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| 1 | Antibacterial and angiogenic chitosan microneedle array patch for promoting wound healing显示文摘A patch with the capability of avoiding wound infection and promoting tissue remolding is of great value for wound healing.In this paper,we develop a biomass chitosan microneedle array(CSMNA)patch integrated with smart responsive drug delivery for promoting wound healing.Chitosan possesses many outstanding features such as the natural antibacterial property and has been widely utilized for wound healing.Besides,the microstructure of microneedles enables the effective delivery of loaded drugs into the target area and avoids the excessive adhesion between the skin and the patch.Also,vascular endothelial growth factor(VEGF)is encapsulated in the micropores of CSMNA by temperature sensitive hydrogel.Therefore,the smart release of the drugs can be controllably realized via the temperature rising induced by the inflammation response at the site of wounds.It is demonstrated that the biomass CSMNA patch can promote inflammatory inhibition,collagen deposition,angiogenesis,and tissue regeneration during the wound closure.Thus,this versatile CSMNA patch is potentially valuable for wound healing in clinical applications. | Junjie Chi Xiaoxuan Zhang Canwen Chen Changmin Shao Yuanjin Zhao Yongan Wang | 2020 | Bioactive Materials2020，5，2： | 25 |
| 2 | Self-healing alginate-carboxymethyl chitosan porous scaffold as an effective binder for silicon anodes in lithium-ion batteries显示文摘Polymer binder plays a pivotal role in electrochemical performance of high-capacity silicon(Si)anode that usually suffers from severe capacity fading due to enormous substantial volume change of Si during cycling.In an effort to find efficient polymer binder that could mitigate such capacity fading,alginate-carboxymethyl chitosan(Alg-C-chitosan)composite polymer was investigated as a low-cost watersoluble binder for silicon anodes in lithium-ion batteries.The electrostatic interaction between carboxylate(-COO-)of Alg and protonated amines(-NH3+)of C-chitosan forms a selfhealing porous scaffold structure.Synergistic effect on the enhanced porous scaffold structure and self-healing electrostatic interaction of Alg-C-chitosan binder effectively can tolerate the tremendous volume change of Si and maintain an integrated electrode structure during cycling process.The Si nanopowder electrodes with Alg-C-chitosan composite binder exhibit an excellent cycling stability,with a capacity of750 mAh·g-1 remaining after 100 th cycling.In addition,an extraordinary areal capacity of 3.76 mAh·cm-2 is achieved for Si-based anodes with Alg-C-chitosan binder. | Zhao-Hui Wu Juan-Yu Yang Bing Yu Bi-Meng Shi Chun-Rong Zhao Zhang-Long Yu | 2019 | Rare Metals2019，38，9： | 22 |
| 3 | Influence of chitosan characteristics on the properties of biopolymeric chitosan-montmorillonite | Pranee Lertsutthiwong Khanittha Noomun Srichalai Khunthon Sarintorn Limpanart | 2012 | Progress in Natural Science:Materials International2012，22，5： | 15 |
| 4 | Chitosan based bioactive materials in tissue engineering applications-A review显示文摘In recent years,there have been increasingly rapid advances of using bioactive materials in tissue engineering applications.Bioactive materials constitute many different structures based upon ceramic,metallic or polymeric materials,and can elicit specific tissue responses.However,most of them are relatively brittle,stiff,and difficult to form into complex shapes.Hence,there has been a growing demand for preparing materials with tailored physical,biological,and mechanical properties,as well as predictable degradation behavior.Chitosan-based materials have been shown to be ideal bioactive materials due to their outstanding properties such as formability into different structures,and fabricability with a wide range of bioactive materials,in addition to their biocompatibility and biodegradability.This review highlights scientific findings concerning the use of innovative chitosan-based bioactive materials in the fields of tissue engineering,with an outlook into their future applications.It also covers latest developments in terms of constituents,fabrication technologies,structural,and bioactive properties of these materials that may represent an effective solution for tissue engineering materials,making them a realistic clinical alternative in the near future. | Md.Minhajul Islam Md.Shahruzzaman Shanta Biswas Md.Nurus Sakib Taslim Ur Rashid | 2020 | Bioactive Materials2020，5，1： | 15 |
