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| 1 | Metal-organic framework derived CoSe2 nanoparticles anchored on carbon fibers as bifunctional electrocatalysts for efficient overall water splitting显示文摘发展有效,便宜,稳定,为切开的水的 non-noble-metal electrocatalysts,特别地能两个都催化氢进化反应的那些(她的) 在在阳极的阴极和氧进化反应(OER ) ,是挑战。我们开发了一个灵巧的方法因为综合从从容容宽敞 2 nanoparticles 一致地在碳纤维纸上抛锚了(经由热分解和 selenization 的从从容容宽敞 2/CF) 在 situ 成年 zeolitic imidazolate framework-67 (ZIF-67 ) 。从从容容宽敞 2/CF 在碱的答案在 HER 和 OER 显示出高、稳定的催化活动。在一个低房间潜力,即, 1.63 V,与二个从从容容宽敞 2/CF 电极装备的水 electrolyzer 给了 10 mAen 的切开水的水流 2007 并且 2014 年 10 月 21 日。我们然后与一个低级术语并且通过临床的描述的一篇详细摘要识别了 PAOD 的盒子。结果我们识别了 POAD 的 25 个盒子。大多数病人比 60 老 ? 年(84 ?%) 或有象血胆脂醇过多那样的另一个心血管的风险因素,钰 ? 钰吗?? | Chencheng Sun Qiuchun Dong Jun Yang Ziyang Dai Jianjian Lin Peng Chen Wei Huang Xiaochen Dong | 2016 | Nano Research2016，9，8： | 16 |
| 2 | Graphene as an intermediary for enhancing the electron transfer rate: A free-standing Ni3S2@graphene@CogSs electrocatalytic electrode for oxygen evolution reaction显示文摘 | Qiuchun Dong Yizhou Zhang Ziyang Dai Peng Wang Min Zhao Jinjun Shao Wei Huang Xiaochen Dong | 2018 | Nano Research2018，11，3： | 3 |
| 3 | Optimization of Process Parameters for in High-Energy Ball Milling of CNTs/Al2024 Composites Through Response Surface Methodology显示文摘The mathematical models are developed to evaluate the ultimate tensile strength( UTS) and hardness of CNTs / Al2024 composites fabricated by high-energy ball milling. The effects of the preparation variables which are milling time,rotational speed,mass fraction of CNTs and ball to powder ratio on UST and hardness of CNTs / Al2024 composites are investigated. Based on the central composite design( CCD),a quadratic model is developed to correlate the fabrication variables to the UST and hardness. From the analysis of variance( ANOVA),the most influential factor on each experimental design response is identified. The optimum conditions for preparing CNTs / Al2024 composites are found as follows: 1. 53 h milling time,900 r / min rotational speed,mass fraction of CNTs 2. 87% and Ball to powder ratio 25 ∶ 1. The predicted maximum UST and hardness are 273.30 MPa and 261.36 HV,respectively. And the experimental values are 283.25 MPa and256.8 HV,respectively. It is indicated that the predicted UST and hardness after process optimization are found to agree satisfactory with the experimental values. | Li Guo Xiaolan Cai Lei Zhou Cui Hu Changjiang Yang Ziyang Wang Wenzhong Zhang Gang Peng | 2016 | Journal of Harbin Institute of Technology(New Series)2016，23，1： | 3 |
| 4 | Nanowires assembled from MnCo2O4@C nanoparticles for water splitting and all-solid-state supercapacitor显示文摘有切开活动的优秀的水的地球丰富的催化剂的合理设计是重要的为持续精力设备获得干净燃料。在这研究,混合了在 nitrogendoped 碳包含的转变金属氧化物 nanoparticles (作为 AB 表示了 2 O 4@NC) 用一个一个壶协议被开发,金属器官的建筑群在那里作为先锋被采用。作为概念的一个证明, MnCo 2 O 4@NC 为水氧化被用作 electrocatalyst,并且与低过电位表明了一项突出的 electrocatalytic 活动完成 10 妈的当前的密度 ??? 娠佮 ? 佧?? | Chencheng Sun Jun Yang Ziyang Dai Xuewan Wang Yufei Zhang Laiquan Li Peng Chen Wei Huang Xiaochen Dong | 2016 | Nano Research2016，9，5： | 2 |
| 5 | LINC00891 regulated by miR-128-3p/GATA2 axis impedes lung cancer cell proliferation,invasion and EMT by inhibiting RhoA pathway显示文摘Long non-coding RNA(lncRNA)LINC00891 knockdown is associated with poor prognosis of lung adenocarcinoma,but the underlying mechanism remains to be further explored.Here,we found that LINC00891 expression is downregulated in lung cancer tissues and cell lines compared with that in adjacent normal tissues and normal lung epithelial cells.LINC00891 overexpression impedes cell proliferation,invasion,migration and epithelial-to-me-senchymal