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| 1 | The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types显示文摘The Genome Sequence Archive(GSA)is a data repository for archiving raw sequence data,which provides data storage and sharing services for worldwide scientific communities.Considering explosive data growth with diverse data types,here we present the GSA family by expanding into a set of resources for raw data archive with different purposes,namely,GSA(https://ngdc.cncb.ac.cn/gsa/),GSA for Human(GSA-Human,https://ngdc.cncb.ac.cn/gsa-human/),and Open Archive for Miscellaneous Data(OMIX,https://ngdc.cncb.ac.cn/omix/).Compared with the 2017 version,GSA has been significantly updated in data model,online functionalities,and web interfaces.GSA-Human,as a new partner of GSA,is a data repository specialized in human genetics-related data with controlled access and security.OMIX,as a critical complement to the two resources mentioned above,is an open archive for miscellaneous data.Together,all these resources form a family of resources dedicated to archiving explosive data with diverse types,accepting data submissions from all over the world,and providing free open access to all publicly available data in support of worldwide research activities. | Tingting Chen Xu Chen Sisi Zhang Junwei Zhu Bixia Tang Anke Wang Lili Dong Zhewen Zhang Caixia Yu Yanling Sun Lianjiang Chi Huanxin Chen Shuang Zhai Yubin Sun Li Lan Xin Zhang Jingfa Xiao Yiming Bao Yanqing Wang Zhang Zhang Wenming Zhao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 38 |
| 2 | Preparation and hydrogen storage properties of MgH2-trimesic acid-TM MOF(TM=Co,Fe) composites显示文摘Two kinds of metal-organic frameworks(MOFs) based on Co(Ⅱ) and Fe(Ⅱ) as metal ions and trimasic acid(TMA) as organic linker were synthesized. They were used to prepare corresponding Mg H2-TM MOF(TM = Co, Fe) composites via ball-milling. X-ray diffraction analyses show the formation of Mg2 Co and α-Fe phases in Mg H2-TMMOF composites after decomposition. Both of the well dispersed Mg2Co andα-Fe nanoparticles exhibit considerable catalytic efficiency in accelerating the sorption kinetics of Mg H2.The dehydrogenated MgH2-Fe MOF composite shows faster hydriding kinetics than the pure Mg H2 and Mg H2-CoMOF. Meanwhile, the apparent dehydrogenation activation energy(Ed) of the Mg H2-Co MOF and Mg H2-Fe MOF composites are 151.3 ± 9.4 and 142.3 ± 6.5 kJ/mol H2, both of which are lower than that of pure Mg H2(181.4 ± 9.2 kJ/mol H2). The improvement on the sorption kinetics of the Mg H2-TM MOF powders is mainly attributed to the catalytic effects of nano-sized Mg2 Co and α-Fe formed on the surface of Mg/Mg H2 particles. | Zhewen Ma Jianxin Zou Darvaish Khan Wen Zhu Chuanzhu Hu Xiaoqin Zeng Wenjiang Ding | 2019 | Journal of Materials Science & Technology2019，35，10： | 6 |
| 3 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 4 | Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome显示文摘To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine. | Zhenglin Du Liang Ma Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 4 |
| 5 | Neoadjuvant radiotherapy for resectable hepatocellular carcinoma with portal vein tumor thrombus:a systematic review显示文摘Background:The prognosis of hepatocellular carcinoma(HCC)with portal vein tumor thrombus(PVTT)is extremely poor.The clinical outcome of preoperative radiotherapy(RT)is still controversial.This study aimed to compare the clinical outcomes of combined neoadjuvant RT and hepatectomy with hepatectomy alone for HCC with PVTT.Methods:Comprehensive database searches were performed in PubMed,the Cochrane Library,EMBASE,and the Web of Science to retrieve studies published from the database creation to July 1,2020.Only comparative studies that measured survival between neoadjuvant RT followed by hepatectomy and hepatectomy alone were included.The characteristics of the included studies and patients were extracted,and the included