| 5 | 壳质、壳聚糖与体育运动显示文摘壳质(chitin)、壳聚糖(chitosan),统称为甲壳质。1811年法国学者braconno在昆虫外壳中发现了此种物质,1823年又一法国学者odier从甲壳动物外壳中提取,并命名为chitin,1859年rouget发现了壳聚糖,1894年hopper—ceyler将其正式命名为chitosan。 壳质、壳聚糖的化学结构和纤维素非常相似,都是六碳糖的多聚体,分子量都在100万以上,纤维素的基本单位是葡萄糖,它是由300~2500个葡萄糖残基通过1.4糖甙链连接而成的聚合体。 | 马亚妮 | 1999 | 体育科学1999，19，3： | 9 |
| 6 | Collagen-chitosan scaffold impregnated with bone marrow mesenchymal stem cells for treatment of traumatic brain injury显示文摘Combinations of biomaterials and cells can effectively target delivery of cells or other therapeutic factors to the brain to rebuild damaged nerve pathways after brain injury.Porous collagen-chitosan scaffolds were prepared by a freeze-drying method based on brain tissue engineering.The scaffolds were impregnated with rat bone marrow mesenchymal stem cells.A traumatic brain injury rat model was established using the 300 g weight free fall impact method.Bone marrow mesenchymal stem cells/collagen-chitosan scaffolds were implanted into the injured brain.Modified neurological severity scores were used to assess the recovery of neurological function.The Morris water maze was employed to determine spatial learning and memory abilities.Hematoxylin-eosin staining was performed to measure pathological changes in brain tissue.Immunohistochemistry was performed for vascular endothelial growth factor and for 5-bromo-2-deoxyuridine(BrdU)/neuron specific enolase and BrdU/glial fibrillary acidic protein.Our results demonstrated that the transplantation of bone marrow mesenchymal stem cells and collagen-chitosan scaffolds to traumatic brain injury rats remarkably reduced modified neurological severity scores,shortened the average latency of the Morris water maze,increased the number of platform crossings,diminished the degeneration of damaged brain tissue,and increased the positive reaction of vascular endothelial growth factor in the transplantation and surrounding areas.At 14 days after transplantation,increased BrdU/glial fibrillary acidic protein expression and decreased BrdU/neuron specific enolase expression were observed in bone marrow mesenchymal stem cells in the injured area.The therapeutic effect of bone marrow mesenchymal stem cells and collagen-chitosan scaffolds was superior to stereotactic injection of bone marrow mesenchymal stem cells alone.To test the biocompatibility and immunogenicity of bone marrow mesenchymal stem cells and collagen-chitosan scaffolds,immunosuppressive cyclosporine was intravenously injected 12 hours before transplantation and 1-5 days after transplantation.The above indicators were similar to those of rats treated with bone marrow mesenchymal stem cells and collagen-chitosan scaffolds only.These findings indicate that transplantation of bone marrow mesenchymal stem cells in a collagen-chitosan scaffold can promote the recovery of neuropathological injury in rats with traumatic brain injury.This approach has the potential to be developed as a treatment for traumatic brain injury in humans.All experimental procedures were approved by the Institutional Animal Investigation Committee of Capital Medical University,China(approval No.AEEI-2015-035)in December 2015. | Feng Yan Ming Li Hong-Qi Zhang Gui-Lin Li Yang Hua Ying Shen Xun-Ming Ji Chuan-Jie Wu Hong An Ming Ren | 2019 | Neural Regeneration Research2019，14，10： | 9 |
| 7 | Inhibitory effects of chitosan on superoxide anion radicals and lipid free radicals显示文摘With the electron spin resonance (ESR) technique, the inhibitory effects of chitosan on superoxide anion radicals and linoleic acid lipid radicals were found. The inhibitory ratio E for these two kinds of radicals is in proportion to the concentration of chitosan. It was also observed that E for linoleic acid lipid radicals increased with the increase of the degree of deacetylation and decreased with the increase of the molecular weight of chitosan. | Wenjun Li Xuan Jiang Peihua Xue Shiming Chen | 2002 | Chinese Science Bulletin2002，47，11： | 9 |
