|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRLIIpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation显示文摘我们以前报导了那 SM934,水溶性的 artemisinin 衍生物,是在鼠科的豺狼座模型的一个可行处理。在当前的学习,我们进一步在豺狼座容易的 MRL/lpr 老鼠上调查了 SM934 的修改剂量政体的治疗学的效果并且在 B 房间回答上探索了它的效果,在全身的豺狼座 erythematosus (SLE ) 的一个中央病原的事件。当口头上地管理了时两次每日, SM934 显著地延长了 MRL/lpr 老鼠的寿命,改善 lymphadenopathy 症状并且减少浆液的层次反原子的抗体(言论集) 并且病原的 cytokines IL-6, IL-10 和 IL-21。而且, SM934 处理由增加静止 B 房间数字在 MRL/lpr 老鼠的怒气恢复了 B 房间分隔空间,维持幼芽的中心 B 房间数字,减少激活的 B 房间数字和减少的血浆房间(PC ) 数字。前 vivo, SM934 压制了触发的像使用费的受体(TLR ) B 房间的激活和增长,以及抗体分泌物。而且,现在的学习证明 SM934 由 downregulating TLR7/9 mRNA 表示, MyD88 蛋白质表示和 NF-κ 防碍 B 房间内在的小径; B phosphorylation。在人的外部血 mononuclear 房间(PBMC ) ,与在 MRL/lpr 鼠标的结果一致, SM934 禁止了联系 TLR 的 B 房间激活和 PC 区别。在结论, SM934 的两次每日的 dosing 政体由压制 B 房间激活和血浆房间形成在豺狼座容易的 MRL/lpr 老鼠上有治疗学的效果。 | Yanwei Wu Shijun He Bingxin Bai Luyao Zhang Lu Xue Zemin Lin Xiaoqian Yang Fenghua Zhu Peilan He Wei Tang Jianping Zuo | 2016 | Cellular & Molecular Immunology2016，13，3： | 31 |
| 2 | Artemisinin analogue SM934 ameliorates DSS- induced mouse ulcerative colitis via suppressing neutrophils and macrophages显示文摘 | Yu-xi YAN Mei-juan SHAO Qing QI Yan-sheng XU Xiao-qian YANG Feng-hua ZHU Shi-jun HE Pei-lan HE Chun-lan FENG Yan-wei WU Heng LI Wei TANG Jian-ping ZUO | 2018 | Acta Pharmacologica Sinica2018，39，10： | 32 |
| 3 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 4 | Fringe pattern analysis using deep learning显示文摘In many optical metrology techniques,fringe pattern analysis is the central algorithm for recovering the underlying phase distribution from the recorded fringe patterns.Despite extensive research efforts for decades,how to extract the desired phase information,with the highest possible accuracy,from the minimum number of fringe patterns remains one of the most challenging open problems.Inspired by recent successes of deep learning techniques for computer vision and other applications,we demonstrate for the first time,to our knowledge,that the deep neural networks can be trained to perform fringe analysis,which substantially enhances the accuracy of phase demodulation from a single fringe pattern.The effectiveness of the proposed method is experimentally verified using carrier fringe patterns under the scenario of fringe projection profilometry.Experimental results demonstrate its superior performance,in terms of high accuracy and edge-preserving,over two representative single-frame techniques:Fourier transform profilometry and windowed Fourier transform profilometry. | Shijie Feng Qian Chen Guohua Gu Tianyang Tao Liang Zhang Yan Hu Wei Yin Chao Zuo | 2019 | Advanced Photonics2019，1，2： | 31 |
| 5 | Integrated Evaluation of Ecological Security at Different Scales Using Remote Sensing: A Case Study of Zhongxian County, the Three Gorges Area, China显示文摘Based on related literature and this research, an ecological security evaluation from the pixel scale to the small watershed or county scale was presented using remote sensing data and related models. With the driver-pressure, state and exposure to pollution-response (DPSER) model as a basis, a conceptual framework of regional ecological evaluation and an index system were established. The extraction and standardization of evaluation indices were carried out with GIS techniques, an information extraction model and a data standardization model. The conversion of regional ecological security results from the pixel scale to a small watershed or county scale was obtained with an evaluation model and a scaling model. Two conceptual scale conversion models of regional ecological security from the pixel scale to the county scale were proposed: 1) scale conversion of ecological security regime results from pixel to small watershed; and 2) scale conversion from pixel to county. These research results could provide useful ideas for regional ecological security evaluation as well as ecological and environmental management. | ZUO Wei ZHOU Hui-Zhen ZHU Xiao-Hua WANG Qiao WANG Wen-Jie WU Xiu-Qin | 2005 | Pedosphere2005，15，4： | 27 |
