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| 1 | Aspirin combined with mechanical measures to prevent venous thromboembolism after total knee arthroplasty: a randomized controlled trial显示文摘 | Jiang Yi Du Hui Liu Jian Zhou Yixin | 2014 | Chinese Medical Journal2014，，12： | 22 |
| 2 | Using balance of seasonal herbage supply and demand to inform sustainable grassland management on the Qinghai–Tibetan Plateau显示文摘To mitigate the impacts of grassland degradation on the Qinghai–Tibetan Plateau(QTP), in recent decades China has been implementing large-scale conservation programs and has invested about 42 billion CNY(7 billion USD). However, these programs are faced with major challenges involving trade-offs between ecological function, livestock production and income of pastoralists.Scientific assessments, as well as technical and policy issues, have not fully captured the complex ecological,social and economic dynamics of the challenges facing grassland management on the QTP. Pastoral livestock production on the QTP is characterized by imbalance in both quality and quantity between livestock seasonal nutrient requirements and herbage production, which forces pastoralists to keep larger numbers of livestock for longer periods, leading to overgrazing. To solve these problems, an integrated crop-livestock system is promoted to improve the efficiency of livestock production and conserve natural grassland as well for a sustainable system for the QTP. | Xinquan ZHAO Liang ZHAO Qi LI Huai CHEN Huakun ZHOU Shixiao XU Quanmin DONG Gaolin WU Yixin HE | 2018 | Frontiers of Agricultural Science and Engineering2018，5，1： | 11 |
| 3 | Self-powered macroscopic Brownian motion of spontaneously running liquid metal motors显示文摘We disclosed the interiorly driven macroscopic Brownian motion behavior of self-powered liquid metal motors. Such tiny motors in millimeter scale move randomly at a velocity magnitude of centimeters per second in aqueous alkaline solution, well resembling the classical Brownian motion. However, unlike the existing phenomena, where the particle motions were caused by collisions from the surrounding molecules, the current random liquid metal motions are internally enabled and self-powered,along with the colliding among neighboring motors, the substrate and the surrounding electrolyte molecules.Through uniformly dissolving only 1 %(mass percentage)Al into Ga In10, many tiny motors can be quickly fabricated and activated to take the Brownian-like random motions. Further, we introduced an experimental approach of using optical image contrast, which works just like the Wilson cloud chamber, to distinctively indicate the motor trajectory resulted from the generated hydrogen gas stream.A series of unusual complicated multi-phase fluid mechanics phenomena were observed. It was also identified that the main driving factor of the motors comes fromthe H2 bubbles generated at the bottom of these tiny motors, which is different from the large size self-fueled liquid metal machine. Several typical mechanisms for such unconventional Brownian-like motion phenomena were preliminarily interpreted. | Bin Yuan Sicong Tan Yixin Zhou Jing Liu | 2015 | Science Bulletin2015，60，13： | 8 |
| 4 | Radial propagation of magnetospheric substorm-injected energetic electrons observed using a BD-IES instrument and Van Allen Probes显示文摘In cases where substorm injections can be observed simultaneously by multiple spacecraft,they can help elucidate the potential mechanisms of particle transport and energization,of great importance to understanding and modeling the magnetosphere.In this paper,using data returned from the BeiDa-IES(BD-IES) instrument onboard a satellite in an inclined(55°) geosynchronous orbit(IGSO),in combination with two geo-transfer orbiting(GTO) satellite Van Allen Probes(A and B),we analyze a substorm injection event that occurred on the 16 th of October 2015.During this substorm injection,the IGSO onboard BD-IES was outbound,while both Van Allen Probe satellites(A and B) were inbound,a configuration of multiple trajectories that provides a unique opportunity to simultaneously investigate both the inward and outward radial propagation of substorm injection.Indicated by AE/AL indices,this substorm was closely related to an IMF/solar wind discontinuity that showed a sharp change in IMF Bz direction to the north.The innermost signature of this substorm injection was detected by Van Allen Probes A and B at L-3.7,while the outermost signature was observed by the onboard BD-IES instrument at L~\0.These data indicate that the substorm had a global,rather than just local,effect.Finally,we suggest that electric fields carried by fast-mode compressional waves around the substorm injection are the most likely candidate mechanism for the electron injection signatures observed in the inner- and outermost inner magnetosphere. | ZONG QiuGang HAO YiXin ZOU Hong FU SuiYan ZHOU XuZhi REN Jie WANG LingHua YUAN ChongJing LIU ZhiYang JIA XiangHong QUAN Lin LIU Ying WANG YongFu | 2016 | Science China Earth Sciences2016，59，7： | 8 |