| 8 | Preparation of magnetic chitosan microspheres and its applications in wastewater treatment显示文摘The methods of preparation of magnetic chitosan microspheres have been introduced. In addition, their applications in the wastewater treatment, based on different kinds of wastewater, have been reviewed, and their mechanisms have been discussed. | YANG Hu YUAN Bo LU YaoBo CHENG RongShi | 2009 | Science China Chemistry2009，52，3： | 9 |
| 9 | In situ forming hydrogels based on chitosan for drug delivery and tissue regeneration显示文摘In situ forming hydrogels with simple sol–gel transition are more practicable as injectable hydrogels for drug delivery and tissue regeneration. State-of-the-art in situ gelling systems can easily and efficiently be formed by different mechanisms in situ. Chitosan is a kind of natural polysaccharide that is widely exploited for biomedical applications due to its good biocompatibility, low immunogenicity and specific biological activities. Chitosan-based in situ gelling systems have already gained much attention as smart biomaterials in the development of several biomedical applications, such as for drug delivery systems and regeneration medicine. Herein, we review the typical in situ gelling systems based on chitosan and mechanisms involved in hydrogel forming, and report advances of chitosan-based in situ gels for the applications in drug delivery and tissue regeneration. Finally, development prospects of in situ forming hydrogels based on chitosan are also discussed in brief. | Li Liu Qi Gao Xuemin Lu Huifang Zhou | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，6： | 8 |
| 10 | Chlorogenic acid loaded chitosan nanoparticles with sustained release property,retained antioxidant activity and enhanced bioavailability显示文摘In this study,chlorogenic acid(CGA),a phenolic compound widely distributed in fruits and vegetables,was encapsulated into chitosan nanoparticles by ionic gelation method.The particles exhibited the size and zeta potential of 210 nm and 33 mV respectively.A regular,spherical shaped distribution of nanoparticles was observed through scanning electron microscopy(SEM)and the success of entrapment was confirmed by FTIR analysis.The encapsulation efficiency of CGA was at about 59%with the loading efficiency of 5.2%.In vitro ABTS assay indicated that the radical scavenging activity of CAG was retained in the nanostructure and further,the release kinetics study revealed the burst release of 69%CGA from nanoparticles at the end of 100th hours.Pharmacokinetic analysis in rats showed a lower level of Cmax,longer Tmax,longer MRT,larger AUC0et and AUC0e∞for the CGA nanoparticles compared to free CGA.Collectively,these results suggest that the synthesised nanoparticle with sustained release property can therefore ease the fortification of food-matrices targeted for health benefits through effective delivery of CGA in body. | Ilaiyaraja Nallamuthu Aishwarya Devi Farhath Khanum | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，3： | 7 |
| 11 | Preparation and characterization of chitosan porous microcarriers for hepatocyte culture显示文摘BACKGROUND: The bioartificial liver (BAL) is considered a possible alternative method for treating liver failure. The core of the BAL system is culturing liver cells in vitro with high density and activity. Microcarrier culture is a mode of high-density culture. We set out to prepare a novel porous microcarrier to improve the activity of liver cells in vitro. METHODS: Chitosan was used to prepare a novel porous spherical microcarrier with interconnected structure. The chitosan porous microcarriers (CPMs) were modified with gelatin to improve their biocompatibility. CPMs were co-cultured with liver cells, HL-7702 (L-02), to evaluate their effect on cell culture. RESULTS: The average size of the CPMs was about 400 μm in diameter and their apertures were less than 30 μm. The pores of the microcarrier were interconnected. After fixation by sodium tripolyphosphate, the structure of the first freeze-dried CPMs was stable. To further improve the biocompatibility, the surface of CPMs was modified with gelatin