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| 1 | Active Fault Exploration and Seismic Hazard Assessment in Fuzhou City显示文摘It has been proven by a number of earthquake case studies that an active fault-induced earthquake beneath a city can be devastating. It is an urgent issue for seismic hazard reduction to explore the distribution of active faults beneath the urban area and identify the seismic source and the risks underneath. As a pilot project of active fault exploration in China, the project, entitled “Active fault exploration and seismic hazard assessment in Fuzhou City', started in early 2001 and passed the check before acceptance of China Earthquake Administration in August 2004. The project was aimed to solve a series of scientific issues such as fault location, dating, movement nature, deep settings, seismic risk and hazard, preparedness of earthquake prevention and disaster reduction, and etc. by means of exploration and assessment of active faults by stages, i.e., the preliminary survey and identification of active faults in target area, the exploration of deep seismotectonic settings, the risk evaluation of active seismogenic faults, the construction of geographic information system of active faults, and so on. A lot of exploration methods were employed in the project such as the detection of absorbed mercury, free mercury and radon in soil, the geological radar, multi-channel DC electrical method, tsansient electromagnetic method, shallow seismic refraction and reflection, effect contrast of explored sources, and various sounding experiments, to establish the buried Quaternary standard section of the Fuzhou basin. By summing up, the above explorations and experiments have achieved the following results and conclusions: (1)The results of the synthetic pilot project of active fault exploration in Fuzhou City demonstrate that, on the basis of sufficient collection, sorting out and analysis of geological, geophysical and borehole data, the best method for active fault exploration (location) and seismic risk assessment (dating and characterizing) in urban area is the combination of various approaches, that is, the possible location of active fault determined by using geochemical exploration as a guide “scout', the shallow seismic sounding as the main tool, the electromagnetic method as a supplement, establishing the standard Quaternary profile or stratigraphic sequence from drilling and various geophysical parameters from borehole logs as methods to correct and verify the data above. And in addition, the method also includes the field surveys on fault exposures, trenching, paleoearthquake investigation, dating and comparison of lithology, strata sequence, absolute or relative ages of the cores on the two sides of buried faults. (2)The Fuzhou basin locates under the regional seismotectonic settings which have the potential of moderate earthquake. Comparatively, the region is less affected by the “Taiwan dynamic Antenna'; (3)The activity of the major faults in Fuzhou basin is weak in general. All the six identified target faults are not Holocene faults, among which the Bayi Reservoir-Shanggan fault and the Minhou-Nanyu fault are dormant at least since the mid Epipleistocene time, and the rest are dormant since the Epipleistocene time; (4)In terms of deep-seated structures beneath the basin, there is no evidence indicating the possible occurrence of the underneath strong destructive earthquakes. The adjacent Changle-Zhao’an fault zone is the potential seismic source which may possibly affect Fuzhou City; (5)There exists potential of moderate-strong earthquake on the major faults of the region, but the probability is low; (6)The seismic hazards are weak in the region and the surface earthquake fractures are not likely to occur; (7)The first geographic information system of active faults is developed with functions of information query and display, data management, analysis and processing, etc. | Zhu Jinfang Huang Zonglin Xu Xiwei Zheng Rongzhang Fang Shengmin Bai Denghai Wang Guangcai Min Wei Wen Xueze Han Zhujun | 2005 | Earthquake Research in China2005，19，3： | 7 |
