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| 1 | Identification and Mapping of Two New Genes Conferring Resistance to Powdery Mildew from Aegilops tauschii (Coss,) Schmal显示文摘二粉的霉抵抗基因从 Aegilops tauschii 就职 Y201 和 Y212 被识别并且印射使用人口从在易受影响的同意之间的十字导出的二不同 F2 Y2272 和 Y201,和易受影响的同意 Y2263 和 Y212。到粉的霉的抵抗的基因分析显示 Y201 的抵抗被单个主导的基因控制,而 Y212 的抵抗被单个后退的基因控制。我们暂时分别地指定了这些基因为 PmY201 和 PmY212。由体积分离分析,包括 Xgwm174, cfd26, cfd57, cfd102, Xgwm583 和 Xgwm639 的六个 microsatellite 标记被发现分别地与 5.2, 7.7, 9.6, 12.5, 20.2 和 22.1 厘米的基因距离被连接到 PmY201。包括 cfd57, Xgwm182, cfd7, cfd102,和 cfd12,五个 SSR 标记被发现分别地与 5.6, 7.2, 11.5, 14.7,和 18.5 厘米的距离被连接到 PmY212。根据连接标记的地点,二抵抗基因位于 5DL 区域。基于 chromosomal 地点和二基因的抵抗模式,我们建议 PmY201 和 PmY212 是二新奇的粉的霉抵抗基因,并且对帮助标记的选择合适。 | Xiao-Li Sun Di Liu Hai-Quan Zhang Na-Xin Huo Rong-Hua Zhou Ji-Zeng Jia | 2006 | Journal of Integrative Plant Biology2006，48，10： | 10 |
| 2 | Neuroimage-Based Consciousness Evaluation of Patients with Secondary Doubtful Hydrocephalus Before and After Lumbar Drainage显示文摘Hydrocephalus is often treated with a cerebrospinal fluid shunt(CFS) for excessive amounts of cerebrospinal fluid in the brain.However,it is very difficult to distinguish whether the ventricular enlargement is due to hydrocephalus or other causes,such as brain atrophy after brain damage and surgery.The non-trivial evaluation of the consciousness level,along with a continuous drainage test of the lumbar cistern is thus clinically important before the decision for CFS is made.We studied 32 secondary mild hydrocephalus patients with different consciousness levels,who received T1 and diffusion tensor imaging magnetic resonance scans before and after lumbar cerebrospinal fluid drainage.We applied a novel machine-learning method to find the most discriminative features from the multi-modal neuroimages.Then,we built a regression model to regress the JFK Coma Recovery Scale-Revised(CRS-R) scores to quantify the level of consciousness.The experimental results showed that our method not only approximated the CRS-R scores but also tracked the temporal changes in individual patients.The regression model has high potential for the evaluation of consciousness in clinical practice. | Jiayu Huo Zengxin Qi Sen Chen Qian Wang Xuehai Wu Di Zang Tanikawa Hiromi Jiaxing Tan Lichi Zhang Weijun Tang Dinggang Shen | 2020 | Neuroscience Bulletin2020，36，9： | 7 |
| 3 | Polar, catalytic, and conductive CoSe2/C frameworks for performance enhanced S cathode in Li–S batteries显示文摘Lithium-sulfur battery(Li-S)is considered as one of the new-generation rechargeable batteries with high performance because of its extremely high theoretical capacity,energy density,environmental harmony and low cost.However,low electrical and ionic conductivity of sulfur,safety concerns and parasitic reaction generated by the dissolved polysulfide species in electrolyte hinder the commercialization of Li-S battery.Herein,we report a polyhedral porous structure comprising of carbon coating metal selenide nanoparticles(CoSe2/C),which could not only host sulfur for Li-S battery owing to its porous and conductive structure,but also mitigate the shuttle phenomenon by polysulfides adsorption and catalytic acceleration of redox kinetics.As a result,a performance enhanced CoSe2/C-S electrode for Li-S battery is achieved. | Bo Yuan Di Hua Xingxing Gu Yu Shen Li-Chun Xu Xiuyan Li Bing Zheng Jiansheng Wu Weina Zhang Sheng Li Fengwei Huo | 2020 | Journal of Energy Chemistry2020，29，9： | 5 |