through chemical crosslinking (GM-CPMs). Comparing the proliferation curves of L-02 cells cultured on simple CPMs, GM-CPMs and tissue culture polystyrene (TCPS, a mode of planar cell culture), the proliferation rates were similar in the first 5 days and the cells proliferated until day 8 in culture with microcarriers. The OD value of liver cells cultured on GM-CPMs was 1.97-fold higher than that on TCPS culture at day 8. Levels of urea and albumin in supernatants of cells cultured on GM-CPMs increased steadily for 8 days, and were clearly higher than those of cells cultured on TCPS (P<0.05).CONCLUSIONS: The novel CPMs were promising microcarriers for hepatocyte culture and the GM-CPM seemed better. Porous microcarrier culture was beneficial for hepatocyte function and activity. | Xu-Bo Wu, Cheng-Hong Peng, Fang Huang, Jie Kuang, Song-Lin Yu, Ya-Dong Dong and Bao-San Han Center of Organ Transplantation, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China Department of General Surgery, Central Hospital, Minhang District, Shanghai 201100, China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 6 |
| 12 | Natural Polysaccharide:Modification and Application显示文摘Natural polysaccharides are synthetic macromolecules located in the cell wall and intracellular,intercellular,and secretory cells.These are essential components of life activities.Cellulose and its derivatives,chitosan,alginic acid,starch,and other natural polymer materials that exist in nature are polysaccharides.This article briefly reviews the structure and sources of several natural polysaccharides,focusing on the modification design strategies of polysaccharides such as graft polymerization,oxidation,etherification,and esterification on cellulose(mainly cellulose nanocrystals,CNC),chitosan(CTS),and other polysaccharides and derivatives in the fields of biomass energy,composite materials,wastewater treatment,and biomedicine.Based on the theory of modification and application of polysaccharides at the present stage,future research goals and modification strategy design are prospected. | Ting Chen Ce Sun Xiuzhi Tian Xue Jiang Meiyun Zhang | 2021 | Paper And Biomaterials2021，6，2： | 6 |
| 13 | Applications of Crown Ether Cross-Linked Chitosan for the Analysis of Lead and Cadmium in Environmental Water Samples显示文摘A new type of crown ether cross-linked chitosan was synthesized by the reaction of chitosan with 4,4’-dibromodibenzo-18-crown-6 (Br-DBC). Its token structure was analyzed with FT-IR and NMR and the adsorption behaviors for lead and cadmium in environmental water samples by FAAS were studied. In addition the best analysis conditions were discussed and the adsorption mechanism was explained. As the enrichment factor is above 100, both recoveries are 94%-106%, the detection limits of lead and cadmium are 0.5 μg·L -1and 0.04 μg·L -1 and the relatively standard deviations of lead and cadmium are 3.1% and 2.8% respectively, this new method was successfully applied to the determination of environmental water samples. This method is fast and simple and it greatly enhances the determination ability of FAAS for lead and cadmium. | Tang Yu-rong Zhang Shu-qin Wang Yu-ting Feng Xue-song | 2002 | Wuhan University Journal of Natural Sciences2002，7，2： | 6 |
| 14 | Intranasal administration of carbamazepine-loaded carboxymethyl chitosan nanoparticles for drug delivery to the brain显示文摘Epilepsy is considered as a common and diverse set of chronic neurological disorders and its symptoms can be controlled by antiepileptic drugs(AEDs). The presence of p-glycoprotein and multi-drug resistance transporters in the blood-brain barrier could prevent the entry of AEDs into the brain, causing drug resistant epilepsy. To overcome this problem, we propose using carboxymethyl chitosan nanoparticles as a carrier to deliver carbamazepine(CBZ) intranasally with the purpose to bypass the blood-brain barrier thus to enhance the brain drug concentration and the treatment efficacy. Results so far indicate that the developed CBZNPs have small particle size(218.76 ± 2.41 nm) with high drug loading(around 35%) and high entrapment efficiency(around 80%). The in vitro release profiles of CBZ from the NPs are in accordance with the Korsmeyer-peppas model. The in vivo results show that both encapsulation of CBZ in nanoparticles and the nasal route determined the enhancement of the drug bioavailability and brain targeting characteristics. | Shanshan Liu Shili Yang Paul C.Ho | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，1： | 6 |
