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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Probabilistic small signal stability analysis of power system with wind power and photovoltaic power based on probability collocation method显示文摘Recently, with increasing improvements in the penetration of wind power and photovoltaic power in the world, probabilistic small signal stability analysis(PSSSA) of a power system consisting of multiple types of renewable energy has become a key problem. To address this problem, this study proposes a probabilistic collocation method(PCM)-based PSSSA for a power system consisting of wind farms and photovoltaic farms. Compared with the conventional Monte Carlo method, the proposed method meets the accuracy and precision requirements and greatly reduces the computation; therefore, it is suitable for the PSSSA of this power system. Case studies are conducted based on a 4-machine 2-area and New England systems, respectively. The simulation results show that, by reducing synchronous generator output to improve the penetration of renewable energy, the probabilistic small signal stability(PSSS) of the system is enhanced. Conversely, by removing part of the synchronous generators to improve the penetration of renewable energy, the PSSS of the system may be either enhanced or deteriorated. | Cai Yan Linli Zhou Wei Yao Jinyu Wen Shijie Cheng | 2019 | Global Energy Interconnection2019，2，1： | 9 |
| 3 | Economic feasibility of large-scale hydro–solar hybrid power including long distance transmission显示文摘Solar PV is expected to become the most cost-competitive renewable energy owing to the rapidly decreasing cost of the system. On the other hand, hydropower is a high-quality and reliable regulating power source that can be bundled with solar PV to improve the economic feasibility of long-distance transmitted power. In this paper, a quantification model is established taking into account the regulating capacity of the reservoir, the characteristics of solar generation, and cost of hydro and solar PV with long-distance transmission based on the installed capacity ratio of hydro–solar hybrid power. Results indicate that for hydropower stations with high regulating capacity and generation factor of approximately 0.5, a hydro–solar installed capacity ratio of 1:1 will yield overall optimal economic performance, whereas for hydropower stations with daily regulating capacity reservoir and capacity factor of approximately 0.65, the optimal hydro–solar installed capacity ratio is approximately 1:0.3. In addition, the accuracy of the approach used in this study is verified through operation simulation of a hydro–solar hybrid system including ultra high-voltage direct current(UHVDC) transmission using two case studies in Africa. | Zhenchen Deng Jinyu Xiao Shikun Zhang Yuetao Xie Yue Rong Yuanbing Zhou | 2019 | Global Energy Interconnection2019，2，4： | 6 |
| 4 | Acoustic emission characterization methods of damage modes identification on carbon fiber twill weave laminate显示文摘In order to get a deep understanding of composite failure mechanisms, the new advanced signal processing methodologies are established for the analysis of the large number of acoustic emission (AE) data obtained from the quasi-static tension test of carbon fiber twill weave composite. For this purpose, AE signals have been collected and post-processed for tension test, and are analyzed with three signal processing methods: Empirical Mode Decomposition (EMD), Hilbert-Huang Transform (HHT) and modified energy entropy algorithm. AE signals can be decomposed into a set of Intrinsic Mode Functions (IMF) components, results from this study reveal that the peak frequency of IMF components based on Fast Fourier Transform (FFT) corresponds to different damage mechanisms of composite. HHT of AE signals can clearly express the frequency distribution of IMF component in time-scale in different damage stages, and can calculate accurate instantaneous frequency for damage modes recognition. The energy entropy based on EMD is introduced to act as a new relevant descriptor of composite damage modes in order to improve the characterization and the discrimination of the damage mechanisms. | HAN WenQin ZHOU JinYu | 2013 | Science China(Technological Sciences)2013，56，9： | 5 |