transition(EMT)process in lung cancer cells.Mechanistic research showed that GATA2 directly binds to LINC00891 promoter and transcriptionally regulates LINC00891 expression.Meanwhile,GATA2 was identified as a target of miR-128-3p,and it is negatively regulated by miR-128-3p.Moreover,overexpression of GATA2 suppresses lung cancer cell proliferation,invasion,migration,and EMT process.Furthermore,LINC00891 restrains the RhoA pathway activity,and treatment with CCG-1423(a specific RhoA pathway inhibitor)antagonizes the promoting effect of LINC00891 knockdown on cell malignant behaviors.Additionally,silencing of LINC00891 promotes xenograft tumor growth,which can be reversed by administration with CCG-1423.In summary,LINC00891 regulated by the miR-128-3p/GATA2 axis restrains lung cancer cell malignant progression and hinders xenograft tumor growth by suppressing the RhoA pathway. | Yunfeng Zhang Dingli Song Ziyang Peng Rui Wang Kai Li Hong Ren Xin Sun Ning Du Shou-Ching Tang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，3： | 2 |
| 6 | Structured search result differentiation显示文摘 | Liu Ziyang Sun Peng Chen Yi | 2009 | Procof VI DB2009，2，1： | 1 |
| 7 | Structured search result differentiation显示文摘 | Liu Ziyang Sun Peng Chert Yi | 2009 | Proceedings of the VLDB Endowment2009，2，1： | 1 |
| 8 | Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1-BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy显示文摘Radiotherapy is widely used in the management of advanced colorectal cancer(CRC).However,the clinical efficacy is limited by the safe irradiated dose.Sensitizing tumor cells to radiotherapy via interrupting DNA repair is a promising approach to conquering the limitation.The BRCA1-BARD1 complex has been demonstrated to play a critical role in homologous recombination(HR)DSB repair,and its functions may be affected by HERC2 or BAP1.Accumulated evidence illustrates that the ubiquitination-deubiquitination balance is involved in these processes;however,the precise mechanism for the cross-talk among these proteins in HR repair following radiation hasn’t been defined.Through activity-based profiling,we identified PT33 as an active entity for HR repair suppression.Subsequently,we revealed that BAP1 serves as a novel molecular target of PT33 via a CRISPR-based deubiquitinase screen.Mechanistically,pharmacological covalent inhibition of BAP1 with PT33 recruits HERC2 to compete with BARD1 for BRCA1 interaction,interrupting HR repair.Consequently,PT33 treatment can substantially enhance the sensitivity of CRC cells to radiotherapy in vitro and in vivo.Overall,these findings provide a mechanistic basis for PT33-induced HR suppression and may guide an effective strategy to improve therapeutic gain. | Xin Yue Tingyu Liu Xuecen Wang Weijian Wu Gesi Wen Yang Yi Jiaxin Wu Ziyang Wang Weixiang Zhan Ruirui Wu Yuan Meng Zhirui Cao Liyuan Le Wenyan Qiu Xiaoyue Zhang Zhenyu Li Yong Chen Guohui Wan Xianzhang Bu Zhenwei Peng Ran-yi Liu | 2023 | Acta Pharmaceutica Sinica B2023，13，8： | 1 |
| 9 | Protein photocrosslinking reveals dimer of dimers formation on MarR protein in Escherichia coli显示文摘The multiple antibiotic resistance regulatory protein(MarR) binds to two promoter sites on the marO operator in Escherichia coli.Our study showed that more than one MarR dimer proteins bound to either of its two promoter sites(Site I and Site II),suggesting that MarR might form higher complexes than homodimers when bound to DNA inside E.coli cells.To further verify this hypothesis,we site-specifically incorporated a photocrosslinking probe at the interface between two MarR dimer proteins.Photolysis in living E.coli cells revealed a covalent linkage between the two interdimer subunits of MarR,suggesting that MarR forms dimer of dimers in vivo. | CHEN Xing HAO ZiYang CHEN Peng R. | 2012 | Science China Chemistry2012，55，1： | 1 |