| 15 | Application of collagen-chitosan/fibrin glue asymmetric scaffolds in skin tissue engineering显示文摘To create a scaffold that is suitable for the construction of tissue-engineered skin, a novel asymmetric porous scaffold with different pore sizes on either side was prepared by combining a collagen-chitosan porous membrane with fibrin glue. Tissue-engineered skin was fabricated using this asymmetric scaffold, fibroblasts, and a human keratinocyte line (HaCaT). Epidermal cells could be seen growing easily and achieved confluence on the fibrin glue on the upper surface of the scaffold. Scanning electron microscopy showed typical shuttle-like fibroblasts adhering to the wall of the scaffold and fluorescence microscopy showed them growing in the dermal layer of the scaffold. The constructed composite skin substitute had a histological structure similar to that of normal skin tissue after three weeks of culture. The results of our study suggest that the asymmetric scaffold is a promising biologically functional material for skin tissue engineering, with prospects for clinical applications. | Chun-mao HAN Li-ping ZHANG Jin-zhang SUN Hai-fei SHI Jie ZHOU Chang-you GAO | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，7： | 6 |
| 16 | A double-network hydrogel for the dynamic compression of the lumbar nerve root显示文摘Current animal models of nerve root compression due to lumbar disc herniation only assess the mechanical compression of nerve roots and the inflammatory response. Moreover, the pressure applied in these models is static, meaning that the nerve root cannot be dynamically compressed. This is very different from the pathogenesis of lumbar disc herniation. In this study, a chitosan/polyacrylamide double-network hydrogel was prepared by a simple two-step method. The swelling ratio of the double-network hydrogel increased with prolonged time, reaching 140. The compressive strength and compressive modulus of the hydrogel reached 53.6 and 0.34 MPa, respectively. Scanning electron microscopy revealed the hydrogel's crosslinked structure with many interconnecting pores. An MTT assay demonstrated that the number of viable cells in contact with the hydrogel extracts did not significantly change relative to the control surface. Thus, the hydrogel had good biocompatibility. Finally, the double-network hydrogel was used to compress the L4 nerve root of male sand rats to simulate lumbar disc herniation nerve root compression. The hydrogel remained in its original position after compression, and swelled with increasing time. Edema appeared around the nerve root and disappeared 3 weeks after operation. This chitosan/polyacrylamide double-network hydrogel has potential as a new implant material for animal models of lumbar nerve root compression. All animal experiments were approved by the Animal Ethics Committee of Neurosurgical Institute of Beijing, Capital Medical University, China(approval No. 201601006) on July 29, 2016. | Hui Li Hua Meng Yan-Yu Yang Jia-Xi Huang Yong-Jie Chen Fei Yang Jia-Zhi Yan | 2020 | Neural Regeneration Research2020，15，9： | 5 |
| 17 | Effects of chitosan inhibitor on the electrochemical corrosion behavior of 2205 duplex stainless steel显示文摘The effects of chitosan inhibitor on the corrosion behavior of 2205 duplex stainless steel were studied by electrochemical measurements, immersion tests, and stereology microscopy. The influences of immersion time, temperature, and chitosan concentration on the corrosion inhibition performance of chitosan were investigated. The optimum parameters of water-soluble chitosan on the corrosion inhibition performance of 2205 duplex stainless steel were also determined. The water-soluble chitosan showed excellent corrosion inhibition performance on the 2205 duplex stainless steel. Polarization curves demonstrated that chitosan acted as a mixed-type inhibitor. When the stainless steel specimen