| 4 | Pharmacokinetics of acteoside following single dose intragastric and intravenous administrations in dogs显示文摘Acteoside(verbascoside), a phenylethanoid glycoside widely distributed in various plants, has been shown to have potential activity against Alzheimer's disease, attracting great attentions recently. The present study was designed to develop a selective and sensitive LC-MS/MS method for the determination of acteoside in biological samples and carry our a phamacokinetic(PK) study in beagle dogs. The PK parameters were calculated using non-compartmental models. Following a single-dose oral administration, acteoside was rapidly absorbed and eliminated, with Tmax being between 30 to 45 min and terminal half-life being about 90 min. The areas under the time-concentration curve(AUC) were 47.28 ± 8.74, 87.86 ± 13.33, and 183.14 ± 28.69 mg·min·L-1 for oral administration of 10, 20, and 40 mg·kg-1, respectively, demonstrating that the exposure of acteoside proportionally increased with the dose level. The absolute bioavailability of acteoside was around 4%. For all the PK parameters, there were large variations between individual dogs. In conclusion, the pharmacokinetic characteristics observed in the present study can be of great value to help better understand the pharmacological properties of acteoside and to improve the outcome of its clinical use. | ZHANG Wei HUO Shi-Xia WEN Yan-Li XING Han ZHANG Qing LI Ning ZHAO Di SUN Xiao-Lin XU Jie YAN Ming CHEN Xi-Jing | 2015 | Chinese Journal of Natural Medicines2015，13，8： | 5 |
| 5 | T Helper 1 and T Helper 2 Cytokines Differentially Modulate Expression of Filaggrin and its Processing Proteases in Human Keratinocytes显示文摘 | Zheng-Hong Di Lei Ma Rui-Qun Qi Xiao-Dong Sun Wei Huo Li Zhang Ya-Ni Lyu Yu-Xiao Hong Hong-Duo Chen Xing-Hua Gao | 2016 | Chinese Medical Journal2016，，3： | 5 |
| 6 | Efficacy of pegylated interferon-alpha-2a plus ribavirin for patients aged at least 60 years with chronic hepatitis C显示文摘 | ZHENG Ying-ying FAN Xiao-hong WANG Li-feng TIAN Di HUO Na LU Hai-ying WU Chi-hong XU Xiao-yuan WEI Lai | 2012 | Chinese Medical Journal2012，，11： | 3 |
| 7 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 8 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 9 | Field Transmission of 100G and Beyond:Multiple Baud Rates and Mixed Line Rates Using Nyquist-WDM Technology显示文摘In this paper,we describe successful joint experiments with Deutsche Telecom on long-haul transmission of 100G and beyond over standard single mode fiber (SSMF) and with in-line EDFA-only amplification.The transmission link consists of 8 nodes and 950 km installed SSMF in DT's optical infrastructure.Laboratory SSMF was added for extended optical reach.The first field experiment involved transmission of 8 × 216.8 Gbit/s Nyquist-WDM signals over 1750 km with 21.6 dB average loss per span.Each channel,modulated by a 54.2 Gbaud PDM-CSRZ-QPSK signal,is on a 50 GHz grid,which produces a net spectral efficiency (SE) of 4 bit/s/Hz.We also describe mixed-data-rate transmission coexisting with 1T,400G,and 100G channels.The 400G channel uses four independent subcarriers modulated by 28 Gbaud PDM-QPSK signals.This yields a net SE of 4 bit/s/Hz,and 13 optically generated subcarriers from a single optical source are used in the 1T channel with 25 Gbaud PDM-QPSK modulation.The 100G signal uses real-time coherent PDM-QPSK transponder with 15% overhead of soft-decision forward-error correction (SD-FEC).The digital post filter and 1-bit maximum-likelihood sequence estimation (MLSE) are introduced at the receiver DSP to suppress noise,linear crosstalk,and filtering effects.Our results show that future 400G and 1T channels that use Nyquist WDM can transmit over long-haul distances with higher SE and using the same QPSK format. | Zhensheng Jia Jianjun Yu Hung-Chang Chien Ze Dong Di Huo | 2012 | ZTE Communications2012，10，3： | 2 |