| 10 | Deep ultraviolet hydrogel based on 2D cobalt-doped titanate显示文摘Birefringent optical elements that work in deep ultraviolet(DUV)region become increasingly important these years.However,most of the DUV optical elements have fixed birefringence which is hard to be tuned.Here,we invent a birefringence-tunable optical hydrogel with mechano-birefringence effect in the DUV region,based on two-dimensional(2D)low-cobalt-doped titanate.This 2D oxide material has an optical anisotropy factor of 1.5×10^(-11) C^(2)J^(-1) m-1,larger than maximum value obtained previously,leading to an extremely large specific magneto-optical Cotton-Mouton coefficient of 3.9×10^(6) T^(-2) m-1.The extremely large coefficient enables the fabrication of birefringent hydrogel in a small magnetic field with an ultra-low concentration of 2D oxide material.The hydrogel can stably and continuously modulate 303 nm DUV light with large phase tunability by varying the strain(compression or stretching)from 0 to 50%.Our work opens the door to design and fabricate new proof-of-concept DUV birefringence-tunable element,as demonstrated by optical hydrogels capable of DUV modulation by mechanical stimuli. | Youan Xu Baofu Ding Ziyang Huang Lixin Dai Peng Liu Bing Li Wei Cai Hui-Ming Cheng Bilu Liu | 2023 | Light(Science & Applications)2023，12，1： | 1 |
| 11 | Protein photocrosslinking reveals dimer of dimers formation on MarR protein in Escherichia coli显示文摘he multiple antibiotic resistance regulatory protein(MarR) binds to two promoter sites on the marO operator in Escherichia coli.Our study showed that more than one MarR dimer proteins bound to either of its two promoter sites(Site I and Site II),suggesting that MarR might form higher complexes than homodimers when bound to DNA inside E.coli cells.To further verify this hypothesis,we site-specifically incorporated a photocrosslinking probe at the interface between two MarR dimer proteins.Photolysis in living E.coli cells revealed a covalent linkage between the two interdimer subunits of MarR,suggesting that MarR forms dimer of dimers in vivo. | CHEN Xing HAO ZiYang CHEN Peng R. | 2012 | 中国科学:化学2012，42，2： | 0 |
| 12 | Experimental study on dense-phase pneumatic conveying of coal powder at high pressures显示文摘Clean utilization and conversion of coal resources is significant to China’s energy sustainable development.Entrained-flow coal gasification technology is an important method used for clean and efficient conversion of coal.The characteristics and stability of high-pressure dense-phase pneumatic conveying of pulverized coal is crucial to the safe and stable operation of dry-feed entrained-flow coal gasifiers.Dense-phase pneumatic conveying experiments were carried out using a high-volatile bituminous coal in pipes with diameters of 25,15 and 10 mm,respectively,and at back pressures of 1.0-4.0 MPag.The conveying characteristics and effects of operating and structure parameters were studied.Pressure drop models were established for horizontal and vertical upward conveying.The prediction uncertainty was within±30%for the horizontal conveying and±20%for the vertical upward conveying.The relative standard deviation of solid flow rate was proposed to explain conveying stability.The effect of operating parameters on conveying stability was systematically analyzed.The gas velocity-related criterion was proposed for stable conveying. | Qingliang Guan Zhen Liu Xinhui Fang Bing Liu Baozai Peng Ziyang Feng Ya Suo Wenhua Li | 2017 | Clean Energy2017，1，1： | 0 |
