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| 1 | ECharts: A declarative framework for rapid construction of web-based visualization显示文摘While there have been a dozen of authoring systems and programming toolkits for visual design and development,users who do not have programming skills,such as data analysts or interface designers,still may feel cumbersome to efficiently implement a web-based visualization.In this paper,we present ECharts,an open-sourced,web-based,cross-platform framework that supports the rapid construction of interactive visualization.The motivation is driven by three goals:easy-touse,rich built-in interactions,and high performance.The kernel of ECharts is a suite of declarative visual design language that customizes built-in chart types.The underlying streaming architecture,together with a high-performance graphics renderer based on HTML5 canvas,enables the high expandability and performance of ECharts.We report the design,implementation,and applications of ECharts with a diverse variety of examples.We compare the utility and performance of ECharts with C3.js,HighCharts,and Chart.js.Results of the experiments demonstrate the efficiency and scalability of our framework.Since the first release in June 2013,ECharts has iterated 63 versions,and attracted over 22,000 star counts and over 1700 related projects in the GitHub.ECharts is regarded as a leading visualization development tool in the world,and ranks the third in the GitHub visualization tab. | Deqing Li Honghui Mei Yi Shen Shuang Su Wenli Zhang Junting Wang Ming Zu Wei Chen | 2018 | Visual Informatics2018，2，2： | 69 |
| 2 | Inhibition of Alveolar Macrophage Pyroptosis Reduces Lipopolysaccharide-induced Acute Lung Injury in Mice显示文摘 | Dong-Dong Wu Pin-Hua Pan Ben Liu Xiao-Li Su Le-Meng Zhang Hong-Yi Tan ZU Cao Zuo-Ren Zhou Hai-Tao Li Hao-Si Li Li Huang Yuan-Yuan Li | 2015 | Chinese Medical Journal2015，，19： | 39 |
| 3 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 4 | Efficient Gene Targeting in Zebrafish Mediated by a Zebrafish-Codon-Optimized Cas9 and Evaluation of Off-Targeting Effect显示文摘Targeted genome modifications with the Cas9/gRNA system derived from the clustered regularly interspaced short palindromic repeat/CRISPR-associated(CRISPR/Cas)system have been successfully used in cultured human cells as well as in most model organisms,including zebrafish(Danio rerio),mouse,and fruit fly(Chang et al.,2013;Cong et al.,2013; | Da Liu Zhanxiang Wang An Xiao Yutian Zhang Wenyuan Li Yao Zu Shaohua Yao Shuo Lin Bo Zhang | 2014 | Journal of Genetics and Genomics2014，41，1： | 18 |
| 5 | Anthocyanins extracted from Chinese blueberry (Vaccinium uliginosum L.) and its anticancer effects on DLD-1 and COLO205 cells显示文摘背景 Vaccinium uliginosum L。蓝莓的一种类型在中国 Changbai 山发现了。我们提取了 Vaccinium uliginosurn Anthocyanins (Av.uli ) 在压制癌症 cells.Methods Av.uli 上调查它的 bioactivity 在温度(10-35 ) 的不同条件下面被提取, pH 1.0-3.0,和硅藻的土(1.0 g-3.0 g ) ,为成分的决心由 HPLC 分析列在后面。它人的冒号和 colorectal 癌症房间( DLD-1 和 COLO205 )上的 anticancer bioactivities 与忍冬 caerulea Anthocyanins ( AL.cae )和 Vaccinium myrtillus Anthocyanins ( Av.myr )上的那些相比,用房间生存能力试金, DNA 电气泳动和包含的 Av.uliextraction 的最佳过程温度 20 调节的原子形态学 assays.Results , pH 2.0 ,并且硅藻的土水果重量的 1.0 g/50 g 。Av.uli 包含了 5 个主要部件:delphinidin (40.70 ??????? 潭 ?? 倠 ????? 敒?瑬 ?? 嘠????????????? 汭???????????????? 楶牴 ????? 洠獥湡楧污?? | ZU Xiao-yan ZHANG Zhen-ya ZHANG Xiao-wen YOSHIOKA Masahiro YANG Ying-nan LI Ji | 2010 | Chinese Medical Journal2010，，19： | 16 |
| 6 | Pairing of integrins with ECM proteins determines migrasome formation显示文摘 | Danni Wu Yue Xu Tianlun Ding Yan Zu Chun Yang Li Yu | 2017 | Cell Research2017，27，11： | 14 |
| 7 | A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and pcsk9 in vivo显示文摘 | Chao Jiang Miao Mei Bin Li Xiurui Zhu Wenhong Zu Yujie Tian Qiannan Wang Yong GUO Yizhou Dong Xu Tan | 2017 | Cell Research2017，27，3： | 12 |
