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| 1 | Management of proximal humerus fractures in adults显示文摘The majority of proximal humerus fractures are lowenergy osteoporotic injuries in the elderly and their incidence is increasing in the light of an ageing population. The diversity of fracture patterns encountered renders objective classification of prognostic value challenging. Non-operative management has been associated with good functional outcomes in stable, minimally displaced and certain types of displaced fractures.Absolute indications for surgery are infrequent and comprise compound, pathological, multi-fragmentary head-splitting fractures and fracture dislocations, as well as those associated with neurovascular injury. A constantly expanding range of reconstructive and replacement options however has been extending the indications for surgical management of complex proximal humerus fractures. As a result, management decisions are becoming increasingly complicated, in an attempt to provide the best possible treatment for each indi-vidual patient, that will successfully address their specific fracture configuration, comorbidities and functional expectations. Our aim was to review the management options available for the full range of proximal humerus fractures in adults, along with their specific advantages, disadvantages and outcomes. | Leonidas Vachtsevanos Lydia Hayden Aravind S Desai Asterios Dramis | 2014 | World Journal of Orthopedics2014，5，5： | 22 |
| 2 | Predictors of kidney tubular dysfunction induced by adefovir treatment for chronic hepatitis B显示文摘AIM:To investigate the predictors of proximal kidney tubular dysfunction(PKTD)induced by adefovir dipivoxil(ADV)treatment for chronic hepatitis B.METHODS:Seventy-nine patients(age at the evaluation of PKTD:56.9±10.7 years)with chronic hepatitis B undergoing long-term oral antiviral nucleos(t)ide analogue treatment were consecutively recruited.PKTD was defined by the presence of at least two of the following five abnormalities:phosphate diabetes,nondiabetic glucosuria,metabolic acidosis,β2-microglobulinuria,or renal hypouricemia.The single-nucleotide polymorphisms(SNPs)in the SLC22A6 gene encoding human organic anion transporter 1(h OAT1)and ABCC2 encoding multidrug resistance protein 2(MRP2)were analyzed using the Taq Man Allelic Discrimination Demonstration Kit.RESULTS:Nine(30.0%)of the 30 ADV-treated patients were diagnosed with PKTD,while no patients without ADV developed PKTD(P<0.001).Three patients with ADV were diagnosed with symptomatic osteomalacia.Among the patients who took ADV,those with PKTD were of higher age at initiation,had significantly longer treatment duration,and had a significantly lower body mass index than those without PKTD.The incidence of PKTD dramatically increased after 96 mo from the start of ADV administration.In contrast,the SNPs were not correlated with PKTD.Logistic regression analysis extracted older age at initiation(OR=5.0,95%CI:1.1-23.4;P=0.040)and longer treatment duration(OR=3.2,95%CI:1.2-8.6;P=0.020)as significant factors associated with PKTD.CONCLUSION:Our results suggest that the tubular function of the kidney of older patients undergoing longterm ADV treatment should be carefully evaluated. | Motohiro Shimizu Norihiro Furusyo Hiroaki Ikezaki Eiichi Ogawa Takeo Hayashi Takeshi Ihara Yuji Harada Kazuhiro Toyoda Masayuki Murata Jun Hayashi | 2015 | World Journal of Gastroenterology2015，21，7： | 18 |
| 3 | PFNA内固定治疗高龄骨质疏松性股骨粗隆间骨折患者的围手术期护理显示文摘股骨粗隆间骨折是临床常见骨折,多见于老年人,随着社会人口老龄化,发生率呈上升趋势[1]。股骨粗隆间骨折的治疗,目前多趋于手术治疗。防旋股骨近端髓内钉(proximal femoral nail antirotation,PFNA)是新型的内固定器材,具有固定可靠,手术创伤小的特点[2],在老年性骨质疏松性骨折中应用广泛。快速康复外科是指在术前、术中及术后采取一系列有效措施而产生协同结果,减少手术应激及并发症,加速患者术后康复,缩短住院时间([3])。 | 梁芳红 黄金美 | 2016 | 全科医学临床与教育2016，14，3： | 15 |
