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| 1 | Crust and Upper Mantle Electrical Resistivity Structure in the Panxi Region of the Eastern Tibetan Plateau and Its Significance显示文摘The Panxi region is located in the frontal zone of positive squeezing subduction and side squeezing shearing between the Indian plate and the Eurasian plate. The long-period magnetotelluric(LMT) and broadband magnetotelluric(MT) techniques are both used to study the deep electrical conductivity structure in this region; magnetic and gravity surveys are also performed along the profile. According to the 2-D resistivity model along the Yanyuan-Yongshan profile,a highconductivity layer(HCL) exists widely in the crust,and a high-resistivity block(HRB) exists widely in the upper mantle in general,as seen by the fact that a large HCL exists from the western Jinpingshan tectonic zone to the eastern Mabian tectonic zone in the crust,while the HRB found in the Panxi tectonic zone is of abnormally high resistivity in that background compared to both sides of Panxi tectonic zone. In addition,the gravity and magnetic field anomalies are of high value. Combined with geological data,the results indicate that there probably exists basic or ultrabasic rock with a large thickness in the lithosphere in the Panxi axial region,which indicates that fracture activity once occurred in the lithosphere. As a result,we can infer that the high-resistivity zone in the Panxi lithosphere is the eruption channel for Permian Emeishan basalt and the accumulation channel for basic and ultrabasic rock. The seismic sources along the profile are counted according to seismic record data. The results indicate that the most violent earthquake sources are located at the binding site of the HRB and the HCL,where the tectonic activity zone is generally acknowledged to be; however,the earthquakes occurring in the HCL are not so violent,which reflects the fact that the HCL is a plastic layer,and the fracture threshold of a plastic layer is low generally,making high stress difficult to accumulate but easy to release in the layer. As a result,a higher number of smaller earthquakes occurred in the HCL at Daliangshan tectonic zone,and violent earthquakes occurred at the binding site of high- and low-resistivity blocks at the Panxi tectonic zone. | ZHANG Gang WANG Xuben FANG Hui GUO Ziming ZHANG Zhaobin LUO Wei CAI Xuelin LI Jun LI Zhong WU Xing | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 9 |
| 2 | Perspectives and challenges for lead-free energy-storage multilayer ceramic capacitors显示文摘The growing demand for high-power-density electric and electronic systems has encouraged the development of energy-storage capacitors with attributes such as high energy density,high capacitance density,high voltage and frequency,low weight,high-temperature operability,and environmental friendliness.Compared with their electrolytic and film counterparts,energy-storage multilayer ceramic capacitors(MLCCs)stand out for their extremely low equivalent series resistance and equivalent series inductance,high current handling capability,and high-temperature stability.These characteristics are important for applications including fast-switching third-generation wide-bandgap semiconductors in electric vehicles,5G base stations,clean energy generation,and smart grids.There have been numerous reports on state-of-the-art MLCC energy-storage solutions.However,lead-free capacitors generally have a low-energy density,and high-energy density capacitors frequently contain lead,which is a key issue that hinders their broad application.In this review,we present perspectives and challenges for lead-free energy-storage MLCCs.Initially,the energy-storage mechanism and device characterization are introduced;then,dielectric ceramics for energy-storage applications with aspects of composition and structural optimization are summarized.Progress on state-of-the-art energy-storage MLCCs is discussed after elaboration of the fabrication process and structural design of the electrode.Emerging applications of energy-storage MLCCs are then discussed in terms of advanced pulsed power sources and high-density power converters from a theoretical and technological point of view.Finally,the challenges and future prospects for industrialization of lab-scale lead-free energy-storage MLCCs are discussed. | Peiyao ZHAO Ziming CAI Longwen WU Chaoqiong ZHU Longtu LI Xiaohui WANG | 2021 | Journal of Advanced Ceramics2021，10，6： | 3 |
| 3 | Managerial power theory, tournament theory, and executive pay in China显示文摘 | Jing Chen Mahmoud Ezzamel Ziming Cai | 2011 | Journal of Corporate Finance2011，，4： | 2 |
| 4 | Chinese speech as a bit of research 显示文摘 | Wang Ziming Cai Lianhong | 2010 | Applied Acoustics2010，3，： | 1 |