| 5 | Small RNA transcriptome investigation based on next-generation sequencing technology显示文摘在过去的十年,有学习小 RNA transcriptome 为理解 transcriptional 规定的复杂性是必要的一条成长认识。与增加的产量和减少的费用,下一代的定序技术提供了一个崭新的机会测量小 RNA transcriptome 的程度和复杂性。同时,大量获得的数据和改变的技术平台也为有效数据分析和采矿提出了多重挑战。提供某卓见进小 RNA transcriptome 调查,这评论描述主要小 RNA 班,识别小 RNA 的试验性的方法,和可得到的生物信息学工具和数据库。 | Linglin Zhou Xueying Li Qi Liu Fangqing Zhao Jinyu Wu | 2011 | Journal of Genetics and Genomics2011，38，11： | 5 |
| 6 | The normal cell proliferation and wound healing effect of polysaccharides from Ganoderma amboinense显示文摘To study the cell proliferation and wound healing activity of polysaccharides from Ganoderma amboinense(GAMPS),the polysaccharide was extracted by water extraction and alcohol precipitation method,and its monosaccharide composition and molecular weight were analyzed.The effects of different concentrations of GAMPS on the cell proliferation were determined by cell survival rate test,and the wound healing ability of GAMPS to NIH/3T3 cells was detected.The preliminary evaluation of the antioxidant ability of GAMPS was conducted by the oxygen radical absorbance capacity(ORAC).The results showed that the GAMPS was composed of glucose,mannose,and galactose at a molar ratio of 67.62:14.07:7.50,and the weightaverage molecular weights were 5.439×10^(6) and 1.704×10^(5) g/mol by using high-performance gel-permeation chromatography-multiple angle laser scatter(HPGPC-MALS)analysis.GAMPS(0.2μg/μL)showed the strongest proliferation ability to THP-1 cells,with cell survival rate of 178.7%.The wound healing effect of GAMPS(0.1μg/μL)was obvious on NIH/3T3 and 3.75μg/μL of GAMPS showed the strongest total antioxidant ability.All the results indicate that GAMPS promotes cell proliferation,and has cell wound healing effect and strong antioxidant activity.The results provide theoretical foundation for the development and utilization of GAMPS. | Shuangzhi Zhao Ming Lei Hui Xu Hailun He Alexander Suvorov Junhua Wang Jiying Qiu Qingxin Zhou Jinyu Yang Leilei Chen | 2021 | Food Science and Human Wellness2021，10，4： | 4 |
| 7 | Genomic landscapes of Chinese sporadic autism spectrum disordersrevealed by whole-genome sequencing显示文摘Autism spectrum disorder (ASD) is a neurodevelopmental disorder with considerable clinical and genetic heterogeneity.In this study,we identified all classes of genomic variants from whole-genome sequencing (WGS) dataset of 32 Chinese trios with ASD,including de novo mutations,inherited variants,copy number variants (CNVs) and genomic structural variants.A higher mutation rate (Poisson test,P<2.2×10^(-16)) in exonic (1.37×10^(-8)) and 3'-UTR regions (1.42×10^(-8)) was revealed in comparison with that of whole genome (1.05×10^(-8)).Using an integrated model,we identified 87 potentially risk genes (P<0.01) from 4832 genes harboring various rare deleterious variants,including CHD8 and NRXN2,implying that the disorders may be in favor to multiple-hit.In particular,frequent rare inherited mutations of several microcephaly-associated genes (ASPM,WDR62,and ZNF335)were found in ASD.In chromosomal structure analyses,we found four de novo CNVs and one de novo chromosomal rearrangement event,including a de novo duplication of UBE3A-containing region at 15q11.2-q13.1,which causes Angelman syndrome and microcephaly,and a disrupted TNR due to de novo chromosomal translocation t (1;5) (q25.1;q33.2).Taken together,our results suggest that abnormalities of centrosomal function and chromatin remodeling of the microcephaly-associated genes may be implicated in pathogenesis of ASD.Adoption of WGS as a new yet efficient technique to illustrate the full genetic spectrum in complex disorders,such as ASD,could provide novel insights into pathogenesis,diagnosis and treatment. | Jinyu Wu Ping Yu Xin Jin Xiu Xu Jinchen Li Zhongshan Li Mingbang Wang Tao Wang Xueli Wu Yi Jiang Wanshi Cai Junpu Mei Qingjie Min Qiong Xu Bingrui Zhou Hui Guo Ping Wang Wenhao Zhou Zhengmao Hu Yingrui Li Tao Cai Yi Wang Kun Xia Yong-Hui Jiang Zhong Sheng Sun | 2018 | Journal of Genetics and Genomics2018，45，10： | 3 |
