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| 1 | Traditional herbal medicine in preventing recurrence after resection of small hepatocellular carcinoma: a multicenter randomized controlled trial显示文摘BACKGROUND: Disease recurrence is a main challenge in treatment of hepatocellular carcinoma (HCC). There is no generally accepted method for preventing recurrence of HCC after resection. OBJECTIVE: To compare the efficacy of a traditional herbal medicine (THM) regimen and transarterial chemoembolization (TACE) in preventing recurrence in post-resection patients with small HCC. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: This is a multicenter, open-label, randomized, controlled study, which was undertaken in five centers of China. A total of 379 patients who met the eligibility criteria and underwent randomization were enrolled in this trial. One hundred and eighty-eight patients were assigned to the THM group and received Cinobufacini injection and Jiedu Granule, and the other 191 patients were assigned to the TACE group and received one single course of TACE. MAIN OUTCOME MEASURES: Primary outcome measures were the annual recurrence rate and the time to recurrence. Incidence of adverse events was regarded as the secondary outcome measure. RESULTS: Among the 364 patients who were included in the intention-to-treat analysis, 67 patients of the THM group and 87 of the TACE group had recurrence, with a hazard ratio of 0.695 (P = 0.048). Median recurrence-free survival of the patients in the THM and TACE groups was 46.89 and 34.49 months, respectively. Recurrence rates at 1, 2 and 3 years were 17.7%, 33.0% and 43.5% for the THM group, and 28.8%, 42.5% and 54.0% for the TACE group, respectively (P = 0.026). Multivariate analysis indicated that the THM regimen had a big advantage for prolonging the recurrence-free survival. Adverse events were mild and abnormality of laboratory indices of the two groups were similar. CONCLUSION: In comparison with TACE therapy, the THM regimen was associated with diminished risk of recurrence of small-sized HCC after resection, with comparable adverse events. TRIAL REGISTRTION IDENTIFIER: This trial was registered in the Chinese Clinical Trial Registry with the identifier ChiCTR-TRC-07000033. | Xiao-feng Zhai Zhe Chen Bai Li Feng Shen Jia Fan Wei-ping Zhou Yun-ke Yang Jing Xu Xiao Qin Le-qun Li Chang-quan Ling | 2013 | Journal of Integrative Medicine2013，11，2： | 49 |
| 2 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 3 | Advanced Space-based Solar Observatory(ASO-S):an overview显示文摘The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar community.The scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single platform.ASO-S is scheduled to be launched into a 720 km Sun-synchronous orbit in 2022.This paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C. | Wei-Qun Gan Cheng Zhu Yuan-Yong Deng Hui Li Yang Su Hai-Ying Zhang Bo Chen Zhe Zhang Jian Wu Lei Deng Yu Huang Jian-Feng Yang Ji-Jun Cui Jin Chang Chi Wang Ji Wu Zeng-Shan Yin Wen Chen Cheng Fang Yi-Hua Yan Jun Lin Wei-Ming Xiong Bin Chen Hai-Chao Bao Cai-Xia Cao Yan-Ping Bai Tao Wang Bing-Long Chen Xin-Yu Li Ye Zhang Li Feng Jiang-Tao Su Ying Li Wei Chen You-Ping Li Ying-Na Su Hai-Yan Wu Mei Gu Lei Huang Xue-Jun Tang | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 17 |