| 5 | Quantile residual lifetime for left-truncated and right-censored data显示文摘This article proposes a simple nonparametric estimator of quantile residual lifetime function under left-truncated and right-censored data. The asymptotic consistency and normality of this estimator are proved and the variance expression is calculated. Two bootstrap procedures are employed in the simulation study,where the latter bootstrap from Zeng and Lin(2008) is 4000 times faster than the former naive one, and the numerical results in both methods show that our estimating approach works well. A real data example is used to illustrate its application. | WANG YiXin LIU Peng ZHOU Yong | 2015 | Science China Mathematics2015，58，6： | 7 |
| 6 | Electrically driven chip cooling device using hybrid coolants of liquid metal and aqueous solution显示文摘Heat dissipation of electronic devices keeps as a tough issue for decades. As the most classical coolant in a convective heat transfer process, water has been widely adopted which however inherits with limited thermal conductivity and relies heavily on mechanical pump. As an alternative, the room temperature liquid metal was increasingly emerging as an important coolant to realize much stronger enhanced heat transfer. However, its thermal capacity is somewhat lower than that of water, which may restrict the overall cooling performance. In addition, the high cost by taking too much amount of liquid metal into the device also turns out to be a big concern for practical purpose. Here, through combining the individual merits from both the liquid metal with high conductivity and water with large heat capacity, we proposed and demonstrated a new conceptual cooling device that integrated hybrid coolants, radiator and annular channel together for chip thermal management. Particularly, the electrically induced actuation effect of liquid metal was introduced as the only flow driving strategy, which significantly simplified the whole system design. This enables the liquid metal sphere and its surrounding aqueous solution to be quickly accelerated to a large speed under only a very low electric voltage. Further experiments demonstrated that the cooling device could effectively maintain the temperature of a hotpot(3.15 W/cm^2) below 55oC with an extremely small power consumption rate(0.8 W). Several situations to simulate the practical working of the device were experimentally explored and a theoretical thermal resistance model was established to evaluate its heat transfer performance. The present work suggests an important way to make highly compact chip cooling device, which can be flexibly extended into a wide variety of engineering areas. | TAN SiCong ZHOU YiXin WANG Lei LIU Jing | 2016 | Science China(Technological Sciences)2016，59，2： | 7 |
| 7 | Ultralow frequency wave characteristics extracted from particle data:Application of IGSO observations显示文摘3 Summary and discussion In the generalized drift resonance theory[17],a characteristic signature of the ULF wave-particle interactions is the increasingly-tilted stripes in the particle energy spectrum.The phase difference across different energy channels is relatively | LI Li ZHOU XuZhi ZONG QiuGang CHEN XingRan ZOU Hong REN Jie HAO YiXin ZHANG XianGuo | 2017 | Science China(Technological Sciences)2017，60，3： | 6 |
| 8 | Imaging energetic electron spectrometer onboard a Chinese navigation satellite in the inclined GEO orbit显示文摘The energetic electron measurement is one of the most important issues to understand dynamics in space physics and the applications for space weather. In this study, the principle and functional components of the imaging energetic electron spectrometer(IES) onboard a Chinese navigation satellite in the inclined GEO orbit(IGSO) was introduced. The IES instrument is developed by the team in Peking University(BeiDa), thus it is named as BD-IES. Based on the pin-hole technique, the instrument can measure 50–600 keV electrons incident from 9 directions over a range of 180° in polar angle. With pulse height analysis(PHA), the spectrum can be determined for each direction. The energy and angular calibrations were performed, which show the good energy and angular characteristics of BD-IES. Monte Carlo simulations show that the anti-proton design of BDIES can effectively decrease the proton contamination on the electron measurements in the inclined GEO orbit. The primary results of BD-IES verify the successful design of this instrument. | ZOU Hong YE YuGuang ZONG QiuGang CHEN HongFei ZOU JiQing CHEN Jiang SHI WeiHong YU XiangQian ZHONG WeiYing WANG YongFu ZHOU XuZhi HAO YiXin CHEN XingRan JIA XiangHong XU Feng SHAO SiPei WANG Bo HAO XiaoYun ZHANG XiaoXin | 2018 | Science China(Technological Sciences)2018，61，12： | 5 |