| 8 | Identification of the Quaternary low gas-saturation reservoirs in the Sanhu area of the Qaidam Basin,China显示文摘低煤气浸透的水库是煤气的忍受其煤气的浸透是不到 47% 的间隔。他们是普通的在在 Qaidam 盆的 Sanhu 区域第四级。由于复杂开始机制和特殊地质的特征,低煤气浸透的水库的记载的曲线被歧义和差异描绘,也就是没有重要木头反应特征。因此,在学习区域识别低煤气浸透的水库是特别地困难的。另外,传统的方法象在岩性学,电的性质,忍受性质的物理性质和气体之中使用关系那样,以及他们的阀值价值,不能有效地识别低 gassaturation 水库。解决这个问题,我们采用决定树,支持向量机器和建立低煤气浸透的水库的一个预兆的模型的不平的集合方法,它能够分类多维、模糊的数据的一个团。根据学习过程和学习结果的可理解性的透明性,预兆的模型被吸收实际水库特征也修订。实际应用显示预兆的模型在在学习区域识别低煤气浸透的水库是有效的。 | Li Xiongyan Li Hongqi Zhou Jinyu He Xu Chen Yihan Yu Hongyan | 2011 | Petroleum Science2011，8，1： | 2 |
| 9 | Implantable blood clot loaded with BMP-2 for regulation of osteoimmunology and enhancement of bone repair显示文摘The treatment of large-area bone defects still faces many difficulties and challenges.Here,we developed a blood clot delivery platform loaded with BMP-2 protein(BMP-2@BC)for enhanced bone regeneration.Blood clot gel platform as natural biomaterials can be engineered from autologous blood.Once implanted into the large bone defect site,it can be used for BMP-2 local delivery,as well as modulating osteoimmunology by recruiting a great number of macrophages and regulating their polarization at different stages.Moreover,due to the deep-red color of blood clot gel,mild localized hyperthermia under laser irradiation further accelerated bone repair and regeneration.We find that the immune niche within the bone defect microenvironment can be modulated in a controllable manner by the blood clots implantation and laser treatment.We further demonstrate that the newly formed bone covered almost 95%of the skull defect area by our strategy in both mice and rat disease models.Due to the great biocompatibility,photothermal potential,and osteoimmunomodulation capacity,such technology shows great promise to be used in further clinical translation. | Qin Fan Jinyu Bai Huajian Shan Ziying Fei Hao Chen Jialu Xu Qingle Ma Xiaozhong Zhou Chao Wang | 2021 | Bioactive Materials2021，6，11： | 2 |
| 10 | CRM1 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas显示文摘 | Fang Zhou Wensheng Qiu Ruyong Yao Jinyu Xiang Xiaoxiao Sun Shihai Liu Jing Lv Lu Yue | 2013 | Medical Oncology2013，，4： | 1 |
| 11 | System-level load-strength interference based reliability modeling of k-out-of-n system 显示文摘 | XIE Liyang ZHOU Jinyu HAO Changzhong | 2004 | Reliability Engineering and System Safety2004，84，： | 1 |
| 12 | System -level Load strength Interference Based Reliability Modeling of k-out-of-n System显示文摘 | Xie Liyang Zhou Jinyu Hao Changzhong | 2004 | Reliability Engineering and System Safety2004，84，： | 1 |
| 13 | Rationalizing the impact of oxygen vacancy on polysulfide conversion kinetics for highly efficient lithium-sulfur batteries显示文摘The“shuttle effect”of lithium polysulfides(LiPSs)is a huge challenge for practical use of high-energydensity lithium-sulfur(Li-S)batteries,and one of the main reasons is the sluggish kinetics of sulfur conversion.Metal oxides are able to expedite the sulfur electrochemistry,and the structural defects enhance the adsorption-conversion ability of metal oxides for polysulfides.However,a significant research gap still remains regarding the relationship between the oxygen vacancy concentration and the adsorptivecatalytic performance of metal oxides.Herein,we establish a correlation between oxygen vacancy concentration and adsorptive-catalytic properties by using tungsten oxide(WO_(x))as model catalysts.It is revealed that high-concentration oxygen vacancy is beneficial for enhancing the binding between tungsten oxide and LiPSs,reducing the energy barrier of Li_(2)S decomposition,and promoting polysulfide conversion kinetics.Consequently,the Li-S batteries using the tungsten oxide with high-concentration oxygen vacancies deliver high initial discharge capacity of 1169 mA h g^(-1)at 0.2 C and 865 mA h g^(-1)at 2 C,low attenuation rate of 0.064%per cycle over 1100 cycles at 2 C.With a high sulfur area loading of 5.34 mg cm^(-2),the Li-S batteries still exhibit high initial gravimetric capacity of 982 mA h g^(-1)at 0.1 C and areal capacity of 5.92 mA h cm^(-2).This work promotes the feasibility of defect engineering on metal oxides as an effective mean to enhance the practicality of Li-S batteries. | Ya Song Huan Li Junfeng Li Jinyu An Jiao-Jing Shao Guangmin Zhou | 2023 | Journal of Energy Chemistry2023，，12： | 1 |
