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| 1 | Epidemiological Characteristics of Newly-Reported HIV Cases Among Youth Aged 15−24 Years-China, 2010−2019显示文摘Summary What is already known about this topic?An estimated 1,400 new cases of human immunodeficiency virus(HIV)occur every day among youths globally.However,HIV distribution among youth aged 15–24 years in China has not been researched extensively. | Hao Zhao Hui Liu Lu Wang Xuan Yang Shaorong Wang Mengjie Han Jian Li | 2020 | China CDC weekly2020，2，48： | 23 |
| 2 | From Intelligence Science to Intelligent Manufacturing显示文摘1.Introduction The aim of intelligent manufacturing is to establish flexible and adaptive manufacturing operations locally or globally by using integrated information technology(IT)and artificial intelligence(AI)that can combine advanced computing power with manufacturing equipment.Intelligent manufacturing depends on the timely acquisition,distribution,and utilization of real-time data from both machines and processes on manufacturing shop floors[1]and even across product life-cycles.Effective information sharing can improve production quality,reliability,resource efficiency,and the recyclability of end-of-life products.Intelligent manufacturing built on digitalization is also intended to be more sustainable and to contribute to the factories of the future.However,intelligent manufacturing depends extensively on AI.To better grasp the future of intelligent manufacturing,it is necessary to understand AI.This paper provides the author’s perspective on AI from intelligence science to intelligent manufacturing. | Lihui Wang | 2019 | Engineering2019，5，4： | 18 |
| 3 | Coronavirus disease(COVID-19):The need to maintain regular physical activity while taking precautions显示文摘The on-going Coronavirus disease(COVID-19)outbreak in China has become the world's leading health headline and is causing major panic and public concerns.On January 30,2020,the World Health Organization(WHO)declared that the new coronavirus outbreak is a public health emergency of international concern.1 The virus has already had a direct impact on more than 10 million people in the city of Wuhan and has reached other parts of China as well,posing a health threat of unknown magnitude globally.As of February 8,2020,WHO reported 34,886 confirmed cases of COVID-19 globally,with 34,589 of them occurring in China(including 6101 severe cases and 723 deaths).A total of 288 other confirmed cases(with 1 death)have been reported in 24 countries,including Japan,Australia,Germany,and United States.2 However,these daily estimates are expected to rise even higher as reports from health authorities in China3 are gathered and near real-time updates of the Johns Hopkins virus dashboard are made 4 The outbreak has caused governments in various countries to take swift and protective measures.In China,these included putting cities on lockdown,5 implementing travel wamings/bans and cancellations,6 extending national holidays,and closing schools and postponing classes7. | Peijie Chen Lijuan Mao George P.Nassis Peter Harmer Barbara E.Ainsworth Fuzhong Li | 2020 | Journal of Sport and Health Science2020，9，2： | 15 |
| 4 | EXPERIMENTAL STUDIES ON THE INHIBITION EFFECTS OF 1000 CHINESE MEDICINAL HERBS ON THE SURFACE ANTIGEN OF HEPATITIS B VIRUS显示文摘Hepatitis B induced by hepatitis B virus(HBV)is a globally spreading common dis-ease which has involved about two hundredmillion victims including hepatitis B patientsand HBV carriers.By means of reversepassive hemagglutination inhibition(RPHI)test,experimental studies on the inhibitioneffects of 1000 traditional Chinese medicinalherbs on the hepatitis B surface antigen(HBsAg)were carried out.The following isa report of the work. | 郑民实 郑有方 | 1992 | Journal of Traditional Chinese Medicine1992，12，3： | 10 |
| 5 | An SIS Epidemic Model with Stage Structure and a Delay显示文摘A disease transmission model of SIS type with stage structure and a delay is formulated. Stability of the disease free equilibrium, and existence, uniqueness, and stability of an endemic equilibrium, are investigated for the model. The stability results arc stated in terms of a key threshold parameter. The effects of stage structure and time delay on dynamical behavior of the infectious disease are analyzed. It is shown that stage structure has no effect on the epidemic model and Hopf bifurcation can occur as the time delay increases. | Yan-ni Xiao, Lan-sun ChenAcademy of Mathematics and System Sciences, Chinese Academy of Sciences. Beijing 100080. China | 2002 | Acta Mathematicae Applicatae Sinica2002，18，4： | 9 |
