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| 1 | Accurate relocation of earthquakes in central-western China using the double-difference earthquake location algorithm显示文摘The double-difference earthquake relocation algorithm (DD algorithm) has been applied to the accurate relocation of 10057 earthquakes in the central-western China (21°-36°N, 98°-112E°) during the period of 1992-1999. In total, 79706 readings for P waves and 72169 readings for S waves were used in the relocation, and the source parameters of 6496 events were obtained. The relocation results revealed a more complete picture of the hypocentral distribution in the central-western China. In several seismic belts the relocated epicenters present a more defined lineation feature, reflecting the close correlation between the seismicity and the active tectonic structures. The relocated focal depths confirmed that most earthquakes (91 percent of the 6496 relocated events) in the central-western China were located at shallower depths not deeper than 20 km. The distribution of focal depths indicates that the seismogenic layer in the central-western China is located in the upper-mid crust with its thickness no deeper than 20 km. | YANG Zhixian (杨智娴) CHEN Yuntai (陈运泰) ZHENG Yuejun (郑月军) Yü Xiangwei (于湘伟) | 2003 | Science China Earth Sciences2003，46，z2： | 32 |
| 2 | The role of m6A modification in the biological functions and diseases显示文摘N6-methyladenosine(m6A)is the most prevalent,abundant and conserved internal cotranscriptional modification in eukaryotic RNAs,especially within higher eukaryotic cells.m6A modification is modified by the m6A methyltransferases,or writers,such as METTL3/14/16,RBM15/15B,ZC3H3,VIRMA,CBLL1,WTAP,and KIAA1429,and,removed by the demethylases,or erasers,including FTO and ALKBH5.It is recognized by m6A-binding proteins YTHDF1/2/3,YTHDC1/2 IGF2BP1/2/3 and HNRNPA2B1,also known as'readers'.Recent studies have shown that m6A RNA modification plays essential role in both physiological and pathological conditions,especially in the initiation and progression of different types of human cancers.In this review,we discuss how m6A RNA methylation influences both the physiological and pathological progressions of hematopoietic,central nervous and reproductive systems.We will mainly focus on recent progress in identifying the biological functions and the underlying molecular mechanisms of m6A RNA methylation,its regulators and downstream target genes,during cancer progression in above systems.We propose that m6A RNA methylation process offer potential targets for cancer therapy in the future. | Xiulin Jiang Baiyang Liu Zhi Nie Lincan Duan Qiuxia Xiong Zhixian Jin Cuiping Yang Yongbin Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 16 |
| 3 | Morphology and mechanical properties of Cybister elytra显示文摘The mechanical properties and the topological structure of cross-sections found in Cybister elytra are presented.SEM images show the similar geometric structure in transverse and longitudinal sections.Elytra consist of several layers:a dense,black epicuticle,an exocuticle that is braided by several parallel chitin fiber layers in a helix structure,and many bridge piers formed by the fiber bundles that connect the exocuticle to the endodermis,forming a composite,light-weight biomaterial.The mechanical properties along the edge of elytra are measured using a nano-indenter.The hardness and modulus of fresh cybister elytra is 0.31 GPa and 6.13 GPa,respectively.The ultimate stresses of fresh elytra,measured by using a tensile test machine,are 169.2 MPa and 194.5 MPa in the transverse and longitudinal directions,respectively,which is twice higher than that of the dried one.The difference in the two directions indicates that this bio-material has been topologically optimized during evolution.The results may provide a biological template to inspire lightweight structure design for aerospace engineering. | YANG ZhiXian DAI ZhenDong GUO Ce | 2010 | Chinese Science Bulletin2010，55，8： | 8 |