| 4 | Proximal gastrectomy with jejunal interposition and TGRY anastomosis for proximal gastric cancer显示文摘AIM: To compare the short-term outcomes of patients who underwent proximal gastrectomy with jejunal interposition(PGJI) with those undergoing total gastrectomy with Roux-en-Y anastomosis(TGRY).METHODS: From January 2009 to January 2011, thirty-five patients underwent PGJI, and forty-one patients underwent TGRY. The surgical efficacy and short-term follow-up outcomes were compared between the two groups.RESULTS: There were no differences in the demographic and clinicopathological characteristics. The mean operation duration and postoperative hospital stay in the PGJI group were statistically longer than those in the TGRY group(P = 0.00). No anastomosis leakage was observed in two groups. No statistically significant difference was found in endoscopic findings, Visick grade or serum albumin level. The single-meal food intake in the PGJI group was more than that in the TGRY group(P = 0.00). The PG group showed significantly better hemoglobin levels in the second year(P = 0.02). The twoyear survival rate was not significantly different(PGJI vsTGRY, 93.55% vs 92.5%, P = 1.0).CONCLUSION: PGJI is a safe, radical surgical method for proximal gastric cancer and leads to better outcomes in terms of the single-meal food intake and hemoglobin level, compared with TGRY in the short term. | Ping Zhao Shuo-Meng Xiao Ling-Chao Tang Zhi Ding Xiang Zhou Xiao-Dong Chen | 2014 | World Journal of Gastroenterology2014，20，25： | 15 |
| 5 | Laparoscopic splenic hilum lymph node dissection for advanced proximal gastric cancer:A modified approach for pancreasand spleen-preserving total gastrectomy显示文摘AIM:To investigate the feasibility and optimal approach for laparoscopic pancreasand spleen-preserving splenic hilum lymph node dissection in advanced proximal gastric cancer.METHODS:Between August 2009 and August 2012,12 patients with advanced proximal gastric cancer treated in Nanfang Hospital,Southern Medical University,Guangzhou,China were enrolled and subsequently underwent laparoscopic total gastrectomy with pancreasand spleen-preserving splenic hilum lymph node(LN)dissection.The clinicopathological characteristics,surgical outcomes,postoperative course and followup data of these patients were retrospectively collected and analyzed in the study.RESULTS:Based on our anatomical understanding of peripancreatic structures,we combined the characteristics of laparoscopic surgery and developed a modified approach(combined supraand infra-pancreatic approaches)for laparoscopic pancreasand spleenpreserving splenic hilum LN dissection.Surgery was completed in all 12 patients laparoscopically without conversion.Only one patient experienced intraoperative bleeding when dissecting LNs along the splenic artery and was handled with laparoscopic hemostasis.The mean operating time was 268.4 min and mean number of retrieved splenic hilum LNs was 4.8.One patient had splenic hilum LN metastasis(8.3%).Neither postoperative morbidity nor mortality was observed.Peritoneal metastasis occurred in one patient and none of the other patients died or experienced recurrent disease during the follow-up period.CONCLUSION:Laparoscopic total gastrectomy with pancreasand spleen-preserving splenic hilum LN dissection using the modified approach for advanced proximal gastric cancer could be safely achieved. | Ting-Yu Mou Yan-Feng Hu Jiang Yu Hao Liu Ya-Nan Wang Guo-Xin Li | 2013 | World Journal of Gastroenterology2013，19，30： | 13 |
| 6 | Retrospective evaluation of lymphatic and blood vessel invasion and Borrmann types in advanced proximal gastric cancer显示文摘BACKGROUND The Borrmann classification system is used to describe the macroscopic appearance of advanced gastric cancer,and Borrmann typeⅣdisease is independently associated with a poor prognosis.AIM To evaluate the prognostic significance of lymphatic and/or blood vessel invasion(LBVI)combined with the Borrmann type in advanced proximal gastric cancer(APGC).METHODS The clinicopathological and survival data of 440 patients with APGC who underwent curative surgery between 2005 and 2012 were retrospectively analyzed.RESULTS In these 440 patients,LBVI+status was associated with Borrmann typeⅣ,low histological grade,large tumor size,and advanced pT and pN status.The 5-year survival rate of LBVI+patients was significantly lower than that of LBVI– patients,although LBVI was not an independent prognostic factor in the multivariate analysis.No significant difference in the prognosis of patients with Borrmann typeⅢ/LBVI+disease and patients with Borrmann typeⅣdisease was observed.Therefore,we proposed a revised Borrmann typeⅣ(r-BorⅣ)as Borrmann typeⅢplus LBVI+,and found that r-BorⅣwas associated with poor prognosis in patients with APGC,which outweighed the prognostic significance of pT status.CONCLUSION LBVI is related to the prognosis of APGC,but is not an independent prognostic factor.LBVI status can be used to differentiate Borrmann typesⅢandⅣ,and the same approach can be used to treat r-BorⅣand Borrmann typeⅣ. | Shan Gao Guo-Hui Cao Peng Ding Yang-Yang Zhao Peng Deng Bin Hou Kai Li Xiao-Fang Liu | 2019 | World Journal of Gastrointestinal Oncology2019，11，8： | 11 |