| 9 | The modified bilobed flap for reconstructing sacral decubitus ulcers显示文摘Background:Sacral pressure ulcers are associated with high morbidity and,in some cases,result in mortality from severe sepsis.Local flaps are frequently used for reconstruction of stage III and IV pressure ulcers.An ideal flap should be simple to design,have a reliable vascular supply and minimal donor site morbidity.Our study evaluates the use of a bilobed flap based on the superficial branch of the superior gluteal artery or the posterior branch of the fourth lumbar artery to reconstruct the sacral pressure ulcer.Case presentation:We performed a retrospective analysis of paraplegic patients with sacral pressure ulcers treated with our bilobed flaps from January 2015 to December 2019.A description of our management,operative protocol,outcome and complications is outlined.Seven paraplegic patients(6 male,1 female;average age 53.1 years)with sacral pressure ulcers were treated with our bilobed flap based on the superficial branch of the superior gluteal artery or the posterior branch of the fourth lumbar artery.The average size of the pressure ulcers was 7×5 cm(range 6.2×4.5 cm to 11×10 cm).All 7 flaps survived.The patients were followed up for 12 months without significant complications,such as flap necrosis or recurrence.Conclusions:The superficial branch of the superior gluteal artery or the posterior branch of the fourth lumbar artery reliably supplies the bilobed flap.The superior cluneal nerve can be included in the design.The technique is simple and reliable.It should be included in the reconstructive algorithm for the management of sacral pressure ulcers. | Xiangong Jiao Chunxiao Cui Sally Kiu-Huen Ng Zhangjia Jiang Chihui Tu Jiemin Zhou Xiandong Lu Xianwen Ouyang Tong Luo Ke Li Yixin Zhang | 2020 | Burns & Trauma2020，8，1： | 4 |
| 10 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet . 2013 (9882)2013，，9882： | 4 |
| 11 | Incidence and prevalence of moyamoya disease in urban China: a nationwide retrospective cohort study显示文摘Background and objective Moyamoya disease(MMD)is an increasingly recognised cause of stroke,mainly described in East Asia.China is the largest nation in Asia,but few studies reported the epidemiology of MMD,especially at a national level.We aimed to estimate the incidence and prevalence of MMD in China.Methods We performed a population-based study using data from the national databases of Urban Basic Medical Insurance between 2013 and 2016,covering approximately 0.50 billion individuals.MMD cases were identified by diagnostic code(International Classification of Diseases,10th Revision I67.5)or related diagnostic text.Results A total of 1987 MMD patients(mean age 44.45±14.30 years,female-to male ratio 1.12)were identified,representing a national crude incidence of 0.59(95%CI:0.49 to 0.68)and a prevalence of 1.01(95%CI:0.81 to 1.21)per 100000 person-years in 2016.Rates were higher in females than in males for the incidence(0.66 vs 0.52)and prevalence(1.05 vs 0.90).And the age-specific rates showed a bimodal distribution,with the highest peak in middle-aged group and the second peak in child group.Conclusions Our results confirm that MMD is relatively common in East Asians,but the rates in China were lower than those in other East Asian countries such as Japan and Korea.The unique epidemiological features,including a relatively weak female predominance and a shift in the highest peak of incidence from children to adults,revealed new sight into MMD.Further research is expected to explore the potential pathogenesis of MMD. | Yixin Sun Guoyu Zhou Jingnan Feng Lu Chen Guozhen Liu Jinxi Wang Qingliang Wang Junyou Yu Xiwang Yang Zheng Yang Pei Gao Shengfeng Wang Siyan Zhan | 2021 | Stroke & Vascular Neurology2021，6，4： | 4 |
| 12 | Monte Carlo simulations of the sensor head of imaging energetic electron spectrometer onboard a Chinese IGSO navigation satellite显示文摘An imaging energetic electron spectrometer built by the Peking University team(BD-IES) onboard a Chinese navigation satellite in an inclined GEO orbit has been launched successfully in September 2015, which measures the spectra of the energetic electrons with the energy range of 50–600 keV in nine directions. In this study, Monte Carlo simulations of the BD-IES sensor head were performed using Geant4 and the corresponding characteristic responses to the isotropic energetic particles were derived. The effective geometric factors were estimated using the typical electron and proton spectra in the GEO orbit and the corresponding simulated sensor head responses. It was found that the average effective geometric factors of nine directions are close to the nominal geometric factors calculated with the traditional method, but the effective geometric factor decreases as the center energy of the energy channel decreases. The BD-IES sensor head also responses to the energetic protons, but the average contamination rate of all 72 channels is about 2%, which means that the proton contamination is acceptable. The spectra of the energetic electrons measured by BD-IES are derived using the effective geometric factors of the sensor head and are comparable with the spectra measured by the magnetic electron ion spectrometer(MagEIS) instrument onboard Van Allen Probes. | ZOU Hong YE YuGuang ZONG QiuGang CHEN HongFei LUO Lin ZHOU XuZhi CHEN XingRan HAO YiXin REN Jie WANG YongFu SHI WeiHong YU XiangQian JIA XiangHong XU Feng ZHANG XiaoXin | 2019 | Science China(Technological Sciences)2019，62，7： | 3 |
