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| 1 | Simultaneous passivation of bulk and interface defects through synergistic effect of anion and cation toward efficient and stable planar perovskite solar cells显示文摘Bulk and interface carrier nonradiative recombination losses impede the further improvement of power conversion efficiency(PCE)and stability of perovskite solar cells(PSCs).It is highly necessary to develop multifunctional strategy to minimize surface and interface nonradiative recombination losses.Herein,we report a bulk and interface defect passivation strategy via the synergistic effect of anions and cations,where multifunctional potassium sulphate(K_(2)SO_(4))is incorporated at SnO_(2)/perovskite interface.We find that K^(+)ions in K_(2)SO_(4)diffuse into perovskite layer and suppress the formation of bulk defects in perovskite films,and the SO_(4)^(2-)ions remain located at interface via the strong chemical interaction with SnO_(2)layer and perovskite layer,respectively.Through this synergistic modification strategy,effective defect passivation and improved energy band alignment are achieved simultaneously.These beneficial effects are translated into an efficiency increase from 19.45%to 21.18%with a low voltage deficit of0.53 V mainly as a result of boosted open-circuit voltage(V_(oc))after K_(2)SO_(4)modification.In addition,the K_(2)SO_(4)modification contributes to ameliorated stability.The present work provides a route to minimize bulk and interface nonradiative recombination losses for the simultaneous realization of PCE and stability enhancement by rational anion and cation synergistic engineering. | Cong Zhang Huaxin Wang Haiyun Li Qixin Zhuang Cheng Gong Xiaofei Hu Wensi Cai Shuangyi Zhao Jiangzhao Chen Zhigang Zang | 2021 | Journal of Energy Chemistry2021，30，12： | 2 |
| 2 | Unexpected effect of concomitantly administered cureumin on the pharmacokinetics of talinolol in healthy Chinese volunteers 显示文摘 | He Juan Terhaag B Zang Cong | 2007 | Eur J Clin Phar- macol2007，63，7： | 1 |
| 3 | Phosphoproteomics Reveals the AMPK Substrate Network in Response to DNA Damage and Histone Acetylation显示文摘AMP-activated protein kinase(AMPK)is a conserved energy sensor that plays roles in diverse biological processes via phosphorylating various substrates.Emerging studies have demonstrated the regulatory roles of AMPK in DNA repair,but the underlying mechanisms remain to be fully understood.Herein,using mass spectrometry-based proteomic technologies,we systematically investigate the regulatory network of AMPK in DNA damage response(DDR).Our system-wide phosphoproteome study uncovers a variety of newly-identified potential substrates involved in diverse biological processes,whereas our system-wide histone modification analysis reveals a link between AMPK and histone acetylation.Together with these findings,we discover that AMPK promotes apoptosis by phosphorylating apoptosis-stimulating of p53 protein 2(ASPP2)in an irradiation(IR)-dependent manner and regulates histone acetylation by phosphorylating histone deacetylase 9(HDAC9)in an IR-independent manner.Besides,we reveal that disrupting the histone acetylation by the bromodomain BRD4 inhibitor JQ-1 enhances the sensitivity of AMPKdeficient cells to IR.Therefore,our study has provided a resource to investigate the interplay between phosphorylation and histone acetylation underlying the regulatory network of AMPK,which could be beneficial to understand the exact role of AMPK in DDR. | Yuejing Jiang Xiaoji Cong Shangwen Jiang Ying Dong Lei Zhao Yi Zang Minjia Tan Jia Li | 2022 | Genomics, Proteomics & Bioinformatics2022，20，4： | 1 |
| 4 | Attenuation of renal ischemia/reperfusion injury by a polysaccharide from the roots of Dipsacus asperoides显示文摘 | Cong G Cui L Zang M | | 0，，： | 1 |
| 5 | Attenuation of renal ischemia/reperfusion in- jury by a polysaccharide from the roots of Dipsacus asperoides显示文摘 | Cong G Cui L Zang M | 2013 | Int J Biol Macromol2013，5，56： | 1 |