| 4 | Hard X-ray Imager (HXI) onboard the ASO-S mission显示文摘Hard X-ray Imager(HXI)is one of the three scientific instruments onboard the Advanced Spacebased Solar Observatory(ASO-S)mission,which is proposed for the 25th solar maximum by the Chinese solar community.HXI is designed to investigate the non-thermal high-energy electrons accelerated in solar flares by providing images of solar flaring regions in the energy range from 30 keV to 200 keV.The imaging principle of HXI is based on spatially modulated Fourier synthesis and utilizes about 91 sets of bi-grid sub-collimators and corresponding LaBr3 detectors to obtain Fourier components with a spatial resolution of about 3 arcsec and a time resolution better than 0.5 s.An engineering prototype has been developed and tested to verify the feasibility of design.In this paper,we present background,instrument design and the development and test status of the prototype. | Zhe Zhang Deng-Yi Chen Jian Wu Jin Chang Yi-Ming Hu Yang Su Yan Zhang Jian-Ping Wang Yao-Ming Liang Tao Ma Jian-Hua Guo Ming-Sheng Cai Yong-Qiang Zhang Yong-Yi Huang Xiao-Yan Peng Zong-Bin Tang Xuan Zhao Hong-He Zhou Lian-Guo Wang Jing-Xing Song Miao Ma Guang-Zhou Xu Jian-Feng Yang Di Lu Ying-Hong He Jin-You Tao Xiao-Long Ma Bao-Gang Lv Yan-Ping Bai Cai-Xia Cao Yu Huang Wei-Qun Gan | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 9 |
| 5 | Cutting-balloon angioplasty before drug-eluting stent implantation for the treatment of severely calcified coronary lesions显示文摘BackgroundSeverely 钙化的冠的损害对汽球 angioplasty 糟糕作出回应,导致不完全、不均匀的 stent 扩大。因此,在 drug-eluting stent (DES ) 以前的足够的匾修正培植是为钙化的损害治疗的钥匙。这研究是评估为严重地钙化的冠的 lesions.MethodsNinety 切汽球 angioplasty 的安全和功效 -- 有严重地钙化的损害的二个连续病人(定义为钙弧 ≥180 °钙长度比率 ≥0.5 ) 在 DES 培植随机基于汽球类型被划分成二个组以前,与汽球膨胀对待:在常规汽球 angioplasty (BA ) 的 45 个病人组织,在切的汽球 angioplasty (CB ) 的 47 个病人组织。在 BA 组的七个盒子令人满意地没完成膨胀并且被变成 CB 组。 Intravascular 超声( IVUS )在汽球膨胀前并且在 stent 培植以后被执行获得质、量的损害特征并且评估 stent ,包括最小的腔代表性的区域( CSA ),钙化的弧和长度,最小的 stent CSA , stent 并置, stent 对称, stent 扩大,容器解剖,并且分叉容器监狱。在里面医院, 1 月、 6 月的主要不利心脏的事件(向) 是 reported.ResultsThere 不是在在二个组之间的临床的特征的统计差别,包括钙弧(222.2 °±22.2 °对 235.0 °±22.1 °, P = 0.570 ) ,钙长度比率(0.67 ±0.06 对 0.77 ±0.05, P = 0.130 ) ,并且在一种总线标准前的最小的腔 CSA (2.59 ±0.08 公里 2 对 2.52 ±0.08 公里 2, P = 0.550 ) 。在 stent 培植以后,最后的最小的 stent CSA (6.26 ±0.40 公里 2 对 5.03 ±0.33 公里 2 ;P = 0.031 ) 并且尖锐的腔获得(3.74 ±0.38 公里 2 对 2.44 ±0.29 公里 2, P = 0.015 ) 比 BA 组的在 CB 组是显著地更大的。没有统计上在在二个组之间的 stent 扩大, stent 对称,不完全的 stent 并置,容器解剖和分支容器监狱的差别。在在严重地钙化的损害的 DES 培植看起来是包括显著地更大的最后的 stent CSA 和更大的尖锐的腔获得的更多的功效以前, 30 天、 6 月的向率也不是 different.ConclusionsCutting 汽球 angioplasty,没有增加在操作和 MACE 率在期间的复杂并发症 6 月。 | Zhe TANG Jing BAI Shao-Ping SU Yu WANG Mo-Han LIU Qi-Cai BAI Jin-Wen TIAN Qiao XUE Lei GAO Chun-Xiu AN Xiao-Juan LIU | 2014 | Journal of Geriatric Cardiology2014，11，1： | 9 |
| 6 | Richness of sputum microbiome in acute exacerbations of eosinophilic chronic obstructive pulmonary disease显示文摘Background:The eosinophilic chronic obstructive pulmonary disease(COPD)is known to be more sensitive to corticosteroid.The sputum microbiome has been shown to affect COPD prognosis,but its role in acute exacerbations of eosinophilic COPD is unclear.This study aimed to investigate the dynamic changes of the airway microbiome in patients with acute exacerbations of eosinophilic COPD.Methods:Fifty-seven patients