| 13 | Strong size effect on deformation twin-me diate d plasticity in body-centered-cubic iron显示文摘Deformation twinning serves as an important mode of plastic dissipation processes in nanoscale body-centered cubic(BCC)metals,but its origin and spatio-temporal features are mysterious.Here,applying in situ tensile experiments,we report a strong size effect on mediating the twinning behaviors and twin boundary(TB)-dislocation interaction mechanisms in BCC iron(Fe)nanowires(NWs).There exists a critical diameter(d)of∼2.5 nm,above which the deformation twinning rather than dislocation slip dominates the plasticity.Unlike the traditional reflection TBs,the intermediate isosceles TBs are consis-tently observed as mediated by the 1/12<111>partial dislocations.Moreover,we uncover two distinct TB-related deformation mechanisms,including twin variant re-orientation and TB cracking for NWs with d<17 nm and d>17 nm,respectively.Further molecular dynamics and statics simulations provide the basic underlying mechanisms for size-dependent plasticity,which have been largely overlooked in previous experimental investigations.Our findings highlight the importance of grain size in mediating the deformation behaviors in Fe,serving as possible guidance for exploring single-crystalline and poly-crystalline Fe-based materials(e.g.steel)with optimized mechanical performance. | Ligong Zhao Guoxujia Chen He Zheng Shuangfeng Jia Kaixuan Li Renhui Jiang Lei Li Ying Zhang Huayu Peng Peili Zhao Ziyang Huang Jianbo Wang | 2023 | Journal of Materials Science & Technology2023，，13： | 0 |
| 14 | Improved dielectric energy storage performance of Pb-free 0.5Na_(0.5)Bi_(0.5)TiO_(3)-0.5SrTiO_(3) ceramics modified with CaO显示文摘CaO doped 0.5Na_(0.5)Bi_(0.5)TiO_(3)-0.5SrTiO_(3)(ST)were prepared by a traditional solid-reaction method under various sintering temperatures.X-ray diffraction(XRD),electron scanning microscopy(SEM),and electrical measurements were employed to check the phases,microstructures,and energy storage properties.The doping of CaO can deeply affect the relaxation nature of NBT-ST ceramics.So the energy storage performance could be modified.Specially,sample with 1 at.%CaO exhibits a high energy storage density of 1.51 J/cm3.Any further details can be found within this study. | Peng Chen Leiyang Zhang Ziyang Wang Yifei Wang Chunlin Song Jinzhu Hu Gang Liu Yan Yan | 2018 | Journal of Advanced Dielectrics2018，8，6： | 0 |
| 15 | Synchronous post-acceleration of laser-driven protons in helical coil targets by controlling the current dispersion显示文摘Post-acceleration of protons in helical coil targets driven by intense,ultrashort laser pulses can enhance ion energy by utilizing the transient current from the targets’self-discharge.The acceleration length of protons can exceed a few millimeters,and the acceleration gradient is of the order of GeV/m.How to ensure the synchronization between the accelerating electric field and the protons is a crucial problem for efficient post-acceleration.In this paper,we study how the electric field mismatch induced by current dispersion affects the synchronous acceleration of protons.We propose a scheme using a two-stage helical coil to control the current dispersion.With optimized parameters,the energy gain of protons is increased by four times.Proton energy is expected to reach 45 MeV using a hundreds-of-terawatts laser,or more than 100 MeV using a petawatt laser,by controlling the current dispersion. | Zhipeng Liu Zhusong Mei Defeng Kong Zhuo Pan Shirui Xu Ying Gao Yinren Shou Pengjie Wang Zhengxuan Cao Yulan Liang Ziyang Peng Jiarui Zhao Shiyou Chen Tan Song Xun Chen Tianqi Xu Xueqing Yan Wenjun Ma | 2023 | High Power Laser Science and Engineering2023，11，4： | 0 |
