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| 1 | Dynamic contrast-enhanced MRI versus ^(18)F-FDG PET/CT: Which is better in differentiation between malignant and benign solitary pulmonary nodules?显示文摘Objective: To prospectively compare the discriminative capacity of dynamic contrast enhanced-magnetic resonance imaging(DCE-MRI) with that of ^(18)F-fluorodeoxyglucose(^(18)F-FDG) positron emission tomography/computed tomography(PET/CT) in the differentiation of malignant and benign solitary pulmonary nodules(SPNs).Methods: Forty-nine patients with SPNs were included in this prospective study. Thirty-two of the patients had malignant SPNs, while the other 17 had benign SPNs. All these patients underwent DCE-MRI and ^(18)F-FDG PET/CT examinations. The quantitative MRI pharmacokinetic parameters, including the trans-endothelial transfer constant(K^(trans)), redistribution rate constant(K_(ep)), and fractional volume(Ve), were calculated using the Extended-Tofts Linear two-compartment model. The ^(18)F-FDG PET/CT parameter, maximum standardized uptake value(SUV_(max)), was also measured. Spearman's correlations were calculated between the MRI pharmacokinetic parameters and the SUV_(max) of each SPN. These parameters were statistically compared between the malignant and benign nodules. Receiver operating characteristic(ROC) analyses were used to compare the diagnostic capability between the DCE-MRI and ^(18)F-FDG PET/CT indexes.Results: Positive correlations were found between K^(trans) and SUV_(max), and between K_(ep) and SUV_(max)(P<0.05).There were significant differences between the malignant and benign nodules in terms of the K^(trans), K_(ep) and SUV_(max) values(P<0.05). The areas under the ROC curve(AUC) of K^(trans), K_(ep) and SUV_(max) between the malignant and benign nodules were 0.909, 0.838 and 0.759, respectively. The sensitivity and specificity in differentiating malignant from benign SPNs were 90.6% and 82.4% for K^(trans); 87.5% and 76.5% for K_(ep); and 75.0% and 70.6%for SUV_(max), respectively. The sensitivity and specificity of K^(trans) and K_(ep) were higher than those of SUV_(max), but there was no significant difference between them(P>0.05).Conclusions: DCE-MRI can be used to differentiate between benign and malignant SPNs and has the advantage of being radiation free. | Feng Feng Fulin Qiang Aijun Shen Donghui Shi Aiyan Fu Haiming Li Mingzhu Zhang Ganlin Xia Peng Cao | 2018 | Chinese Journal of Cancer Research2018，30，1： | 10 |
| 2 | Myt1L Promotes Differentiation of Oligodendrocyte Precursor Cells and is Necessary for Remyelination After Lysolecithin-Induced Demyelination显示文摘The differentiation and maturation of oligodendrocyte precursor cells(OPCs) is essential for myelination and remyelination in the CNS. The failure of OPCs to achieve terminal differentiation in demyelinating lesions often results in unsuccessful remyelination in a variety of human demyelinating diseases. However, the molecular mechanisms controlling OPC differentiation under pathological conditions remain largely unknown. Myt1 L(myelin transcription factor 1-like), mainly expressed in neurons,has been associated with intellectual disability, schizophrenia, and depression. In the present study, we found that Myt1 L was expressed in oligodendrocyte lineage cells during myelination and remyelination. The expression level of Myt1 L in neuron/glia antigen 2-positive(NG^(2+))OPCs was significantly higher than that in mature CC1^+ oligodendrocytes. In primary cultured OPCs,overexpression of Myt1 L promoted, while knockdown inhibited OPC differentiation. Moreover, Myt1 L was potently involved in promoting remyelination after lysolecithin-induced demyelination in vivo. Ch IP assays showed that Myt1 L bound to the promoter of Olig1 and transcriptionally regulated Olig1 expression. Taken together, our findings demonstrate that Myt1 L is an essential regulator of OPC differentiation, thereby supporting Myt1 L as a potential therapeutic target for demyelinating diseases. | Yanqing Shi Qi Shao Zhenghao Li Ginez A. Gonzalez Fengfeng Lu Dan Wang Yingyan Pu Aijun Huang Chao Zhao Cheng He Li Cao | 2018 | Neuroscience Bulletin2018，34，2： | 6 |