| 6 | Performance evaluation for bandlimited DS-CDMA systems based on simplified improved gaussian approximation显示文摘 | ZANG Guo-zhen LING Cong | 2003 | IEEE Transactions on Communications2003，24，7： | 1 |
| 7 | Performance evaluation for band-limited DS-CDMA systems based on simplified im- proved gaussian approximation 显示文摘 | Zang Guozhen Ling Cong | 2003 | IEEE Transactions on Communications2003，51，7： | 1 |
| 8 | High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors显示文摘The global COVID-19 coronavirus pandemic has infected over 109 million people,leading to over 2 million deaths up to date and still lacking of effective drugs for patient treatment.Here,we screened about 1.8 million small molecules against the main protease(M^(pro))and papain like protease(PL^(pro)),two major proteases in severe acute respiratory syndrome-coronavirus 2 genome,and identified 1851M^(pro)inhibitors and 205 PL^(pro)inhibitors with low nmol/l activity of the best hits.Among these inhibitors,eight small molecules showed dual inhibition effects on both M^(pro)and PL^(pro),exhibiting potential as better candidates for COVID-19 treatment.The best inhibitors of each protease were tested in antiviral assay,with over 40%of M^(pro)inhibitors and over 20%of PL^(pro)inhibitors showing high potency in viral inhibition with low cytotoxicity.The X-ray crystal structure of SARS-CoV-2 M^(pro)in complex with its potent inhibitor 4a was determined at 1.8Åresolution.Together with docking assays,our results provide a comprehensive resource for future research on anti-SARS-CoV-2 drug development. | Yi Zang Mingbo Su Qingxing Wang Xi Cheng Wenru Zhang Yao Zhao Tong Chen Yingyan Jiang Qiang Shen Juan Du Qiuxiang Tan Peipei Wang Lixin Gao Zhenming Jin Mengmeng Zhang Cong Li Ya Zhu Bo Feng Bixi Tang Han Xie Ming-Wei Wang Mingyue Zheng Xiaoyan Pan Haitao Yang Yechun Xu Beili Wu Leike Zhang Zihe Rao Xiuna Yang Hualiang Jiang Gengfu Xiao Qiang Zhao Jia Li | 2023 | Protein & Cell2023，14，1： | 0 |
| 9 | Ion diffusion-induced double layer doping toward stable and efficient perovskite solar cells显示文摘The perovskite layer,electron transport layer(ETL)and their interface are closely associated with carrier transport and extraction,which possess a pronounced effect on current density.Consequently,the dissatisfactory electric properties of functional layers pose a serious challenge for maximizing the thermodynamic potential of current density of perovskite solar cells(PSCs).Herein,we report an ion diffusion-induced double layer doping strategy for efficient and stable PSCs,where LiOH is directly added into SnO_(2)colloidal dispersion solution.It is uncovered that a small amount of Li+ions remain in the ETL and doped SnO2 while a large amount of Li+ions diffuse to SnO_(2)/perovskite interface and into perovskite layer and gradient concentration distribution is spontaneously formed.The Li+ion doping endows both perovskite and SnO_(2)layers improved electric properties,which contributes to facilitated carrier transport and extraction.Moreover,the crystallinity and grain size of perovskite films are enhanced after doping.The doped device delivers a higher power conversion efficiency(PCE)of 21.31%together with improved ambient stability in comparison with the control device(PCE=19.26%).This work demonstrates a simple and effective ion diffusion-induced double layer by chemical doping strategy to advance the development of perovskite photovoltaics. | Qixin Zhuang Huaxin Wang Cong Zhang Cheng Gong Haiyun Li Jiangzhao Chen Zhigang Zang | 2022 | Nano Research2022，15，6： | 0 |