| 2 | High expression of FABP4 in colorectal cancer and its clinical significance显示文摘Objective:To investigate the relationship between the fatty acid-binding protein 4(FABP4)and colorectal cancer(CRC).Methods:Using an enzyme-linked immunosorbent assay(ELISA),we measured the expression of FABP4 in plasma of50 patients who underwent surgery for CRC from October 2017 to May 2018 and 50 healthy controls.The content of the visceral fat area(VFA)as seen with abdominal computed tomography(CT)scanning was measured by ImageJ software.The expression levels of FABP4,E-cadherin,and Snail proteins in CRC and adjacent tissues were determined by immunohistochemistry.Results:The mean concentration of plasma FABP4 of CRC patients was higher than that of the control group(22.46 vs.9.82 ng/m L;P<0.05).The concentration of plasma FABP4 was related to the tumor,node,metastatis(TNM)stage and lymph node metastasis and was independent of age,body mass index(BMI),tumor size and location,and the degree of differentiation of CRC.The concentration of plasma FABP4 was positively correlated with high VFA and lipoprotein-a(LPA)(P<0.05);but it was not correlated with total cholesterol(TG),total triglyceride(TC),low-density lipoprotein(LDL),high-density lipoprotein(HDL),or apolipoprotein AI(Apo-AI).The expression of FABP4 protein in CRC tissues was positively correlated with the degree of CRC differentiation,tumor stage,and lymph node metastasis.The level of FABP4 protein was negatively correlated with E-cadherin protein(r=-0.3292,P=0.0196)and positively correlated with Snail protein(r=0.5856,P<0.0001).Conclusions:High LPA and VFA were risk factors for increased plasma FABP4 in CRC patients.FABP4 protein was highly expressed in CRC tissues and associated with TNM stage,differentiation,and lymph node metastasis of CRC.The level of FABP4 in CRC tissue was correlated with E-cadherin and Snail expression,suggesting that FABP4 may promote CRC progression related to epithelial-mesenchymal transition(EMT). | Yan ZHANG Wenjia ZHANG Min XIA Zhujun XIE Fangmei AN Qiang ZHAN Wenying TIAN Tianyue ZHU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，2： | 5 |
| 3 | Expression Analysis of Genes Related to Auxin Metabolism at Different Growth Stages of Pak Choi显示文摘Pak choi is a low-temperature vernalized plant that readily undergoes premature bolting during spring, but little is known about the governing molecular regulation of vernalization. In order to enhance our understanding of mechanism about premature bolting, we discussed the relationship between auxin(indole-3-acetic acid, IAA) and flowering of pak choi. During vernalization, hormone metabolism is an important regulatory pathway, and IAA plays a specific role. IAA metabolism has been studied in Arabidopsis thaliana and other plants, but not in pak choi. In this paper, the IAA content in pak choi shoot apices during vernalization and different growth stages was compared. The IAA content decreased significantly after low-temperature treatment(4 °C) and then increased rapidly during vegetative growth. During floral bud initiation,the IAA content decreased rapidly and was the lowest. Expressions of genes encoding key IAA metabolic enzymes were analyzed, and a major synthetase-encoding gene was downregulated, while a key degrading enzyme-encoding gene was upregulated during each comparison period,resulting in decreased IAA content. Expressions of four genes(Bra034975, Bra030246, Bra012239 and Bra040296) were consistent with changes in the IAA content. The functions of differentially expressed genes(DEGs) were analyzed, and 15 DEGs were found to be related to IAA metabolism.The findings illuminated the molecular mechanism regulating IAA content during vernalization in pak choi. | Yuxiang Hou Xueting Wang Zhujun Zhu Mengxia Sun Meilan Li Leiping Hou | 2020 | Horticultural Plant Journal2020，6，1： | 4 |
| 4 | A Numerical Convex Lens for the State-Discretized Modeling and Simulation of Megawatt Power Electronics Systems as Generalized Hybrid Systems显示文摘Modeling and simulation have emerged as an indispensable approach to create numerical experiment platforms and study engineering systems.However,the increasingly complicated systems that engineers face today dramatically challenge state-of-the-art modeling and simulation approaches.Such complicated systems,which are composed of not only continuous states but also discrete events,and which contain complex dynamics across multiple timescales,are defined as generalized hybrid systems(GHSs)in this paper.As a representative GHS,megawatt power electronics(MPE)systems have been largely integrated into the modern power grid,but MPE simulation remains a bottleneck due to its unacceptable time cost and poor convergence.To address this challenge,this paper proposes the numerical convex lens approach to achieve state-discretized modeling and simulation of GHSs.This approach transforms conventional time-discretized passive simulations designed for pure-continuous systems into state-discretized selective simulations designed for GHSs.When this approach was applied to a largescale MPE-based renewable energy system,a 1000-fold increase in simulation speed was achieved,in comparison with existing software.Furthermore,the proposed approach uniquely enables the switching transient simulation of a largescale megawatt system with high accuracy,compared with experimental results,and with no convergence concerns.The numerical convex lens approach leads to the highly efficient simulation of intricate GHSs across multiple timescales,and thus significantly extends engineers’capability to study systems with numerical experiments. | Bochen Shi Zhengming Zhao Yicheng Zhu Zhujun Yu Jiahe Ju | 2021 | Engineering2021，7，12： | 3 |
