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| 1 | Asymptotic behavior of the shock solution for a class of nonlinear equations显示文摘The high precision approximation of the shock solution for a class of nonlinear problems is obtained using a simple method. | MOJiaqi ZHUJiang WANGHui | 2003 | Progress in Natural Science:Materials International2003，13，10： | 141 |
| 2 | Inhibitory effect of IGF-Ⅱ antisense RNA on malignant phenotype of hepatocellular carcinoma显示文摘INIRODUCTIONAccording to the therapeutic effect and strategy ofantisense RNA for hepatoccllular carcinoma(HCC),we have specifically synthesized partialcDNA of human insulin-like growth factor Ⅱ(IGF-Ⅱ)and constructed IGF-Ⅱ cDNA antisenseeukaryotic expression vector.The constructedvector was introduced into hepatoma cell lineSMMC-7721 to block the intrinsic IGF-Ⅱexpression.The biological behavior changes ofhepatoma cells were observed.All these | Dong Hua Yang Ming Qing Zhang Jiang Du Chong Xu Oiao Ming Liang Ji Fang Mao Han Rong Qin Zi Rong Fan Department of Gastroenterology,Zhujiang Hospital,the First Military Medical University,Guangzhou 510282,China Laboratory of Molecular Biology,Zhujiang Hospital,the First Military Medical University,Guangzhou,China Departrnent of Biochemistry,the Second Military Medical University,Shanghai,China | 2000 | World Journal of Gastroenterology2000，6，2： | 54 |
| 3 | Evaluation of diffusion weighted imaging of magnetic resonance imaging in small focal hepatic lesions:a quantitative study in 56 cases显示文摘Diffusion-weighted imaging (DWI) as a new technique of magnetic resonance imaging (MRI) is used to detect focal hepatic lesions. This study was designed to evaluate the significance of DWI to differentiate focal hepatic lesions less than 3 cm in diameter by the quantitation of apparent diffusion coefficient (ADC) values. METHODS:DWI using 1.5T MRI scanner unit was performed with a spin-echo single-shot echo planar imaging (EPI) in 56 cases of small focal hepatic lesions, including hepatocellular carcinoma (11), hepatic metastatic tumor (15 ), hepatic cavernous hemangioma (14), and hepatic cyst (16).The ADC values of these lesions were calculated respectively. The ratios of the ADC values of lesion/liver in hepatocellular carcinomas and hepatic metastatic tumors were also estimated. RESULTS:The mean ADC values (mm2/s) were (0.93±0.06) ×10-3 in hepatocellular carcinomas, (1.09±0.18)×10-3 in hepatic metastatic tumors,(1.95±0.38)×10-3 in hepatic cavernous hemangiomas, and (3.18±0.33) ×10-3 in hepatic cysts. The ratios of ADC values of lesion/liver were 0.90±0.06 and 1.15±0.14 in hepatocellular carcinoma and hepatic metastatic tumors respectively, which were significantly different (P<0.05). CONCLUSION:The measurement of ADC values and the ratios of ADC values of lesion/liver are helpful in MR diagnosis and differentiation of focal hepatic lesions. | Xian-Yue Quan, Xi-Jie Sun, Zhi-Jian Yu and Ming Tang Imaging Center, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 39 |
| 4 | A variational iteration method for studying the ENSO mechanism显示文摘 | MOJiaqi LINWantao ZHUJiang | 2004 | Progress in Natural Science:Materials International2004，14，12： | 36 |
| 5 | The perturbed solution of sea-air oscillator for ENSO model显示文摘A class of delayed oscillators and coupled systems to oscillation of El Nio-Southern Oscillation (ENSO) models are considered. Using the perturbed theory and other methods,the exact solution or asymptotic expansions of the solution for ENSO models is obtained and the asymptotic behavior of solution of corresponding problem is studied. | MOJiaqi LINWantao ZHUJiang | 2004 | Progress in Natural Science:Materials International2004，14，6： | 38 |