| 16 | Role of autoreactive Tc17 cells in the pathogenesis of experimental autoimmune encephalomyelitis显示文摘Background:The pathogenesis of multiple sclerosis(MS)and experimental autoimmune encephalomyelitis(EAE-an animal model of MS)is primarily mediated by T cells.However,recent studies have only focused on interleukin(IL)-17-secreting CD4^(+)T-helper cells,also known as Th17 cells.This study aimed to compare Th17 cells and IL-17-secreting CD8^(+)T-cytotoxic cells(Tc17)in the context of MS/EAE.Methods:Female C57BL/6 mice were immunized with myelin oligodendrocyte glycoprotein peptides 35-55(MOG35-55),pertussis toxin,and complete Freund's adjuvant to establish the EAE animal model.T cells were isolated from the spleen(12-14 days postimmunization).CD4^(+)and CD8^(+)T cells were purified using isolation kit and then differentiated into Th17 and Tc17,respectively,using MOG35-55 and IL-23.The secretion levels of interferon-(IFN-γ)and IL-17 were measured via enzyme-linked immunosorbent assay using cultured CD4^(+)and CD8^(+)T cell supernatants.The pathogenicity of Tc17 and Th17 cells was assessed through adoptive transfer(tEAE),with the clinical course assessed using an EAE score(0-5).Hematoxylin and eosin as well as Luxol fast blue staining were used to examine the spinal cord.Purified CD8^(+)CD3^(+)and CD4^(+)CD3^(+)cells differentiated into Tc17 and Th17 cells,respectively,were stimulated with MOG35-55 peptide for proliferation assays.Results:The results showed that Tc17 cells(15,951±19855VS.55,709±4196cpm;p<0.050)exhibited a weaker response to highest dose(20μg/mL)MOG35-55 than Th17 cells.However,this response was not dependent on Th17 cells.After the 48h stimulation,at the highest dose(20μg/mL)of MOG35-55.Tc17 cells secreted lower levels of IFN-(280.00±15.00vs.556.67±15.28pg/mL,p<0.050)and IL-17(102.67±5.86 pg/mL vs.288.33±12.58 pg/mL;p<0.050)than Th17 cells.Similar patterns were observed for IFN-γsecretion at 96 and 144h.Furthermore,Tc17 cell-induced tEAE mice exhibited similar EAE scores to Th17 cell-induced tEAE mice and also showed similar inflammation and demyelination.Conclusion:The degree of pathogenicity of Tc17 cells in EAE is lower than that of Th17 cells.Future investigation on different immune cells and EAE models is warranted to determine the mechanisms underlying MS. | Yong Peng Xiuli Zhang Yandan Tang Shunqing He Guilan Rao Quan Chen Yahui Xue Hong Jin Shu Liu Ziyang Zhou Yun Xiang | 2024 | Neuroprotection2024，2，1： | 0 |
| 17 | Thermal comfort in a building with Trombe wall integrated with phase change materials in hot summer and cold winter region without air conditioning显示文摘Trombe wall and phase change materials(PCMs)are two effective ways to regulate indoor thermal comfort.However,Trombe wall surfers from overheating in summer and PCMs suffer from low heat transfer rate caused by the limited thermal conductivity.To compensate the shortcomings of the two methods,this paper proposed a Trombe wall system integrated with PCMs.Based on a light-weight building envelope in Changsha,China,the thermal comfort of 10 kinds of Trombe wall systems with PCMs with a melting temperature of 18-28℃ were studied.Taking the integrated indoor discomfort duration(I_(D)),integrated indoor discomfort degree-hour(I_(DH)),indoor air temperature(T_(in)),PCM liquid fraction(γ)and heat flux across wall(q)as evaluation indexes,the indoor thermal comfort was assessed in hot summer and cold winter region.Results show that the Trombe wall helped PCMs complete the phase change