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| 1 | The Preliminary Discussion of the Potential of GNSS-IR Technology for Terrain Retrievals显示文摘The expansion of research and applications of Global Navigation Satellite Systems(GNSS)has revealed the information of reflecting surface in inherent multipath errors.GNSS signals,usually used to measure position,have been demonstrated that they can be used to retrieve water properties including water level,soil moisture,snow depth,and vegetation water content,which are important for climate analysis and water resources monitoring.Reflected GNSS signals with different azimuths can carry information of the corresponding reflecting zone,which means every reflected signal has distinct'signal-tonoise ratio(SNR)characteristics'influenced by specific reflecting zones—and the parameter named'Reflector Height(RH)'deduced from SNR frequency is focused on in this study.Thus,after interpolation of a series of reflector height by coordinates of the footprint,products describing highly detailed terrain over a reflecting footprint can be produced.Data of three GNSS sites in Earth Scope Plate Boundary Observatory,named P025,P351 and P101,was used to evaluate the terrain after calculating the terrain slopes and correcting the footprint following the slopes.A comparison of the results with a digital elevation model(DEM)showed that it is possible to retrieve terrain by GNSS-Interferometric Reflectometry(GNSS-IR);and the comparison with terrain slopes from DEMs in previous research also validated its potential. | Xiaolei WANG Xiufeng HE Qin ZHANG Zijin NIU | 2021 | Journal of Geodesy and Geoinformation Science2021，4，2： | 6 |
| 2 | Angle Dependence Analysis Method to Determine SNRArc Applied to GNSSMRSea Level Retrieval显示文摘The Global Navigation Satellite Systems(GNSS)broadcast radio signals are continuously at two or more frequencies in the L-band,and the multipath signals from sea surface recorded by off-the-shelf geodetic receivers have been demonstrated they can be used to estimate sea level,using a technology called GNSS multipath reflectometry(GNSS-MR).Before proceeding to estimate reflection parameters,the azimuth range and elevation angle range are needed to be defined,as only with suitable azimuths and elevation angles the sensing zones can be guaranteed on water.So,this study presents an angle dependence analysis method to jointly select the azimuth range and elevation angle range based on wavelet analysis which can describe the nonstationary power of different sinusoidal oscillations changed with elevation angle.The key of this method is to use one grid model to screen the spectrum power of multipath oscillation on different elevation angles and azimuths in this work.Then the elevation angles and the azimuths can be determined by searching grids with greater power.The GPS and GLONASS data of two MultiGNSS Experiment(MGEX)stations named BRST and MAYG was analyzed and used to retrieve.Firstly,the angle dependence analysis was carried out to determine the elevation range and azimuth range.Secondly,the sea levels were retrieved from individual signals.Finally,the retrievals of individual signals are combined to form a 10-min sea level retrieval series.The RMSEs of the combined retrievals are both less than 15 cm.The results show the effectiveness of the selection of angle range based on the angle dependence analysis method. | Xiaolei WANG Xiufeng HE Qin ZHANG Mingfeng SONG Zijin NIU | 2021 | Journal of Geodesy and Geoinformation Science2021，4，2： | 6 |