| 4 | Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy显示文摘Objective:Hepatocellular carcinoma(HCC),the main type of liver cancer,has a high morbidity and mortality,and a poor prognosis.RNA helicase DDX5,which acts as a transcriptional co-regulator,is overexpressed in most malignant tumors and promotes cancer cell growth.Heat shock protein 90(HSP90)is an important molecular chaperone in the conformational maturation and stabilization of numerous proteins involved in cell growth or survival.Methods:DDX5 m RNA and protein expression in surgically resected HCC tissues from 24 Asian patients were detected by quantitative real-time PCR and Western blot,respectively.The interaction of DDX5-HSP90 was determined by molecular docking,immunoprecipitation,and laser scanning confocal microscopy.The autophagy signal was detected by Western blot.The cell functions and signaling pathways of DDX5 were determined in 2 HCC cell lines.Two different murine HCC xenograft models were used to determine the function of DDX5 and the therapeutic effect of an HSP90 inhibitor.Results:HSP90 interacted directly with DDX5 and inhibited DDX5 protein degradation in the AMPK/ULK1-regulated autophagy pathway.The subsequent accumulation of DDX5 protein induced the malignant phenotype of HCC by activating theβ-catenin signaling pathway.The silencing of DDX5 or treatment with HSP90 inhibitor both blocked in vivo tumor growth in a murine HCC xenograft model.High levels of HSP90 and DDX5 protein were associated with poor prognoses.Conclusions:HSP90 interacted with DDX5 protein and subsequently protected DDX5 protein from AMPK/ULK1-regulated autophagic degradation.DDX5 and HSP90 are therefore potential therapeutic targets for HCC. | Ting Zhang Xinrui Yang Wanping Xu Jing Wang Dawei Wu Zhixian Hong Shengxian Yuan Zhen Zeng Xiaodong Jia Shanshan Lu Rifaat Safadi Sen Han Zhihong Yang Leonard M.Neckers Suthat Liangpunsakul Weiping Zhou Yinying Lu | 2021 | Cancer Biology & Medicine2021，18，3： | 7 |
| 5 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 6 | Geochronological and Geochemical Constrains on Petrogenesis of the Jietebutiao A-type Granite in West Junggar,Xinjiang显示文摘晚古生代的 post-collisional granitoids 在西方 Junggar,以及北 Xinjiang 是普遍的。作为那些侵入的一个代表, Jietebutiao 花岗石在西方 Junggar (西北中国) 的西南的边缘发生,并且由中间纹理粗糙的 monzogranite 和 syenogranite 主要构成。在现在的学习,我们报导第一次在 Jietebutiao 花岗石上标明日期的高精确的锆石 laser-ablationinductively-coupled 血浆 massspectrometry UPb 的结果,吗并且产出 287 的加权的吝啬的 206Pb/238U 年龄?????????????????????????????? | YANG Gaoxue LI Yongjun TONG Lili ZHANG Bing TIAN Zhixian YANG Baokai | 2013 | Acta Geologica Sinica(English Edition)2013，87，1： | 3 |
| 7 | Universal Mechanism Modeling Method in Virtual Assembly Environment显示文摘Motion simulation and performance analysis of mechanism are important methods for analyzing assembly quality after finishing assembly simulation in virtual assembly environment. However, most simulation systems have no function of mechanism motion simulation due to the randomicity of mechanism and lack of universal mechanism modeling method. In order to realize the simulation of any mechanism after finishing assembly simulation in a virtual environment, a new universal mechanism modeling method is presented. Two main models are contained in the mechanism model: information model and mathematical model. Firstly, the information model of mechanism is proposed to describe the data structure of mechanism which contains bottom geometry data, information of constraint, link, kinematic pair and physical data. Because the object of mechanism simulation is the assembly, which is assembled during the process of assembly simulation, the information of mechanism can be obtained automatically through mechanism automatic search method. Secondly, mathematical model of mechanism is presented. The mathematical model uses mathematical method to express the mechanism. In order to realize the automatic expression of any random mechanism, basic constraint library is presented, consequently random mechanism can be described based on the basic constraint library. Finally, two examples are introduced to validate the method in the prototype system named VAPP(Virtual Assembly Process Planning). The validation result shows that the mechanism modeling provides a universal modeling method for mechanism motion simulation in virtual assembly environment. This research has important effect on the development both of mechanism motion simulation and virtual assembly. | LIU Jianhua ZHANG Zhixian LIU Yang | 2012 | Chinese Journal of Mechanical Engineering2012，25，6： | 2 |