| 5 | A LINE SEARCH FILTER SECANT METHOD FOR NONLINEAR EQUALITY CONSTRAINED OPTIMIZATION显示文摘This paper formulates and analyzes a line search method for general nonlinear equalityconstrained optimization based on filter methods for step acceptance and secant methods for searchdirection.The feature of the new algorithm is that the secant algorithm is used to produce a searchdirection,a backtracking line search procedure is used to generate step size,some filtered rules areused to determine step acceptance,second order correction technique is used to reduce infeasibility andovercome the Maratos effect.Global convergence properties of this method are analyzed:under mildassumptions it is showed that every limit point of the sequence of iterates generated by the algorithmis feasible,and that there exists at least one limit point that is a stationary point for the problem.Moreover,it is also established that the Maratos effect can be overcome in our new approach by addingsecond order correction steps so that fast local superlinear convergence to a second order sufficient localsolution is achieved.Finally,the results of numerical experiments are reported to show the effectivenessof the line search filter secant method. | Zhujun WANG Detong ZHU | 2010 | Journal of Systems Science & Complexity2010，23，2： | 3 |
| 6 | Silicon alleviates salt stress and increases antioxidant enzymes activity in leaves of salt-stressed cucumber ( Cucumis sativus L.)显示文摘 | Zhujun Zhu Guoqiang Wei Juan Li Qiongqiu Qian Jingquan Yu | 2004 | Plant Science2004，，3： | 1 |
| 7 | A reduced Hessian algo- rithm with line search filter method for nonlinear programming显示文摘 | Wang Zhujun Zhu Detong | 2011 | Applied Mathematics and Compu- tation2011，217，19： | 1 |
| 8 | (}rafting in- creases the salt tolerance of tomato by improvement of photosynthesis and enhancement of antioxidant en- zymes activity 显示文摘 | He Yong Zhu Zhujun Yang Jing | 2009 | Environmental and Experimental Botany2009，66，： | 1 |
| 9 | Silicon-mediated alleviation of Mn toxicity in Cucumis sativus in relation to activities of superoxide dismutase and ascorbate peroxidase显示文摘 | Qinghua Shi Zhiyi Bao Zhujun Zhu etal | 2005 | Phytochemistry2005，66，： | 1 |
| 10 | Shelf Life Extension of Minimally Processed Water Caltrop (Trapa acornis Nakano) Fruits Coated with Chitosan 显示文摘 | Lijuan Zhan Jinqiang Hu Zhujun Zhu | 2011 | International Journal of Food Science & Technology2011，46，12： | 1 |
| 11 | Characterization of polyphenol oxidasefrom water caltrop (Trapa Acomis Nakano) fruits 显示文摘 | ZHU Zhujun ZHAN Lijuan | 2010 | Journal of FoodBiochemistry2010，34，： | 1 |
| 12 | Research on Tectonic Features and Dynamics in the Northwestern Yunnan Extensional Region显示文摘The paper discusses the features of active tectonics,seismicity and neotectonic environment in the Northwestern Yunnan extensional region.The intensity of both tectonic activity and seismicity is strong near the south and north boundaries in the areas,but weak in the middle.The distribution of the strongest subsided areas,lacustrine terrace and Quaternary fold is characterized by the diagonal symmetry.Formation of extensional tectonics in the Northwestern Yunnan can be explained by passive model,experiencing the action of compressional force in the N-S direction and shear force in the SW-NE direction,and classified as a special pull-apart tectonics.The direction of the composite force is NNE,which is coincided with the results acquired by the methods of water-compressed rupture and physical modelling. | Han Zhujun,Xu Jie,Guo Shunming,Yang Zhu’en,Xiang Hongfa,and Wu DaningInstitute of Geology,SSB,Beijing 100029,China | 1995 | Earthquake Research in China1995，9，2： | 1 |