data are presented as relative ratio(RR)estimates with 95%confidence intervals(CIs)for all outcomes.The RRs of each study were pooled using a fixed or random effects model with Review Manager(the Cochrane Collaboration,Oxford,UK)version 5.3.The response rate to RT and the overall survival(OS)rate in neoadjuvant RT followed by hepatectomy and hepatectomy alone were measured.Results:One randomized and two non-randomized controlled trials with 302 patients were included.Most patients were classified as Child-Pugh A,and Type II and III PVTT were the most common types.After RT,29(22.8%)patients were evaluated as partial response(PR)and had a positive RT response,but nine(7.1%)had progressive disease(PD).Neoadjuvant RT followed by hepatectomy was received by 127(42.1%)patients after excluding 15(5.0%)patients with severe complications or PD after RT,and 160(53.0%)patients received hepatectomy alone.In the randomized controlled trial(RCT),the 1-year OS rate in the neoadjuvant RT group and the surgery alone group was 75.2%and 43.1%,respectively(P<0.001).In the two non-randomized studies,a meta-analysis with a fixed effects model showed a longer OS in patients undergoing neoadjuvant RT followed by hepatectomy compared with hepatectomy alone at 1-year follow-up(RR=2.02;95%CI:1.45-2.80;P<0.0001).Conclusions:This systematic review showed that neoadjuvant RT followed by hepatectomy in patients with resectable HCC and PVTT was associated with a longer OS than patients who received hepatectomy alone. | Zhewen Wei Jianjun Zhao Xinyu Bi Yefan Zhang Jianguo Zhou Zhiyu Li Zhen Huang Hong Zhao Jianqiang Cai | 2022 | Hepatobiliary Surgery and Nutrition2022，11，5： | 4 |
| 6 | Recent advances in fire-retardant rigid polyurethane foam显示文摘Driven by global environmental concerns,many efforts have been made to develop halogen-free flame retardants for rigid polyurethane foam(RPUF).These environmentally benign flame retardants are mainly divided into(i)reactive,(ii)additive,and(iii)coating types.The last decade has witnessed great progress of these three strategies,which enhance the fire safety of RPUF and maintain even improve the thermal insulation properties.This comprehensive review focuses on the up-to-date design of the reactive,additive,and coating flame retardants,and their effects on flame retardancy and thermal conductivity of RPUF.Moreover,the practical applications of the as-prepared flame-retardant RPUFs are highlighted.Finally,key challenges associated with these three kinds of flame retardants are discussed and future research opportunities are also proposed. | Menghe Zhu Zhewen Ma Lei Liu Jianzhong Zhang Siqi Huo Pingan Song | 2022 | Journal of Materials Science & Technology2022，，17： | 3 |
| 7 | Optimization of the Ultrasonic-assisted Extraction Process for Protocatechuic Acid from Emilia sonchifolia DC by Response Surface Methodology显示文摘[Objectives] This study was conducted to optimize the extraction process of protocatechuic acid from Emilia sonchifolia DC. [Methods] The optimal extraction conditions were determined by single factor,response surface analysis and variance analysis,and the content of protocatechuic acid was determined by HPLC. [Results] The protocatechuic acid standard curve equation was: y = 1 435 x + 8 403,R^2= 0. 999 8,indicating a good linear relationship. The optimal extraction conditions were as follows: a temperature at 80 ℃,an extraction time of 1 h,a material-to-liquid ratio at 1:10 and an ultrasonic power of 600 W,and the content of protocatechuic acid extracted was 1. 93 mg/g. The method showed a RSD of 0. 41%,less than 2%,and the detection limit was 0. 0000047261 g/ml.The experimental sample X1 was the low-level 0. 1 mg/ml standard solution,which showed recovery of protocatechuic acid between 100.8% and 105.2%,with a RSD of 0. 013%;and the sample X2 was the high-level 1. 0 mg/ml standard solution,which exhibited recovery between 100. 6% and 102. 2%,with a RSD of 0.076%. Thus,the recovery was high,and the requirements of the performance index were met. [Conclusions] The detection method is stable and reliable and can produce satisfactory results. | Wen CHEN Xiangjun WANG Lingyan LI Zhewen ZHAI Xiaoling HUANG Wubing RAO Chenghan ZOU Tengtong LI | 2020 | Agricultural Biotechnology2020，9，3： | 3 |