with acute exacerbations of COPD from the First Affiliated Hospital of Guangxi Medical University between June 2017 and June 2018 were divided into two groups.Patients with eosinophils≥300 cells/mL in the peripheral venous blood were assigned to the eosinophilic group(Eos)and the rest to the non-eosinophilic group(Noneos).All patients received similar treatment including inhaled budesonide according to the guidelines.The induced sputum microbiome was analyzed on the 1st and 7th day of treatment using the 16S ribosomal RNA(rRNA)method.The levels of interleukin(IL)-6 and IL-8 were measured in the plasma and the sensitivity to corticosteroids was determined in isolated peripheral blood mononuclear cells.Quantitative data were compared between the two groups using the independent samples t test or Mann-Whitney U test.Categorical data were evaluated using Chi-squared test or Fisher’s exact test.Results:Twenty-six patients were classified into Eos group and 31 patients were classified into Noneos group.Prior to treatment,the alpha diversity(Shannon index)(2.65±0.63 vs.2.56±0.54,t=0.328,P=0.747)and the structure of the sputum microbiome were similar in the Eos group and the Noneos group.After 7 days of treatment,alpha diversity increased in both groups,while the microbiome richness(Ace index)was significantly lower in the Eos group(561.87±109.13 vs.767.88±148.48,t=-3.535,P=0.002).At the same time,IL-6(12.09±2.85 pg/mL vs.15.54±2.45 pg/mL,t=-4.913,P<0.001)and IL-8(63.64±21.69 pg/mL vs.78.97±17.13 pg/mL,t=-2.981,P=0.004)decreased more significantly in the Eos group,and the percentages of inhibition of IL-8 at dexamethasone concentrations 10-8 to 10-6 mol/L were significantly higher in the Eos group than those in the Noneos group(all P<0.05).Conclusions:The induced sputum microbiome richness decreased more significantly following treatment in the Eos patients compared to the Noneos patients.The lower plasma inflammatory factor levels and the higher percentage of inhibition of IL-8 might be due to higher corticosteroid sensitivity in Eos patients. | Yu-Jing Qi Xue-Jiao Sun Zhe Wang Yan-Fei Bin Ying-Hua Li Xiao-Ning Zhong Jing Bai Jing-Min Deng Zhi-Yi He | 2020 | Chinese Medical Journal2020，，5： | 8 |
| 7 | Establishment and gene expression profiling of LKB1 stable knockdown lung cancer cell line显示文摘背景肺癌症是在中国的癌症相关的死亡的领先的原因。变化分析表明 LKB1 inactivation 在 30% non-small-cell 肺癌症(NSCLC ) 是在场的,显示它象肿瘤 suppressor 的角色。然而,分子的机制仍然不是清楚的。我们试图建立 LKB1 稳定的击倒的 NSCLC 房间线,在基因表示检测改变并且识别基因的学习由 LKB1.Methods LKB1 稳定的击倒的 H1299 房间线调整了用 lentiviral 被建立短发卡 RNA。为了识别击倒的效果, LKB1 mRNA 和蛋白质,表示水平与量的即时 PCR 并且西方的弄污被评估。我们与 2-deoxyglucose 对待房间线决定 LKB1 蛋白质功能是否被影响。基因 microarray 分析被执行在 LKB1 稳定的击倒的 H1299 cells.Results LKB1 mRNA 检测基因表示改变,蛋白质表示显著地在 LKB1 稳定的击倒的 H1299 房间线被压制。2-DG 处理几乎没在 AMPK 的 phosphorylation 上有很少影响,它是 LKB1 的下游的目标,显示 LKB1 的功能的损失。microarray 数据显示出那 LKB1 击倒导致了 1243 种基因的表达式改变,包括涉及房间移植,房间增长和房间 apoptosis.Conclusions 的那些, LKB1 稳定的击倒的 H1299 房间线的建立向我们提供一个大工具调查 LKB1 通过 microarray 调整的各种各样的基因。LKB1 调整的房间增长和迁居相关的基因的发现为解开是批评的 LKB1 在肺癌症的发展和转移的角色的分子的机制。 | SUN Lin-lin ZHONG Dian-sheng WU Song BAI Hua CHEN Zhe | 2011 | Chinese Medical Journal2011，，13： | 7 |
| 8 | Risk factors of prognosis after acute kidney injury in hospitalized patients显示文摘 | Sasa Nie Zhe Feng Lihua Xia Jiuxu Bai Fenglin Xiao Jian Liu Li Tang Xiangmei Chen | 2017 | Frontiers of Medicine2017，11，3： | 7 |