| 8 | Transmission patterns of COVID-19 in the mainland of China and the efficacy of different control strategies: a data-and model-driven study显示文摘Background:The coronavirus disease 2019(COVID-19)outbreak has seriously endangered the health and lives of Chinese people.In this study,we predicted the COVID-19 epidemic trend and estimated the efficacy of several intervention strategies in the mainland of China.Methods:According to the COVID-19 epidemic status,we constructed a compartmental model.Based on reported data from the National Health Commission of People's Republic of China during January 10-February 17,2020,we estimated the model parameters.We then predicted the epidemic trend and transmission risk of COVID-19.Using a sensitivity analysis method,we estimated the efficacy of several intervention strategies.Results:The cumulative number of confirmed cases in the mainland of China will be 86763(95%CI:86067-87460)on May 2,2020.Up until March 15,2020,the case fatality rate increased to 6.42%(95%CI:6.16-6.68%).On February 23,2020,the existing confirmed cases reached its peak,with 60890 cases(95%CI:60350-61431).On January 23,2020,the effective reproduction number was 2.620(95%CI:2.567-2.676)and had dropped below 1.0 since February 5,2020.Due to governmental intervention,the total number of confirmed cases was reduced by 99.85%on May 2,2020.Had the isolation been relaxed from February 24,2020,there might have been a second peak of infection.However,relaxing the isolation after March 16,2020 greatly reduced the number of existing confirmed cases and deaths.The total number of confirmed cases and deaths would increase by 8.72 and 9.44%,respectively,due to a 1-day delayed diagnosis in non-isolated infected patients.Moreover,if the coverage of close contact tracing was increased to 100%,the cumulative number of confirmed cases would be decreased by 88.26%on May 2,2020.Conclusions:The quarantine measures adopted by the Chinese government since January 23,2020 were necessary and effective.Postponing the relaxation of isolation,early diagnosis,patient isolation,broad close-contact tracing,and strict monitoring of infected persons could effectively control the COVID-19 epidemic.April 1,2020 would be a reasonable date to lift quarantine in Hubei and Wuhan. | Jian Zu Miao-Lei Li Zong-Fang Li Ming-Wang Shen Yan-Ni Xiao Fan-Pu Ji | 2020 | Infectious Diseases of Poverty2020，9，4： | 11 |
| 9 | The effect of melt overheating on the melt structure transition and solidified structures of Sn-Bi40 alloy显示文摘Evolution of the electrical resistivity of Sn-40wt%Bi melt with time under different overheating temperatures during isothermal experiments has been studied, and the relationship between different melt state, solidification behavior and solidified structure has also been investigated. The results show that the melt structure transition revealed by the abnormal change of resistivity would take place within a certain holding time just when the holding temperature is above a certain critical, and that the higher the temperature above the critical, the shorter the 'incubation period' of the melt structure transition, and the faster the transition speed. The results of solidification experiments suggest that the melt structure transition caused by different holding time at the same temperature can lead to a higher so-lidification undercooling degree, finer grain size and change of microscopic pattern. Further exploration indicates that the solidification undercooling degree can come to a head when the melt is held at the specific temperature for a given time. The functionary mechanism of the phenomena above is also discussed briefly. | CHEN HongSheng ZU FangQiu CHEN Jie ZOU Li DING GuoHua HUANG ZhongYue | 2008 | Science China(Technological Sciences)2008，51，9： | 11 |
| 10 | Caveolae and caveolin-1 mediate endocytosis and transcytosis of oxidized low density lipoprotein in endothelial cells显示文摘 | Shao-wei SUN Xu-yu ZU Qin-hui TUO Lin-xi CHEN Xiao-yong LEI Kai LI Chao-ke TANG Duan-fang LIAO | 2010 | Acta Pharmacologica Sinica2010，31，10： | 9 |