| 3 | Virus-Mediated Overexpression of ETS-1 in the Ventral Hippocampus Counteracts Depression-Like Behaviors in Rats显示文摘ETS-1 is a transcription factor that is a member of the E26 transformation-specific(ETS) family. Galanin receptor 2(Gal R2), a subtype of receptors of the neuropeptide galanin, has been shown to have an antidepressant-like effect after activation in rodents. Our previous study has shown that overexpression of ETS-1 increases the expression of Gal R2 in PC12 phaeochromocytoma cells. However, whether ETS-1 has an antidepressant-like effect is still unclear. In this study, we found that chronic mild stress(CMS) decreased the expression of both ETS-1 and Gal R2 in the ventral hippocampus of rats. Meanwhile,we demonstrated that overexpression of ETS-1 increased the expression of Gal R2 in primary hippocampal neurons.Importantly, we showed that overexpression of ETS-1 in the ventral hippocampus counteracted the depression-like behaviors of CMS rats. Furthermore, we found that overexpression of ETS-1 increased the level of downstream phosphorylated extracellular signal-regulated protein kinases 1 and 2(p-ERK1/2) of Gal R2 in the ventral hippocampus of CMS rats. Taken together, our findings suggest that ETS-1 has an antidepressant-like effect in rats,which might be mediated by increasing the level of Gal R2 and its downstream p-ERK1/2 in the ventral hippocampus. | Hanjiang Luo Zijin Liu Bo Liu Hui Li Yutao Yang Zhi-Qing David Xu | 2019 | Neuroscience Bulletin2019，35，6： | 5 |
| 4 | Epidermal growth factor receptor mutation analysis in cytological specimens and responsiveness to gefitinib in advanced non-small cell lung cancer patients显示文摘Background: Epidermal growth factor receptor(EGFR) mutation is the key predictor of EGFR tyrosine kinase inhibitors(TKIs) efficacy in non-small cell lung cancer(NSCLC). We conducted this study to verify the feasibility of EGFR mutation analysis in cytological specimens and investigate the responsiveness to gefitinib treatment in patients carrying EGFR mutations.Methods: A total of 210 cytological specimens were collected for EGFR mutation detection by both direct sequencing and amplification refractory mutation system(ARMS). We analyzed EGFR mutation status by both methods and evaluated the responsiveness to gefitinib treatment in patients harboring EGFR mutations by overall response rate(ORR), disease control rate(DCR) and progression free survival(PFS).Results: Of all patients, EGFR mutation rate was 28.6%(60/210) by direct sequencing and 45.2%(95/210) by ARMS(P<0.001) respectively. Among the EGFR wild type patients tested by direct sequencing, 26.7% of them were positive by ARMS. For the 72 EGFR mutation positive patients treated with gefitinib, the ORR, DCR and median PFS were 69.4%, 90.2% and 9.3 months respectively. The patients whose EGFR mutation status was negative by direct sequencing but positive by ARMS had lower ORR(48.0% vs. 80.9%, P=0.004) and shorter median PFS(7.4 vs. 10.5 months, P=0.009) as compared with that of EGFR mutation positive patients by both detection methods. Conclusions: Our study verified the feasibility of EGFR analysis in cytological specimens in advanced NSCLC. ARMS is more sensitive than direct sequencing in EGFR mutation detection. EGFR Mutation status tested on cytological samples is applicable for predicting the response to gefitinib. Abundance of EGFR mutations might have an influence on TKIs efficacy. | Lin Li Zijin Zhang Zhixin Bie Zheng Wang Ping Zhang Xin Nie Yuanming Li Hui Wang Bin Ai Gang Cheng | 2015 | Chinese Journal of Cancer Research2015，27，3： | 5 |
| 5 | Changes in Global Cloud Cover Based on Remote Sensing Data from 2003 to 2012显示文摘As is well known,clouds impact the radiative budget,climate change,hydrological processes,and the global carbon,nitrogen and sulfur cycles.To understand the wide-ranging effects of clouds,it is necessary to assess changes in cloud cover at high spatial and temporal resolution.In this study,we calculate global cloud cover during the day and at night using cloud products estimated from Moderate Resolution Imaging Spectroradiometer(MODIS)data.Results indicate that the global mean cloud cover from 2003 to 2012 was 66%.Moreover,global cloud cover increased over this recent decade.Specifically,cloud cover over land areas(especially North America,Antarctica,and Europe)decreased(slope=–0.001,R^2=0.5254),whereas cloud cover over ocean areas(especially the Indian and Pacific Oceans)increased(slope=0.0011,R^2=0.4955).Cloud cover is relatively high between the latitudes of 36°S and 68°S compared to other regions,and cloud cover is lowest over Oceania and Antarctica.The highest rates of increase occurred over Southeast Asia and Oceania,whereas the highest rates of decrease occurred over Antarctica and North America.The global distribution of cloud cover regulates global temperature change,and the trends of these two variables over the 10-year period examined in this study(2003–2012)oppose one another in some regions.These findings are very important for studies of global climate change. | MAO Kebiao YUAN Zijin ZUO Zhiyuan XU Tongren SHEN Xinyi GAO Chunyu | 2019 | Chinese Geographical Science2019，29，2： | 5 |