| 6 | 现代土力学的基本问题显示文摘现代土力学可望在今后30年内建成基本框架,其主要内容将包括新一代的本构模型及一个变形理论和两个破坏理论.本文介绍了作者对这些问题的今后研究重点及发展方向的一些看法. | SHEN Zhujiang (Nanjing Hydraulic Research Institute, Nanjing \ 210024, China) | 1998 | 力学与实践1998，20，6： | 32 |
| 7 | Expression of insulin-like growth factor Ⅱ and its receptor in hepatocellular carcinogenesis显示文摘INTRODUCTIONInsulin-like growth factor Ⅱ(IGF-Ⅱ) is a mitogenic peptide of 74 kD and is mostly synthesized in fetal liver tissue .IGF-Ⅱ is believed to play an important role in fetal growth and development and is involved in cellular proliferation and differentiation[1-5]. Recently ,several researchers have reported increased expression of the IGF-Ⅱgene in human hepatocellular carcinoma (HCC) and adjacent non-cancerous liver tissues [6-10]. | Zi Rong Fan Dong Hua Yang Jun Cui Han Rong Qin Chun Chi Huang Department of Gastroenterology, Zhujiang Hospital. The First Military Medical University, Guangzhou 510282.Guangdong Province. China | 2001 | World Journal of Gastroenterology2001，7，2： | 24 |
| 8 | Methylation status of c-fms oncogene in HCC and its relationship with clinical pathology显示文摘INTRODUCTIONThe mechanism that DNA hypomethylation leads toactivation of oncogene and occurrence of malignantneoplasm is being increasingly recognized byresearchers. Normal DNA methylation playsimportant role in stabilizing the phenotype of cell.DNA methylation status reduction and/or patternalteration are related to activation and abnormallyhigh expression of some oncogenes and cellularmalignancy[1-6]. c-fms oncogene encodes for colonystimulating factor 1 receptor (CSF-1R)[7], c-fms/CSF-1R was highly expressed in hepatocellularcarcinoma (HCC) tissue, but the mechanismremained obscure[8,9]. | Jun Cui Dong Hua Yang Xiang Jun Bi Zi Rong Fan Department of Gastroenterology, Zhujiang Hospital, The First Military Medical University, Guangzhou 510282, Guangdong Province, China | 2001 | World Journal of Gastroenterology2001，7，1： | 16 |
| 9 | Gastrin,somatostatin,G and D cells of gastric ulcer in rats显示文摘AIM: To investigate the relationship among gastrin,somatostatin, G and D calls in gastric ulcer and in its healing process in rats.METHODS: Fourty-nine Wistar rats were divided into 7groups. The gastric ulcer model was induced by acetic acid successfully. The gastrin and the somatostatin in rat plasma, gastric fluid and antral tissue were measured by radioimmunoassay(RIA). G and D cells in antral mucosa were analyzed with polyclonal antibody of gastrin and somatostatin by immunohistochemical method and Quantimet 500 image analysis systemRESULTS: In gastric ulcer, the level of gastrin in plasma,gastric fluid, and antral tissue increased, that ofsomatostatin declined, and the disorder gradually recoveredto the normal level in the healing process.Immunohistochemical technique of G and D cells in antralmucosa demonstrated that the number of G cells increasedand that of D cells decreased, both areas of G and D cellsdeclined, the ratio of number and area of G/D increased ingastric ulcer, and the disorder gradually recovered in thehealing process.CONCLUSION: In gastric ulcer, the increased gastrinsecreted by G cells, the declined somatostatin secreted by Dcells, and the disordered G/D cell ratio can lead togastrointestinal dysfunction. | Feng-Peng Sun Yu-Gang Song Wei Cheng Tong Zhao Yong-Li Yao,Department of Gastroenterology,Zhujiang Hospital,First Military Medical University,Guangzhou 510282,Guangdong Province,China | 2002 | World Journal of Gastroenterology2002，8，2： | 14 |
