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| 1 | μ-and m-calpain expression and activity changes following diethylstilbestrol injection in the rat anterior pituitary显示文摘Little is known about changes in calpain activity in the pituitary gland.In the present study,μ-and m-calpain activity changes were detected in the rat anterior pituitary following intraperitoneal injection of diethylstilbestrol.Double-immunofluorescence labeling confirmed colocalization of μ-and m-calpain in prolactin-secreting cells(lactotrophs).Western blot analysis revealed significantly increased expression of both calpains,which accompanied upregulated cytosol and membrane zymographic activities at 12 weeks following diethylstilbestrol injection,compared with rats injected with sunflower oil.Moreover,following estrogen injection,pituitary gland pathological damage gradually worsened with increasing time.Results demonstrated that estrogen regulated calpain expression and activity,and both calpains participated in the pathophysiological processes of the pituitary gland.Ubiquitous calpain expression could serve as an effective target for anti-estrogen drugs. | Weijiang Zhao Zhongfang Shi Fang Yuan Guilin Li Yazhuo Zhang Zhongcheng Wang | 2011 | Neural Regeneration Research2011，6，1： | 7 |
| 2 | OxLDL up-regulates Niemann-Pick type C1 expression through ERK1/2/COX-2/ PPARα-signaling pathway in macrophages显示文摘NiemannPick 类型 C1 (NPC1 ) 主要位于迟了的 endosome/lysosome 的膜并且从迟了的 endosome/lysosome 控制细胞内部的胆固醇 trafficking 到血浆膜。它被报导了那氧化低密度的脂蛋白(oxLDL ) 罐头起来调整 NPC1 表情。然而,详细机制充分没被理解。在这研究,我们在 THP-1 巨噬细胞在 NPC1 表示上调查了 oxLDL 刺激的效果。我们的结果显示出在 mRNA 和蛋白质的起来调整的 NPC1 表示在一个剂量依赖者和时间依赖者举止铺平的那 oxLDL。另外, oxLDL 也导致了细胞外的调整信号的 kinase 1/2 (ERK1/2 ) 的 phosphorylation。有 oxLDL 的处理显著地在巨噬细胞增加了 cyclooxygenase-2 (COX-2 ) mRNA 和蛋白质表示,并且这些增加被 ERK1/2 禁止者 PD98059 或 ERK1/2 压制小介入 RNA (siRNA ) 处理。OxLDL 起来调整在 mRNA 和蛋白质的激活 proliferator 的受体(PPAR ) 铺平的 peroxisome 的表示,它能被 COX-2 siRNA 或 COX-2 禁止者 NS398 处理在这些巨噬细胞废除。OxLDL 戏剧性地提高了细胞的胆固醇流出,它被禁止 ERK1/2 或 COX-2 废除。另外,导致 oxLDL 的 NPC1 表示和细胞的胆固醇流出被 PPAR siRNA 或 GW6471 颠倒, PPAR 的一个对手。一起拿,这些结果提供证据那 oxLDL 罐头起来调整通过在巨噬细胞的 ERK1/2/COX-2/PPAR-signaling 小径的 NPC1 的表示。 | Xiaohua Yu Xiaoxu Li Guojun Zhao Ji Xiao Zhongcheng Mo Kai Yin Zhisheng Jiang Yuchang Fu Xiaohui Zha Chaoke Tang | 2012 | Acta Biochimica et Biophysica Sinica2012，44，2： | 6 |
| 3 | Anti-biofilm and remineralization effects of chitosan hydrogel containing amelogeninderived peptide on initial caries lesions显示文摘In this study,we have designed a more clinically powerful anti-caries treatment by applying the amelogenin-derived peptide QP5 to the antibacterial carrier material chitosan in a hydrogel(CS-QP5 hydrogel),and characterized its effects on the inhibition of a cariogenic biofilm and the promotion of the remineralization of the initial caries lesions.The results indicated that the CS-QP5 hydrogel sustainably inhibited the growth of the Streptococcus mutans biofilm,lactic acid production and the metabolic activity over a prolonged period of time.Moreover,the CS-QP5 hydrogel promoted the remineralization of early enamel lesions,which were indicated by surface microhardness(,polarized light microscopy and transverse microradiography.In conclusion,the CS-QP5 hydrogel shows good potential for caries control in the clinic because of its antibacterial effects as well as the remineralization of initial enamel carious lesions even in a biofilm model over a prolonged period of time. | Qian Ren Zhongcheng Li Longjiang Ding Xiuqing Wang Yumei Niu Xi Qin Xuedong Zhou Linglin Zhang | 2018 | Regenerative Biomaterials2018，5，2： | 5 |
| 4 | THE ROLE OF AN EMERGING CHINA IN WORLD POLITICS显示文摘The rise of China highlights the 20th century and draws great attention from theinternational community.Within the next 10 to 15 years,with rapid economicdevelopment and steady growth of overall national strength,China will carry moreweight in world politics.People have good reasons to believe that a prosperous,powerful and stable China will make more contributions to the progress of civiliza- | Li Zhongcheng Li Zhongcheng Research Professor,Division for China and World Studies,China Institute of Contemporary International Relations. | 1998 | Contemporary International Relations1998，8，2： | 4 |