| 6 | Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy显示文摘目的: SM934 是有习惯于对待的 immunoregulatory 活动的新奇水溶性的 artemisinin 衍生物鼠科的豺狼座肾炎。在当前的学习,我们在老鼠上调查了 SM934 的效果试验性的膜的 nephropathy。 | Tian-tian LI Xiao-hui ZHANG Jing-feng JING Xin LI Xiao-qian YANG Feng-hua ZHU Wei TANG Jian-ping ZUO | 2015 | Acta Pharmacologica Sinica2015，36，2： | 21 |
| 7 | One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs显示文摘CRISPR/Cas9 系统是一个有效编辑基因的方法,但是编辑基因的动物的多数显示出 mosaicism,与编辑仅仅在房间的部分发生。这里,我们证明那单个基因或多重基因能被 Cas9 mRNA 和多重邻近的单个指南的 RNA 的 zygotic 注射完全在老鼠和猴子胚胎击倒(spaced 10-200 bp 分开) 指向仅仅一把单个钥匙每基因的 exon。个别地在 Y 染色体上跟随八基因的指向的删除的 F0 老鼠的 Phenotypic 分析在产生猛烈老鼠表明了这条途径的坚韧性。重要地,这条途径在高效率交付完全的基因大美人(Arntl 上的 100% 并且 91% 在 Prrt2 上) 在猴子胚胎。最后,我们能在一个单个步骤产生一只完全的 Prrt2 猛烈猴子,表明在很快建立编辑基因的猴子模型的这条途径的实用性。 | Erwei Zuo Yi-Jun Cai Kui Li Yu Wei Bang-An Wang Yidi Sun Zhen Liu Jiwei Liu Xinde Hu Wei Wei Xiaona Huo Linyu Shi Cheng Tang Dan Liang Yan Wang Yan-Hong Nie Chen-Chen Zhang Xuan Yao Xing Wang Changyang Zhou Wenqin Ying Qifang Wang Ren-Chao Chen Qi Shen Guo-Liang Xu Jinsong Li Qiang Sun Zhi-Qi Xiong Hui Yang | 2017 | Cell Research2017，27，7： | 21 |
| 8 | Fegeneration of functional alveoli by adult human SOX9^+ airway basal cell transplantation显示文摘 | Qiwang Ma Yu Ma Xiaotian Dai Tao Ren Yingjie Fu Wenbin Liu Yufei Han Yingchuan Wu Yu Cheng Ting Zhang Wei Zuo | 2018 | Protein & Cell2018，9，3： | 20 |
| 9 | New precut sphincterotomy for endoscopic retrograde cholangiopancreatography in difficult biliary duct cannulation显示文摘AIM:To retrospectively investigate the effect and safety of various new type precut sphincterotomy techniques (VNTPST) in endoscopic retrograde cholangiopancreato-graphy (ERCP) due to difficult biliary duct cannulation (DBC). METHODS:A plough-like pull-type sphincterotome (PLPTS) or improved short nose sphincterotome or improved needle knife was applied. VNTPST was carried out in 30 of 280 patients,whose biliary tract could not be exposed well or deep cannulation was difficult to perform during ERCP with traditional methods. Patients were followed up for short-term complications and the therapeutic effect of VNTPS was observed and compared with that of traditional endoscopic sphincterotomy (EST). RESULTS:A total 280 patients underwent ERCP,of which 3 failed in operation because of pathological features in stomch or duodenum,247 successfully underwent traditional ERCP (89.1%,247/277),30 failed (10.8%,30/277). VNTPS technique succeeded in 24 (80%,24/30) of 30 cases. The successful rate of deep biliary duct cannulation increased 8.6% (24/277),the total cannulation successful rate following precut was 97.7%. There was a significant difference between the two groups (97.7% vs 89.1%,χ2 = 17.1,P < 0.01). The incidence of complications was 9.3% (26/277) for traditional ERCP group and 13.3% (4/30) for VNTPS technique group. Guideline tip was broken in pancreatic duct (KPDGP) of one patient,and there was no pancreatitis,slight or moderate bleeding postoperatively occurred in 2 patients,1 patient had bleeding during operation (PDWN). There were no differences between VNTPS technique group and traditional ERCP (TRERCP)group (13.3% vs 9.3%,χ2 = 0.478,P > 0.05). CONCLUSION:VNTPS procedure and Deng's precut are highly effective methods to get biliary access during ERCP with DBC. With skillful techniques,it can increase the successful rate for deep cannulation of biliary duct and decrease complications. VNTPS technique,especially Deng's precut is as effective and safe as EST. This technique can be well performed in hospitals without particular equipments. | Deng-Hao Deng Hong-Nei Zuo Jia-Feng Wang Zhi-E Gu Hong Chen Yuan Luo Ming Chen Wen-Nuo Huang Lu Wang Wei Lu | 2007 | World Journal of Gastroenterology2007，13，32： | 20 |