| 11 | Asymmetry in interface and bending property of Al/Cu/Al bimetallic laminates显示文摘This work was aimed to study the interfacial microstructures and three-point bending properties of Al/Cu/Al bimetallic laminates produced by the asymmetrical roll bonding and annealing. It is found that the microstructure and bonding strength of the Al/Cu interface are different with those of the Cu/Al interface. The interfacial microstructure of Cu/Al interface is improved due to the large interfacial plastic deformation caused by the different rotation speeds of roll in the asymmetrical roll bonding process. The bonding strength between Al and Cu layer can be enhanced by the moderate atomic diffusion, but is dramatically depressed by the formation of intermetallic compounds in the interface.The bending strength of bimetallic laminates is enhanced when the Cu/Al interface is loaded in tension because of the improvement of stress transition and damping by the Cu/Al interface during the three-point bending deformation. The bending fracture reveals that the interfacial cracks can be inhibited from the restricted stress concentration in the improved Cu/Al interface. | Xiao-Bing Li Guo-Yin Zu Ping Wang | 2014 | Rare Metals2014，33，5： | 8 |
| 12 | Biocompatible and biodegradable nanoparticles for enhancement of anti-cancer activities of phytochemicals显示文摘Many phytochemicals show promise in cancer prevention and treatment, but their low aqueous solubility, poor stability, unfavorable bioavailability, and low target specificity make administering them at therapeutic doses unrealistic. This is particularly true for(-)-epigallocatechin gallate, curcumin, quercetin, resveratrol, and genistein. There is an increasing interest in developing novel delivery strategies for these natural products. Liposomes, micelles, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers and poly(lactide-co-glycolide) nanoparticles are biocompatible and biodegradable nanoparticles. Those nanoparticles can increase the stability and solubility of phytochemicals, exhibit a sustained release property, enhance their absorption and bioavailability, protect them from premature enzymatic degradation or metabolism, prolong their circulation time, improve their target specificity to cancer cells or tumors via passive or targeted delivery, lower toxicity or side-effects to normal cells or tissues through preventing them from prematurely interacting with the biological environment, and enhance anti-cancer activities. Nanotechnology opens a door for developing phytochemical-loaded nanoparticles for prevention and treatment of cancer. | LI Chuan ZHANG Jia ZU Yu-Jiao NIE Shu-Fang CAO Jun WANG Qian NIE Shao-Ping DENG Ze-Yuan XIE Ming-Yong WANG Shu | 2015 | Chinese Journal of Natural Medicines2015，13，9： | 8 |
| 13 | Dauricine can inhibit the activity of proliferation of urinary tract tumor cells显示文摘Objective:To explore the anti-tumor effects of asiatic moonseed rhizome extraction-dauricine on bladder cancer EJ cell strain,prostate cancer PC-3Mcell strain and primary cell culture system.Methods:The main effective component-phenolic alkaloids of Menispermum dauricum was extracted and separated from asiatic moonseed rhizome by chemical method.MTT method was used to detect dauricine anti-tumor effect.Results:Dauricine had an obvious proliferation inhibition effect on the main tumor cells in urinary system.The minimum drug sensitivity concentration was between 3.81-S.ISμg/mL,and the inhibition ratio increased with the increase of concentration.Condusioiis:Dauricine,the main effective component extracted from asiatic moonseed rhizome,had a good inhibition effect on tumor cells in urinary system.At the same time,Dauricine has certain inhibition effects on the primary cultured tumor cell. | Jun Wang Yuan Li Xiong-Bing Zu Min-Feng Chen Lin Qi | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 8 |
| 14 | Purification and characterization of Moschatin, a novel type Ⅰ ribosomeinactivating protein from the mature seeds of pumpkin (Cucurbita moschata), and preparation of its immunotoxin against human melanoma cells显示文摘A novel ribosome-inactivating protein designated Moschatin from the mature seeds of pumpkin (Cucurbita moschata) has been successively purified to homogeneity, using ammonium sulfate precipitation, CM-cellulose 52 column chromatography, Blue Sepharose CL-6B Affinity column chromatography and FPLC size-exclusion column chromatography. Moschatin is a type 1 RIP with a pI of 9.4 and molecular weight of-29 kD. It is a rRNA Nglycosidase and potently blocked the protein synthesis in the rabbit reticulocyte lysate with a ICs0 of 0.26 nM. Using the anti-human melanoma McAb Ng76, a novel immunotoxin Moschatin-Ng76 was prepared successfully and it efficiently inhibited the growth of targeted melanoma cells M21 with a IC50 of 0.04 nM, 1500 times lower than that of free Moschatin. The results implied that Moschatin could be used as a new potential anticancer agent. | HENG CHUAN XIA, FENG LI, ZHEN LI, Zu CHUAN ZHANG~* Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. | 2003 | Cell Research2003，13，5： | 8 |