| 6 | Climate change and multi-dimensional sustainable urbanization显示文摘Global large-scale urbanization and climate change have become indisputable scientific facts yet are unresolved issues,and are a common concern for mankind.The relationship between these two topics is unclear and it is not known how to deal appropriately at the scientific level with climate change in the process of urbanization.Further exploration of the science,management and practice,are needed to achieve global and regional sustainadevelopment.This paper first considers the basic facts concerning mass urbanization and climate change and summarizes the interactions and possible mechanisms of urbanization and climate change.Urbanization leads to the heat island effect,an uneven distribution of precipitation and extreme weather,together with a local-regional-global multi-scale superposition effect,which aggravates the consequences of global climate change.The impact of climate change on urbanization is mainly manifested in aspects such as changes of energy consumption,mortality,and the spread of infectious diseases,sea level rise,extreme weather damage to infrastructure,and water shortages.This paper also briefly reviews relevant international research programs and action coalitions and puts forward an analysis framework multi-dimensional sustainable urbanization which can adapt to and mitigate climate change,from the perspective of the four key dimensions—population,land use,economy,and society.It is imperative that we strengthen the interdisciplinary activities involving the natural and social sciences,take urbanization and other human activities into consideration of the land-atmosphere system,and explore the human-land-atmosphere coupling process.The adaptation and mitigation from the perspective of human activities,as represented by urbanization,might be the most critical and realistic way to deal with climate change. | CHEN Mingxing XIAN Yue WANG Pengling DING Zijin | 2021 | Journal of Geographical Sciences2021，31，9： | 4 |
| 7 | Preparation of Silver Nanowires via a Rapid,Scalable and Green Pathway显示文摘Rapid synthesis of silver nanowires(Ag NWs) with high quality and a broad processing window is challenging because of the low selectivity of the formation of multiply twinned particles at the nucleation stage for subsequent Ag NWs growth.Herein we report a systematic study of the water-involved heterogeneous nucleation of Ag NWs with high rate(less than 20 min) in a simple and scalable preparation method.Using glycerol as a reducing agent and a solvent with a high boiling point,the reaction is rapidly heated to 210 ℃ in air to synthesize Ag NWs with a very high yield in gram level.It is noted that the addition of a small dose of water plays a key role for obtaining highly pure Ag NWs in high yield,and the optimal water/glycerol ratio is0.25%.After investigating a series of forming factors including reaction temperature and dose of catalysts,the formation kinetics and mechanism of the Ag NWs are proposed.Compared to other preparation methods,our strategy is simple and reproducible.These Ag NWs show a strong Raman enhancement effect for organic molecules on their surface. | Cheng Yang Youhong Tang Zijin Su Zhexu Zhang Cheng Fang | 2015 | Journal of Materials Science & Technology2015，31，1： | 3 |