| 8 | A multi-fidelity simulation method research on front variable area bypass injector of an adaptive cycle engine显示文摘Front Variable Area Bypass Injector(Front-VABI) is a component of the Adaptive Cycle Engine(ACE) with important variable-cycle features. The performance of Front-VABI has a direct impact on the performance and stability of ACE, but the current ACE performance model uses approximate models for Front-VABI performance calculation. In this work, a multi-fidelity simulation based on a de-coupled method is developed which delivers a more accurate calculation of the Front-VABI performance based on Computational Fluid Dynamics(CFD) simulation. This simulation method proposes a form of Front-VABI characteristic and its matching calculation method between it and the ACE performance model, constructs a coupling method between the(2-D) Front-VABI model and the(0-D) ACE performance model. The result shows, when ACE works in triple bypass mode, the approximate model cannot account for the effect of FrontVABI pressure loss on Core Driven Fan Stage(CDFS) design pressure ratio, and the calculated error of high-pressure turbine inlet total temperature is more than 40 K in mode transition condition(the transition operating condition between triple bypass mode and double bypass mode). In double bypass mode, the approximate model can better simulate the performance of FrontVABI by considering the local loss of area expansion. This method can be applied to the performance-optimized design of Front-VABI and the ACE control law design during mode transition. | Zhewen XU Ming LI Hailong TANG Min CHEN | 2022 | Chinese Journal of Aeronautics2022，35，4： | 3 |
| 9 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 10 | Separation of arenols from a high-temperature coal tar显示文摘A high-temperature coal tar collected from Xuzhou Coking Plant,Saint-Gobain Pipelines(Xuzhou) Co.,Ltd.was exhaustively extracted with petroleum ether(PE).The extract was sequentially eluted through silica gel with PE and PE/ethyl acetate(EA) mixed solvents(volume ratio 2:1) to afford two eluted fractions.The extract and eluted fractions were analyzed with gas chromatography/mass spectrometry.In total,14 arenols were detected,including phenol,cresols,xylenols,fluorenols,phenanthren-3-ol and pyren-1-ol. | Ting Yao Zhi-Min Zong ZheWen Robert Mukasa Nan-Hua Yuan Xian-Yong Wei | 2012 | International Journal of Mining Science and Technology2012，22，2： | 3 |
| 11 | Exergy Analysis of a Novel Chemical Looping Hydrogen Generation System Integrated with SOFC显示文摘In this paper,a novel system integrating chemical-looping hydrogen generation(CLH)system and solid oxide fuel cell(SOFC)has been proposed.This new methane-fuelled energy system was investigated with energy balance and exergy analysis.CLH produces the hydrogen as the fuel of the SOFC,and the Fe O and Fe3O4 are selected as the looping material.Waste heat from the SOFC is absorbed by the CLH and converted to chemical energy through the reduction reaction of CLH.Owing to the cascade utilization of the fuel between the CLH and SOFC,the net efficiency of this novel system can achieve 62.8%considering CO_(2)separation,more than 10 percentage points higher than a methane reforming fuelled SOFC system.Meanwhile,by using the CLH to produce the hydrogen,the CO_(2)can be recovered without an energy penalty.Through the analysis of the graphical exergy,the cascade utilization of waste heat and the high-efficiency hydrogen production is the main reason of high performance.This novel system also has the advantage of CO_(2)capture without energy penalty,so this combined system is an advantaged method to accomplish the efficient utilization of methane. | ZHANG Xiaosong CHEN Zhewen CHEN Zhenbin LI Jinsong | 2021 | Journal of Thermal Science2021，30，1： | 2 |