| 6 | Germplasm resources and genetic breeding of Paeonia:a systematic review显示文摘Members of the genus Paeonia,which consists of globally renowned ornamentals and traditional medicinal plants with a rich history spanning over 1500 years,are widely distributed throughout the Northern Hemisphere.Since 1900,over 2200 new horticultural Paeonia cultivars have been created by the discovery and breeding of wild species.However,information pertaining to Paeonia breeding is considerably fragmented,with fundamental gaps in knowledge,creating a bottleneck in effective breeding strategies.This review systematically introduces Paeonia germplasm resources,including wild species and cultivars,summarizes the breeding strategy and results of each Paeonia cultivar group,and focuses on recent progress in the isolation and functional characterization of structural and regulatory genes related to important horticultural traits.Perspectives pertaining to the resource protection and utilization,breeding and industrialization of Paeonia in the future are also briefly discussed. | Yong Yang Miao Sun Shanshan Li Qihang Chen Jaime A.Teixeira da Silva Ajing Wang Xiaonan Yu Liangsheng Wang | 2020 | Horticulture Research2020，7，1： | 8 |
| 7 | 松辽盆地大陆科学钻探松科2井新资料:对下白垩统沙河子组沉积起始时间的限定显示文摘The Songliao Basin is one of the largest non-marine petroliferous basins in the globally and contains nearly complete Cretaceous terrestrial sedimentary records[1,2].The Shahezi Formation,named after Shahezi Village,Changtu County,Liaoning Province,is a thick terrestrial clastic sedimentary succession deposited during the rift period of the Songliao Basin[1].Accordingly,it is significant for research on initial basin history restoration and global continental–marine stratigraphic correlation,to certificate the deposition time of the Shahezi Formation[2–4]. | 刘海波 王璞珺 高有峰 侯贺晟 尹永康 李宏浩 冯玉辉 | 2021 | Science Bulletin2021，66，5： | 6 |
| 8 | Contributions and challenges of general practitioners in China fighting against the novel coronavirus crisis显示文摘IntroduCtIon As the World Health Organisation calls for urgent,aggressive actions to combat COVID-19,China has been making positive contri-butions in the fight against the pandemic during the past few months.General practi-tioners(GPs)in China are at the forefront of tackling the spread of the virus.While the health sector in China has been under scrutiny globally,many articles have been disseminated within the country about the response.GPs in China hope that by sharing their experiences,international colleagues could benefit from what worked well and what went less well. | Donald Kwok Tung Li Shanzhu Zhu | 2020 | Family Medicine and Community Health2020，8，2： | 5 |
| 9 | Advances in COVID-19 mRNA vaccine development显示文摘To date,the coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has determined 399,600,607 cases and 5,757,562 deaths worldwide.COVID-19 is a serious threat to human health globally.The World Health Organization(WHO)has declared COVID-19 pandemic a major public health emergency.Vaccination is the most effective and economical intervention for controlling the spread of epidemics,and consequently saving lives and protecting the health of the population.Various techniques have been employed in the development of COVID-19 vaccines.Among these,the COVID-19 messenger RNA(mRNA)vaccine has been drawing increasing attention owing to its great application prospects and advantages,which include short development cycle,easy industrialization,simple production process,flexibility to respond to new variants,and the capacity to induce better immune response.This review summarizes current knowledge on the structural characteristics,antigen design strategies,delivery systems,industrialization potential,quality control,latest clinical trials and real-world data of COVID-19 mRNA vaccines as well as mRNA technology.Current challenges and future directions in the development of preventive mRNA vaccines for major infectious diseases are also discussed. | Enyue Fang Xiaohui Liu Miao Li Zelun Zhang Lifang Song Baiyu Zhu Xiaohong Wu Jingjing Liu Danhua Zhao Yuhua Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 5 |
| 10 | Analysis and Simulation of Evolution Induced Catastrophe显示文摘A model of evolution induced catastrophe(EIC)characterized by a nonlocal interaction is proposed.The general feature of the model is its two bias states:explosively catastrophic and globally stable,both consisting in a cascade of locally unstable states.A one-dimensional analysis reveals a transition region from globally stable to catastrophe.A two-dimensional simulation gives a thin fractal fracture profile similar to that observed and also a possible spectrum of fracture fractal.All these are different from percolation.Hence,the EIC model may represent a prototype of natural processes. | BAI Yilong XIA Mengfen KE Fujiu LU Chunsheng LING Zhong | 1993 | Chinese Physics Letters1993，10，3： | 5 |