| 13 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet2013，，9882： | 3 |
| 14 | Ecological principle meets cancer treatment: treating children with acute myeloid leukemia with low-dose chemotherapy显示文摘Standard chemotherapy regimens for remission induction of pediatric acute myeloid leukemia(AML) are associated with significant morbidity and mortality. We performed a cohort study to determine the impact of reducing the intensity of remission induction chemotherapy on the outcomes of selected children with AML treated with a low-dose induction regimen plus granulocyte colony stimulating factor(G-CSF)(low-dose chemotherapy(LDC)/G-CSF). Complete response(CR) after two induction courses was attained in 87.0%(40/46) of patients receiving LDC/G-CSF. Post-remission therapy was offered to all patients, and included standard consolidation and/or stem cell transplantation. During the study period, an additional 94 consecutive children with AML treated with standard chemotherapy(SDC) for induction(80/94(85.1%) of the patients attained CR after induction Ⅱ, P = 0.953) and post-remission. In this non-randomized study, there were no significant differences in 4-year event-free(67.4 vs. 70.7%;P = 0.99)and overall(70.3 vs. 74.6%, P = 0.69) survival in the LDC/G-CSF and SDC cohorts, respectively. After the first course of induction, recovery of white blood cell(WBC) and platelet counts were significantly faster in patients receiving LDC/G-CSF than in those receiving SDC(11.5 vs. 18.5 d for WBCs(P < 0.001);15.5 vs. 22.0 d for platelets(P < 0.001)). To examine the quality of molecular response, targeted deep sequencing was performed. Of 137 mutations detected at diagnosis in 20 children who attained hematological CR after two courses of LDC/G-CSF(n = 9) or SDC(n = 11), all of the mutations were below the reference value(variant allelic frequency <2.5%) after two courses, irrespective of the treatment group. In conclusion, children with AML receiving LDC/G-CSF appear to have similar outcomes and mutation clearance levels, but significantly lower toxicity than those receiving SDC. Thus, LDC/G-CSF should be further evaluated as an effective alternative to remission induction in pediatric AML. | Yixin Hu Aili Chen Xinchang Zheng Jun Lu Hailong He Jin Yang Ya Zhang Pinpin Sui Jingyi Yang Fuhong He Yi Wang Peifang Xiao Xin Liu Yinmei Zhou Deqing Pei Cheng Cheng Raul C. Ribeiro Shaoyan Hu Qian-fei Wang | 2019 | National Science Review2019，6，3： | 3 |
| 15 | Fuzzy-Immune PID Control for AMB Systems显示文摘In order to improve the dynamic performance of active magnetic bearing systems with highly nonlinear and naturally unstable dynamics, a new nonlinear fuzzy-immune proportional-integral-derivative (PID) controller is proposed by combining the immune feedback law with linear PID control. This controller consists of a PID controller and a basic immune proportional controller in cascaded connection, the nonlinear function of the immune proportional controller is realized by using fuzzy reasoning. Simulation results demonstrate that the active magnetic bearing system with the proposed controller has better dynamic performance and disturbance rejection ability than using the linear PID controller. | SU Yixin LI Xuan ZHOU Zude CHEN Youping ZHANG Danhong | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 3 |
| 16 | Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster显示文摘Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness.To experimentally demonstrate the epidemiological results,we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2.Remarkably,high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss,weakness,piloerection,hunched back and abdominal respiration,as well as severe pneumonia,pulmonary edema,consolidation,and fibrosis.In contrast with the males,the female hamsters showed much lower shedding viral titers,moderate symptoms,and relatively mild lung pathogenesis.The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender. | Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Yao Chen Liqiang Chen Kun Wu Minping Cai Junping Hong Lifeng Li Che Liu Huan Yu Yali Zhang Jia Wang Tianying Zhang Shengxiang Ge Jun Zhang Quan Yuan Yixin Chen Qiyi Tang Honglin Chen Tong Cheng Yi Guan Ningshao Xia | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 17 | Tectonic and Hydrocarbon Accumulation Elements Characteristics of the Tethyan Realm in South China显示文摘The evolution of the global Tethys Sea can be classified