process effectively.Trombe wall with PCM25 next to the wall inner surface possessed the lowest annual I_(D) and I_(DH),as 2877 h and 12,974℃·h,respectively.Compared with the values in a traditional building,the I_(D) and I_(DH) were reduced by 7.01% and 14.14%.In order to give full play to the heat storage and heat release of the Trombe wall with PCMs,PCMs with phase change temperature 7℃ lower than the peak ambient temperature in summer or 8℃ higher than the winter night temperature was recommended according to regional climate conditions. | Jie Li Yuan Zhang Ziyang Zhu Jiangtian Zhu Jing Luo Fen Peng Xiaoqin Sun | 2024 | Energy and Built Environment2024，5，1： | 0 |
| 18 | Co-alteration of Myc and RTK-RAS pathways defines a liver-metastatic propensity and immune-cold subgroup of pancreatic adenocarcinoma显示文摘Co-altered pathways refer to the phenomenon where multiple biological pathways exhibit aberrant changes simultaneously within the same tumor sample.This phenomenon can facilitate a better understanding of the mechanism and evolution of tumors and serve as a biological marker for diagnosing,classifying,and treating tumors.1 However,the nature of alteration occurrence and the impact on pancreatic adenocarcinoma(PAAD)remain elusive.The SELECT algorithm was originally designed to systematically assess the evolutionary dependencies and their impact between altered genes in cancer for anticipating drug resistance and proposing alternative strategies.Here,to better characterize the etiology of PAAD and develop an improved risk assessment strategy,2 by utilizing SELECT,we identified a co-altered pathway subgroup of PAAD that demonstrated an elevated risk for unfavorable prognosis,a propensity for liver metastasis,and an immunologically cold microenvironment. | Yuyuan Zhang Ziyang Zu Hui Xu Siyuan Weng Yuqing Ren Quan Cheng Peng Luo Jian Zhang Zaoqu Liu Xinwei Han | 2024 | Genes & Diseases2024，11，3： | 0 |
| 19 | A Novel Named Entity Recognition Scheme for Steel E-Commerce Platforms Using a Lite BERT显示文摘In the era of big data,E-commerce plays an increasingly important role,and steel E-commerce certainly occupies a positive position.However,it is very difficult to choose satisfactory steel raw materials from diverse steel commodities online on steel E-commerce platforms in the purchase of staffs.In order to improve the efficiency of purchasers searching for commodities on the steel E-commerce platforms,we propose a novel deep learning-based loss function for named entity recognition(NER).Considering the impacts of small sample and imbalanced data,in our NER scheme,the focal loss,the label smoothing,and the cross entropy are incorporated into a lite bidirectional encoder representations from transformers(BERT)model to avoid the over-fitting.Moreover,through the analysis of different classic annotation techniques used to tag data,an ideal one is chosen for the training model in our proposed scheme.Experiments are conducted on Chinese steel E-commerce datasets.The experimental results show that the training time of a lite BERT(ALBERT)-based method is much shorter than that of BERT-based models,while achieving the similar computational performance in terms of metrics precision,recall,and F1 with BERT-based models.Meanwhile,our proposed approach performs much better than that of combining Word2Vec,bidirectional long short-term memory(Bi-LSTM),and conditional random field(CRF)models,in consideration of training time and F1. | Maojian Chen Xiong Luo Hailun Shen Ziyang Huang Qiaojuan Peng | 2021 | Computer Modeling in Engineering & Sciences2021，，10： | 0 |
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