| 10 | Evolution of the magmatic–hydrothermal system and formation of the giant Zhuxi W–Cu deposit in South China显示文摘The Zhuxi deposit is a recently discovered W–Cu deposit located in the Jiangnan porphyry–skarn W belt in South China. The deposit has a resource of 3.44 million tonnes of WO3, making it the largest on Earth,however its origin and the evolution of its magmatic–hydrothermal system remain unclear, largely because alteration–mineralization types in this giant deposit have been less well-studied, apart from a study of the calcic skarn orebodies. The different types of mineralization can be classified into magnesian skarn, calcic skarn, and scheelite–quartz–muscovite(SQM) vein types. Field investigations and mineralogical analyses show that the magnesian skarn hosted by dolomitic limestone is characterized by garnet of the grossular–pyralspite(pyrope, almandine, and spessartine) series, diopside, serpentine,and Mg-rich chlorite. The calcic skarn hosted by limestone is characterized by garnet of the grossular–andradite series, hedenbergite, wollastonite, epidote, and Fe-rich chlorite. The SQM veins host highgrade W–Cu mineralization and have overprinted the magnesian and calcic skarn orebodies. Scheelite is intergrown with hydrous silicates in the retrograde skarn, or occurs with quartz, chalcopyrite, sulfide minerals, fluorite, and muscovite in the SQM veins.Fluid inclusion investigations of the gangue and ore minerals revealed the evolution of the ore-forming fluids, which involved:(1) melt and coexisting high–moderate-salinity, high-temperature, high-pressure(>450 ℃and >1.68 kbar), methane-bearing aqueous fluids that were trapped in prograde skarn minerals;(2) moderate–low-salinity, moderate-temperature, moderate-pressure(~210–300 ℃and ~0.64 kbar),methane-rich aqueous fluids that formed the retrograde skarn-type W orebodies;(3) low-salinity,moderate–low-temperature, moderate-pressure(~150–240 ℃and ~0.56 kbar), methane-rich aqueous fluids that formed the quartz–sulfide Cu(–W) orebodies in skarn;(4) moderate–low-salinity,moderate-temperature, low-pressure(~150–250 ℃and ~0.34 kbar) alkanes-dominated aqueous fluids in the SQM vein stage, which led to the formation of high-grade W–Cu orebodies. The S–Pb isotopic compositions of the sulfides suggest that the ore-forming materials were mainly derived from magma generated by crustal anatexis, with minor addition of a mantle component. The H–O isotopic compositions of quartz and scheelite indicate that the ore-forming fluids originated mainly from magmatic water with later addition of meteoric water. The C–O isotopic compositions of calcite indicate that the ore-forming fluid was originally derived from granitic magma, and then mixed with reduced fluid exsolved from local carbonate strata. Depressurization and resultant fluid boiling were key to precipitation of W in the retrograde skarn stage. Mixing of residual fluid with meteoric water led to a decrease in fluid salinity and Cu(–W) mineralization in the quartz–sulfide stage in skarn. The high-grade W–Cu mineralization in the SQM veins formed by multiple mechanisms, including fracturing, and fluid immiscibility, boiling, and mixing. | Xiaolong He Da Zhang Yongjun Di Ganguo Wu Bojie Hu Hailong Huo Ning Li Fang Li | 2022 | Geoscience Frontiers2022，13，1： | 2 |
| 11 | Potential of amphiphilically modified low molecular weight chitosan as a novel carrier for hydrophobic anticancer drug: Synthesis, characterization, micellization and cytotoxicity evaluation显示文摘 | Yong Zhang Meirong Huo Jianping Zhou Di Yu Yiping Wu | 2009 | Carbohydrate Polymers2009，，2： | 1 |