| 11 | Coriander Genomics Database:a genomic,transcriptomic,and metabolic database for coriander显示文摘Coriander(Coriandrum sativum L.),also known as cilantro,is a globally important vegetable and spice crop.Its genome and that of carrot are models for studying the evolution of the Apiaceae family.Here,we developed the Coriander Genomics Database(CGDB,http://cgdb.bio2db.com/)to collect,store,and integrate the genomic,transcriptomic,metabolic,functional annotation,and repeat sequence data of coriander and carrot to serve as a central online platform for Apiaceae and other related plants.Using these data sets in the CGDB,we intriguingly found that seven transcription factor(TF)families showed significantly greater numbers of members in the coriander genome than in the carrot genome.The highest ratio of the numbers of MADS TFs between coriander and carrot reached 3.15,followed by those for tubby protein(TUB)and heat shock factors.As a demonstration of CGDB applications,we identified 17 TUB family genes and conducted systematic comparative and evolutionary analyses.RNA-seq data deposited in the CGDB also suggest dose compensation effects of gene expression in coriander.CGDB allows bulk downloading,significance searches,genome browser analyses,and BLAST searches for comparisons between coriander and other plants regarding genomics,gene families,gene collinearity,gene expression,and the metabolome.A detailed user manual and contact information are also available to provide support to the scientific research community and address scientific questions.CGDB will be continuously updated,and new data will be integrated for comparative and functional genomic analysis in Apiaceae and other related plants. | Xiaoming Song Fulei Nie Wei Chen Xiao Ma Ke Gong Qihang Yang Jinpeng Wang Nan Li Pengchuan Sun Qiaoying Pei Tong Yu Jingjing Hu Xinyu Li Tong Wu Shuyan Feng Xiu-Qing Li Xiyin Wang | 2020 | Horticulture Research2020，7，1： | 4 |
| 12 | Toward Systemic Thinking in Managing Environmental Risks显示文摘1.Introduction The world today is strongly interconnected.Numerous interdependent and complex networks have been formed between environmental,economic,and social systems,through which people,resources,materials,goods,and information are exchanged at unprecedented speeds[1].At the same time,however,such networks are profoundly changing the global risk landscape and making the whole system more vulnerable[2].In particular,there is a growing concern about cascading and systemic risks.In such cases,a localized initial damaging event(e.g.,the coronavirus disease 2019(COVID-19)pandemic)can spread rapidly and globally,resulting in disruptive influences and countless societal costs[3]. | Jun Bi Jianxun Yang Miaomiao Liu Zongwei Ma Wen Fang | 2021 | Engineering2021，7，11： | 4 |
| 13 | Chromosome-level genome assembly,annotation and evolutionary analysis of the ornamental plant Asparagus setaceus显示文摘Asparagus setaceus is a popular ornamental plant cultivated in tropical and subtropical regions globally.Here,we constructed a chromosome-scale reference genome of A.setaceus to facilitate the investigation of its genome characteristics and evolution.Using a combination of Nanopore long reads,Illumina short reads,10×Genomics linked reads,and Hi-C data,we generated a high-quality genome assembly of A.setaceus covering 710.15 Mb,accounting for 98.63%of the estimated genome size.A total of 96.85%of the sequences were anchored to ten superscaffolds corresponding to the ten chromosomes.The genome of A.setaceus was predicted to contain 28,410 genes,25,649(90.28%)of which were functionally annotated.A total of 65.59%of the genome was occupied by repetitive sequences,among which long terminal repeats were predominant(42.51%of the whole genome).Evolutionary analysis revealed an estimated divergence time of A.setaceus from its close relative A.officinalis of~9.66 million years ago,and A.setaceus underwent two rounds of whole-genome duplication.In addition,762 specific gene families,96 positively selected genes,and 76 resistance(R)genes were detected and functionally predicted in A.setaceus.These findings provide new knowledge about the characteristics and evolution of the A.setaceus genome,and will facilitate comparative genetic and genomic research on the genus Asparagus. | Shu-Fen Li Jin Wang Ran Dong Hong-Wei Zhu Li-Na Lan Yu-Lan Zhang Ning Li Chuan-Liang Deng Wu-Jun Gao | 2020 | Horticulture Research2020，7，1： | 4 |