| 7 | 两种髓内固定系统在治疗老年股骨粗隆骨折的临床疗效比较显示文摘近年来,高龄患者股骨粗隆间骨折多采用积极的闭合复位髓内固定治疗。我们回顾性分析了2012年8月至2014年6月在我科应用联合加压交锁髓内钉系统(Tri Gen Inter TAN Hip Fracture Nailing Sys-tem,Inter TAN)及股骨近端防旋髓内钉(proximal fem-oral nail antirotation,PFNA)治疗老年股骨粗隆间骨折67例,报告如下。 | 陈楚鹰 彭永胜 李宏涧 | 2016 | 北京医学2016，38，7： | 10 |
| 8 | Reverse polarity shoulder replacement: Current concepts and review of literature显示文摘Shoulder replacement in cuff tear arthropathy(CTA)is an unsolved challenge.CTA poses a soft tissue deficiency in an arthritic glenohumeral joint which the anatomical total shoulder replacement and hemiarthroplasty cannot reliably provide stability,range of movement,function or satisfactory long term outcome.In the past two decades since the introduction of the reverse shoulder replacement,the prosthesis has evolved and has shown promising results.It is a partially constraint joint by virtue of its design features.The reversal of the concavity and convexity of the joint to the proximal humerus and the glenoid,respectively,also shifts and improves its center of rotation onto the osseous surface of the glenoid with less exposure to shear stress.It is a successful pain relieving procedure,offering good outcome in patients with irreparable massive rotator cuff tear with or without osteoarthritis.Consequently,this has led to wider use and expansion of its indication to include more complex elective and trauma cases.Whereas originally used in the more elderly patients,there is increasingly more demand in the younger patients.It is important to have good quality long term data to support these increasing indications.Therefore,we review the literature on the concepts of reverseshoulder replacement and the contemporary evidence. | Ling Hong Lee Aravind Desai | 2014 | World Journal of Orthopedics2014，5，3： | 9 |
| 9 | A new approximate proximal point algorithm for maximal monotone operator显示文摘The problem concerned in this paper is the set-valued equation 0 ∈ T(z) where T is a maximal monotone operator. For given xk and βk > 0, some existing approximate proximal point algorithms take xk+1 = xk such that xk +ek∈ xk + βkT(xk) and||ek|| ≤ηk||xk - xk||, where {ηk} is a non-negative summable sequence. Instead of xk+1 = xk, the new iterate of the proposing method is given by xk+1 = PΩ[xk - ek], where Ω is the domain of T and PΩ(@) denotes the projection on Ω. The convergence is proved under a significantly relaxed restriction supk>0 ηk < 1. | 何炳生 杨振华 廖立志 | 2003 | Science China Mathematics2003，46，2： | 9 |
| 10 | Clinical importance and surgical decision-making regarding proximal resection margin for gastric cancer显示文摘Because of the intramural spread of gastric cancer,a sufficient length of a resection margin has to be attained to ensure complete excision of the tumor.There has been debate on an adequate length of proximal resection margin(PRM) and its related issues.Thus,the objective of this article is to review several studies on PRM and to summarize the current evidence on the subject.Although there is some discrepancy in the recommended values for PRM between authors,a PRM of more than 2-3 cm for early gastric cancer and 5-6 cm for advanced gastric cancer is thought to be acceptable.Once the margin is confirmed to be clear,however,the length of PRM measured in postoperative pathologic examination does not affect the patient's survival,even when it is shorter than the recommended values.Hence,the recommendations for PRM length should be applied only to intraoperative decision-making to prevent positive margins on the final pathology.Given that a negative resection margin is the ultimate goal of determining an adequate PRM,development and improvement of reliable methods to confirm a negative resection margin intraoperatively would minimize the extent of surgery and offer a better quality of life to more patients.In the same context,special attention has to be paid to patients who have advanced stage or diffuse-type gastric cancer,because they are more likely to have a positive margin.Therefore,a