| 5 | COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors显示文摘Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear mechanism.In this study,we retrospectively investigated a cohort of COVID-19 patients without pre-existing metabolic-related diseases,and found new-onset in suli n resista nee,hyperglycemia,and decreased HDL-C in these patie nts.Mecha nistically,SARS-CoV-2 infecti on in creased the expression of RE1-silencing transcription factor(REST),which modulated the expression of secreted metabolic factors including myeloperoxidase,apelin,and myostatin at the transcriptional level,resulting in the perturbation of glucose and lipid metabolism.Furthermore,several lipids,including(±)5-HETE,(±)12-HETE,propionic acid,and isobutyric acid were identified as the potential biomarkers of COVID-19-induced metabolic dysregulation,especially in insulin resistance.Taken together,our study revealed insulin resistance as the direct cause of hyperglycemia upon COVID-19,and further illustrated the underlying mechanisms,providing potential therapeutic targets for COVID-19-induced metabolic complications. | Xi He Chenshu Liu Jiangyun Peng Zilun Li Fang Li Jian Wang Ao Hu Meixiu Peng Kan Huang Dongxiao Fan Na Li Fuchun Zhang Weiping Cai Xinghua Tan Zhongwei Hu Xilong Deng Yueping Li Xiaoneng Mo Linghua Li Yaling Shi Li Yang Yuanyuan Zhu Yanrong Wu Huichao Liang Baolin Liao Wenxin Hong Ruiying He Jiaojiao Li Pengle Guo Youguang Zhuo Lingzhai Zhao Fengyu Hu Wenxue Li Wei Zhu Zefeng Zhang Zeling Guo Wei Zhang Xiqiang Hong Wei kang Cai Lei Gu Ziming Du Yang Zhang Jin Xu Tao Zuo Kai Deng Li Yan Xinwen Chen Sifan Chen Chunliang Lei | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 6 | Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway显示文摘Hepatocellular carcinoma(HCC)is a common malignancy that is driven by multiple genes and pathways.The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin(ZYX)in HCC.We found that the expression of ZYX was significantly higher in HCC tissues compared to that in normal liver tissues.In addition,overexpression of ZYX in hepatoma cell lines(PLC/PRF/5,HCCLM3)enhanced their proliferation,migration and invasion,whereas ZYX knockdown had the opposite effects(SK HEP-1,Huh-7).Furthermore,the change in the expression levels of ZYX also altered that of proteins related to cell cycle,migration and invasion.Similar results were obtained with xenograft models.The AKT/mTOR signaling pathway is one of the key mediators of cancer development.While ZYX overexpression upregulated the levels of phosphorylated AKT/mTOR proteins,its knockdown had the opposite effect.In addition,the AKT inhibitor MK2206 neutralized the pro-oncogenic effects of ZYX on the HCC cells,whereas the AKT activator SC79 restored the proliferation,migration and invasion of HCC cells with ZYX knockdown.Taken together,ZYX promotes the malignant progression of HCC by activating AKT/mTOR signaling pathway,and is a potential therapeutic target in HCC. | TIANYING CAI JUNJIE BAI PENG TAN ZHIWEI HUANG CHEN LIU ZIMING WU YONGLANG CHENG TONGXI LI YIFAN CHEN JIAN RUAN LIN GAO YICHAO DU WENGUANG FU | 2023 | Oncology Research2023，31，5： | 0 |
| 7 | Weipixiao ameliorates gastric precancerous lesions in a rat's model by regulating GSK3β and C-myc显示文摘OBJECTIVE: To investigate the mechanism underlying the action of Weipixiao(WPX) in a rat's model with ameliorating gastric precancerous lesions(GPL).METHODS: HPLC analysis was performed to identify the chemical constituents of WPX preparation.Sprague-Dawley rats were randomly assigned into control group, model group, vitacoenzyme group,high-dose WPX group(H-WPX), medium-dose WPX group(M-WPX) and low-dose WPX group(L-WPX).After modeling, the treated rats were administrated WPX or vitacoenzyme intragastrically for consecutive 10 weeks. Gene and protein expressions ofGSK3β, C-myc, Cylin E were evaluated by quantitative real-time reverse transcription-polymerase chain reaction(RT-qPCR) and immunohistochemistry, respectively.RESULTS: WPX could efficiently attenuate the pathological alterations of 'non-progressive GPL' in rats.As expected, mRNA and protein levels of C-myc and Cylin E were up-regulated in model rats, while GSK3β expression down-regulated(P < 0.01). WPX treatment, especially at low dose, could significantly down-regulate the m RNA as well as protein levels of C-myc, and could lead to remarkable up-regulation of mRNA and protein levels of GSK3β in GPL rats(P < 0.05). However, no significant changes were observed in WPX-treated rats.CONCLUSION: Our findings suggested that WPX-mediated attenuation of GPL pathological alterations might be due to its regulatory effect on the expressions of GSK3β and C-myc, and on the dysregulation of Wnt/GSK3β pathway. | Zeng Jinhao Pan Huafeng Guo Jing Gong Daoyin Cai Tiantian Chen Xiaodong Zhang Yi You Fengming Chen Longhui Zhao Ziming Liang Chao | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 0 |
| 8 | Configuration Synthesis and Performance Analysis of 9‑Speed Automatic Transmissions显示文摘Current research of automatic transmission(AT)mainly focuses on the improvement of driving performance,and configuration innovation is one of the main research directions.However,finding new configurations of ATs is one of the main limitations of configuration innovation.In the present study,epicyclic gear trains(EGTs)are applied to investigate mechanisms of 9-speed ATs.Then four kinematic configurations are proposed for automatic transitions.In order to evaluate the performance of proposed mechanisms,the lever analogy method is applied to conduct kinematic and mechanical analyses.The power flow analysis is conducted,and then transmission efficiencies are calculated based on the torque method.The comparative analysis between the proposed and existing mechanisms is carried out where obtained results show that proposed mechanisms have reasonable performance and can be used in ATs.The prototype of an AT is manufactured and the speed test is conducted,which proves the accuracy of analysis and the feasibility of proposed mechanisms. | Huafeng Ding Changwang Cai Ziming Chen Tao Ke Bowen Mao | 2020 | Chinese Journal of Mechanical Engineering2020，33，3： | 0 |
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