| 9 | Design and Synthesis of Cu@CuS Yolk–Shell Structures with Enhanced Photocatalytic Activity显示文摘Non-spherical Cu@Cu S yolk–shell structures are successfully obtained using Cu_2 O cube templates in a process combining rapid surface sulfidation followed by disproportionation of the Cu_2 O core upon treatment with a hydrochloric acid solution. By employing the above method,Cu@Cu S yolk–shell structures with different morphologies,including octahedral, truncated octahedral, and cuboctahedral shapes, can be synthesized. The void space within the hollow structures provides a unique confined space, where the metallic copper present in the core of a shell can be protected from agglomeration and oxidation. Furthermore,the presence of metal copper in these hollow structurescontributes to improvement in the photocatalytic properties of these materials. The application of these Cu@Cu S structures indeed shows clearly improved photocatalytic performance. | Qiuyan Li Fan Wang Linqiang Sun Zhe Jiang Tingting Ye Meng Chen Qiang Bai Chao Wang Xiguang Han | 2017 | Nano-Micro Letters2017，9，3： | 6 |
| 10 | Prognostic analysis of transarterial chemoembolization combined with a traditional Chinese herbal medicine formula for treatment of unresectable hepatocellular carcinoma显示文摘 | YU Yang LANG Qing-bo CHEN Zhe LI Bai YU Chao-qin ZHU De-zeng HUANG Xue-qiang ZHAI Xiao-feng LING Chang-quan | 2009 | Chinese Medical Journal2009，，17： | 5 |
| 11 | An improved fruit fly optimization algorithm for solving traveling salesman problem显示文摘The traveling salesman problem(TSP), a typical non-deterministic polynomial(NP) hard problem, has been used in many engineering applications. As a new swarm-intelligence optimization algorithm, the fruit fly optimization algorithm(FOA) is used to solve TSP, since it has the advantages of being easy to understand and having a simple implementation. However, it has problems, including a slow convergence rate for the algorithm, easily falling into the local optimum, and an insufficient optimization precision. To address TSP effectively, three improvements are proposed in this paper to improve FOA. First, the vision search process is reinforced in the foraging behavior of fruit flies to improve the convergence rate of FOA. Second, an elimination mechanism is added to FOA to increase the diversity. Third, a reverse operator and a multiplication operator are proposed. They are performed on the solution sequence in the fruit fly's smell search and vision search processes, respectively. In the experiment, 10 benchmarks selected from TSPLIB are tested. The results show that the improved FOA outperforms other alternatives in terms of the convergence rate and precision. | Lan HUANG Gui-chao WANG Tian BAI Zhe WANG | 2017 | Frontiers of Information Technology & Electronic Engineering2017，18，10： | 4 |
| 12 | Aggressive plaque modification with rotational atherectomy and cutting balloon for optimal stent expansion in calcified lesions显示文摘为了评估在钙化的损害影响最佳的 stent 扩大的因素,与旋转 atherectomy ( RA )和一个切的汽球( CB )由好攻击的匾修正对待 .MethodsFrom 2014年1月到2015年5月, 92 个病人与对严重冠的钙化的损害中等在中国 PLA 医院将军(中国北京)经历了旋转 atherectomy 和 intravascular 超声成像在这研究被包括。他们被划分成与切汽球(RACB ) 组(对待, RA 由 CB angioplasty 列在后面的 46 个病人) 和一个 RA 组(对待, RA 由平凡汽球 angioplasty 列在后面的 46 个病人) 相结合的旋转 artherectomy。有他们的钙化的损害的类似的严厉的 40 个病人与平凡旧汽球 angioplasty (POBA ) 对待的另外一个人口统计地被匹配到另外的组并且定义为 POBA 组。所有病人在匾准备以后收到了 drug-eluting stent。腔直径和腔直径狭窄(LDS ) 被量的冠的 angiography 在基线测量,在 RA 以后,在膨胀以后,并且在 stenting 以后。最佳的 stent 扩大被定义为最后的 LDS < 起始的 10%.ResultsThe 和 post-RA LDS 价值在三个组之中是类似的。在膨胀以后,然而, LDS 显著地在 RACB 组减少了(从 54.5% | Zhe TANG Jing BAI Shao-Ping SU Pui-Wai LEE Liang PENG Tao ZHANG Ting SUN Jing-Guo NONG Tian-De LI Yu WANG | 2016 | Journal of Geriatric Cardiology2016，13，12： | 4 |