| 10 | Anus-preserving rectectomy via telescopic colorectal mucosal anastomosis for low rectal cancer: Experience from a Chinese cohort显示文摘AIM: To investigate the safety and efficacy of anus-preserving rectectomy via telescopic colorectal mucosal anastomosis (TCMA) for low rectal cancer. METHODS: From August 1993 to October 2012, 420 patients including 253 males and 167 females with low rectal cancer underwent transabdominal and transanal anterior resection, followed by TCMA. The distance be-tween the anus and inferior margin of the tumor ranged from 5 to 7 cm, and was 5 cm in 6 patients, 6 cm in 127, and 7 cm in 287 patients. Tumor-node-metastasis staging showed that 136 patients had stage Ⅰ, 252 had stage Ⅱ and 32 had stage Ⅲ. Fifty-six patients with T3 or over received preoperative neoadjuvant chemoradio-therapy. RESULTS: The postoperative follow-up rate was 91.9% (386/420) with a median time of 6.4 years. All 420 pa-tients underwent radical resection. No postoperativedeath occurred. Postoperative complications included anastomotic leakage in 13 (3.1%) patients and anas-tomotic stenosis in 7 (1.6%). The local recurrence rate after surgery was 6.2%, the hepatic metastasis rate was 13.2% and the pulmonary metastasis rate was 2.3%. The 5-year survival rate was 74.0% and the disease-free survival rate was 71.0%. Kirwan classification showed that continence was good in 94.4% of patients with stage I when scored 12 mo after resection. CONCLUSION: TCMA for patients with low rectal cancer leads to better quality of life and satisfactory defecation function, and lowers anastomotic leakage occurrence, and might be one of the safe operative procedures in anus-preserving rectectomy. | Shi-Yong Li Gang Chen Xue Bai Fu-Yi Zuo Guang Chen Jun-Feng Du Xiao-Jun Wei Wei Cui | 2013 | World Journal of Gastroenterology2013，19，24： | 19 |
| 11 | Immunosuppressant discovery from Tripterygium wilfordii Hook f: the novel triptolide analog (5R)-5- hydroxytriptolide (LLDT-8)显示文摘中国传统的植物 Tripterygium wilfordii 钩 f (TwHF ) 广泛地在自体免疫、煽动性的疾病的处理被使用了。在过去几十年,大努力被作了与更高的功效,溶解度,和更低的毒性探索 TwHF 的现代准备。在这研究,我们在 TwHF 自然地发生的混合物和他们的衍生物两个都考察了几个例子,并且关于自体免疫、煽动性的疾病总结了现出症状之前的潜的评估。候选人,此处描述的混合物是或当前在临床的试用的所有。尽管一些研究遇到了问题,数据仍然为未来研究提供了珍贵引用。(5R )-5-hydroxytriptolide (LLDT-8, Leitengshu ) 有抑制免疫力的有势力的新奇 triptolide 衍生物和反煽动性的活动在 Materia Medica 的上海研究所被开发。确实,一个阶段我为这混合物的临床的试用在风湿性关节炎病人被完成了。结果将为这古老的植物的进一步的探索提供基础并且鼓励珍贵繁体中文药的研究和发展。 | Wei TANG Jian-ping ZUO | 2012 | Acta Pharmacologica Sinica2012，33，9： | 19 |
| 12 | Laparoscopic resection of lower rectal cancer with telescopic anastomosis without abdominal incisions显示文摘AIM:To assess laparoscopic radical resection of lower rectal cancer with telescopic anastomosis through transanal resection without abdominal incisions.METHODS:From March 2010 to June 2014, 30 patients(14 men and 16 women, aged 36-78 years, mean age 59.8 years) underwent laparoscopic radical resection of lower rectal cancer with telescopic anastomosis through anus-preserving transanal resection.The tumors were 5-7 cm away from the anal margin in 24 cases, and 4 cm in six cases.In preoperative assessment, there were 21 cases of T1N0M0 and nine of T2N0M0.Through the middle approach, the sigmoid mesentery was freed at the root with an ultrasonic scalpel and the roots of the inferior mesenteric artery and vein were dissected, clamped and cut.Following the total mesorectal excision principle, the rectum was separated until the anorectal ring reached 3-5 cm from the distal end of the tumor.For perineal surgery, a ring incision was made 2 cm above the dentate line, and sharp dissection was performed submucosally towards the superior direction, until