| 8 | Seismic Hazard Assessment in the Boundary Region of Indo-China:First Phase of Implementation of the Global Seismic Hazard Assessment Program (GSHAP) in Continental Asia显示文摘The primary goal of the demonstration project endorsed by the Scientific and Technical Committee for IDNDR in 1992 is to ensure that national agencies are able to assess seismic hazard in a regionally coordinated fashion by using advanced methods.China,as a Regional Center of Central Southern Asia,has contacted with countries of the region to realistically practice seismic hazard assessments of Continental Asia.A test area located in the collision boundary between the Indian and Eurasian plates was chosen to examine the seismic hazard assessment approach in the regional coordinates.The seismotectonics and three versions of seismic sources of the test area are described in this paper and under the Global Seismic Hazard Assessment Program(GSHAP),guidelines an earthquake catalogue of the test area was assembled.Because of the incompleteness of earthquake data in different countries,we adopt different time windows for different magnitude intervals in order to obtain the seismicity parameters of sources.By | Yang Zhixian and Zhang PeizhenInstitute of Crustal Dynamics,SSB,Beijing 100085,China Institute of Geology,SSB,Beijing 100029,China | 1997 | Earthquake Research in China1997，11，3： | 2 |
| 9 | Vegetation Restoration Technique System and Its Ecological Functions of the Degraded Ecosystem in the Arid-Hot Valleys——Taking the Example of Typical Mode in Small Watershed of Yuanmou显示文摘This paper concluded the vegetation restoration technique system in the arid-hot valleys and studied the anti-erosion function, environmental function and biological diversity effects of vegetation restoration on the ecosystem in the arid-hot valleys. The results showed that the soil erodibility decreased significantly after the vegetation restoration. The climate environment of the small watershed had a great improvement after the vegetation restoration, of which the temperature decreased, the humidity increased, the harsh environment of dry and hot in this region changed. The studies of the ecosystem biodiversity were mainly on the analysis of the relations between biodiversity and ecological function of the artificial ecological forest pattern and the natural enclosed treatment mode on the severely of degraded land. It could conclude that the natural en-closed treatment mode is helpful to the biodiversity of the ecosystem and the improvement and stability of the ecosystem, and Leucaena artificial forest restoration pattern reduced the species diversity but optimized the ecological function. Therefore, as to the severely and extremely severely degraded ecosystem in the arid-hot valleys, Leucaena pattern of gully control and natural enclosed treatment mode are the relatively optimal choices. | JI Zhonghua LIAO Chengfei YANG Yanxian FANG Haidong PAN Zhixian SHA Yucang | 2008 | Wuhan University Journal of Natural Sciences2008，13，3： | 2 |
| 10 | Landscape Ecological Evaluation on the Artificial Forest of Leucaena leucocephala——Taking the Example of Xiaokua Hill of Yuanmou显示文摘Based on the theory of ecology, this article conducted a landscape ecological evaluation on Leucaena leucocephala artificial forest in the arid-hot valley, Yuanmou Xiaokua hill,using a combination method of qualitative analysis and landscape comprehensive evaluation. The comprehensive evaluation indexes of landscape include forest coverage, biodiversity, stability, soil erosion, environmental quality, availability, scientific research characteristic, economic benefits. Using AHP (analytical hierarchy process), determine the grade of ecological evaluation factors and the weight of evaluation index and calculate the CEI (comprehensive evaluation index) on ecological evaluation. Evaluation results showed that the area CEI was 0.714 225, a better quality of the eco-logical level, but biodiversity indicators was the lowest. To sum up, it was difficult to maintain ecological restoration effectiveness and process but also guarantee a good biodiversity in the arid-hot valleys. We must reasonably arrange the alien species and the native species, in order to obtain a stable and sustainable eco-system. | HE Shoujia LIAO Chengfei YANG Yanxian PAN Zhixian SHA Yucang JI Zhonghua | 2008 | Wuhan University Journal of Natural Sciences2008，13，3： | 2 |