| 8 | D-A-D structured selenadiazolesbenzothiadiazole-based near-infrared dye for enhanced photoacoustic imaging and photothermal cancer therapy显示文摘Near-infrared(NIR)small molecular organic dyes as photothermal agents for cancer photothermal therapy(PTT)have attracted considerable research attention.Herein,two donor-acceptor-donor(D-A-D)structured NIR dyes,BBTT and SeBTT,are rationally designed,where the only difference is one heteroatom within the acceptor unit varying from sulfur to selenium(Se).More importantly,SeBTT NPs exhibit stronger NIR absorbance and higher photothermal conversion efficiency(PTCE≈65.3%).In vivo experiments illustrate that SeBTT NPs can be utilized as a high contrast photoacoustic imaging(PAI)agent,and succeed in tumor suppression without noticeable damage to main organs under NIR photoirradiation.This study presents an effective molecular heteroatom surgery strategy to regulate the photothermal properties of NIR small molecules for enhanced PAI and PTT. | Zijin Cheng Tian Zhang Weili Wang Qing Shen Ying Hong Jinjun Shao Xiaoji Xie Zhenghao Fei Xiaochen Dong | 2021 | Chinese Chemical Letters2021，32，4： | 3 |
| 9 | In tegrative iTRAQ-based proteomic and transcriptomic analysis reveals the accumulation patter ns of key metabolites associated with oil quality during seed ripening of Camellia oleifera显示文摘Camellia oleifera(C.oleifera)is one of the four major woody oil-bearing crops in the world and has relatively high ecological,economic,and medicinal value.Its seeds undergo a series of complex physiological and biochemical changes during ripening,which is mainly manifested as the accumulation and transformation of certain metabolites closely related to oil quality,especially flavonoids and fatty acids.To obtain new insights into the underlying molecular mechanisms,a parallel analysis of the transcriptome and proteome profiles of C.oleifera seeds at different maturity levels was conducted using RNA sequencing(RNA-seq)and isobaric tags for relative and absolute quantification(iTRAQ)complemented with gas chromatography-mass spectrometry(GC-MS)data.A total of 16,530 transcripts and 1228 proteins were recognized with significant differential abundances in pairwise comparisons of samples at various developmental stages.Among these,317 were coexpressed with a poor correlation,and most were involved in metabolic processes,including fatty acid metabolism,a-linolenic acid metabolism,and glutathione metabolism.In addition,the content of total flavonoids decreased gradually with seed maturity,and the levels of fatty acids generally peaked at the fat accumulation stage;these results basically agreed with the regulation patterns of genes or proteins in the corresponding pathways.The expression levels of proteins annotated as upstream candidates of phenylalanine ammonia-lyase(PAL)and chalcone synthase(CHS)as well as their cognate transcripts were positively correlated with the variation in the flavonoid content,while shikimate O-hydroxycinnamoyltransferase(HCT)-(encoding genes had the opposite pattern.The increase in the abundance of proteins and mRNAs corresponding to alcohol dehydrogenase(ADH)was associated with a reduction in linoleic acid synthesis.Using weighted gene coexpression network analysis(WGCNA),we further identi fied six unique modules related to flavonoid,oil,and fatty acid anabolism that contained hub genes or proteins similar to transcription factors(TFs),such as MADS intervening keratin-like and C-terminal(MIKC_MAD s),type-B authentic response regulator(ARR-B),and basic helix-loop-helix(bH〔H).Finally,based on the known metabolic pathways and WGCNA combined with the correlation analysis,fi ve coexpressed transcripts and proteins composed of cinnamyl-alcohol dehyd rogenases(CADs),caffeicacid 3-O-methyltransferase(COMT),fl avonol synthase(FLS),and 4-coumarate:CoA ligaas(4CL)were screened out.With this exploratory multiomics dataset,our results presented a dynamic picture regarding the maturation process of C.oleifera seeds on Hainan Island,not only revealing the temporal specific expression of key candidate genes and proteins but also providing a scientific basis for the genetic improvement of this tree species. | Zhouchen Ye Jing Yu Wuping Yan Junfeng Zhang Dongmei Yang Guanglong Yao Zijin Liu Yougen Wu Xilin Hou | 2021 | Horticulture Research2021，8，1： | 3 |