| 13 | YL064 activates proteasomal-dependent degradation of c-Myc and synergistically enhances the anti-tumor activity of ABT-199 in diffuse large B cell lymphoma显示文摘Dear Editor,c-Myc is highly associated with poor prognosis and aggressive progression of diffuse large B cell lymphoma(DLBCL)and is thus a desirable drug target.Moreover,studies indicate that 5–15%of DLBCL patients harbor MYC and BCL-2 translocations,while 20–35%DLBCL patients simultaneously overexpress of c-Myc and BCL-2 proteins without gene rearrangements.1 These two types of DLBCL are referred as“double-hit”lymphoma(DHL)and“double-expressor”lymphoma(DEL),respectively.Both DHL and DEL lymphomas have inferior clinical outcomes and are refractory to R-CHOP or even hematopoietic stem cell transplant.2 Thus,targeting both c-Myc and BCL-2 is a promising strategy to treat high-risk DLBCLs.3 Although BCL-2 inhibitors are clinically available,c-Myc remains to be“undruggable”owing to its lack of kinase activity and intrinsically disordered structure.4 Thus,developing clinically applicable c-Myc inhibitor remains challenging. | Huizhuang Shan Yang Cao Xinhua Xiao Meng Liu Yunzhao Wu Qi Zhu Hanzhang Xu Hu Lei Zhujun Yao Yingli Wu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 14 | The effect of glutathione on glucosinolate biosynthesis through the sulfur assimilation pathway in pakchoi associated with the growth conditions显示文摘Glucosinolates(GSLs) are a group of nitrogen-and sulfur-containing secondary metabolites, synthesized primarily in members of the Brassicaceae family, that play an important role in food flavor, plant antimicrobial activity, resistance to insect attack, stress tolerance, and human anti-cancer effects. As a sulfur-containing compound, glutathione has a strong connection with GSLs biosynthesis as a sulfur donor or redox system, and exists in reduced(glutathione;GSH) and oxidized(glutathione disulfide;GSSG) forms. However, the mechanism of GSH regulating GSLs biosynthesis remainds unclear. Hence, the exogenous therapy to pakchoi under normal growth condition and sulfur deficiency condition were conducted in this work to explore the relevant mechanism. The results showed that exogenous application of buthionine sulfoximine, an inhibitor of GSH synthesis, decreased the transcript levels of GSLs synthesis-related genes and transcription factors, as well as sulfur assimilation-related genes under the normal growth condition. Application of exogenous GSH inhibited the expression of GSLs synthesis-and sulfur assimilation-related genes under the normal condition, while the GSLs biosynthesis and the sulfur assimilation pathway were activated by exogenous application of GSH when the content of GSH in vivo of plants decreased owing to sulfur deficiency. Moreover,exogenous application of GSSG increased the transcript levels of GSLs synthesis-and sulfur assimilation-related genes under the normal growth condition and under sulfur deficiency. The present work provides new insights into the molecular mechanisms of GSLs biosynthesis underlying glutathione regulation. | Biao Zhu Zhile Liang Dan Wang Chaochao He Zhujun Zhu Jing Yang | 2024 | Horticultural Plant Journal2024，10，2： | 0 |
| 15 | Impairment of rigidity sensing caused by mutant TP53 gain of function in osteosarcoma显示文摘Osteosarcoma(OS)is the most common primary malignant pediatric bone tumor and is characterized by high heterogeneity.Studies have revealed a wide range of phenotypic differences among OS cell lines in terms of their in vivo tumorigenicity and in vitro colony-forming abilities.However,the underlying molecular mechanism of these discrepancies remains unclear.The potential role of mechanotransduction in tumorigenicity is of particular interest.To this end,we tested the tumorigenicity and anoikis resistance of OS cell lines both in vitro and in vivo.We utilized a sphere culture model,a soft agar assay,and soft and rigid hydrogel surface culture models to investigate the function of rigidity sensing in the tumorigenicity of OS cells.Additionally,we quantified the expression of sensor proteins,including four kinases and seven cytoskeletal proteins,in OS cell lines.The upstream core transcription factors of rigidity-sensing proteins were further investigated.We detected anoikis resistance in transformed OS cells.The mechanosensing function of transformed OS cells was also impaired,with general downregulation of rigidity-sensing components.We identified toggling between normal and transformed growth based on the expression pattern of rigidity-sensing proteins in OS cells.We further uncovered a novel TP53 mutation(R156P)in transformed OS cells,which acquired gain of function to inhibit rigidity sensing,thus sustaining transformed growth.Our findings suggest a fundamental role of rigidity-sensing components in OS tumorigenicity as mechanotransduction elements through which cells can sense their physical microenvironment.In addition,the gain of function of mutant TP53 appears to serve as an executor for such malignant programs. | Ming Luo Mingyang Huang Ningning Yang Yufan Zhu Peng Huang Zhujun Xu Wengang Wang Lin Cai | 2023 | Bone Research2023，11，2： | 0 |