| 10 | 脑损伤早期神经细胞c-fos基因表达变化与脑水肿显示文摘采用免疫细胞化学方法(ABC)研究大鼠脑损伤早期神经细胞c-fos基因表达变化,探讨脑损伤时神经细胞c-fos基因表达变化与脑水肿的关系。结果发现,脑损伤后仅0.5h,脑损伤区周围神经细胞中c-fos基因表达已明显,伤后3~6h更为显著。同时伴有相应部位脑灰质及脑白质水含量增加。初步研究结果提示,脑损伤早期神经细胞c-fos基因表达变化与脑水肿的发生有密切关系。 | Xu Ruxiang Chen Changcai Yuan Guanqian (Zhujiang Hospital, First Military Medical University ,Guangzhou 510282) | 1995 | 解放军医学杂志1995，20，2： | 11 |
| 11 | The expression of c-kit and proliferating cell nuclear antigen in oval cells of rats with hepatocellular carcinoma显示文摘OBJECTIVE: To study the relationship between oval cells and primary hepatocarcinoma and theexpression of c-kit and proliferating cell nuclear antigen (PCNA) in oval cells of rats with hepatocellularcarcinoma.METHODS: A hundred and twenty clean SD rats were divided into three groups: normal group,cancer-induction group and intervention group. The normal group was fed with standard forage while therest two groups were fed with 3’-methyl-2-methylamino-azobenzene (DAB) to induce carcinoma for 14weeks and then fed with standard forage and water. Uscharidin was injected abdominally to theintervention group from the first week to the 14th week. All rats were killed and biopsy specimens weretaken from the left and right liver lobes for immunohistochemical staining of c-kit and PCNA on the 2nd,4th, 6th, 8th, 10th, 12th, 14th, 16th, 18th, 20th, 22nd, and 24th week.RESULTS: From the 2nd to 14th week after liver infection, c-kit positive cells, mainly oval cells werefound in the portal area in the carcinoma-induction group and dotted positive pigmentations in liverlobules. In the 22nd week, a large number of cancerous nodes occurred and nuclei heteromorphi-m wasapparent; the number of positive cell decreased but positive cells could be sparsely observed in cancerousnodes. In the 2nd week of the carcinoma-induction process, PCNA positive cells were oval cells in theportal area. In the 4th week, a lot of hepatic cells were positively stained, especially in the central veinarea. In the 6th week, PCNA positive cells could be seen in the lobules of the liver. In the 8th week, thenumber of PCNA cells decreased comparatively. From the 10th to 14th week, oval cells in the portal areawere still over-expressed. From the 16th to 24th week, a large number of cancerous nodes occurred andPCNA was over-expressed in some of them. In necrotic cancerous nodes, the para-cancerous PCNApositive cells were sparsely distributed and their number was less than that of PCNA positive cells ofcancerous tissues.CONCLUSIONS: Hepatic stem cells originating from the terminal biliary plexus of the portal area areinvolved in the development of hepatocarcinoma because c-kit positive cells expressed in cancerousnodes, accompany the whole process of the development. In the middle inflammatory period ofcarcinoma-induction, the expression of PCNA in hepatic cells peaked, but the index decreased in the lateinflammatory period and in the proliferated fibrosis stage. The expression of PCNA is a tortuous process,going up, down, then up again from normal tissues to cancerous tissues. Combined with pathologicalfindings, PCNA can be considered as a warning index for carcinomatous cells. | Chi-Hua Fang Wei Zhang Xin-Yong Zhu Jia-Qing Gong Gang-Qing Zhang the Department of Hepatobiliary Surgery, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China | 2003 | Hepatobiliary & Pancreatic Diseases International2003，2，4： | 7 |