| 12 | Iron Status Among Children Aged 6−17 Years by Serum Ferritin—China,2016−2017显示文摘Summary What is already known on this topic?Iron deficiency(ID)is the most widespread micronutrient deficiency and have several adverse effects on health.Consequences of ID among children include delayed psychomotor development and impaired cognitive performance,which makes it important to monitor the iron status of children. | Lijuan Wang Junsheng Huo Di Chen Qingqing Man Yanbin Tang Jian Zhang Jian Huang | 2021 | China CDC weekly2021，3，11： | 1 |
| 13 | Synthesis of Monodispersed Spherical Yttrium Aluminum Garnet ( YAG ) Powders by a Homogeneous Precipitation Method显示文摘 | Xiaojuan Xu Xudong Sun Hong Liu Ji‐Guang Li Xiaodong Li Di Huo Shaohong Liu | 2012 | J Am Ceram Soc2012，，12： | 1 |
| 14 | A novel prodrug of the green tea polyphenol (-)-Epigallocatechin-3-Gallate as a potential anticancer agent显示文摘 | LANDIS-PIWOWAR K R HUO Congde CHEN Di | 2007 | Cancer Research2007，67，9： | 1 |
| 15 | Study on Extraction of Alumina from Sericite Phyllite显示文摘 | Jin Sheng Li Xu Dong Sun Shao Hong Liu Di Huo Xiao Dong Li Ji Guang Li Qi Zhu Mu Zhang | 2013 | 2013 (544)2013，，544： | 1 |
| 16 | A functional missense variant in ITIH3 affects protein expression and neurodevelopment and confers schizophrenia risk in the Han Chinese population显示文摘The Psychiatric Genomics Consortium(PGC)has recently identified 10 potential functional coding variants for schizophrenia.However,how these coding variants confer schizophrenia risk remains largely unknown.Here,we investigate the associations between eight potential functional coding variants identified by PGC and schizophrenia in a large Han Chinese sample(n=4022 cases and 9270 controls).Among the eight tested single nucelotide polymorphisms(SNPs),rs3617(a missense variant,p.K315 Q in the ITIH3 gene)showed genome-wide significant association with schizophrenia in the Han Chinese population(P=8.36×10-16),with the same risk allele as in PGC.Interestingly,rs3617 is located in a genomic region that is highly evolutionarily conserved,and its schizophrenia risk allele(C allele)was associated with lower ITIH3 mRNA and protein expression.Intriguingly,mouse neural stem cells stably overexpressing ITIH3 with different alleles of rs3617 exhibited significant differences in proliferation,migration,and differentiation,suggesting the impact of rs3617 on neurodevelopment.Subsequent transcriptome analysis found that the differentially expressed genes in neural stem cells stably overexpressing different alleles of rs3617 were significantly enriched in schizophrenia-related pathways,including cell adhesion,synapse assembly,MAPK and PI3 K-AKT pathways.Our study provides convergent lines of evidence suggesting that rs3617 in ITIH3 likely affects protein function and neurodevelopment and thereby confers risk of schizophrenia. | Kaiqin Li Yifan Li Junyang Wang Yongxia Huo Di Huang Shiwu Li Jiewei Liu Xiaoyan Li Rong Liu Xiaogang Chen Yong-Gang Yao Ceshi Chen Xiao Xiao Ming Li Xiong-Jian Luo | 2020 | Journal of Genetics and Genomics2020，47，5： | 1 |
| 17 | Formation mechanism of high-quality reservoirs of Lower Cretaceous volcaniclastic sedimentary rocks in Songliao Basin显示文摘High abundance gas reservoirs were discovered in the volcaniclastic sedimentary rocks of Wangfu faulted depression in Songliao Basin,but the distribution pattern and formation mechanism of this type of high-quality reservoirs were not clear.In the Shahezi Formation of Well Block CS6 in Wangfu faulted depression,the void space type,reservoir property,pore throat and pore diameters were studied by means of the casting thin section,helium intrusion porosimetry,mercury intrusion porosimetry(MIP)and nuclear magnetic resonance(NMR)methods,moreover,formation mechanism and main controlling factors of the high-quality reservoirs were discussed.Results showed that lithology of high-quality reservoirs consisted of the volcaniclastic