| 11 | Oil‐paper insulation partial discharge ultrasonic multifrequency sensing array based on fibre‐optic Fabry-Perot sensor显示文摘In order to improve the sensitivity and accuracy of oil‐paper insulation partial discharge detection by the fibre‐optic Fabry-Perot(FP)ultrasonic sensor,this work studied the ultrasonic signal’s frequency characteristics of typical oil‐paper insulation partial dis-charges and the vibration characteristics of the FP sensor’s diaphragm in the liquid environment.Based on the works above,a multifrequency FP sensor array is proposed,consisting of several FP sensors with different resonant frequencies to detect partial discharges.The experimental results show that the liquid environment has a significant effect on the vibration characteristics of the FP sensor’s diaphragm,and the sensitivity and accuracy of partial discharge detection can be improved based on the multifrequency FP sensing array,which can also be applied in the pattern recognition and localisation of partial discharges. | Zhixian Zhang Jiali Lei Weigen Chen Tianhe Yang Yuxuan Song Kejie Wu Fan Liu | 2022 | High Voltage2022，7，2： | 1 |
| 12 | Risk factors for pulmonary hemorrhage following ultrasound-guided percutaneous biopsy of peripheral lung lesions显示文摘Lung cancer is a leading cause of cancer-associated death worldwide,and the morbidity and mortality of lung cancer have increased over the past few decades.Imaging techniques are limited in providing a definitive diagnosis,which requires a tissue sample for pathologic evaluation.Adenocarcinomas account for 40%of all lung cancers and tend to occur peripherally in the lung,[1]making them amenable to ultrasound-guided percutaneous biopsy for pathologic diagnosis.Peripheral lung cancers are usually close to the pleura,enabling ultrasound to clearly show the internal structure of the lesion,its blood supply,and its relationship with surrounding tissues.Although ultrasound-guided transthoracic cutting needle biopsy is considered a safe and efficient method for obtaining a definitive pathologic diagnosis,the technique is associated with several complications,including air embolism,pneumothorax,pulmonary hemorrhage,and tumor seeding.[1]Severe hemoptysis can necessitate endobronchial tamponade,arterial embolization,or surgery and can be life-threatening.[2]Data regarding the risk factors for pulmonary hemorrhage after ultrasound-guided percutaneous lung biopsy are scarce. | Qing Li Zhixian Li Xinhong Liao Li Zhang Lei Wang Shi Tang Xiyue Yang Jihan Wang | 2022 | Chinese Medical Journal2022，，1： | 1 |
| 13 | A Review of Catalogues of Chinese Earthquakes显示文摘In the past decade, the most authoritative catalogues of Chinese earthquakes and the most popular with seismologists in China are the following:(1) Gu Gongxu, 1983, Catalogue of Chinese Earthquakes;(2) Min Ziqun, 1988, Concise Catalogue of Chinese Earthquakes;(3) Xie Yusuou, 1989, Catalogue of Chinese Earthquakes (M≥ 4.7) from 1900-1980 with Uniform Magnitudes; and(4) Min Ziqun, 1995, Catalogue of Chinese Historical Strong Earthquakes. Earthquakes that occurred before 1900 are mainly documented in historical records.Since 1950s, more recent earthquakes were documented in two major compilations of historical records finished in 1956 and 1983-1987. Separately this effort resulted in two chronicles: two volumes for the first one and five volumes for the second one. The magnitudes are converted from the maximum intensity. These magnitudes, by convention, are connected with surface wave magnitudes. However, it is clear that they do not have any strict seismological definition.The period of 1900-1962 | Yang Zhixian and Su GangInstitute of Crustal Dynamics, SSB, P.O. Box 2855, Beijing 100085, China | 1996 | Earthquake Research in China1996，10，2： | 1 |
| 14 | Upregulation of CENPM facilitates lung adenocarcinoma progression via PI3K/AKT/mTOR signaling pathway显示文摘Centromere protein M(CENPM)is essential for chromosome separation during mitosis.However,its roles in lung adenocarcinoma(LUAD)progression and metastasis remain unknown.In this study,we aimed to explore the effects of CENPM on LUAD progression as well as the underlying mechanisms.We analyzed the expression of CENPM and its correlation with clinicopathological characteristics using GEO LUAD chip datasets and TCGA dataset.We further investigated the impact of CENPM on LUAD in vitro and in vivo.In silico analysis and qRT-PCR revealed that CENPM is upregulated in LUAD compared with that in normal lung tissues.Via gain/loss-of-function