was immersed in the 0.2 g/L chitosan solution for 4 h, a dense and uniform adsorption film covered the sample surface and the inhibition efficiency(IE) reached its maximum value. Moreover, temperature was found to strongly influence the corrosion inhibition of chitosan; the inhibition efficiency gradually decreased with increasing temperature. The 2205 duplex stainless steel specimen immersed in 0.4 g/L water-soluble chitosan at 30°C displayed the best corrosion inhibition among the investigated specimens. Moreover, chitosan decreased the corrosion rate of the 2205 duplex stainless steel in an FeCl_3 solution. | Se-fei Yang Ying Wen Pan Yi Kui Xiao Chao-fang Dong | 2017 | International Journal of Minerals,Metallurgy and Materials2017，24，11： | 5 |
| 18 | Anti-biofilm and remineralization effects of chitosan hydrogel containing amelogeninderived peptide on initial caries lesions显示文摘In this study,we have designed a more clinically powerful anti-caries treatment by applying the amelogenin-derived peptide QP5 to the antibacterial carrier material chitosan in a hydrogel(CS-QP5 hydrogel),and characterized its effects on the inhibition of a cariogenic biofilm and the promotion of the remineralization of the initial caries lesions.The results indicated that the CS-QP5 hydrogel sustainably inhibited the growth of the Streptococcus mutans biofilm,lactic acid production and the metabolic activity over a prolonged period of time.Moreover,the CS-QP5 hydrogel promoted the remineralization of early enamel lesions,which were indicated by surface microhardness(,polarized light microscopy and transverse microradiography.In conclusion,the CS-QP5 hydrogel shows good potential for caries control in the clinic because of its antibacterial effects as well as the remineralization of initial enamel carious lesions even in a biofilm model over a prolonged period of time. | Qian Ren Zhongcheng Li Longjiang Ding Xiuqing Wang Yumei Niu Xi Qin Xuedong Zhou Linglin Zhang | 2018 | Regenerative Biomaterials2018，5，2： | 5 |
| 19 | Chitosan-DNA介导关节基因转移的体外研究显示文摘目的 :探索体外Chitosan对关节软骨细胞、滑膜细胞的转染。方法 :分离培养兔正常滑膜细胞、软骨细胞 ,使用荧光质粒 pEGFP -C3作为报道基因 ,制备Chitosan -DNA超微颗粒转染兔正常软骨细胞、滑膜细胞 ,荧光显微镜观察绿色荧光蛋白的表达。结果 :Chitosan能将DNA带入胞内 ,该DNA超微颗粒随时间的延长可缓慢进入胞内 ,其包被的DNA也可以被缓慢释放 ,且对软骨细胞的转染能力强。结论 :Chitosan在体外可介导关节软骨细胞、滑膜细胞基因转移 ,为今后关节疾病非病毒基因转移的研究提供实验依据。 | 张晓玲 史须 于长隆 傅欣 张继英 | 2003 | 中国运动医学杂志2003，22，3： | 5 |
| 20 | Hierarchically electrospraying a PLGA@chitosan sphere-in-sphere composite microsphere for multi-drug-controlled release显示文摘Sequential administration and controlled release of different drugs are of vital importance for regulating cellular behaviors and tissue regeneration,which usually demands appropriate carriers like microspheres(MS)to control drugs releases.Electrospray has been proven an effective technique to prepare MS with uniform particle size and high drug-loading rate.In this study,we applied electrospray to simply and hierarchically fabricate sphere-in-sphere composite microspheres,with smaller poly(lactic-co-glycolic acid)MS(~8-10 lm in diameter)embedded in a larger chitosan MS(~250-300 lm in diameter).The scanning electron microscopy images revealed highly uniform MS that can be accurately controlled by adjusting the nozzle diameter or voltage.Two kinds of model drugs,bovine serum albumin and chlorhexidine acetate,were encapsulated in the microspheres.The fluorescence-labeled rhodamine-fluoresceine isothiocyanate(Rho-FITC)and ultraviolet(UV)spectrophotometry results suggested that loaded drugs got excellent distribution in microspheres,as well as sustained,slow release in vitro.In addition,far-UV circular dichroism and matrixassisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF-MS)results indicated original secondary structure and molecular weight of drugs after electrospraying.Generally speaking,our research proposed a modified hierarchically electrospraying technique to prepare sphere-in-sphere composite MS with two different drugs loaded,which could be applied in sequential,multi-modality therapy. | Zhu Liu Weilong Ye Jingchuan Zheng Qindong Wang Guowu Ma Huiying Liu Xiumei Wang | 2020 | Regenerative Biomaterials2020，7，4： | 5 |
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