| 14 | System-level loadstrength interference based reliability modeling of k-out-of-n system 显示文摘 | Xie Liyang Zhou Jinyu Hao Changzhong | 2004 | Reliability Engineering and System Safety2004，84，： | 1 |
| 15 | System-level load strength interference based reliability modeling of k-out-of-n system 显示文摘 | Xie Liyang Zhou Jinyu Hao Changzhong | 2004 | Reliability Engineering and System Safety2004，84，： | 1 |
| 16 | System-level load-strength interference based reliability modeling of k-out-of n system显示文摘 | XIE Liyang ZHOU Jinyu HAO Changzhong | 2004 | Reliability Engineering and System Safety2004，84，3： | 1 |
| 17 | Interaction of citrate with Pt(100) surface investigated by cyclic voltammetry towards understanding the structure-tuning effect in nanomaterials synthesis显示文摘This study aims to understand the effects of functional agents such as capping agents, stabilizers, surfactants and additives in shape-controlled synthesis of nanomaterials. The well-defined Pt(100) single crystal surface was used as a model to investigate its interaction with citrate, a capping agent that is often used in shape-controlled synthesis of nanomaterials. It demonstrated that, through a systematic study of electrochemical cyclic voltammetry, the presence of citrate in solution could increase the current peak density of hydrogen adsorption at high potential (j p,L ), while decrease proportionally the current peak density of hydrogen adsorption at low potential (j p,S ). Furthermore, the increase of citrate concentration shifted negatively the peak potentials (E p,L and E p,S ) of both j p,L and j p,S . The results indicated that the interaction of citrate with Pt(100) surface could induce increasing the (100) surface domains of two-dimensional long range order (2D-(100)), and decreasing the (100) surface domains of one-dimensional short range order (1D-(100)). It also revealed that the interaction of citrate with Pt(100) surface could stabilize the 2D-(100) structure. The findings gained in this study implied that the citrate may lead to form stable 2D-(100) domains on Pt nanoparticles upon the shape-controlled synthesis of Pt nanomaterials. | CHEN DeHao YE JinYu XU ChangDeng LI Xin LI JunTao ZHEN ChunHua TIAN Na ZHOU ZhiYou SUN ShiGang | 2012 | Science China Chemistry2012，55，11： | 1 |
| 18 | System level load-strength interference based reliability modeling of k-out-of n system显示文摘 | Xie Liyang Zhou Jinyu Hao Changzhao | | 0，，： | 1 |
| 19 | Systemlevel Load-strength Interference Based Reliability Modeling of k- out - of- n System显示文摘 | Xie Liyang Zhou Jinyu Hao Changzhong | 2004 | Reliability Engineering and System Safety2004，84，： | 1 |
| 20 | Dynamic Modeling and Operations of a Heat-power Station System Based on Renewable Energy显示文摘The coexistence of pollution from coal-fired heating and inefficient utilization of renewable resources in northern China has raised great concern.Current studies on heat-power systems are primarily focused on traditional combined heat and power(CHP)systems and are limited to static energy flow analysis or the dynamic characteristics of a single system component.Hence,it is difficult to make full use of the complementary potential of electrical energy and heat energy.This paper proposes a heat-power station(HPS)system based on renewable energy for the purpose of utilizing the surplus renewable energy to generate heat and meet heating demands.The overall architecture of the HPS system is established and its operational principle and dynamic characteristics of both the electrical and heating components in the system are analyzed and dynamic mathematical models are also presented.In addition,a coordinated electro-thermal control method based on system characteristics is designed to ensure the normal operation of a HPS.Simulation results verify the effectiveness of the model and control in the case of renewables fuctuation and heat load variations. | Zhenxing Li Jianyu Zhou Jinyu Wen Xia Chen | 2022 | CSEE Journal of Power and Energy Systems2022，8，4： | 1 |
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