| 14 | Immune checkpoint inhibitor for hepatocellular carcinoma recurrence after liver transplantation显示文摘To the Editor:Liver cancer is the fifth most common cancer and the second most frequent cause of cancer-related death globally.Hepatocellular carcinoma(HCC)accounts for 90%of primary liver cancers with the highest incidence in China(more than 50%of all cases worldwide)[1].Liver transplantation(LT)is regarded as an optimal therapy for selected HCC patients.The Milan criteria are the benchmark for candidate selection that ensure excellent prognosis for patients with HCC[2].The Hangzhou criteria expand 51.5%more of Milan criteria for LT candidates with comparable posttransplant survivals[3].However,LT recipients fulfilling Milan criteria or Hangzhou criteria are at the risk of up to 13%−18%HCC recurrence rate within five years[4].Only 25%−50%of recurrent HCC patients post-LT are eligible for surgical treatment which have consistently presented favored survival benefit than systemic therapy[5]. | Li Zhuang Hai-Bo Mou Lan-Fang Yu Heng-Kai Zhu Zhe Yang Qin Liao Shu-Sen Zheng | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 4 |
| 15 | Efficient genetic transformation and CRISPR/Cas9-mediated genome editing of watermelon assisted by genes encoding developmental regulators显示文摘Cucurbitaceae is an important family of flowering plants containing multiple species of important food plants,such as melons,cucumbers,squashes,and pumpkins.However,a highly efficient genetic transformation system has not been established for most of these species(Nanasato and Tabei,2020).Watermelon(Citrullus lanatus),an economically important and globally cultivated fruit crop,is a model species for fruit quality research due to its rich diversity of fruit size,shape,flavor,aroma,texture. | Wenbo PAN Zhentao CHENG Zhiguo HAN Hong YANG Wanggen ZHANG Huawei ZHANG | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，4： | 4 |
| 16 | Co-selection may explain the unexpectedly high prevalence of plasmid-mediated colistin resistance gene mcr-1 in a Chinese broiler farm显示文摘DEAR EDITOR,The rise of the plasmid-encoded colistin resistance gene mcr-1 is a major concern globally.Here,during a routine surveillance,an unexpectedly high prevalence of Escherichia coli with reduced susceptibility to colistin (69.9%) was observed in a Chinese broiler farm.Fifty-three (63.9%) E.coli isolates were positive for mcr-1.All identified mcr-1-positive E. | Yu-Ping Cao Qing-Qing Lin Wan-Yun He Jing Wang Meng-Ying Yi Lu-Chao Lv Jun Yang Jian-Hua Liu Jian-Ying Guo | 2020 | Zoological Research2020，41，5： | 4 |
| 17 | Guangdong’s Study of the Effectiveness of China’s Inactivated Vaccines Against the SARS-CoV-2 B.1.617.2(Delta)Variant显示文摘Guangdong CDC published in preprint a critically important study of the effectiveness of China’s inactivated vaccines against the B.1.617.2(Delta)variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)—a strain of the virus that causes coronavirus disease 2019(COVID-19)and is circulating globally(1–2).The Delta variant managed to get through China’s strong international border quarantine protection and spark an outbreak in Guangdong Province in May–June 2021.While the outbreak was being stopped using guidance of the Protocol for Prevention and Control of COVID-19(3),the investigators took advantage of provisions in the Protocol that identified close contacts of anyone infected with SARS-CoV-2。 | Fuzhen Wang Zhijie An Lance Rodewald Dan Wu Lin Tang Hui Zheng Qianqian Liu George F.Gao Zundong Yin | 2021 | China CDC weekly2021，3，34： | 3 |
| 18 | The Incoming Influenza Season—China,the United Kingdom,and the United States,2021–2022显示文摘Introduction:Seasonal influenza activity has declined globally since the widespread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)transmission.There has been scarce information to understand the future dynamics of influenza—and under different hypothesis on relaxation of nonpharmaceutical interventions(NPIs)in particular—after the disruptions to seasonal patterns.Methods:We collected data from public sources in China,the United Kingdom,and the United States,and forecasted the influenza dynamics in the incoming 2021–2022 season under different NPIs.We considered Northern China and Southern China separately,due to the sharp difference in the patterns of seasonal influenza.For the United Kingdom,data were collected for England only.Results:Compared to the epidemics in 2017–2019,longer and blunter influenza outbreaks could occur should NPIs be fully lifted,with percent positivity varying from 10.5 to 18.6 in the studying regions.The rebounds would be smaller if the maskwearing intervention continued or the international