| 16 | A Novel Simulation Method for Power Electronics: Discrete State Event Driven Method显示文摘In the analysis of power electronics system,it is necessary to simulate ordinary differential equations(ODEs)with discontinuities and stiffness.However,there are many difficulties in using traditional discrete-time algorithms to solve such equations.Kofman and others presented the quantized state systems(QSS)algorithm in the discrete event system specification(DEVS)formalism.The discretization is applied to the state variables instead of time range in QSS.QSS is efficient to solve ODEs,but it is difficulty to be used when simulating actual power electronics systems with controller’s and other events.Based on the idea of this numerical algorithm and discrete event,a Discrete State Event Driven(DSED)simulation method is presented in this paper,which is fit for simulation of power electronics system.The method is developed to deal with non-linearity,stiffness and multi-time scale of power electronics systems.The DSED simulation method includes event definition,module seperation and modeling,event-driven mechanisms,numerical computation based on QSS,and some other operations.Simulation results verified the effectiveness and validity of the proposed method. | Boyang Li Zhengming Zhao Yi Yang Yicheng Zhu Zhujun Yu | 2017 | CES Transactions on Electrical Machines and Systems2017，1，3： | 0 |
| 17 | Diversity of glucosinolates among common Brassicaceae vegetables in China显示文摘Brassicaceae vegetables are an important traditional daily food in China and around the world, which provide nutrients and phytochemicals that are beneficial for human health. Among them, Brassica and Raphanus are widely cultivated and eaten, have been evolved and/or bred for special characteristics during the long history of cultivation. Epidemiological studies suggest that the health benefits of Brassicaceae vegetables are mainly associated with glucosinolates(GSLs) and their hydrolytic products. In this review, we discuss the diversity of common consumed Brassicaceae vegetables and their GSL composition in edible parts. We also discuss the diversity factors affecting GSL content, and the diversity roles and functions of GSL. The information in this review provides guidance for consumers to select vegetables with a high GSL content,optimum edible stages, suitable edible methods, and provides a theoretical basis for crop molecular breeding and market development of GSL products. | Biao Zhu Zhile Liang Yunxiang Zang Zhujun Zhu Jing Yang | 2023 | Horticultural Plant Journal2023，9，3： | 0 |
| 18 | NITROGEN USE AND MANAGEMENT IN ORCHARDS AND VEGETABLE FIELDS IN CHINA: CHALLENGES AND SOLUTIONS显示文摘China is the largest producer and consumer of fruits and vegetables in the world.Although the annual planting areas of orchards and vegetable fields(OVF)account for 20%of total croplands,they consume more than 30%of the mineral nitrogen fertilizers in China and have become hotspots of reactive N emissions.Excess N fertilization has not only reduced the N use efficiency(NUE)and quality of grown fruits and vegetables but has also led to soil acidification,biodiversity loss and climate change.Studies using 15N labeling analysis showed that the recovery rate of N fertilizer in OVFs was only 16.6%,and a high proportion of fertilizer N resided in soils(48.3%)or was lost to the environment(35.1%).Nitrate accumulation in the soil of OVFs is the main fate of N fertilizer in northern China,which threatens groundwater quality,while leaching and denitrification are the important N fates of N fertilizer in southern China.Therefore,taking different measures to reduce N loss and increase NUE based on the main pathways of N loss in the various regions is urgent,including rational N fertilization,substituting mineral N fertilizers with organic fertilizers,fertigation,and adding mineral N fertilizers with urease inhibitors and nitrification inhibitors. | Xueqiang ZHU Peng ZHOU Peng MIAO Haoying WANG Xinlu BAI Zhujun CHEN Jianbin ZHOU | 2022 | Frontiers of Agricultural Science and Engineering2022，9，3： | 0 |
| 19 | A NONMONOTONE FILTER LINE SEARCH TECHNIQUE FOR THE MBFGS METHOD IN UNCONSTRAINED OPTIMIZATION显示文摘This paper presents a new nonmonotone filter line search technique in association with the MBFGS method for solving unconstrained minimization.The filter method,which is traditionally used for constrained nonlinear programming(NLP),is extended to solve unconstrained NLP by converting the latter to an equality constrained minimization.The nonmonotone idea is employed to the filter method so that the restoration phrase,a common feature of most filter methods,is not needed.The global convergence and fast local convergence rate of the proposed algorithm are established under some reasonable conditions.The results of numerical experiments indicate that the proposed method is efficient. | WANG Zhujun ZHU Detong | 2014 | Journal of Systems Science & Complexity2014，27，3： | 0 |
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