| 10 | Magnetostrictive and Kinematic Model Considering the Dynamic Hysteresis and Energy Loss for GMA显示文摘Due to the influence of magnetic hysteresis and energy loss inherent in giant magnetostrictive materials(GMM), output displacement accuracy of giant magnetostrictive actuator(GMA) can not meet the precision and ultra precision machining. Using a GMM rod as the core driving element, a GMA which may be used in the field of precision and ultra precision drive engineering is designed through modular design method. Based on the Armstrong theory and elastic Gibbs free energy theory, a nonlinear magnetostriction model which considers magnetic hysteresis and energy loss characteristics is established.Moreover, the mechanical system differential equation model for GMA is established by utilizing D'Alembert's principle. Experimental results show that the model can preferably predict magnetization property, magnetic potential orientation, energy loss for GMM. It is also able to describe magnetostrictive elongation and output displacement of GMA. Research results will provide a theoretical basis for solving the dynamic magnetic hysteresis,energy loss and working precision for GMA fundamentally. | Huifang LIU Xingwei SUN Yifei GAO Hanyu WANG Zijin GAO | 2017 | Chinese Journal of Mechanical Engineering2017，30，2： | 3 |
| 11 | Diketopyrrolopyrrole-Au(I) as singlet oxygen generator for enhanced tumor photodynamic and photothermal therapy显示文摘Diketopyrrolopyrrole(DPP)derivatived photosensitizers(PSs)with near infrared(NIR)absorption and good photophysical properties have drawn tremendous attention in cancer phototherapy.However,current DPP derivatives present unsatisfactory quantum yield of singlet oxygen(1O2)due to the large energy gap between the excited singlet and triplet states.To tackle this challenge,herein the DPP core is functionalized with triphenylphosphine-Au(I)group(Th DPP-Au),leading to a high1O2 quantum yield of 0.65.Theoretical calculation attributes the enhancement to spin-orbit coupling and population of the triplet excition upon photoexcitation.The hydrophilic Th DPP-Au nanoparticals(NPs)are prepared via nano-reprecipitation,which displays homogeneous size and excellent light absorption ability(ε=4.382×104 M-1cm-1).And the Th DPP-Au NPs exhibit low dark toxicity and high phototoxicity,which can effectively kill tumor cells via 1O2 induced mitochondrial apoptotic pathway upon irradiation.Furthermore,in vivo experiments demonstrate that Th DPP-Au NPs can selective accumulation in tumor and present excellent synergistic photodynamic/photothermal therapy guided by fluorescence and photothermal dual imaging. | Xiaoyu Huang Rui Gu Jiewei Li Nan Yang Zijin Chen Weili Si Peng Chen Wei Huang Xiaochen Dong | 2020 | Science China Chemistry2020，63，1： | 3 |
| 12 | 14.46% Efficiency small molecule organic photovoltaics enabled by the well trade-off between phase separation and photon harvesting显示文摘Small molecule organic photovoltaics(SMPVs) were prepared by utilizing liquid crystalline donor material BTR-Cl and two similar optical bandgap non-fullerene acceptor materials BTP-BO-4 F and Y6.The BTPBO-4 F and Y6 have the similar optical bandgap and different absorption coefficients.The corresponding binary SMPVs exhibit different short circuit current density(/sc)(20.38 vs.23.24 mA cm^(-2)),and fill factor(FF)(70.77% vs.67.21%).A 14.46% power conversion efficiency(PCE) is acquired in ternary SMPVs with 30 wt% Y6,companied with a JSC of 24.17 mA cm^(-2) a FF of 68.78% and an open circuit voltage(Voc) of 0.87 V.The improvement on PCE of ternary SMPVs should originate from the well trade-off between phase separation and photon harvesting of ternary active layers by incorporating 30 wt% Y6 in acceptors.This work may deliver insight onto the improved performance of SMPVs by superposing the superiorities of binary SMPVs with similar optical bandgap acceptors into one ternary cell. | Chunyu Xu Haiyan Chen Zijin Zhao Jinhua Gao Xiaoling Ma Shirong Lu Xiaoli Zhang Zeyun Xiao Fujun Zhang | 2021 | Journal of Energy Chemistry2021，30，6： | 2 |
| 13 | Fibroblast Growth Factor 23 is a Predictor of Aortic Artery Calcification in Maintenance Hemodialysis Patients显示文摘 | Zijin Chen Xiaonong Chen Jingyuan Xie Xiaobo Ma Fang Zhong Liang Hou Huawei Ling Xiao Li Hong Ren Nan Chen | 2013 | Renal Failure2013，，5： | 2 |