the plane of the levator ani muscle, to transect the rectum.The rectum and distal sigmoid colon were removed together from the anus, followed by a telescopic anastomosis between the full thickness of the proximal colon and the mucosa and submucosal tissue of the rectum.RESULTS:For the present cohort of 30 cases,the mean operative time was 178 min,with an average of 13 positive lymph nodes detected.One case of postoperative anastomotic leak was observed,requiring temporary colostomy,which was closed and recovered3 mo later.The postoperative pathology showed T1-T2N0M0 in 19 cases and T2N1M0 in 11 cases.Twelve months after surgery,94.4%patients achieved anal function Kirwan grade 1,indicating that their analfunction returned to normal.The patients were followed up for 1-36 mo,with an average of 23 mo.There was no local recurrence,and 17 patients survived for>3years(with a survival rate of 100%).CONCLUSION:Laparoscopic radical resection of lower rectal cancer with telescopic anastomosis through transanal resection without abdominal incisions is safe and feasible. | Shi-Yong Li Gang Chen Jun-Feng Du Guang Chen Xiao-Jun Wei Wei Cui Fu-Yi Zuo Bo Yu Xing Dong Xi-Qing Ji Qiang Yuan | 2015 | World Journal of Gastroenterology2015，21，16： | 19 |
| 13 | Inhibitory effects of miRNA-200c on chemotherapy-resistance and cell proliferation of gastric cancer SGC7901/DDP cells显示文摘Background and Objective: miRNA-200c can not only inhibit the aggressiveness of cancer cells but also increase the sensitivity of cells to antitumor drugs. However, some mechanisms are still unclear. Recent researches revealed that E-cadherin is more than an inhibitor of metastasis, and it also plays important roles in reversing drug resistance. We had previously found that miRNA-200c could not only induce the expression of E-cadherin but also increase the sensitivity of gastric cancer SGC7901/DDP cells to cisplatin (DDP). This study aimed to explore the effects of miRNA-200c on biological characteristics of SGC7901/DDP cells and the roles of E-cadherin in the regulatory pathway of miRNA-200c. Methods: SGC7901/DDP cells and its parental cell line SGC7901 cells were transfected with miRNA-200c precursor (Pre-200c) and E-cadherin siRNA, respectively. Real-time RT-PCR was used to detect miRNA-200c expression after transfection with Pre-200c in SGC7901/DDP cell line. Drug sensitivities to DDP, 5-fluorouracil (5-FU), paclitaxel, and adriamycin (ADR) after transfection were tested using MTT assay. The proliferation of SGC7901/DDP cells was also detected after transfection. The protein changes of E-cadherin, Bax, and Bcl-2 after transfection were detected by Western blot. Results: The miRNA-200c expression in SGC7901/DDP cells after transfection of Pre-200c was 7.128 ± 0.159 times of that in negative control (P < 0.05). The IC50 of DDP, 5-FU, paclitaxel, and ADR in Pre-200c-transfected group were significantly lower than that in negative control group (P < 0.05). Compared to the control group, cell proliferation was significantly decreased (P < 0.05). The relative protein expressions of E-cadherin and Bax in Pre-200c-transfected group were significantly higher than those in negative control group (P < 0.05), whereas Bcl-2 was significantly lower than that in control (P < 0.05). Additionally, E-cadherin protein expression was significantly inhibited after transfected with E-cadherin siRNA in SGC7901 cells. The Bax protein expression was significantly down-regulated by E-cadherin siRNA (P < 0.05), whereas the Bcl-2 expression was significantly up-regulated (P < 0.05). Conclusion: miRNA-200c can indirectly regulate apoptosis through E-cadherin in SGC7901/DDP cells, which may be a possible mechanism of miRNA-200c in reversing drug resistance and inhibiting proliferation. | Yong Chen Jing Zuo Ying Liu Hong Gao Wei Liu | 2010 | Chinese Journal of Cancer2010，29，12： | 18 |