assays,we further found that CENPM promotes the LUAD cell cycle,cell proliferation,migration and invasion,and inhibits cell apoptosis in vitro.The in vivo study showed that loss of CENPM inhibits the growth of A549 xenografts.Furthermore,we found that CENPM can promote the phosphorylation of mTOR rather than directly affect the mTOR content.Inhibition of mTOR activity abrogates the promoting effects of CENPM on cell cycle progression,cell proliferation,migration and invasion.Taken together,these results show that CENPM plays an important role in the growth and metastasis of LUAD and may be a promising therapeutic target in LUAD. | Chao Liu Yun Wang Yuyang Dao Shuting Wang Fei Hou Zhixian Yang Pengjie Liu Juan Lv Ling Lv Gaofeng Li Youjun Zhou Zhiyong Deng | 2022 | Acta Biochimica et Biophysica Sinica2022，54，1： | 1 |
| 15 | Hydrogen sulfide may improve the hippocampal damage induced by recurrent febrile seizures in rats显示文摘 | Ying Han Jiong Qin Xingzhi Chang Zhixian Yang Xiuying Tang Junbao Du | 2004 | Biochemical and Biophysical Research Communications2004，，2： | 1 |
| 16 | Mesh relationship modeling and dynamic characteristic analysis of external spur gears with gear wear显示文摘Gear wear is one of the most common gear failures,which changes the mesh relationship of normal gear.A new mesh relationship caused by gear wear affects meshing excitations,such as mesh stiffness and transmission error,and further increases vibration and noise level.This paper aims to establish the model of mesh relationship and reveal the vibration characteristics of external spur gears with gear wear.A geometric model for a new mesh relationship with gear wear is proposed,which is utilized to evaluate the influence of gear wear on mesh stiffness and unloaded static transmission error(USTE).Based on the mesh stiffness and USTE considering gear wear,a gear dynamic model is established,and the vibration characteristics of gear wear are numerically studied.Comparison with the experimental results verifies the proposed dynamic model based on the new mesh relationship.The numerical and experimental results indicate that gear wear does not change the structure of the spectrum,but it alters the amplitude of the meshing frequencies and their sidebands.Several condition indicators,such as root-mean-square,kurtosis,and first-order meshing frequency amplitude,can be regarded as important bases for judging gear wear state. | Zhixian SHEN Laihao YANG Baijie QIAO Wei LUO Xuefeng CHEN Ruqiang YAN | 2022 | Frontiers of Mechanical Engineering2022，17，1： | 0 |
| 17 | A Catalogue of Earthquakes With Moment Magnitude of the Center-Southern Asia Test Area of the Global Seismic Hazard Assessment Program显示文摘We compile a regional catalogue of earthquakes with moment magnitude of the Center-Southern Asia test area(20°-35°N,85°-105°E)for the Global Seismic Hazard Assessment Program(GSHAP).There are significant inhomogeneous and uncompleted data,and n uniformity of earthquake magnitudes in this test area because this region is situated on the boundaries of many countries,such as China,India,Nepal,Vietnam,etc.We establish a relationship between Gutenberg surface-wave magnitude and IASPEI surface-wave magnitude,which can be used for conversion of different magnitude scales into moment magnitude for this catalogue.A catalogue of events with Mw≥6.0 of this test area is given at the end of this paper. | Yang Zhixian and Zhang PeizhenInstitute of Crustal Dynamics,SSB,Beijing 100085,China Institute of Geology,SSB,Beijing 100029,China | 1998 | Earthquake Research in China1998，12，1： | 0 |
| 18 | Expert consensus on clinical applications of high-frequency oscillations in epilepsy显示文摘Studies in animal models of epilepsy and pre-surgical patients have unanimously found a strong correlation between high-frequency oscillations(HFOs,>80 Hz)and the epileptogenic zone,suggesting that HFOs can be a potential biomarker of epileptogenicity and epileptogenesis.This consensus includes the definition and standard detection techniques of HFOs,the localizing value of pathological HFOs for epileptic foci,and different ways to distinguish physiological from epileptic HFOs.The latest clinical applications of HFOs in epilepsy and the related findings are also discussed.HFOs will advance our understanding of the pathophysiology of epilepsy. | Yuping Wang Dong Zhou Xiaofeng Yang Xin Xu Liankun Ren Tao Yu Wenjing Zhou Xiaoqiu Shao Zhixian Yang Shuang Wang Dezhi Cao Chunyan Liu Shang Yeong Kwan Jing Xiang | 2020 | Acta Epileptologica2020，2，1： | 0 |