| 14 | Highly sensitive,sub-microsecond polymer photodetectors for blood oxygen saturation testing显示文摘Bottom surface of active layers and interface of indium tin oxide(ITO)electrodes and active layers play a crucial role in determining the performance of polymer photodetectors with photomultiplication(PM-PPDs).The interfacial trapped electron distribution closing to ITO electrodes will determine spectral response range and external quantum efficiency(EQE)of PMPPDs.The bottom interface is more sensitive than top interface when light is coming from the ITO side,and the larger density of generated charge on the bottom interfaces will induce interfacial band more bending for efficient charge tunneling injection.Highly sensitive and sub-microsecond PM-PPDs are achieved with PMBBDT:Y6(100:7,w/w)as active layers under forward bias,yielding EQE of 18,700%at 320 nm,21,700%at 600 nm and 16,400%at 810 nm under a bias of 7 V,respectively,as well as fast response time of 79μs.The high EQE of the PM-PPDs is attributed to efficient hole tunneling injection from ITO electrode under forward bias.The electron traps closing to ITO electrode will be quickly filled up when light is coming from ITO side,leading to interfacial band more bending for hole tunneling injection.Importantly,the PM-PPDs is performed to measure heart rate(HR)and blood oxygen saturation(SpO_(2)),and the measured data by the PM-PPDs are very similar with those obtained by commercial photodetectors. | Zijin Zhao Baiqiao Liu Changlin Xie Yao Ma Jian Wang Ming Liu Kaixuan Yang Yunhua Xu Jian Zhang Weiwei Li Liang Shen Fujun Zhang | 2021 | Science China Chemistry2021，64，8： | 2 |
| 15 | Distinct Clinicohistologic Features of Inflammatory Bowel Disease-associated Colorectal Adenocarcinoma: In Comparison With Sporadic Microsatellite-stable and Lynch Syndrome-related Colorectal Adenocarcinoma显示文摘 | Xiuli Liu John R. Goldblum Zijin Zhao Michael Landau Brandie Heald Rish Pai Jingmei Lin | 2012 | The American Journal of Surgical Pathology2012，，8： | 2 |
| 16 | Anaerobic toxicity and biodegradation of formaldehyde in batch cultures 显示文摘 | LU Zijin HEGEMANN W | 1998 | Water Res1998，32，1： | 1 |
| 17 | Changes on the disease pattern of primary colorectal cancers in Southern China: a retrospective study of 20?years显示文摘 | Shenghong Zhang Yi Cui Zijin Weng Xiaorong Gong Minhu Chen Bihui Zhong | 2009 | International Journal of Colorectal Disease2009，，8： | 1 |
| 18 | Boron difluoride formazanate dye for high-efficiency NIR-Ⅱ fluorescence imaging-guided cancer photothermal therapy显示文摘The small molecular second near-infrared(NIR-Ⅱ, 1000–1700 nm) dye-based nanotheranostics can concurrently combine deep-tissue photodiagnosis with in situ phototherapy, which occupies a vital position in the early detection and precise treatment of tumors. However, the development of small molecular NIR-Ⅱ dyes is still challenging due to the limited electron acceptors and cumbersome synthetic routes.Herein, we report a novel molecular electron acceptor, boron difluoride formazanate(BDF). Based on BDF, a new small molecular NIR-Ⅱ dye BDF1005 is designed and synthesized with strong NIR-I absorption at 768 nm and bright NIR-Ⅱ peak emission at 1034 nm. In vitro and in vivo experiments demonstrate that BDF1005-based nanotheranostics can be applied for NIR-Ⅱ fluorescence imaging-guided photothermal therapy of 4T1 tumor-bearing mice. Under 808 nm laser irradiation, tumor growth can be effectively inhibited. This work opens up a new road for the exploitation of NIR-Ⅱ small molecular dyes for cancer phototheranostics. | Hanming Dai Zijin Cheng Tian Zhang Weili Wang Jinjun Shao Wenjun Wang Yongxiang Zhao Xiaochen Dong Liping Zhong | 2022 | Chinese Chemical Letters2022，33，5： | 1 |
| 19 | Anaerobic toxicity and biodegredation of formaldehyde to batch cultures显示文摘 | Zijin Lu W Hegenann | 1998 | Water Research1998，32，1： | 1 |
| 20 | Study on deactivation of Ni/Al 2 O 3 catalyst for liquid phase hydrogenation of crude 1,4-butanediol aqueous solution显示文摘 | Haitao Li Yongxiang Zhao Chunguang Gao Yongzhao Wang Zijin Sun Xiaoyuan Liang | 2011 | Chemical Engineering Journal2011，，： | 1 |
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