| 13 | Protective effect of chrysoeriol against doxorubicin-induced cardiotoxicity in vitro显示文摘背景 doxorubicin (纪录影片)的使用被它的剂量依赖者 cardiotoxicity.Reactive 氧种类(粗糙表面)限制在这研究的导致纪录影片的 cardiotoxicity.The 目的病理学的过程起一个重要作用是评估 chrysoeriol 的保护的效果,黄酮混合物,对在 H9c2 房间并且到的导致纪录影片的 apoptosis 和死亡发现它我们使用了的初步的 mechanism.Methods 3-( 4,5-dimethylthiazol-2-yl ) -2,5-diphenyl-2H-tetrazolium 溴化物( MTT )试金, Hoechst33258 | LIU Zhe SONG Xiao-dong XIN Ying WANG Xiao-jian YU Hui BAI Yong-yi LIU Jun-hao HANG Chan-na HUI Ru-tai | 2009 | Chinese Medical Journal2009，，21： | 4 |
| 14 | Optical fiber amplifiers for space-division multiplexing显示文摘最近,空间部门 multiplexing (SDM ) 技术使用多核心纤维(MCF ) 和很少模式纤维(FMF ) 被介绍了进光纤维通讯增加传播能力。光纤维放大器的二种主要类型基于 Erbiumdoped 纤维(EDF ) 和拉曼效果被开发了在 MCF 和 FMF 放大信号。在这份报纸,我们考察了这些放大器的原则和配置。 | Dagong JIA Haiwei ZHANG Zhe JI Neng BAI Guifang LI | 2012 | Frontiers of Optoelectronics2012，5，4： | 3 |
| 15 | Pediatric cancer surveillance in China:A hospital-based introduction显示文摘Background In recent years,increasing numbers of families have been affected by childhood cancer.According to data from the International Agency for Research on Cancer(IARC)of the World Health Organization,approximately 279000 new cases of cancer were predicted in children and adolescents aged 0–19 years worldwide in 2020.The global incidence of childhood cancer is 10.9 per 100000(global standard rate)and the mortality rate is 4.2 per 100000.1 According to data from the China National Cancer Center,the incidences of cancer in 2017 were 9.9 per 100000 in children aged 0–14 years and 11.5 per 100000 in adolescents aged 15–19 years.2 There are estimated to be approximately 22000 new cases of childhood cancer in China each year,and the incidence of malignant tumors in children aged 0–14 years has increased by 2.5%annually in the past decade. | Zhe Li Rongshou Zheng Xin Xu Yuanhu Liu Chenguang Jia Guoshuang Feng Xiao Zhang Xinping Li Guoliang Bai Xin Ni | 2021 | Pediatric Investigation2021，5，2： | 3 |
| 16 | Effect of Overlaid Material on Optical Transmission of Side-Polished Fiber Made by Wheel Side Polishing显示文摘The performance of optical power transmission through a side-polished fiber on which materials of different refractive indices were overlaid is investigated. The experiments show that the transmitted optical power through the side-polished fiber varies with the refractive index of the overlaid material. The result of our experiments fits well the theoretical calculation. Side-polished fiber manufactured by wheel polishing method can be used not only to control optical power transmission through the fiber core but also as a refractive index sensor. | Zhe Chen Chun-He Bai | 2008 | Journal of Electronic Science and Technology of China2008，6，4： | 3 |