| 19 | Clinical phenotype features and genetic etiologies of 38 children with progressive myoclonic epilepsy显示文摘Background:Progressive myoclonic epilepsy(PME)is a group of neurodegenerative diseases with genetic heterogeneity and phenotypic similarities,and many cases remain unknown of the genetic causes.This study is aim to summarize the clinical features and study the genetic causes of PME patients.Methods:Sanger sequencing of the target gene,Next Generation Sequencing(NGS)panels of epilepsy,trio-based Whole Exome Sequencing(WES)and detection of cytosine-adenine-guanine(CAG)repeat number were used to investigate the genetic causes of PME patients.Results:Thirty-eight children with PME whose seizure onset age ranged from 3 months to 12 years were collected from February 2012 to November 2019 in three hospitals in Beijing,China.The seizure types included myoclonic seizures(n=38),focal seizures(n=19),generalized tonic-clonie seizure(GTCS)(n=13),absence seizures(n=4),atonic seizures(n=3),epileptic spasms(n=2)and tonic seizures(n=1).Twenty-seven cases were sporadic and 11 had family members affected.Established PME-related genes were identified in 30 out of 38(78.9%)patients who had either recessively inherited or de novo heterozygous mutations.Among these 30 cases,there were 12 cases(31.6%)of neuronal ceroid lipofuscinoses(the causing gene contains TPP1,PPT1,CLN5,CLN6 and MFSD8),two cases of sialidosis(the causing gene is NEU1),two cases of neuronopathic Gaucher disease(the causing gene is GBA),one case of spinal muscular atrophy-progressive myoclonic epilepsy(the causing gene is ASAH1),four cases of KCNC1 mutation-related PME,four cases of KCTD7 mutation-related PME,two cases of TBC1D24 mutation-related PME,one case of GOSR2 related PME,and two of dentatorubral-pallidoluysian atrophy(the causing gene is ATN1).In total,13 PME genes were identified in our cohort.The etiology was not clear in eight patients.Conclusion:PME is a group of clinically and genetically heterogeneous diseases.Genetic diagnosis was clear in 78.9%of PME patients.Various of genetic testing methods could increase the rate of genetic diagnosis.Neuronal ceroid lipofuscinoses(NCL)is the most common etiology of PME in children.Nearly one third PME children were diagnosed with NCL.GOSR2 related PME was in our cohort in Asia for the first time. | Jing Zhang Ying Yang Xueyang Niu Jiaoyang Chen Wei Sun Changhong Ding Lifang Dai Liping Zhang Qi Zeng Yi Chen Xiaojuan Tian Xiaoling Yang Taoyun Ji Zhixian Yang Yanling Yang Yuwu Jiang Yuehua Zhang | 2020 | Acta Epileptologica2020，2，1： | 0 |
| 20 | Multilayer two-dimensional lignin/ZnO composites with excellent anti-UV aging properties for polymer films显示文摘Lignin is a kind of natural green polymer with abundant active functional groups and designable molecular structure.In this work,the quaternized lignosulfonate(QLS)with amphoteric characteristic was prepared through chemical modification using lignosulfonate sodium(LS).Then,a lignin-confined multilayered two-dimensional composite(QLS/ZnO)was prepared by one-step dynamic hydrothermal method using QLS,zinc nitrate,and hexamethylenetetramine.The QLS/ZnO has a regular pie-shaped structure,which is composed of 3-5 layers of two-dimensional nanosheets with a thickness of~10 nm.It shows excellent ultraviolet light absorption performance and active photoelectron scavenging performance,and thus showing great application potential in polymer materials.The water polyurethane(WPU)and polyvinyl alcohol(PVA)films showed excellent UV shielding performance and good mechanical properties when doped with the QLS/ZnO.The tensile strength of WPU t 0.6 wt%QLS/ZnO and PVA t 0.8 wt%QLS/ZnO composite films is increased by 49%and 24%,respectively,and the elongation at break is increased by 138%and 33%.Furthermore,the composite films showed excellent anti-UV aging resistance after being aged under strong UV irradiation for 14 days.This work is of great significance to the high-value application of industrial lignin in the field of nano-functional materials. | Lizhu Zhang Yuanyuan Wang Dongjie Yang Huan Wang Weifeng Liu Zhixian Li | 2022 | Green Chemical Engineering2022，3，4： | 0 |
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