| 10 | Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis显示文摘Idiopathic pulmonary fibrosis(IPF)is a chronic fatal lung disease with a median survival time of 3–5 years.Inaccurate diagnosis,limited clinical therapy and high mortality together indicate that the development of effective therapeutics for IPF is an urgent need.In recent years,it was reported that DDRs are potential targets in anti-fibrosis treatment.Based on previous work we carried out further structure modifications and led to a more selective inhibitor 47 by averting some fibrosis-unrelated kinases,such as RET,AXL and ALK.Extensive profiling of compound 47 has demonstrated that it has potent DDR1/2 inhibitory activities,low toxicity,good pharmacokinetic properties and reliable in vivo anti-fibrosis efficacy.Therefore,we confirmed that discoidin domain receptors are promising drug targets for IPF,and compound 47 would be a promising candidate for further drug development. | Qi Wang Bixi Tang Dandan Sun Ying Dong Yinchun Ji Huanyu Shi Liwei Zhou Yueyue Yang Menglan Luo Qian Tan Lin Chen Yue Dong Cong Li Rongrong Xie Yi Zang Jingkang Shen Bing Xiong Jia Li Danqi Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
| 11 | Method of Separating Cosmic-Ray Positrons from Electrons in the DAMPE Experiment显示文摘A method of identifying positron/electron species from the cosmic rays was studied in the DArk Matter Particle Explorer(DAMPE)experiment.As there is no onboard magnet on the satellite,the different features imposed by the geomagnetic field on these two species were exploited for the particle identification.Application of this method to the simulation of on-orbit electrons/positrons/protons and the real flight data proves that separately measuring the CR positrons/electrons with DAMPE is feasible,though limited by the field of view for the present observation data.Further analysis on the positron flux with this method can be expected in the future. | Hao-Ting Dai Jing-Jing Zang Ying Wang Chuan-Ning Luo Yun-Long Zhang Zhi-Yong Zhang Yi-Feng Wei Li-Bo Wu Cheng-Ming Liu Cong Zhao Xiao-Lian Wang Zi-Zong Xu Guang-Shun Huang | 2022 | Research in Astronomy and Astrophysics2022，22，3： | 0 |
| 12 | Immobilization of Functionalized Ionic Liquid on Sol-Gel Derived Silica for Efficient Removal of H_2S显示文摘An innovative approach to H2 S capture has been developed using several metal-based ionic liquids([Bmim]Cl·CuCl_2, [Bmim]Cl·FeCl_3, [Bmim]Cl·ZnCl_2, [Bmim]Br·CuCl_2, and [Bmim]Br·FeCl_3) immobilized on the sol-gel derived silica, which is superior to purely viscous ionic liquid with a crucial limit of high temperature, low mass transfer rate,and mass loss. The adsorbents were characterized by the Fourier transform infrared spectrometer, transmission electron microscope, N_2 adsorption/desorption, X-ray photoelectron spectroscopy, and thermal analysis techniques. The effects of the metal and halogen in IL, the loading amount of IL, and the adsorption temperature were studied by dynamic adsorption experiments at a gas flow rate of 100 mL/min. The H2 S adsorption results have showed that the optimal adsorbent and adsorption temperature are 5% [Bmim]Cl·CuCl_2/silica gel and 20—50 ℃, respectively. H_2 S can be captured and oxidized to elemental sulfur, and [Bmim]Cl·CuCl_2/silica gel can be readily regenerated by air. The excellent efficiency of H2 S removal may be attributed to the formation of nano-scaled and high-concentration [Bmim]Cl·CuCl_2 confined in silica gel, indicating that the immobilization of [Bmim]Cl·CuCl_2 on the sol-gel derived silica can be used for H2 S removal promisingly. | Ma Yunqian Mao Jiaming Xiao Cong Li Yan Zang Lihua | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，1： | 0 |
| 13 | Stabilizing Buried Interface via Synergistic Effect of Fluorine and Sulfonyl Functional Groups Toward Efficient and Stable Perovskite Solar Cells显示文摘The interfacial defects and energy barrier are main reasons for interfacial nonradiative recombination.In addition,poor perovskite crystallization and incomplete conversion of PbI_(2) to perovskite restrict further enhancement of the photovoltaic performance of the devices using sequential deposition.Herein,a buried interface stabilization strategy that relies on the synergy of fluorine(F)and sulfonyl(S=O)functional groups is proposed.A series of potassium salts containing halide and non-halogen anions are employed to modify SnO_(2)/perovskite buried interface.Multiple chemical bonds