into three stages, Proto-Tethys, Paleo-Tethys and Neo-Tethys. The Tethyan realm has distinctive features of zonations and segmentations along north-south and east-west, respectively, and has variable richness in oil and gas. The petroleum geological conditions of Tethys are complicated, partly represented by multi-layer of source and seal rocks, and reservoirs. The hydrocarbon accumulation elements and periods of the Tethyan realm show gradually younger from west to east and north to south. South China is located in the north belt and Yangtze segment of the Tethyan realm, and its polycyclic tectonic movements were governed by the Tethyan and Pacific realms. The blocks in South China rotated clockwise and counter-clockwise during their drift northward from Gondwana. The belts and segmentations of Tethys in South China are also clear, with six tectonic belts including: Chuxiong-Sichuan; middle Guizhou-Hunan-Hubei; lower Yangtze; Xuefeng-Jiangnan; Guangxi-Hunan-Jiangxi; and Cathaysia. Numerous faults, including compressional, compressional-shear, extensional, extensional-shear and shear are well developed in South China. The fault strikes are mainly NE, NW and NS, in which the NE is the dominant direction. Lower, middle and upper hydrocarbon assemblages, respectively corresponding to Proto-, Paleo- and Neo-Tethys, formed in the Tethyan realm of South China with the lower and middle having excellent hydrocarbon accumulation conditions. An integrated analysis of tectonic evolution, superimposed deformation and later hydrocarbon preservation shows that during the Neo-Tethyan stage in South China, continental sediments were deposited and experienced intense tectonic deformation, which had resulted in different hydrocarbon pool-forming features from those of the Neo-Tethyan realm. | YU Yixin TANG Liangjie YIN Jinyin DONG Li WANG Pengwan ZHOU Yan | 2009 | Acta Geologica Sinica(English Edition)2009，83，6： | 3 |
| 18 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | 2013 (9882)2013，，9882： | 3 |
| 19 | Review on observational studies of western tropical Pacific Ocean circulation and climate显示文摘The Western Tropical Pacific(WTP) Ocean holds the largest area of warm water(>28℃) in the world ocean referred to as the Western Pacific Warm Pool(WPWP),which modulates the regional and global climate through strong atmospheric convection and its variability.The WTP is unique in terms of its complex 3-D ocean circulation system and intensive multiscale variability,making it crucial in the water and energy cycle of the global ocean.Great advances have been made in understanding the complexity of the WTP ocean circulation and associated climate impact by the international scientific community since the 1960 s through field experiments.In this study,we review the evolving insight to the 3-D structure and multi-scale variability of the ocean circulation in the WTP and their climatic impacts based on in-situ ocean observations in the past decades,with emphasis on the achievements since 2000.The challenges and open que stions remaining are reviewed as well as future plan for international study of the WTP ocean circulation and climate. | HU Dunxin WANG Fan SPRINTALL Janet WU Lixin RISER Stephen CRAVATTE Sophie GORDON Arnold ZHANG Linlin CHEN Dake ZHOU Hui ANDO Kentaro WANG Jianing LEE Jae-Hak HU Shijian WANG Jing ZHANG Dongxiao FENG Junqiao LIU Lingling VILLANOY Cesar KALUWIN Chalapan QU Tangdong MA Yixin | 2020 | Journal of Oceanology and Limnology2020，38，4： | 3 |
| 20 | A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases显示文摘Cross-kingdom herbal mi RNA was first reported in 2012.Using a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique sequences.We constructed a Bencao(herbal)small RNA(s RNA)Atlas(http://bencao.bmicc.cn),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s RNAs.The profiles of 21,757 mi RNAs in the Atlas were highly consistent with those of plant mi RNAs in mi RBase.Using software tools,our results demonstrated that all human genes might be regulated by s RNAs from the Bencao s RNA Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s RNAs might be one of the main bioactive components of herbal medicines.We established roadmaps for oligonucleotide drugs development and optimization of TCM prescriptions.Moreover,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical effects.We propose a Bencao(herbal)Index,including small-molecule compounds(SM),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(LM)and elements from Mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic medicine.The Bencao s RNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine. | Yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song Mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan Zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song Fengming Huang Xiaoyue Wang Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 2 |
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