wider excision with intraoperative frozen section(IFS) examination of the resection margin is necessary.Despite all the attempts to avoid positive margins,there is still a certain rate of positive-margin cases.Since the negative impact of a positive margin on prognosis is mostly obvious in low N stage patients,aggressive further management,such as extensive re-operation,is required for these patients.In conclusion,every possible preoperative and intraoperative evaluation should be thoroughly carried out to identify in advance the patients with a high risk of having positive margins;these patients need careful management with a wider excision or an IFS examination to confirm a negative margin during surgery. | Doosup Shin Sung-Soo Park | 2013 | World Journal of Gastrointestinal Oncology2013，5，1： | 8 |
| 11 | 股骨近端防旋髓内钉内固定微创治疗股骨粗隆间骨折临床研究显示文摘为进一步提高和完善股骨粗隆间骨折(intertrochanteric fracture,ITF)的临床治疗,本次研究于选取住院并接受手术治疗的80例股骨粗隆间骨折患者,对比股骨近端防旋髓内钉(proximal femoral nail anti-rotation,PFNA)内固定微创与动力髋螺钉(dyramic hip screw,DHS)治疗临床差异性分析,现将结果报告如下。 | 戴海 黄宗贵 吴永祥 | 2017 | 山西医药杂志2017，46，23： | 8 |
| 12 | 股骨近端防旋髓内钉联合利塞膦酸钠治疗老年骨质疏松性股骨粗隆间骨折患者的效果分析显示文摘股骨粗隆间骨折是临床上老年人常见复杂髋部骨折,主要涉及股骨颈基底部至小粗隆之间的部位。本研究对我院收治的97例老年骨质疏松性股骨粗隆间骨折分别实施股骨近端防旋髓内钉(proximal femoral nail anti-rotation,PFNA)与联合利塞膦酸钠治疗,且对比分析其临床疗效。 | 王冶 付伦 喻锋 石卫星 陈军 陈志龙 | 2015 | 山西医药杂志2015，44，24： | 7 |
| 13 | DME Interference mitigation for L-DACS1 based on system identification and sparse representation显示文摘L-band digital aeronautical communication system 1(L-DACS1) is a promising candidate data-link for future air-ground communication, but it is severely interfered by the pulse pairs(PPs) generated by distance measure equipment. A novel PP mitigation approach is proposed in this paper. Firstly, a deformed PP detection(DPPD) method that combines a filter bank, correlation detection, and rescanning is proposed to detect the deformed PPs(DPPs) which are caused by multiple filters in the receiver. Secondly, a finite impulse response(FIR) model is used to approximate the overall characteristic of filters, and then the waveform of DPP can be acquired by the original waveform of PP and the FIR model. Finally, sparse representation is used to estimate the position and amplitude of each DPP, and then reconstruct each DPP. The reconstructed DPPs will be subtracted from the contaminated signal to mitigate interference. Numerical experiments show that the bit error rate performance of our approach is about 5 dB better than that of recent works and is closer to interference-free environment. | Li Douzhe Wu Zhijun | 2016 | Chinese Journal of Aeronautics2016，29，6： | 6 |
| 14 | Sensitivity and regionally proximal relation in minimal systems显示文摘A topological dynamical system is n-sensitive,if there is a positive constant such that in each non-empty open subset there are n distinct points whose iterates will be apart from the constant at least for a same moment.The properties of n-sensitivity in minimal systems are investigated.It turns out that a minimal system is n-sensitive if and only if the n-th regionally proximal relation Q_n contains a point whose coordinates are pairwise distinct.Moreover,the structure of a minimal system which is n-sensitive but not(n+1)-sensitive(n≥2)is determined. | SHAO Song YE XiangDong ZHANG RuiFeng | 2008 | Science China Mathematics2008，51，6： | 5 |
| 15 | 脊柱畸形矫形术后近端交界性后凸相关研究进展显示文摘脊柱畸形矫形手术通过矫正矢状面和冠状面的畸形并进行长节段固定融合以重建躯干的平衡。近端交界性后凸(proximal junctional kyphosis,PJK)是发生在脊柱侧凸或后凸畸形矫形术后的一种特定的影像学表现,通常因手术近端内固定交界区的应力改变引起[1]。 | 王天昊 赵永飞 王岩 | 2016 | 中国脊柱脊髓杂志2016，26，1： | 5 |
| 16 | Operative vs non-operative management of displaced proximal humeral fractures in the elderly: A systematic review and meta-analysis of randomized controlled trials显示文摘AIM: To perform a systematic review and meta-analysis comparing operative vs non-operative treatment of displaced proximal humerus fractures in elderly patients.METHODS: A systematic literature search was performed using EMBASE and MEDLINE through the OVID interface,CINAHL,the Cochrane Central Register of Controlled Trials(CENTRAL),Proquest,Web of Science,SAE digital library,and Transportation Research Board's TRID database.Searches of conference proceedings were also conducted.All available randomized controlled trials comparing operative vs non-operative management of displaced three- and four-part proximal humerus