|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A Handwritten Character Recognition System Using Directional Element Feature and Asymmetric Mahalanobis Distance显示文摘 | Kato N Suzuki M Omachi S | 1999 | IEEE Transactions on Pattern Analysis and Machine Intelligence1999，21，3： | 2 |
| 2 | Purification and characterization of caffeine synthase from tea leaves显示文摘 | Kato M Mizuno K Fujimura T | 1999 | Plant Physiology1999，120，： | 2 |
| 3 | Three pollination guilds and variation in floral characteristics of Boenean gingers (Zingiberaceae and Costaceae)显示文摘 | Sakai S Kato M Inoue T | 1999 | Amer J Bot1999，86，： | 2 |
| 4 | Terminal differentation and calcification in rabbit chondrocyte cultures grown in centrifuge tubes: Rgulation by trasforming growth factor-βand serum factor 显示文摘 | Kato Y Iwamoto M Koike T | 1988 | Proc Natl Acad Sci U S A1988，85，： | 2 |
| 5 | A prospective evaluation of new rapid urease tests before and after eradication treatment of Helicobacterpylori, in comparison with histology, culture and 13Curea breath test显示文摘 | Nishikawa K Sugiyama T Kato M | 2000 | Gastrointest Endosc2000，51，： | 2 |
| 6 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 7 | Protective effect of Irsogladine on monochloramineinduced gastric mucosallesions in rats:a comparative study with rebamipide显示文摘AIM To examine the effect of irsogladine, a novel antiulcer drug, on the mucosal ulcerogenic response to monochloramine (NH 2Cl) in rat stomach, in comparison with rebamipide, another antiulcer drug with cytoprotective activity. METHODS AND RESULTS Oral administration of NH 2Cl (120*!mM) produced severe hemorrhagic lesions in unanesthetized rat stomachs. Both irsogladine ( 1*!mg/*!kg - 10*!mg/*!kg , po ) and rebamipide ( 30*!mg/*!kg - 100*!mg/*!kg , po ) dose dependently prevented the development of these lesions in response to NH 2Cl, the effect of irsogladine was significant at 3*!mg/*!kg or greater, and that of rebamipide only at 100*!mg/*!kg . The protective effect of irsogladine on NH 2Cl induced gastric lesions was significantly reduced by N G nitro L arginine methyl ester (L NAME) but not by indomethacin, while that of rebamipide was significantly mitigated by indomethacin but not by L NAME. Topical application of NH 2Cl (20*!mM) caused a marked reduction of potential difference (PD) in ex vivo stomachs. This PD reduction was not affected by mucosal application of irsogladine, but significantly prevented by rebamipide. The mucosal exposure to NH 4OH (120*!mM) also caused a marked PD reduction in the ischemic stomach (bleeding from the carotid artery), resulting in gastric lesions. These ulcerogenic and PD responses caused by NH 4OH plus ischemia were also significantly mitigated by rebamipide, in an indomethacin sensitive manner, while irsogladine potently prevented such lesions without affecting the PD response, in a L NAME sensitive manner. CONCLUSION These results suggest that ① NH 2Cl generated either exogenously or endogenously damages the gastric mucosa, ② both irsogladine and rebamipide protect the stomach against injury caused by NH 2Cl, and ③ the mechanism underlying the protective action of irsogladine is partly mediated by endogenous nitric oxide, while that of rebamipide is in part mediated by endogenous prostaglandins. | H Yamamoto, M Umeda, H Mizoguchi, S Kato and K Takeuchi | 1999 | World Journal of Gastroenterology1999，5，6： | 2 |
| 8 | Lack of effect of aciclovir on metabolism of theophylline and expression of hepatic cytochrome p450 1A2 in rats显示文摘 | Nadai, M Kato, M Yasui, K Kimura, M Zhao, YL Ueyama, J Tsunekawa, Y Yoshizumi, H Hasegawa, T | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 9 | Expression pattern of CXC ehemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma显示文摘 | Kato M Kitayama J Kazama S | 2003 | Breast Cancer Res2003，5，5： | 1 |
| 10 | Enhanced biodegradation of aromatic pollutants in cocultures of anaerobic and aerobic bacterial consortia 显示文摘 | FELDJ A STAMS A J M KATO M | 1995 | Antonievall Leeuwenhoek1995，67，： | 1 |
| 11 | A therapeutic strategy based on histological assessment of hyperpigmented skin lesions in Asians 显示文摘 | Kurita M Kato H Yoshimura K | 2008 | Plast Reconstr Aesthet Surg2008，19，： | 1 |
| 12 | Allelic variation at the VRN-1 promoter region in polyploid wheat显示文摘 | Yan L Helguera M Kato K | 2004 | Theor Appl Genet2004，109，： | 1 |
| 13 | Changes in coagulation-fibrinolysis marker and neutrophil elastase following the use of tourniquet during total knee arthroplasty and the influence of neutrophil elastase on thromboembolism显示文摘 | Katsumata S Nagashima M Kato K | 2005 | Acta Anaesthesiol Scand2005，49，4： | 1 |
| 14 | 5 - HT2A gene variants influence specific and different aspects of antidepressant response in Japanese and Italian mood disorder patients 显示文摘 | Kato M Zanardi R Rossini D | 2009 | Psychiatry Res2009，167，12： | 1 |
| 15 | Relationship between serum pre-B cell colony-enhancing factor/visfatin and atherosclerotic parameters in chronic hemodialysis patients显示文摘 | Kato A Odamaki M Ishida J | 2009 | Am J Ment Retard2009，29，1： | 1 |
| 16 | Stress-strain behavior and shape memory effect in power metallurgy TiNi alloy 显示文摘 | Kato h Kokizane M Miura S | 1994 | Acta Metall Mater1994，42，4： | 1 |
| 17 | Development of Ti-Bearing High Performance Ferritic Stainless Steels R430XT and RSX-1显示文摘 | Yazawa Y Kato Y Kobayashi M | 1999 | Kawasaki Steel Technical Report1999，23，： | 1 |
| 18 | Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo显示文摘 | K D Bowman A M Harrington | 1995 | J Natl Cancer Inst1995，87，： | 1 |
| 19 | Prognostic significance of microvessel count in low stage renal cell carcinoma显示文摘 | Kato M Okada K | 1995 | Int J Urol1995，2，3： | 1 |
| 20 | Caspases cleave the amino-terminal calpain inhibitory unit of calpastatin during apoptosis in human Jurkat T cells 显示文摘 | Nonaka T Maki M Kikuchi H Imajoh-Ohmi S | 2000 | J Biochem2000，127，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员