| 5 | Prediction Model of Coal Reservoir Pressure and its Implication for the Law of Coal Reservoir Depressurization显示文摘The main methods of coalbed methane(CBM)development are drainage and depressurization,and a precise prediction of coal reservoir pressure is thus crucial for the evaluation of reservoir potentials and the formulation of reasonable development plans.This work established a new reservoir pressure prediction model based on the material balance equation(MBE)of coal reservoir,which considers the self-regulating effects of coal reservoirs and the dynamic change of equivalent drainage area(EDA).According to the proposed model,the reservoir pressure can be predicted based on reservoir condition data and the actual production data of a single well.Compared with traditional reservoir pressure prediction models which regard EDA as a fixed value,the proposed model can better predict the average pressure of reservoirs.Moreover,orthogonal experiments were designed to evaluate the sensitivity of reservoir parameters on the reservoir pressure prediction results of this proposed model.The results show that the saturation of irreducible water is the most sensitive parameter,followed by Langmuir volume and reservoir porosity,and Langmuir pressure is the least sensitive parameter.In addition,the pressure drop of reservoirs is negatively correlated with the saturation of irreducible water and the Langmuir volume,while it is positively correlated with porosity.This work analyzed the reservoir pressure drop characteristics of the CBM wells in the Shizhuangnan Block of the Qinshui Basin,and the results show that the CBM reservoir depressurization can be divided into three types,i.e.,rapidly drop type,medium-term stability type,and slowly drop type.The drainage features of wells were reasonably interpreted based on the comprehensive analysis of the reservoir depressurization type;the latter was coupled to the corresponding permeability dynamic change characteristics,eventually proving the applicability of the proposed model. | YAN Xinlu ZHANG Songhang TANG Shuheng LI Zhongcheng WANG Kaifeng YI Yongxiang DANG Feng HU Qiuping | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 2 |
| 6 | Synthesis and purification of trialkyl compounds of gallium and indium显示文摘The research progress in trialkyl compounds of gallium and indium was discussed from two aspects, one was the chemical synthesis of the compounds and the other was the purification of them. There are three synthesis routes being reported in the first aspect, i.e. the route staring from pure metal, the route starting from the pure metal trihalides, and the electrochemical route. In the second aspect, the purifying methods of decomposition-distillation and zone refining were reviewed. | SHU Wangen, ZHOU Zhongcheng and LI Xiong Chemistry and Chemical Engineering College, Central South University, Changsha 410083, China | 2002 | Rare Metals2002，21，1： | 2 |
| 7 | Privacy Protection for Blockchains with Account and Multi-Asset Model显示文摘The blockchain technology has been applied to wide areas.However,the open and transparent properties of the blockchains pose serious challenges to users’privacy.Among all the schemes for the privacy protection,the zero-knowledge proof algorithm conceals most of the private information in a transaction,while participants of the blockchain can validate this transaction without the private information.However,current schemes are only aimed at blockchains with the UTXO model,and only one type of assets circulates on these blockchains.Based on the zero-knowledge proof algorithm,this paper proposes a privacy protection scheme for blockchains that use the account and multi-asset model.We design the transaction structure,anonymous addresses and anonymous asset metadata,and also propose the methods of the asset transfer and double-spending detection.The zk-SNARKs algorithm is used to generate and to verify the zero-knowledge proof.And finally,we conduct the experiments to evaluate our scheme. | Donghui Ding Kang Li Linpeng Jia Zhongcheng Li Jun Li Yi Sun | 2019 | China Communications2019，16，6： | 2 |
| 8 | Cross-Layer Design for Proportional Delay Differentiation and Network Utility Maxi- mization in Multi-Hop Wireless Networks 显示文摘 | ZHOU Anfu LIU Min LI Zhongcheng | 2012 | IEEE Transactions on Wireless Commu- nications2012，11，4： | 1 |
| 9 | Melatonin modulates the effects of diethylstilbestrol (DES) on the anterior pituitary of the female Wistar rat显示文摘 | Zhao Weijiang Shi Zhongfang Yuan Fang Li Guilin Sun Yilin Zhang Yazhuo Wang Zhongcheng | 2010 | Folia Histochemica et Cytobiologica2010，，2： | 1 |
| 10 | EfficientLarge-scale Content Distribution with Combinationof CDN and P2P Networks显示文摘 | HAI Jiang LI Jun LI Zhongcheng | 2009 | International Journalof Hybrid Information Technology2009，2，02： | 1 |
| 11 | IC Testing by Phase Classification Based on Behavioral Description of RTL显示文摘The growing complexity of integrated circuits (ICs) is driving the trend of IC testing towards testing based on behavioral descriptions of register-transfer level (RTL). A behavioral description contains an algorithmic specification of functionality of design. It may contain little or even no information about the design’s cycle-by-cycle behavior or structural implementation. However, it usually has an interior variable to lead the process of its functional phases. This interior variable is named phase variable. The functional behavior of a digital circuit changes according to different values of a phase variable. By analyzing some ITC99 benchmark circuits, this paper presents a way to generate tests for a circuit by tracing the value change of a phase variable in the circuit. | Huawei Li Yinghua Min Zhongcheng Li | 2000 | 湖南大学学报(自然科学版)2000，27，S2： | 1 |