| 15 | Direct observation of ultrafast plasmonic hot electron transfer in the strong coupling regime显示文摘Achieving strong coupling between plasmonic oscillators can significantly modulate their intrinsic optical properties.Here,we report the direct observation of ultrafast plasmonic hot electron transfer from an Au grating array to an MoS_(2) monolayer in the strong coupling regime between localized surface plasmons(LSPs)and surface plasmon polaritons(SPPs).By means of femtosecond pump-probe spectroscopy,the measured hot electron transfer time is approximately 40 fs with a maximum external quantum yield of 1.65%.Our results suggest that strong coupling between LSPs and SPPs has synergetic effects on the generation of plasmonic hot carriers,where SPPs with a unique nonradiative feature can act as an‘energy recycle bin’to reuse the radiative energy of LSPs and contribute to hot carrier generation.Coherent energy exchange between plasmonic modes in the strong coupling regime can further enhance the vertical electric field and promote the transfer of hot electrons between the Au grating and the MoS_(2) monolayer.Our proposed plasmonic strong coupling configuration overcomes the challenge associated with utilizing hot carriers and is instructive in terms of improving the performance of plasmonic opto-electronic devices. | Hangyong Shan Ying Yu Xingli Wang Yang Luo Shuai Zu Bowen Du Tianyang Han Bowen Li Yu Li Jiarui Wu Feng Lin Kebin Shi Beng Kang Tay Zheng Liu Xing Zhu Zheyu Fang | 2019 | Light(Science & Applications)2019，8，1： | 7 |
| 16 | Distribution of solanesol in Nicotiana tabacum显示文摘Solanesol is an important secondary metabolite in Nicotiana tabacum. Distribution of solanesol in Nicotiana tabacum was investigated by High Performance Liquid Chromatography (HPLC) method. The quantitative distribution of solanesol in various organs and tissues of N. tabacum showed that solanesol content, obviously different in all organs, was 6.8, 18.3, 27.5, 45.8, and 68.0 times higher in leaves than that in the stalks, flowers, seeds, fruits and roots, respectively. The contents of solanesol in various parts of leaf, stalk and flower were determined. The content of solanesol in top leaf, middle leaf and bottom leaf gradually decreased (6.124, 5.813 and 5.687 mg·g^(-1), respectively) and the content of solanesol in various leaf-parts (leaf apex, leaf middle and leaf base) also gradually decreased. The content of solanesol in top stalk was 1.19 times and 1.92 times higher than that in the middle stalk and the bottom stalk, respectively. The content of solanesol in various tissues of stalk (epidermis, cortex and stele) dramatically decreased. The sepal contained higher concentration of solanesol (1.192 mg·g^(-1)) compared to any other parts in flower. The study will provide the base data for the regulation and control of solanesol, moreover, it will provide the scientific evidences for the rational development and utilization of N. tabacum resources. | ZHAO Chun-jian ZU Yuan-gang LI Chun-ying TIAN Cheng-yu | 2007 | Journal of Forestry Research2007，18，1： | 7 |
| 17 | Functions and mechanism of modification elements in eutectic solidification of Al-Si alloys:A brief review显示文摘Being used more and more widely in engineering,AlSi alloys comprise about 80%of all kinds of aluminum alloys,which are the most widely utilized nonferrous alloys.Although most Al-Si alloys consist of multiple components,the eutectics in the structure accounts for 50%-90%of the sum volume of such alloys.Therefore,understanding the modification mechanism and function rules of the AlSi eutectic solidification is the technical key in controlling the structures and properties of such casting alloys.The present paper chiefly reviews recent investigation developments and important conclusions along the lines of the functions of modification elements and their modification mechanism in the eutectic solidification of Al-Si alloys. | Zu Fangqiu Li Xiaoyun | 2014 | China Foundry2014，11，4： | 6 |