including hydrogen bond,coordination bond and ionic bond are realized,which strengthens interfacial contact and defect passivation effect.The chemical interaction between modification molecules and perovskite along with SnO_(2) heightens incessantly as the number of S=O and F augments.The chemical interaction strength between modifiers and perovskite as well as SnO_(2) gradually increases with the increase in the number of S=O and F.The defect passivation effect is positively correlated with the chemical interaction strength.The crystallization kinetics is regulated through the compromise between chemical interaction strength and wettability of substrates.Compared with Cl−,all non-halogen anions perform better in crystallization optimization,energy band regulation and defect passivation.The device with potassium bis(fluorosulfonyl)imide achieves a tempting efficiency of 24.17%. | Cheng Gong Cong Zhang Qixin Zhuang Haiyun Li Hua Yang Jiangzhao Chen Zhigang Zang | 2023 | Nano-Micro Letters2023，15，2： | 0 |
| 14 | Forrestiacids C and D,unprecedented triterpene-diterpene adducts from Pseudotsuga forrestii显示文摘Forrestiacids C(1)and D(2),a pair of C-25 epimeric triterpene–diterpene adducts were isolated from the needles and twigs of the vulnerable conifer Pseudotsuga forrestii.This unprecedented class of compounds might be generated via an intermolecular Michael addition reaction of a rearranged 6/6/5/5-fused spiro-lanostene with an abietene.Their structures were established by spectroscopic data and X-ray crystallography.The adducts showed inhibitory activities against the ATP-citrate lyase(ACL)and acetyl-CoA carboxylase 1(ACC1),two rate-limiting enzymes in the de novo lipogenesis pathway. | Peng-Jun Zhou Yi Zang Cong Li Lin Yuan Huaqiang Zeng Jia Li Jin-Feng Hu Juan Xiong | 2022 | Chinese Chemical Letters2022，33，9： | 0 |
| 15 | Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis显示文摘Idiopathic pulmonary fibrosis(IPF)is a chronic fatal lung disease characterized by destruction of lung parenchyma and deposition of extracellular matrix in interstitial and alveolar spaces.But known drugs for IPF are far from meeting clinical demands,validation of drug targets against pulmonary fibrosis is in urgent demand.Tyrosine kinase receptor DDRs has been considered as a potential therapeutic target for pulmonary fibrosis due to its pathological collagen binding property and the roles in regulating extracellular matrix remodeling.In this study we designed and synthesized a new indazole derivative XBLJ-13,and identified XBLJ-13 as a highly specific and potent DDRs inhibitor with anti-inflammation and anti-fibrosis activities.We first demonstrated that DDR1/2 was highly expressed in the lung tissues of IPF patients.Then we showed that XBLJ-13 potently inhibited DDR1 and DDR2 kinases with IC50 values of 17.18 nM and 15.13 nM,respectively.Among a panel of 34 kinases tested,XBLJ-13 displayed relatively high selectivity for DDRs with minimal inhibitory effect on PDGFR family and FGFR1,as well as Abl kinase that had high homology with DDRs.Extensive profiling of XBLJ-13 revealed that the new inhibitor had much lower toxicity than nintedanib and better pharmacokinetic properties in mice.Furthermore,pharmacodynamic evaluation conducted in bleomycin-induced pulmonary fibrosis mice showed that administration of XBLJ-13(30,60,90 mg·kg^(−1)·d^(−1),i.g.)for 12 days significantly and dose-dependently ameliorated lung inflammation and fibrosis.Together,this study confirms that DDRs kinase is a potential target for PF,Particularly,compound XBLJ-13 is a highly potent and specific DDRs inhibitor,along with good pharmacokinetics profiles,and preferable in vivo efficacy,suggesting that it is a potential candidate for the treatment of PF. | Ying Dong Bi-xi Tang Qi Wang Li-wei Zhou Cong Li Xuan Zhang Dan-dan Sun Xin Sun Xue-mei Zhang Bing Xiong Jia Li Hong Shi Dan-qi Chen Yi Zang | 2022 | Acta Pharmacologica Sinica2022，43，7： | 0 |
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