| 14 | Astragaloside II triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity显示文摘 | Chun-ping WAN Li-xin GAO Li-fei HOU Xiao-qian YANG Pei-lan HE Yi-fu YANG Wei TANG Jian-min YUE Jia LI Jian-ping ZUO | 2013 | Acta Pharmacologica Sinica2013，34，4： | 17 |
| 15 | Microwave Exposure Impairs Synaptic Plasticity in the Rat Hippocampus and PC12 Cells through Over-activation of the NMDA Receptor Signaling Pathway显示文摘Objective The aim of this study is to investigate whether microwave exposure would affect the N-methyl-D-aspartate receptor(NMDAR) signaling pathway to establish whether this plays a role in synaptic plasticity impairment. Methods 48 male Wistar rats were exposed to 30 m W/cm2 microwave for 10 min every other day for three times. Hippocampal structure was observed through H&E staining and transmission electron microscope. PC12 cells were exposed to 30 m W/cm2 microwave for 5 min and the synapse morphology was visualized with scanning electron microscope and atomic force microscope. The release of amino acid neurotransmitters and calcium influx were detected. The expressions of several key NMDAR signaling molecules were evaluated. Results Microwave exposure caused injury in rat hippocampal structure and PC12 cells, especially the structure and quantity of synapses. The ratio of glutamic acid and gamma-aminobutyric acid neurotransmitters was increased and the intracellular calcium level was elevated in PC12 cells. A significant change in NMDAR subunits(NR1, NR2 A, and NR2B) and related signaling molecules(Ca2+/calmodulin-dependent kinase II gamma and phosphorylated c AMP-response element binding protein) were examined. Conclusion 30 m W/cm2 microwave exposure resulted in alterations of synaptic structure, amino acid neurotransmitter release and calcium influx. NMDAR signaling molecules were closely associated with impaired synaptic plasticity. | XIONG Lu SUN Cheng Feng ZHANG Jing GAO Ya Bing WANG Li Feng ZUO Hong Yan WANG Shui Ming ZHOU Hong Mei XU Xin Ping DONG Ji YAO Bin Wei ZHAO Li PENG Rui Yun | 2015 | Biomedical and Environmental Sciences2015，28，1： | 16 |
| 16 | Effects of residual organics in municipal wastewater on hydrogenotrophic denitrifying microbial communities显示文摘Hydrogenotrophic denitrification is promising for tertiary nitrogen removal from municipal wastewater. To reveal the influence of residual organics in municipal wastewater on hydrogenotrophic denitrifiers, we adopted high-throughput 16 S r RNA gene amplicon sequencing to examine microbial communities in hydrogenotrophic denitrification enrichments. Using effluent from a municipal wastewater treatment plant as water source, COD,nitrate and p H were controlled the same except for a gradient of biodegradable carbon(i.e., primary effluent(PE), secondary effluent(SE), or combined primary and secondary effluent(CE)). Inorganic synthetic water(IW) was used as a control. Hydrogenophaga, a major facultative autotroph, accounted for 17.1%, 5.3%, 32.7% and 12.9% of the sequences in PE, CE,SE and IW, respectively, implicating that Hydrogenophaga grew well with or without organics.Thauera, which contains likely obligate autotrophic denitrifiers, appeared to be the most dominant genera(23.6%) in IW and accounted for 2.5%, 4.6% and 8.9% in PE, CE and SE,respectively. Thermomonas, which is related to heterotrophic denitrification, accounted for 4.2% and 7.9% in PE and CE fed with a higher content of labile organics, respectively.In contrast, Thermomonas was not detected in IW and accounted for only 0.6% in SE. Our results suggest that Thermomonas are more competitive than Thauera in hydrogenotrophic denitrification with biodegradable organics. Moreover, facultative autotrophic denitrifiers,Hydrogenophaga, are accommodating to residual organic in effluent wastewater, thus we propose that hydrogenotrophic denitrification is amenable for tertiary nitrogen removal. | Wei Xing Jinlong Li Peng Li Chong Wang Yanan Cao Desheng Li Yunfeng Yang Jizhong Zhou Jiane Zuo | 2018 | Journal of Environmental Sciences2018，30，3： | 16 |