| 12 | Superhydrophobic self-extinguishing cotton fabrics for electromagnetic interference shielding and human motion detection显示文摘Multifunctional intelligent fire-safe cotton fabric promises next-generation fire-fighting uniform and sen-sor applications.However,cotton fabrics’hygroscopicity and intrinsic flammability significantly impede their potential applications in industries.Herein,we report a superhydrophobic fireproof cotton fabric(PEI-APP-PEI-MXene)generated via sequential layer-by-layer deposition of polyethyleneimine(PEI),am-monium polyphosphate(APP),and titanium carbide(MXene),followed by hydrophobic treatment with silicone elastomer.Compared to untreated cotton,the treated cotton fabric with 10 polymolecular layers exhibits∼43%and∼42%reductions in the peak heat release rate and total heat release,respectively,a desired UL-94 V-0 rating,and a high limiting oxygen index(LOI)value of 39.5 vol.%.In addition to that,the treated fabrics displayed improved electromagnetic interference(EMI)shielding and motion-sensing abilities.The presented work provides a facile and effective surface modification approach to generate multifunctional cotton fabrics with promising practical applications. | Lei Liu Zhewen Ma Menghe Zhu Lina Liu Jinfeng Dai Yongqian Shi Jiefeng Gao Toan Dinh Thanh Nguyen Long-Cheng Tang Pingan Song | 2023 | Journal of Materials Science & Technology2023，，1： | 2 |
| 13 | Poly(benzobisoxazole divinylene):synthesis,photophysical properties,and electron paramagnetic resonance studies显示文摘 | Guo Peiying Wang Shanfeng Wu Pingping Han Zhewen | 2004 | Polymer2004，45，6： | 1 |
| 14 | Supramolecular regulation of photophysical properties and electron paramagnetic resonance studies of novel rod-coil ordered copolymers based on poly (p-phenylene benzobisoxazole)显示文摘 | Wang Shanfeng Guo Peiying Wu Pingping Han Zhewen | 2004 | Macromolecules2004，37，10： | 1 |
| 15 | Center particle swarm optimization显示文摘 | LIU Yu QIN Zheng SHI Zhewen | 2007 | Neurocomputing2007，70，456： | 1 |
| 16 | Phase morphology and mechanical properties of a poly ( ether sul- fone) -modified bismaleimide resin 显示文摘 | LIU Xiaoyun ZHAN Guozhu HAN Zhewen | 2007 | J Appl Polym Sci2007，106，1： | 1 |
| 17 | Prepatation and surface properties of fluorine-containing diblock copolymers显示文摘 | Wu Pingping Han Zhewen | 2002 | Polymer2002，43，： | 1 |
| 18 | Electron paramagnetic resonance of poly(benzazole)s and conducting properties of N^+- implanted poly (benzazole) s 显示文摘 | Wang Shanfeng Wu Pingping Han Zhewen | 2001 | Polymer2001，42，1： | 1 |
| 19 | A Brief Review of Software Tools for Pangenomics显示文摘Since the proposal for pangenomic study, there have been a dozen software tools actively in use for pangenomic analysis. By the end of 2014, Panseq and the pan-genomes analysis pipeline(PGAP) ranked as the top two most popular packages according to cumulative citations of peerreviewed scientific publications. The functions of the software packages and tools, albeit variable among them, include categorizing orthologous genes, calculating pangenomic profiles, integrating gene annotations, and constructing phylogenies. As epigenomic elements are being gradually revealed in prokaryotes, it is expected that pangenomic databases and toolkits have to be extended to handle information of detailed functional annotations for genes and non-protein-coding sequences including non-coding RNAs, insertion elements, and conserved structural elements. To develop better bioinformatic tools, user feedback and integration of novel features are both of essence. | Jingfa Xiao Zhewen Zhang Jiayan Wu Jun Yu | 2015 | Genomics, Proteomics & Bioinformatics2015，13，1： | 1 |
| 20 | Center particle swarm optimization显示文摘 | Yu Liu Zheng Qin Zhewen Shi Jiang Lu | | 0，，4： | 1 |
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