| 18 | Subcellular distribution and chemical form of Pb in hyperaccumulator Arenaria orbiculata and response of root exudates to Pb addition显示文摘答案文化被进行以便在 Arenaria orbiculata 理解累积特征和 Pb 的化学形式(一。orbiculata ) 并且到 Pb 增加的根流出物的反应。结果显示出那:1 ) 在 A 的射击和根的 Pb 内容。orbiculata 与在答案在 Pb 集中增加增加了。2 ) 在 Pb 增加下面的 Pb 化学形式的内容是列在后面: HAc 可引出的部分( F <潜水艇class=“ a-plus-plus ”> HAC )> HCl 可引出的部分( F <潜水艇class=“ a-plus-plus ”> HCl )> NaCl 可引出的部分( F <潜水艇class=“ a-plus-plus ”> NaCl )>乙醇可引出的部分( F <潜水艇class=“ a-plus-plus ”> E )>浇可引出的部分( F <潜水艇class=“ a-plus-plus ”> W )。3 ) 在引起的媒介的增加的 Pb 水平在射击和根的四 subcellular 部分在 Pb 内容增加,与在 FIV 的大多数累积(部分 IV,可溶的部分) 在射击和 FI (部分我,房间墙部分) 在根。4 ) 可溶的糖和根流出物的免费氨基酸的内容与在溶液增加 Pb 集中增加了。在可溶的糖和免费氨基酸的 Pb 和内容之间的显著地积极的关联被观察。5 ) 与在答案的 Pb 集中,低分子的重量器官的酸(LMWOA ) 内容跟随了趋势:酒石的酸 > 醋酸 > 苹果酸酸 > 柠檬性的酸。显著地积极的关联在 Pb 和柠檬性的酸内容之间被观察。结果显示在 A.orbiculata 的根流出物的可溶的糖,免费氨基酸和柠檬性的酸便于 Pb 的吸收和累积,它在 NaCl- , HCl- 和 HAc- 存在可引出的 Pb 形式, FI 和 FIV 部分,导致 A.orbiculata 的忍耐到 Pb。 | Yanqun ZU Yuan LI Huan MIN Fangdong ZHAN Li QIN Jixiu WANG | 2015 | Frontiers of Environmental Science & Engineering2015，9，2： | 6 |
| 19 | Intercropping of Sonchus asper and Vicia faba affects plant cadmium accumulation and root responses显示文摘The cadmium(Cd)pollution of farmland soil is serious in the world.The present study investigated the effects of intercropping Vicia faba and the hyperaccumulator Sonchus asper on the Cd accumulation and root responses(morphology and secreted organic acids)of plants grown on soil from a mining area in Yunnan Province,China,under different Cd stress levels(0,50,100,and 200 mg kg-1).Intercropping increased the biomass of both S.asper and V.faba,as well as the Cd accumulation and Cd transfer coefficient from roots to shoots of S.asper,but decreased those of V.faba in the 200 mg kg-1Cd treatment.The Cd concentrations in roots,shoots,and grains from intercropped V.faba plants were positively correlated(P<0.05)with the N,N-diethyl phenylacetamide-extractable Cd content in soil.In the 50 mg kg-1Cd treatment,intercropping decreased citric and malic acids in root secretions of S.asper.Intercropped V.faba secreted more citric,oxalic,acetic,and malic acid compared with S.asper.Intercropping also increased root length and root surface area of both S.asper and V.faba.At 50 mg kg-1Cd,root length for S.asper was higher than that at 0 mg kg-1Cd,whereas V.faba roots had significantly decreased length and mean diameter.Intercropping of S.asper and V.faba is suggested as an in situ phytoremediation strategy of Cd-contaminated soils and may improve the food quality of V.faba. | Yanqun ZU Li QIN Fangdong ZHAN Jiong WU Yuan LI Jianjun CHEN Jixiu WANG Wenyou HU | 2020 | Pedosphere2020，30，4： | 6 |
| 20 | LncRNA-MALAT1 mediates cisplatin resistance via miR-101-3p/VEGF-C pathway in bladder cancer显示文摘The mitotically associated lncRNA(MANCR)participates in breast cancer cell proliferation,while its involvement in other cancers is still unknown.In this study,we therefore studied the role of MANCR in mantle cell lymphoma(MCL).We found that serum MANCR and Runt-related transcription factor 2(RUNX2)were upregulated in MCL patients when compared with those in healthy controls.A positive correlation between serum MANCR and RUNX2 was found in MCL patients but not in controls.Upregulation of serum MANCR distinguished MCL patients from controls.MANCR overexpression promoted RUNX2 expression in MCL cells,while RUNX2 overexpression failed to significantly change the expression levels of MANCR.MANCR overexpression promoted the proliferation of MCL cells,while MANCR silencing inhibited the proliferation of MCL cells.In addition,RUNX2 overexpression attenuated the inhibitory effects of MANCR silencing on cell proliferation.However,MANCR overexpression and silencing had no significant effects on cell migration and invasion.Further bioinformatics analysis showed that MANCR may sponge miR-218 to upregulate RUNX2.Therefore,we conclude that downregulation of MANCR may inhibit cancer cell proliferation in MCL possibly by interacting with RUNX2. | Peihua Liu Xiaozhou Li Yu Cui Jinbo Chen Chao Li Qiaqia Li Huihuang Li Xiangyang Zhang Xiongbing Zu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，11： | 6 |
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