| 17 | Impact of main vessel calcification on procedural and clinical outcomes of bifurcation lesion undergoing provisional single-stenting intervention: a multicenter, prospective, observational study显示文摘Background Few data on the combined effects of bifurcation and calcification on coronary artery disease(CAD)patients undergoing percutaneous coronary intervention(PCI)are available.This study evaluated the impact of main vessel(MV)calcification on the procedural and long-term outcomes in patients with CAD who underwent provisional single stent PCI.Methods This is a multicenter,prospective,observational study.Patients with bifurcation lesions were enrolled at 10 PCI centers in China from January 2015 to December 2017.Intravascular ultrasound or optical coherence tomography was performed in all patients to evaluate the MV calcification.Patients were treated with provisional single stent strategy using drug eluting stents and followed-up at 1 month,6 months and 12 months after discharge by telephone contact or outpatient visit.Repeated coronary imaging was performed within one year.We compared the procedural success rates in MV and in side branch(SB),and target lesion failure(TLF),defined as a composite of cardiac death,non-fatal myocardial infarction,definite or possible stent thrombosis and target lesion revascularization between patients with and without MV calcification.Results A total of 185 subjects were enrolled according to the inclusion and exclusion criteria of this study.MV calcification was detected in 119(64.3%,calcification group)and not found in 66(35.7%,non-calcification group)patients.The angiographic success rate of MV was 95.8%in the calcification group and 97.0%in the non-calcification group(P=0.91);the angiographic success rate of SB was 32.8%in the calcification group and 53.0%in the non-calcification group(P<0.05).During the one-year follow-up period,TLF occurred in 14(11.8%)patients in the calcification group and in 13(19.7%)in the non-calcification group{P=0.31).Multivariate regression analysis showed the same result(HR=1.23,95%CI:0.76-1.52,P=0.47).Calcification on group had higher recurrent angina than non-calcification group(13.51%vs.17.65%,P<0.05).Conclusions In patients with coronary bifurcation lesion treated with provisional one stent approach,calcification of MV is associated with lower SB procedural success rate,it could increase recurrence of angina;however,it was not associated with an increased risk of TLF. | Jing BAI Yan YUE Hong-Qi FENG Shu-Xin HAO Liang PENG Ming ZHANG Shaheena Nazneen Li-Feng LIU Zhe TANG Xiao-Lin YU Yu-Tao XIE Fu-Xiang SHAN Ming-Zhi SHEN Jiang-Tao WANG Xue-Hua WAN Yun-Dai CHEN Yu WANG | 2019 | Journal of Geriatric Cardiology2019，16，2： | 3 |
| 18 | Anti-diabetic effects of linarin from Chrysanthemi Indici Flos via AMPK activation显示文摘Objective:The purpose of this study is to investigate the anti-diabetic effects of linarin,a flavonoid extracted from Chrysanthemi Indici Flos(CIF),and its potential mechanisms.Methods:The effects of linarin on cell viability and glucose consumption in Hep G2 cells were measured.Meanwhile,monosodium glutamate(MSG) mouse model was constructed to monitor the changes of insulin tolerance,glucose tolerance,triglyceride and cholesterol.The protein expression levels of pAMPK,p-ACC,PEPCK and p-GS were detected by Western blot.Results:Linarin could increase the relative glucose consumption of Hep G2 cells,improve insulin tolerance and glucose tolerance,and decrease the levels