment for clinical confounding factors, this association remained statistically significant(OR = 5.65, 95% CI: 2.53–12.60, P < 0.001). The analysis included further adjustment for the presence of lipid-rich necrotic core, intraplaque hemorrhage and stenosis and the results included that this association also remained statistically significant(OR = 6.08, 95% CI: 2.52–14.68, P < 0.001). Conclusions The irregular plaque surface was determined by multidimensional MRI as an independent indicator for ipsilateral acute cerebral infarction. | Dan ZHOU Jin LI Dong LIU Li-Ya JI Na-Qin WANG Jie DENG Ji-Chen WANG Min YE Xi-Hai ZHAO | 2019 | Journal of Geriatric Cardiology2019，16，12： | 13 |
| 16 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 17 | Prostate Cancer Detection with Multiparametric Magnetic Resonance Imaging: Prostate Imaging Reporting and Data System Version 1 versus Version 2显示文摘 | Zhao-Yan Feng Liang Wang Xiang-De Min Shao-Gang Wang Guo-Ping Wang Jie Cai | 2016 | Chinese Medical Journal2016，，20： | 12 |
| 18 | Saposhnikovia divaricata——An Ethnopharmacological,Phytochemical and Pharmacological Review显示文摘Saposhnikovia divaricata(Turcz.)Schischk.,a perennial herb belonging to the family Umbelliferae,is widely distributed in Northeast Asia.Its dried root(Radix Saposhnikoviae)is used as a Chinese herbal medicine for the treatment of immune system,nervous system,and respiratory diseases.Phytochemical and pharmacological studies have shown that the main constituents of S.divaricata are chromones,coumarins,acid esters,and polyacetylenes,and these compounds exhibited significant anti-inflammatory,analgesic,antioxidant,antiproliferative,antitumor,and immunoregulatory activities.The purpose of this review is to provide comprehensive information on the botanical characterization and distribution,traditional use and ethnopharmacology,phytochemistry,and pharmacology of S.divaricata for further study concerning its mechanism of action and development of better therapeutic agents and health products from S.divaricata. | YANG Min WANG Cong-cong WANG Wen-le XU Jian-ping WANG Jie ZHANG Chun-hong LI Min-hui | 2020 | Chinese Journal of Integrative Medicine2020，26，11： | 12 |
| 19 | Computed morphometric analysis and expression of alpha fetoprotein in hepatocellular carcinoma and its related lesion显示文摘INTRODUCTION Hepatocellular carcinoma(HCC)is closely relatedwith hepatitis and cirrhosis.In order to investigatethe pathogenesis and early pathologic diagnosis ofHCC,HCC and related lesions were analyzedqualitively and quantitively by automatic imageanalysor and immunohistochemical assay. | Li Juan Shen Zong Ji Zhang Yang Ming Ou Hua Xian Zhang Run Huang Yun He Min Jie Wang Guo Shu Xu | 2000 | World Journal of Gastroenterology2000，6，3： | 11 |
| 20 | Near-field surface movement during the Wenchuan M_s8.0 earthquake measured by high-rate GPS显示文摘Based on high-rate (1 Hz) GPS data from the Sichuan GPS Continuous Observation Network on the footwall of the Longmenshan Fault, we have characterized the near-field surface movement process during the 5.12 Wenchuan Earthquake. Results show that the maximum deformation near the fault is larger than the deformation set. Stations on the northern segment of the fault moved towards the epicenter first, and then turned toward the vertical orientation of the fault. Deformation of stations on the southern segment is smaller and recovered. The initial motion at all of the stations was downward followed by periodic up and down movements. Comparing the displacement from high-rate GPS and accelerograph data, we can see that they are consistent prior to the arrival of the principal shock, but afterwards a 10 cm difference is found, even though they are synchronized and in phase. More work is yet to be done to explain this. This is the first time that actual the real near-field surface movements of an earth- quake of M >7.0 have been determined in china. These measurements are therefore of high value for studies of surface rupture processes and the analysis of seismic wave travels paths in this region. | YIN HaiTao ZHANG PeiZhen GAN WeiJun WANG Min LIAO Hua LI XiaoJun LI Jie XIAO GenRu | 2010 | Chinese Science Bulletin2010，55，23： | 11 |
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