| 3 | Wenyang Huazhuo Fang exerts transient receptor potential cation channel subfamily C member-dependent nephroprotection in a rat model of doxorubicin-induced nephropathy显示文摘OBJECTIVE:To determine the effect of Wenyang Huazhuo Fang(WHF),a Traditional Chinese Medicine decoction,on renal function in a rat model of doxorubicin-induced nephropathy,and to elucidate the underlying mechanism.METHODS:Sprague-Dawley rats were randomly divided into six groups:control,doxorubicin-nephropathy,and prednisone-treated(6.45 mg·kg^-1·d^-1)doxorubicin nephropathy groups,as well as high-(7.26 g·kg^-1·d^-1),medium-(2.42 g·kg-1·d-),and low-dose(0.81 g·kg^-1·d^-1)WHF-treated doxorubicin-nephropathy groups.The nephropathy rat model was established by two tail vein injections of doxorubicin,followed by prednisone or WHF treatment for 8 weeks.Body weights were monitored and urinary protein was measured every 2 weeks.After the end of the treatment period,the rats were euthanized.Serum biochemical indicators were determined and renal morphological alterations were assessed using histological staining.The expression of transient receptor potential cation channel subfamily C member 6(TRPC6),stromal interaction molecule 1(STIM1),and calcium release-activated calcium channel protein 1(Orai1)was detected using western blotting,and their mRNA levels were examined using quantitative real-time reverse transcription-polymerase chain reaction.RESULTS:WHF treatment was found to significantly ameliorate weight loss,proteinuria,hypoalbuminemia,and dyslipidemia in doxorubicin-nephropathy rats.The protein and mRNA levels of TRPC6,STIM1,and Orai1 were partially,but significantly suppressed by prednisone or WHF treatment.CONCLUSION:Treatment with WHF significantly ameliorates renal injury in a rat model of doxorubicin-induced nephropathy,which could be at least partially related to repression of the TRPC6 pathway. | An Peng Dong Sheng Li Xingyao Cai Zimo Ye Bingyu Zhang Aijun Shi Xingmin Wu Xili | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 3 |
| 4 | Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial显示文摘Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this treatment.We conducted a randomized,controlled,open-label multicenter trial among COVID-19 patients.The patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care alone.The cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were observed.Thirty-three patients were randomized to the tocilizumab group,and 32 patients to the control group.The cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events occurred.More mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes negative.For patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome. | Dongsheng Wang Binqing Fu Zhen Peng Dongliang Yang Mingfeng Han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu | 2021 | Frontiers of Medicine2021，15，3： | 2 |
| 5 | Yield and quality properties of silage maize and their influencing factors in China显示文摘Silage maize(Zea mays L.) is one of the most important forages in the world, and its yield and quality properties are critical parameters for livestock production and assessment of forage values. However, relationships between its yield and quality properties and the controlling factors are not well documented. In this study, we collected 5,663 observations from 196 publications across the country to identify the relationships between yield and quality properties of silage maize and to assess the impact of management practices and climatic factors on its yield and quality in China. The average dry matter yield of silage maize was(19.98±6.93) Mg ha^(-1), and the average value of crude protein, ether extract, crude ash, crude fiber, acid detergent fiber, neutral detergent fiber, nitrogen-free extract, and relative feed value was 7.86%±1.71%, 2.53%±1.01%, 5.05%±1.66%,23.97%±6.34%, 27.62%±7.12%, 51.60%±9.85%, 59.68%±7.72%, and 131.17±31.49, respectively. In general, its nutritive value decreased as its yield increased. Increasing planting density could increase the yield but inhibit the nutritive values, while increasing fertilization could benefit the nutritive values. Geographically, the yield increased and the nutritive value decreased from warm(south) to cold(north) regions. The length of growth duration was a major controlling factor for the patterns of these properties. Our findings provide insights for police-makers to make strategy for achieving high yield and good quality of silage maize and help local people to implement better management practices. | Mengying Zhao Yinping Feng Yue Shi Haihua Shen Huifeng Hu Yongkai Luo Longchao Xu Jie Kang Aijun Xing Shaopeng Wang Jingyun Fang | 2022 | Science China(Life Sciences)2022，65，8： | 2 |