fractures in elderly patients were included.The primary outcomes measures included physical function,pain,health related quality of life,mortality,and the re-operation rate.RESULTS: Six randomized controlled trials(n = 287) were included.There was no statistically significant difference in function(MD = 1.72,95%CI:-2.90-6.34,P = 0.47),as measured by the Constant score,between the operative and the non-operative treatment groups.There was no statistically significance difference insecondary outcomes of health related quality of life(standardized MD = 0.27,95%CI:-0.05-0.59,P = 0.09),and mortality(relative risk 1.29,95%CI: 0.50-3.35,P = 0.60).Operative treatment had a statistically significant higher re-operation rate(relative risk 4.09,95%CI: 1.50-11.15,P = 0.006),and statistically significant decreased pain(MD = 1.26,95%CI: 0.02-2.49,P = 0.05).CONCLUSION: There is moderate quality evidence to suggest that there is no difference in functional outcomes between the two treatments.Further high quality randomized controlled trials are required to determine if certain subgroup populations benefit from surgical management. | Santa Rabi Nathan Evaniew Sheila A Sprague Mohit Bhandari Gerard P Slobogean | 2015 | World Journal of Orthopedics2015，6，10： | 5 |
| 17 | Management bone loss of the proximal femur in revision hip arthroplasty: Update on reconstructive options显示文摘The number of revision total hip arthroplasties is expected to rise as the indications for arthroplasty will expand due to the aging population. The prevalence of extensive proximal femoral bone loss is expected to increase subsequently. The etiology of bone loss from the proximal femur after total hip arthroplasty is multifactorial. Stress shielding, massive osteolysis, extensive loosening and history of multiple surgeries consist the most common etiologies. Reconstruction of extensive bone loss of the proximal femur during a revision hip arthroplasty is a major challenge for even the most experienced orthopaedic surgeon. The amount of femoral bone loss and the bone quality of the remaining metaphyseal and diaphyseal bone dictate the selection of appropriate reconstructive option. These include the use of impaction allografting, distal press-fit fixation, allograft-prosthesis composites and tumor megaprostheses. This review article is a concise review of the current literature and provides an algorithmic approachfor reconstruction of different types of proximal femoral bone defects. | Vasileios I Sakellariou George C Babis | 2014 | World Journal of Orthopedics2014，5，5： | 5 |
| 18 | Clinical characteristics of sentinel polyps and their correlation with proximal colon cancer: A retrospective observational study显示文摘BACKGROUND Colorectal cancer is a common malignant tumor of the digestive tract.The relationship between sentinel polyps(rectal polyps with proximal colon cancer)and proximal colon cancer has received extensive attention in recent years.However,there is still no clear conclusion regarding the relationship.AIM To investigate the clinical characteristics of sentinel polyps and their correlation with proximal colon cancer.METHODS A retrospective analysis of 2587 patients with rectal polyps from January 2006 to December 2017 was performed.According to whether or not proximal colon cancer was diagnosed,the patients were divided into either a sentinel polyp group(192 patients)or a pure rectal polyp group(2395 patients).The endoscopic features,clinicopathological features,therapeutic effects,and short-term prognosis were analyzed and compared between the two groups.RESULTS The mean age of patients in the sentinel polyp group was generally higher than that of the pure rectal polyp group,and the positivity rates of anemia,stool occult blood,and tumor markers of the sentinel polyp group were also significantly higher than those in the rectal polyp group(χ^2=90.56,P<0.01;χ^2=70.30,P<0.01;χ^2=92.80,P<0.01).The majority of the patients in the sentinel polyp group had multiple polyps,large polyps,adenomatous polyps,or sessile polyps(χ^2=195.96,P<0.01;χ^2=460.46,P<0.01;χ^2=94.69,P<0.01;χ^2=48.01,P<0.01).Most of the proximal colon cancers were Duke’s A and B stages in the sentinel polyp group.In the pure rectal polyp group,2203 patients underwent endoscopic treatment,and all of the patients were cured and discharged.In the