mobility stayed low,but sharper if the mask-wearing intervention was lifted in the middle of influenza season.Further,influenza activity could stay low under a much less stringent mask-wearing intervention coordinated with influenza vaccination.Conclusions:The results added to our understandings of future influenza dynamics after the global decline during the coronavirus disease 2019(COVID-19)pandemic.In light of the uncertainty on the incoming circulation strains and the relatively low negative impacts of mask wearing on society,our findings suggested that wearing mask could be considered as an accompanying mitigation measure in influenza prevention and control,especially for seasons after long periods of low-exposure to influenza viruses.Seasonal influenza activity declines globally during the coronavirus disease 2019(COVID-19)pandemic(1–4).For instance,in China,influenza activity,as measured by percentage of submitted specimens testing positive,dropped from 11.8%to 2.0%in 2020–2021 influenza season,compared to the past 5 years(5).The long-period of low-exposure to influenza viruses adds great uncertainty on preparedness for the incoming 2021–2022 influenza season.Influenza vaccination is one of the most effective measures in seasonal influenza prevention and control,but with only a few influenza viruses circulating,it could be difficult to determine the targeted strains for vaccination.In this context,it is of primary importance to identify alternative mitigation measures for the incoming 2021–2022 influenza season,the first season after long periods of virtually no influenza outbreaks worldwide.Using data from China,the United Kingdom,and the United States,we forecasted the influenza activity in the incoming 2021–2022 influenza season under hypothetical scenarios without non-pharmaceutical interventions(NPIs)and with different assumptions on mask-wearing and mobility levels. | Shasha Han Ting Zhang Yan Lyu Shengjie Lai Peixi Dai Jiandong Zheng Weizhong Yang Xiaohua Zhou Luzhao Feng | 2021 | China CDC weekly2021，3，49： | 3 |
| 19 | Detection and Initial Response to a Type 2 Vaccine-Derived Poliovirus—Sichuan Province,China,2019显示文摘What is already known about this topic?After the type 2 strain of the live,attenuated poliovirus vaccine was withdrawn globally in 2016,any identification of a type 2 poliovirus is a Public Health Emergency of International Concern.A vaccinederived type 2 poliovirus(VDPV2)was identified in Sichuan,prompting an urgent,comprehensive investigation and response.What is added by this report?Type 2 monovalent,live,attenuated oral poliovirus vaccine(mOPV2)is being used to respond to the numerous VDPV2 outbreaks seen around the world.In contrast,the response in Sichuan used Sabin strain inactivated poliovirus(sIPV)to stop circulation of the VDPV2.In the 6 months following the vaccination response,there have been no VDPV2s detected in Sichuan,despite extensive search.What are the implications for public health practices?Further search for the VDPV2 must continue in order to determine whether transmission has been stopped.The ongoing investigation and response to the Sichuan VDPV2 is providing evidence to the Global Polio Eradication Initiative on managing VDPV2 outbreaks. | Jiushun Zhou Ning Wen Yong Zhang Qi Qi Chunxiang Fan Dongmei Yan Xiaoping Zhu Lixin Hao Shuangli Zhu Yu Liu Xiaozhen Ma Chao Ma Lei Nan Yong Chen Qianli Ma Cheng Wang Kun Deng Lei Cao Ge Shao Xianxiang Ding Hong Yang Zhijie An Lance ERodewald Aiqiang Xu Huaqing Wang Zijian Feng Zundong Yin Xianping Wu Wenbo Xu | 2020 | China CDC weekly2020，2，11： | 3 |
| 20 | Risk Assessment of Food Allergens显示文摘GLOBAL STRATEGIES FOR RISK ASSESSMENT OF FOOD ALLERGENS Held on the 8th of July every year,World Allergy Day is a global joint initiative launched by the World Health Organization(WHO)and the World Allergy Organization(WAO)as well as other national allergy agencies,which aims to raise the general public awareness of the importance of managing and preventing allergic diseases.Food allergies are a major source of exposure to allergens and a significant public health problem globally with increasing prevalence(1).Importantly,there is currently no effective cure for food allergies and the only strategy for preventing food allergic reactions is to practice a strict avoidance diet.Notably,implementation and adherence to a diet that is free of allergenic foods is challenging because a consumer may be allergic to more than one food or food ingredient and must face a wide variety of food choices in daily life. | Hongbing Chen Yongning Wu | 2022 | China CDC weekly2022，4，34： | 3 |
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