| 6 | The selective catalytic reduction of NO over Ce_(0.3)TiO_x^-supported metal oxide catalysts显示文摘A Ce_(0.3)TiO_xoxide carrier was synthesized via a sol–gel process,and Ce_(0.3)TiO_xsupported metal(M=Cd,Mn,Fe,W,Mo)oxide catalysts were prepared by the method of incipient-wetness impregnation.The catalysts were characterized by means of X-ray diffraction(XRD),Brunauer–Emmett–Teller(BET)analysis,scanning electron microscopy(SEM),transmission electron microscopy(TEM),Fourier transform infrared(FT–IR)spectroscopy,UV–Visdiffusereflectancespectroscopy(UV–VisDRS),and Temperature-programmed reduction with H_2(H_2-TPR).The catalytic activities for de-NO_(x )were evaluated by the NH_3-SCR reaction.Among all the catalysts tested,the 2 wt.%Cd/Ce_(0.3)TiO_xcatalyst exhibited the best NH_3-SCR performance,with a wide temperature window of 250–450°C for NO conversion above 90%.Moreover,the catalyst showed N_2 selectivity greater than 99%from 200 to 450°C. | Zhichen Duan Jian Liu Juan Shi Zhen Zhao Yuechang Wei Xiao Zhang Guiyuan Jiang Aijun Duan | 2018 | Journal of Environmental Sciences2018，30，3： | 2 |
| 7 | Change of Cytokines in Chronic Hepatitis B Patients and HBeAg are Positively Correlated with HBV RNA, Based on Real-world Study显示文摘Background and Aims:The natural course of chronic hepatitis B virus(HBV)infection is widely studied;however,follow-up studies of the same patients are scanty.Here,we studied the dynamic changes of serum HBV RNA and cytokines in hepatitis B virus e antigen(HBeAg)-positive patients treated with entecavir(ETV)to explore the relationship between the HBV serum viral nucleic acids and host immunity.Methods:Thirty-three chronic hepatitis B patients who are HBeAg-positive,with high virus load(HBV DNA>20,000 IU/mL),and received standard nucleos(t)ide analogue(NA)antiviral therapy(ETV)for more than 48 weeks were included.The serum levels of HBV nucleic acids and selected cytokines were measured at 0,12,24,and 48 weeks respectively.Results:Serum HBV RNA could still be detected while serum HBV DNA had fallen below the detection limit in patients treated with ETV.There was a strong positive correlation between HBV RNA and HBeAg,with a concomitant decrease in the secretion of cytokines from type 1 helper T(Th1)/type 2 helper T(Th2)/interleukin(IL)-17 producing T(Th17)cells.IL-4 and IL-10 were the main cytokines negatively associated with serum HBV RNA.Conclusions:HBeAg can be used to reflect the load of HBV RNA indirectly,because serum HBV RNA has not been widely used in clinical practice.Meanwhile,serum IL-4 and IL-10 might be explored in combination with HBV RNA in guiding future clinical antiviral therapy. | Qiqi Zhang Hui Huang Aijun Sun Chunyan Liu Zhidong Wang Feifan Shi Wei Duan Xueying Sun Qi Wang Ping Sun Chunwen Pu Yong Zhang | 2022 | Journal of Clinical and Translational Hepatology2022，10，3： | 1 |
| 8 | Pt-confinement catalyst with dendritic hierarchical pores on excellent sulfur-resistance for hydrodesulfurization of dibenzothiophene and 4,6-dimethyldibenzothiophene显示文摘Metal confinement catalyst Mo S_(2)/Pt@TD-6%Ti(TD,TS-1/Dendritic mesoporous silica nanoparticles composite) in dendritic hierarchical pore structures was synthesized and showed excellent sulfur-resistance performance and stabilities in catalytic hydrodesulfurization reactions of probe sulfide molecules.The Mo S_(2)/Pt@TD-6%Ti catalyst combines the concepts of Pt-confinement effect and hydrogen spillover of Pt noble metal.The modified micropores of Mo/Pt@TD-6%Ti only allow the migration and dissociation of small H_(2) molecules(0.289 nm),and effectively keep the sulfur-containing compounds(e.g.H_(2)S,0.362 nm) outside.Thus,the Mo S_(2)/Pt@TD-6%Ti catalyst exhibits higher DBT and 4,6-DMDBT HDS activities because of the synergistic effect of the strong H_(2) dissociation ability of Pt and desulfurization ability of Mo S_(2) with a lower catalyst cost.This new concept combining H2dissociation performance of noble metal catalyst with the desulfurization ability of transition metal sulfide Mo S_(2) can protect the noble metal catalyst avoiding deactivation and poison,and finally guarantee the higher activities for DBT and 4,6-DMDBT HDS. | Xilong Wang Chengkun Xiao Mohnnad H.Alabsi Peng Zheng Zhengkai Cao Jinlin Mei Yu Shi Aijun Duan Daowei Gao Kuo-Wei Huang Chunming Xu | 2022 | Green Energy & Environment2022，7，2： | 0 |