| 17 | Clinical profiles and outcomes of acute type A aortic dissection and intramural hematoma in the current era: lessons from the first registry of aortic dissection in China显示文摘Background::Acute type A aortic dissection(ATAAD)and acute type A intramural hematoma(ATAIMH)are life-threatening diseases with high mortality.To better understand their clinical features in the Chinese population,we analyzed the data from the first Registry of Aortic Dissection in China(Sino-RAD)to promote the understanding and management of the diseases.Methods::All patients with ATAAD and ATAIMH enrolled in Sino-RAD from January 1,2012 to December 31,2016 were involved.The data of patients’selection,history,symptoms,management,outcomes,and postoperation complications were analyzed in the study.The continuous variables were compared using the Student’s t test for normal distributions and the Mann-Whitney U test for non-normal distributions.Categorical variables were compared using the Chi-square test or Fisher exact test.Results::A total of 1582 patients with ATAAD and 130 patients with ATAIMH were included.The mean age of all patients was 48.4 years.Patients with ATAAD were significantly younger than patients with ATAIMH(48.9 years vs.55.6 years,P<0.001).For the total cohort,males were dominant,but the male ratio of patients with ATAAD was significantly higher compared to those with ATAIMH(P=0.01).The time range from the onset of symptom to hospitalization was 2.0 days.More patients of ATAIMH had hypertension than that of ATAAD(82.3%vs.67.6%,P<0.05).Chest and back pain were the most common clinical symptoms.Computerized tomography(CT)was the most common initial diagnostic imaging modality.84.7%received surgical treatment and in-hospital mortality was 5.3%.Patients with ATAAD mainly received surgical treatment(89.6%),while most patients with ATAIMH received medical treatment(39.2%)or endovascular repair(35.4%).Conclusions::Our study suggests that doctors should comprehensively use clinical examination and genetic background screening for patients with ATAAD and ATAIMH and further shorten the time range from symptoms onset to intervention,achieving early diagnosis and treatment,thereby reducing the mortality rate of patients with aortic dissection in China.We should standardize the procedures of aortic dissection treatment and improve people’s understanding.Meanwhile,the curing and transferring efficiency should also be improved. | Wei-Xun Duan Wei-Guang Wang Lin Xia Chao Xue Bo Yu Kai Ren Wei Yi Hong-Liang Liang Xiao-Chao Dong Jian Zuo Jin-Cheng Liu Shi-Qiang Yu Ding-Hua Yi | 2021 | Chinese Medical Journal2021，，8： | 15 |
| 18 | Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development. | Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding | 2020 | Science China Chemistry2020，63，6： | 15 |
| 19 | Periplocoside A prevents experimental autoimmune encephalomyelitis by suppressing IL-17 production and inhibits differentiation of Th17 cells显示文摘 | Jing ZHANGt Jia NI Zhen-hua CHEN Xin LI Ru-jun ZHANG Wei TANG Wei-min ZHAO Yi-fu YANG Jian-ping ZUO | 2009 | Acta Pharmacologica Sinica2009，30，8： | 14 |
| 20 | Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation显示文摘 | Li YANG Li-ping SHI Hai-jun CHEN Xian-kun TONG Gui-feng WANG Yang-ming ZHANG Wen-long WANG Chun-lan FENG Pei-lan HE Feng-hua ZHU You-hua HAO Bao-ju WANG Dong-liang YANG Wei TANG Fa-jun NAN Jian-ping ZUO | 2014 | Acta Pharmacologica Sinica2014，35，3： | 14 |
您所在的机构暂未开通此部分的功能，请联系管理员