sedimentary agglomerate and the volcaniclastic sedimentary breccia,and exhibited the coarsening-upward characteristics.Furthermore,three types(seven subtypes)of void spaces were identified,among which the intragranular vesicles with primary abundant pores were uniquely developed in the high-quality reservoirs of volcaniclastic sedimentary rocks,indicating this high-quality reservoir belonged to the large-pore and small-throat reservoir;porosity and permeability of volcaniclastic sedimentary agglomerate were slightly higher than those of volcaniclastic sedimentary breccia,and both were significantly higher than those of sedimentary rock in the Shahezi Formation,the porosity was closely related with the burial depth.Formation mechanisms of reservoirs in the volcaniclastic sedimentary rocks were release of volatile matters in parent rocks,grain support,dissolution and tectonic modification,among which the former two were the main controlling factors.The high-quality reservoirs over the study area were mainly distributed in the central part of the fan of volcaniclastic sedimentary rocks,among which the grain-supported,coarse-grained volcaniclastic sedimentary rocks with high content of intragranular vesicular detritus and burial depth less than 3000 m were the most favorable area for development of the high-quality reservoirs. | Huafeng Tang Tan Kong Xiang Liu Di Yang Hongyu Huo Yulong Huang | 2017 | Petroleum Research2017，2，2： | 1 |
| 18 | Clearance of genital warts in pregnant women by mild local hyperthermia: a pilot re- port 显示文摘 | Huo W Di ZH Xiao BH | 2014 | Oermatol Ther2014，27，2： | 1 |
| 19 | Preparation of heteropolyacid/ TiOJfly-ash-cenosphere photocalalyst for the degradation of ciprofloxa- cin from aqueous solutions 显示文摘 | Wu Di Huo Pengwei Lu Ziyang | 2012 | Applied Supplied Surface Science2012，258，18： | 1 |
| 20 | Associations of Residential Greenness with Depression and Anxiety in Rural Chinese Adults显示文摘BACKGROUND Depression and anxiety are top contributors to non-fatal health loss globally.Several studies have indicated the association between residential greenness and mental health.METHOD The participants(n=27,366)were recruited from four counties in Henan Province,China during 2015–2017.Symptoms of depression and anxiety were evaluated using the Patient Health Questionnaire-2(PHQ-2)and the Generalized Anxiety Disorder-2(GAD-2)in the baseline survey.The level of residential greenness during the 3-year period before the baseline survey was assessed using the Moderate Resolution Imaging Spectroradiometer(MODIS)Normalized Difference Vegetation Index(NDVI)and Enhanced Vegetation Index(EVI).The mixed-effect linear regression model was applied to examine the associations of residential greenness with depression and anxiety.RESULTS The results of adjusted models showed that the score of PHQ-2(Dscore and 95%confidence interval[CI])decreased by-0.024(-0.041,-0.006)and-0.022(-0.038,-0.004)with an interquartile range(IQR)increase in NDVI and EVI within a 1,000-m buffer radius,respectively.The score of GAD-2(Dscore and 95%CI)decreased by-0.024(-0.040,-0.006)and-0.028(-0.044,-0.011),in relation to an IQR increase in NDVI and EVI within a 1,000-m buffer radius,respectively.CONCLUSIONS A higher level of residential greenness was significantly associated with lower risk of depression and anxiety in rural areas of Henan Province.Improving residential greenness accessibility may help to promote the mental health of rural populations. | Niu Di Shanshan Li Hao Xiang Yinyu Xie Zhenxing Mao Jian Hou Xiaotian Liu Wenqian Huo Boyi Yang Guanghui Dong Chongjian Wang Gongbo Chen Yuming Guo | 2020 | The Innovation2020，1，3： | 1 |
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