| 12 | Angiogenesis inhibitor TNP-470 suppresses growth of peritoneal disseminating foci of human colon cancer line Lovo显示文摘AIM: To study the effect of angiogenesis inhibitor TNP-470on peritoneal dissemination of colon cancer in nude mice,METHODS: The MTT assay was used to evaluate theinhibitory effect of TNP-470 on human colon cancer cell lineLovo. Lovo cells were injected into the peritoneal cavity ofBABL/C nu/nu mice and the models of peritonealdissemination were developed. Thirty nude mice wererandomly divided into control and TNP-470-treated group.In TNP-470-treated group, TNP-470 was injectedsubcutaneously every other day from day 1 until sacrifice ordeath (30 mg.kg-1). The control group received a shaminjection of the same volume saline solutionRESULTS: In vltro, TNP-470 inhibited the growth of Lovocells, with its IC50 at 2.14x102μg.L-1 In vivo, TNP-470demonstrated growth inhibition of tumors. Mice body weightand abdominal circumferences were significantly differentbetween TNP-470-treated group (24.5±3.2 g, 7.0±1.1 cm)and control group (29.5±2.1 g, 10.3±1.5 cm), P=0.005 andP=0.001. The number of disseminated foci was significantlydifferent between the control group (92.1±20.6) and theTNP-470-treated group (40.3±12.3), P<0.001. The maximalsize of foci was significantly smaller in TNP-470-treated group(3.3±0.7 mm) than that of control (7.3±2.3 mm), P=0.004.Mean survival time was significantly longer in TNP-470-treated group(98.00±12.06 d) than that in control group(41.86±9.51 d), P<0.001.CONCLUSION: Angiogenesis inhibitor TNP-470 might beeffective in treating peritoneal dissemination of colon cancerand improve the survival rate of nude mice. | Ying-Fang Fan Zong-Hai Huang Department of Surgery,Zhujiang Hospital,First Military Medical University,Guangzhou 510282,China | 2002 | World Journal of Gastroenterology2002，8，5： | 6 |
| 13 | Distribution of oval cells and c-myc mRNA expression in mouse hepatocarcinogenesis显示文摘BACKGROUND: This study was designed to assess theroles of oval cells and c-myc mRNA in the process of hepa-tocarcinogenesis and to clarify the function of carcinogenec-myc in the development of hepatocellular carcinoma( HCC) and the mechanism of inhibitory function of uscha-ridin on HCC in mouse hepatocarcinogenesis.METHODS: A total of 120 clean SD mice were divided intonormal group, cancer induction group, and interventiongroup. The normal group was fed with standard foragewhile the rest two groups were given p-dimethylaminoazo-benzene (DAB) to induce cancer. Thirteen weeks after in-duction of cancer, the two groups were fed with standardforage and water. Once the pattern was set up, the inter-vention group was given uscharidin injection into the ab-dominal cavity from the first week to the 14th week. Onthe 2nd, 4th, 6th, 8th, 10th, 12th, 14th, 16th, 18th, 20th,22nd, and 24th week, all mice were killed and biopsiedfrom the liver lobe for pathological analysis. At the sametime, the number of tumor nodes was counted and the ex-pression of c-myc mRNA was tested by RT-PCR.RESULTS: Since the 2nd week after cancer induction, pro-liferated oval cells could be seen in the portal area. Initially,the oval cells appeared in the cortical layer of the portalarea, then proliferated gradually and immigrated into theliver parenchyma. In the period of fibrosis after liver proli-feration, proliferated heaps of oval cells were noted in bothportal and peripheral areas. In the period of carcinomatouschange, oval cells could be seen both outside and inside ofcancer nodes, but most of them were distributed outside.The c-myc gene was expressed negatively in the liver tissueof mice. The quantity of the expression began to increaseat the time of