sentinel polyp group,65 patients underwent radical operation,and 61 patients received endoscopic submucosal dissection or endoscopic mucosal resection.Additionally,21 patients were lost to follow-up after 6-12 mo,and the loss rate was 10.94%.A total of 63.16%of patients experienced remission without tumor recurrence or metastasis,33.33%of patients experienced tumors regression or improved symptoms,and the other 3.51%of the patients died.CONCLUSION If there are multiple,sessile,and adenomatous rectal polyps with a maximum diameter>1 cm,the possibility of the carcinogenesis of the polyps or of the proximal colon should be monitored closely.These patients should be followed in the short-term and should undergo a whole-colon examination. | Man Wang Jia-Jie Lu Wen-Jie Kong Xiao-Jing Kang Feng Gao | 2019 | World Journal of Clinical Cases2019，7，20： | 4 |
| 19 | Assessment of proximal gastric accommodation in patients with functional dyspepsia显示文摘Impaired gastric accommodation is one of the most important etiologic factors in the pathophysiology of functional dyspepsia.Ultrasound is a potential alternative method to study changes in gastric volume as a reflection of gastric accommodation.Ultrasound is suitable for patients because it is a non-invasive,easily repeated and non-radioactive procedure,and a previous study has demonstrated the feasibility of 3-dimensional ultrasound in examining functional dyspepsia.The brief article by Fan et al demonstrated that both the proximal gastric area and volume,measured by 2-and 3-dimensional ultrasound respectively,were significantly smaller in patients with functional dyspepsia than in healthy controls.These results are very interesting,but we raise the relevant point that it should have been mandatory to study both changes in gastric volume and their relationship with upper gastrointestinal symptoms in functional dyspepsia.In fact,the relationship between cardinal symptoms and several pathophysiologic mechanisms in functional dyspepsia remains a matter of debate.Moreover,further evaluation of distal gastric volume that has been previously implicated in the origin of functional dyspeptic symptoms is advisable.Therefore,impaired gastric accommodation does not serve as a clear marker of the cardinal symptoms experienced by patients with functional dyspepsia in daily life. | Paola Iovino Antonella Santonicola Carolina Ciacci | 2013 | World Journal of Gastroenterology2013，19，47： | 4 |
| 20 | Characteristics of symptomatic reflux episodes in Japanese proton pump inhibitor-refractory non-erosive reflux disease patients显示文摘AIM: To clarify the pathogenesis of gastroesophageal reflux disease symptoms in non-erosive reflux disease(NERD) patients.METHODS: Thirty-five NERD patients with persistent symptoms, despite taking rabeprazole 10 mg twice daily for at least 8 wk, were included in this study. All patients underwent 24 h combined impedance- p H on rabeprazole. The symptom index(SI) was considered to be positive if ≥ 50%, and proximal reflux episodes were determined when reflux reached 15 cm above the proximal margin of the lower esophageal sphincter.RESULTS: In 14(40%) SI-positive patients, with liquid weakly acid reflux, the occurrence rate of reflux symptoms was significantly more frequent in proximal reflux episodes(46.7%) than in distal ones(5.7%)(P < 0.001). With liquid acid reflux, there were no significant differences in the occurrence rate of reflux symptoms between proximal reflux episodes(38.5%) and distal ones(20.5%)(NS). With mixed liquid-gas weakly acid reflux, the occurrence rate of reflux symptoms in proximal reflux episodes was significantly more frequent(31.0%) than in distal reflux ones(3.3%)(P < 0.001). With mixed liquid-gas acid reflux, there were no significant differences in the occurrence rate of reflux symptoms between proximal reflux episodes(29.4%) and distal ones(14.3%)(NS).CONCLUSION: The proximal extent of weakly acidic liquid and mixed liquid-gas reflux is a major factor associated with reflux perception in SI-positive patients on proton pump inhibitor therapy. | Kenichiro Nakagawa Tomoyuki Koike Katsunori Iijima Masahiro Saito Hiroki Kikuchi Waku Hatta Nobuyuki Ara Kaname Uno Naoki Asano Tooru Shimosegawa | 2015 | World Journal of Gastroenterology2015，21，47： | 4 |
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