of triglyceride and cholesterol of MSG mice.Simultaneously,the expression levels of p-AMPK and p-ACC in Hep G2 cells and the liver tissue of MSG mice were increased,while the expression levels of PEPCK and p-GS were decreased after treatment with linarin.Conclusion:Insulin resistance could be ameliorated by linarin in type 2 diabetes,and its mechanism may be related to AMPK signaling pathway. | Zhenji Wang Zhe Bai Jinghua Yan Tengteng Liu Yingmei Li Jiahui Xu Xiaoqian Meng Yuefeng Bi | 2022 | Chinese Herbal Medicines2022，14，1： | 2 |
| 19 | Inducing Macrophages M2 Polarization by Dexamethasone Laden Mesoporous Silica Nanoparticles from Titanium Implant Surface for Enhanced Osteogenesis显示文摘The study conveys an idea to enhance the osseointegration of titanium implant (Ti) through modulating macrophages M2 polarization. The ?100 nm spherical mesoporous silica nanoparticles (MSN) that compromised of ~4-nm-diameter nano? tunnels were synthesized by the conventional 'sol-gel' method, into which the dexamethasone (DEX) was loaded (DEX@ MSN). The DEX@MSN could consistently release DEX and showed favorable cytocompatibility in RAW264.7 cells. The arginase-1 expression, a specific marker for macrophages M2 polarization, was also enhanced by DEX @ MSN treatment. Then, the Ti was pre-treated with anodization under 5 V to generate the titania nanotubes with ?30 nm diameter (NT-30) and the DEX @ MSN was introduced onto NT-30 surface via electrophoretic deposition, with the aid of chitosan. After optimizing the deposition parameters, the supernatants of RAW264.7 from the decorated implant surface could significantly promote the osteogenic differentiation of murine primary bone marrow mesenchymal stem cells. These findings demonstrate that delivery of DEX from implant surface can modulate the macrophages M2 polarization and result in favorable osteogenesis. | Jing Luo Xin Ding Wen Song Jian-Ying Bai Jing Liu Zhe Li Fan-Hui Meng Fang-Hao Chen Yu-Mei Zhang | 2019 | Acta Metallurgica Sinica(English Letters)2019，32，10： | 2 |
| 20 | Successful opening in-stent chronic total occlusion lesion of coronary artery by excimer laser coronary angioplasty显示文摘In percutaneous coronary intervention (PCI), chronic total occlusion (CTO) coronary artery disease still remains difficult to treat. One of the reasons for the failure is the hard of the CTO lesions that balloon is difficult to pass through or expand. Previous methods to deal with CTO lesions that cannot be passed by balloon, include selecting reinforced catheter (such as 5 in 6 guiding catheter, Guidzilla catheter, or Tornus microcatheter), guidewire extrusion or rotary grinding technology. In recent years, excimer laser coronary angioplasty (ELCA) has been gradually applied to CTO lesions. Using inert halide as the laser medium, ELCA emits a 308 nm high-intensity unidirectional light wave with absorption depth of only 50 μmL, resulting in less thermal effect and less damage to non-target lesions. In this paper, we will describe a successful PCI case of an in-stent CTO lesion using ELCA with long term coronary angiography follow-up. | Jing BAI Hai-Xia WANG Jiang-Tao WANG Jing ZHAO Liang PENG Xue-Dong YANG Zhe TANG Shaheena Nazneen Gao-Kun WANG Yu WANG | 2019 | Journal of Geriatric Cardiology2019，16，6： | 2 |
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