| 12 | Electrode position of nickel oxide and platinum nanoparticles on electrochemically re- duced graphene oxide film as a nonenzymatic glucose sensor显示文摘 | Li Mian Bo Xiangjie Mu Zhongcheng | 2014 | Sensors and Actuators B2014，192，： | 1 |
| 13 | Adaptive cubature Kalman filter with the estimation of correlation between multiplicative noise and additive measurement noise显示文摘Mobile robots are often subject to multiplicative noise in the target tracking tasks,where the multiplicative measurement noise is correlated with additive measurement noise.In this paper,first,a correlation multiplicative measurement noise model is established.It is able to more accurately represent the measurement error caused by the distance sensor dependence state.Then,the estimated performance mismatch problem of Cubature Kalman Filter(CKF)under multiplicative noise is analyzed.An improved Gaussian filter algorithm is introduced to help obtain the CKF algorithm with correlated multiplicative noise.In practice,the model parameters are unknown or inaccurate,especially the correlation of noise is difficult to obtain,which can lead to a decrease in filtering accuracy or even divergence.To address this,an adaptive CKF algorithm is further provided to achieve reliable state estimation for the unknown noise correlation coefficient and thus the application of the CKF algorithm is extended.Finally,the estimated performance is analyzed theoretically,and the simulation study is conducted to validate the effectiveness of the proposed algorithm. | Quanbo GE Zhongcheng MA Jinglan LI Qinmin YANG Zhenyu LU Hong LI | 2022 | Chinese Journal of Aeronautics2022，35，5： | 1 |
| 14 | Efficient Large-scale Content Distribution with Combination of CDN and P2P Networks显示文摘 | Jiang Hai Li Jun Li Zhongcheng | 2009 | International Journal of Hybrid Information Technology2009，2，2： | 1 |
| 15 | Assessment of infectivity and the impact on neutralizing activity of immune sera of the COVID-19 variant,CAL.20C显示文摘Dear Editor,New variants of SARS-CoV-2 have been emerging since the initial outbreak in 2019;1 one of the latest ones was identified in Southern California in October 2020 and was subsequently detected in 26 other states in the United States as well as other countries as of January 2021. | Zhongcheng Zhou Peng Du Meixing Yu Daniel T.Baptista-Hon Man Miao Andy P.Xiang Johnson Yiu-Nam Lau COVID-Immunity Investigation Group Gen Li Kang Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 1 |
| 16 | Physiological responses of somaclonal variants of triploid bermudagrass (Cynodon transvaalensis?×?Cynodon dactylon) to drought stress显示文摘 | Shaoyun Lu Chuanhao Chen Zhongcheng Wang Zhenfei Guo Haihang Li | 2009 | Plant Cell Reports2009，，3： | 1 |
| 17 | First-principles study of He point-defects in HCP rare-earth metals显示文摘He defect properties in Sc, Y, Gd, Tb, Dy, Ho, Er and Lu were studied using first-principles calculations based on density functional theory. The results indicate that the formation energy of an interstitial He atom is smaller than that of a substitutional He atom in all hcp rare-earth metals considered. Furthermore, the tetrahedral interstitial position is more favorable than an octahedral position for He defects. The results are compared with those from bcc and fcc metals. | YANG LI CHEN RuCheng PENG ShuMing LONG XingGui WU ZhongCheng GAO Fei ZU XiaoTao | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，5： | 1 |
| 18 | Reduction of Number of Paths to Be Tested in Delay Testing显示文摘 | Zhongcheng Li Yinghua Min | 2000 | Journal of Electronic Testing: Theory and Applications2000，16，5： | 1 |
| 19 | Efficient large-scale content distribution with combination of CDN and P2P networks显示文摘 | Jiang Hai Li Jun Li Zhongcheng | | 0，，02： | 1 |
| 20 | Predominant expression of β-chain variable region genes of T-cell receptor in TILs from human renal cell carcinoma显示文摘THE repertoire of T-cell antigen receptor(TcR)can be effectively analysed by an approachwith quantitative polymerase chain reaction(qPCR),which allows to characterize the ex-panding T-cell clones by the patterns of restricted usage of TcR V and J region genes. | LI Xueyi, WANG Ying, ZHENG Zhongcheng, ZHANG Dongqing, FUSaili, LING Jianyu and ZHOU Guangyan (CHOU Kuangyen)1. Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai 200025, China 2. Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai 200031, China 3. Shanghai Ruijin Hospital, Shanghai 200025, China | 1997 | Chinese Science Bulletin1997，42，8： | 0 |
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