infection of the liver and tended to increasewith the degree of hepatic injury. In the period of cancera-tion, the expression level of c-myc mRNA increased gra-dually. The intervention of uscharidin could not inhibit butdelay the increase of the expression of c-myc mRNA.CONCLUSION: Oval cells are closely related to hepatocar-cinoma cells, which play an important role in the occur-rence and development of hepatocarcinogenesis. Uschari-din can inhibit the occurrence of hepatocarcinogenesis orlocal spreading at the early stage of cancer induction byDAB, but it cannot inhibit the expression of c-myc. | Chi-Hua Fang, Gang-Qing Zhang, Xin-Yong Zhu and Jia-Qing Gong Department of Hepatobiliary Surgery, Zhujiang Hos-pital of the First Military Medical University, Guangzhou 510282, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，3： | 6 |
| 14 | Limit Analysis of Soft Ground R e i n f o r c e d b y G e o s y n t h e t i c s显示文摘 | SHEN Zhujiang | | 0，，04： | 1 |
| 15 | SINGULAR PERTURBATION FOR REACTION DIFFUSION EQUATIONS显示文摘The singularly perturbed initial boundary value problems for reaction diffusion equations are considered.Under suitable conditions and by using the theory of differential inequality,the asymptotic behavior of solution for initial boundary value problems are studied,where the reduced problems possess two intersecting solutions. | MoJiaqi WangHui ZhuJiang | 2003 | Applied Mathematics(A Journal of Chinese Universities)2003，18，3： | 1 |
| 16 | 血停跳液对复杂型先天性心脏病心肌保护作用的研究显示文摘在52例复杂先天性心脏病心内矫正术中,应用血停跳液(BCP)加强心肌保护,与晶体停跳液(CCP)比较。记录转流前和再灌注10min时心肌ATP、环磷酰胺(CP)含量及术前,术后6、12、24、48、72h内肌酸磷酸激酶(CPK)、肌-脑混合肌酸磷酸激酶同工酶(CK-MB)、天门冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)变化。结果显示:BCP组心肌ATP、CP贮备较CCP组增加;术后72h内,BCP组CK-MB值低于CCP组。其峰值只是CCP组的55.2%(P<0.05)。血停跳液能增加心肌能量储备,提高心肌抗缺血的能力,减轻心肌损伤的程度。BCP心肌保护的效果优于CCP. | zhu Ping Wang Zengwei (Zhujiang Hospita1 , First Military Medical University, Guangzhou 5l0282) | 1995 | 解放军医学杂志1995，20，6： | 1 |
| 17 | REPLACEMENT OF ARTERIES WITH ePTFE VASCULARGRAFTS LINED WITH CONFLUENT AUTOLOGOUS ENDOTHELIAL CELLS IN NON-HUMAN PRIMATES显示文摘REPLACEMENTOFARTERIESWITHePTFEVASCULARGRAFTSLINEDWITHCONFLUENTAUTOLOGOUSENDOTHELIALCELLSINNON-HUMANPRIMATESREPLACEMENTOFARTER... | Situ Pn Hou Wenming Zhuang Yuguang et al.(Department of Plastic Surgery of Zhujiang Hospitial,the First Military Medical University) | 1995 | Chinese Journal of Biomedical Engineering(English Edition)1995，4，4： | 1 |
| 18 | Assessing glomerular filtration rate (GFR) in elderly Chinese patients with chronic kidney disease (CKD): A comparison of various predictive equations显示文摘 | Liu Xun Wang Cheng Tang Hua Shi Chenggang Chen Zhujiang Ye Zengchun Lou Tanqi | 2009 | Archives of Gerontology and Geriatrics2009，，1： | 1 |
| 19 | Depletion of DNMT3A Suppressed Cell Proliferation and Restored PTEN in Hepatocellular Carcinoma Cell显示文摘 | Zhujiang Zhao Qingxiang Wu Jian Cheng Xuemei Qiu Jianqiong Zhang Hong Fan Mouldy Sioud | 2010 | Journal of Biomedicine and Biotechnology2010，，： | 1 |
| 20 | CLINICAL USE OF BIOLOGICAL HEMOSTATIC GLUE IN NEUROSURGERY显示文摘CLINICALUSEOFBIOLOGICALHEMOSTATICGLUEINNEUROSURGERYCLINICALUSEOFBIOLOGICALHEMOSTATICGLUEINNEUROSURGERYLiZhao-jie;LinZhi-iun;L... | He Hong - bing Pan Yu -xian Ma Su -zhen Wang Zhe -shen(Zhujiang Affiliated Hospital,First Military Medical University,Guangzhou,China)Instant confluent endothelial cell monolayers were produced after a high inoculum of 5 × 105endothelial cell/cm2. | 1995 | Chinese Journal of Biomedical Engineering(English Edition)1995，4，4： | 0 |
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