| 9 | Demands and challenges for construction of marine infrastructures in China显示文摘The oceans are crucial to human civilization.They provide core support for exploitation and utilization of marine space,resources,and energy.Thus,marine infrastructures are vital to a nation’s economic sustainable development.To this end,this article first describes the main challenges in current ocean utilization,and then reviews the China’s ocean engineering progress.As such,six major sectors are evaluated:1)global climate change and marine environment,2)comprehensive utilization of marine space,3)marine transportation infrastructure interconnection,4)ocean clean energy development and maricultural facilities,5)ecological crisis and marine engineering countermeasures,and 6)marine infrastructure operation safety and maintenance.Finally,perspectives on future directions of ocean utilization and marine infrastructure construction in China are provided. | Huajun LI Yong LIU Bingchen LIANG Fushun LIU Guoxiang WU Junfeng DU Huimin HOU Aijun LI Luming SHI | 2022 | Frontiers of Structural and Civil Engineering2022，16，5： | 0 |
| 10 | Understand the local and regional contributions on air pollution from the view of human health impacts显示文摘The source-receptor matrix of PM_(2.5)concentration from local and regional sources in the Beijing-Tianjin-Hebei(BTH)and surrounding provinces has been created in previous studies.However,because the spatial distribution of concentration does not necessarily match with that of the population,such concentration-based source-receptor matrix may not fully reflect the importance of pollutant control effectiveness in reducing the PM_(2.5)-related health impacts.To demonstrate that,we study the source-receptor matrix of the PM_(2.5)-related deaths instead,with inclusion of the spatial correlations between the concentrations and the population.The advanced source apportionment numerical model combined with the integrated exposure-response functions is used for BTH and surrounding regions in 2017.We observed that the relative contribution to PM_(2.5)-related deaths of local emissions was 0.75%to 20.77%larger than that of PM_(2.5)concentrations.Such results address the importance of local emissions control for reducing health impacts of PM_(2.5)particularly for local residents.Contribution of regional transport to PM_(2.5)-related deaths in rural area was 22%larger than that in urban area due to the spatial pattern of regional transport which was more related to the rural population.This resulted in an environmental inequality in the sense that people staying in rural area with access to less educational resources are subjected to higher impacts from regional transport as compared with their more resourceful and knowledgeable urban compatriots.An unexpected benefit from the multi-regional joint controls is suggested for its effectiveness in reducing the regional transport of PM_(2.5)pollution thus mitigating the associated environmental inequality. | Yueqi Jiang Jia Xing Shuxiao Wang Xing Chang Shuchang Liu Aijun Shi Baoxian Liu Shovan Kumar Sahu | 2021 | Frontiers of Environmental Science & Engineering2021，15，5： | 0 |
| 11 | Mechanical Property Evaluation of a SLMed Martensitic Stainless Steel显示文摘A martensitic stainless steel AISI420 fabricated by selective laser melting(SLM)and post-processed by austenitizing and tempering heat treatment was investigated in this study.The as-fabricated SLMed AISI420 showed a strong mechanical property anisotropy and low ductility in the longitudinal direction.Detailed microstructural characterization revealed the presence of austenite and a relatively sharp solidification texture in the as-fabricated state,while the sharp texture was considered as the cause for the mechanical property anisotropy.In contrast,a fully martensitic microstructure with a very weak texture was achieved after the austenitizing and tempering heat treatment.The mechanical property anisotropy was also fully eliminated,witnessing a significant improvement in the ductility,and thus,comparable mechanical performance with the wrought product was achieved in this study. | Yun Shi Xiaojing Xiong Zhengwu Liu Yi Yang Juan Hou Songquan Wu Jeremy H.Rao Kai Zhang Aijun Huang | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，11： | 0 |
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