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| 1 | The age of the plant fossil assemblage in the Liuqu Conglomerate of southern Tibet and its tectonic significance显示文摘Liuqu 集团企业,位于到 Yarlung Tsangbo 缝术地区(YTSZ ) 的南方,一套糖蜜在在印第安人和 Eurasion 的二个盘子之间的碰撞以后在喜玛拉雅的 orogenic 带的低岬盆被形成。大意义大意义构造进化和西藏高原的高举的历史。然而,这件糖蜜西装的年龄和它到在南部的西藏散布的另外的同步阶层的关联很长时间在大争论。特别在最近的年里,在它的年龄争论与这糖蜜的大沉积构造意义的识别猛烈地正在成长。在最近在这件糖蜜西装上执行的域工作期间,很多计划石块被发现阶层在这的上面的部分处于相当好的条件保存了,它具有在决定的大帮助是它的年龄。由鉴定,植物 fosils 的集合属于一条回归线代替在中间期间在北半球超级大陆的南部的边缘开发到以后的 Eocence 的回归线植物群,它能在它的形成年龄提供好限制。这篇论文是给植物集合和它的年龄的简短介绍,并且讨论他们的构造意义。 | FANG Aimin YAN Zhen LIU Xiaohan PAN Yusheng LI Jiliang YU Liangjun HUANG Feixing TAO Junrong | 2006 | Progress in Natural Science:Materials International2006，16，1： | 9 |
| 2 | Trend and Development of Semi-Solid Metal Processing显示文摘This paper reviewed the trend and development of semi-solid metal technique. The processes and mechanisms for producing slurry of SSM and its industrial applications have been summarized and discussed. Discussions on the basic rheological theory are presented for more applications. Further consideration of the development and application of SSM technique is also proposed. | Xianfeng PAN, Haifeng ZHANG, Aimin WANG, Bingzhe DING, Keqiang QIU and Zhuangqi HU (State Key Laboratory of Rapidly Solidified Nonequilibrium Alloys, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China) | 2000 | Journal of Materials Science & Technology2000，16，5： | 7 |
| 3 | Efficacy of water fraction from Dioscorea cirrhosa on oxidative stress and apoptosis in H9c2 cardiomyocytes induced by H2O2显示文摘OBJECTIVE:To investigate the efficacy of water fraction from Dioscorea cirrhosa(WF)on oxidative damage and apoptosis of cardiomyocytes induced by H2O2,and to study its mechanism.METHODS:Cell viability was measured by the MST assay kit.The content of malondialdehyde(MDA),release of lactate dehydrogenase(LDH)and activity of catalase(CAT)and superoxide dismutase(SOD)were detected by biochemical kit.The content of reactive oxygen species(ROS)was assessed by nonfluorescent probe 2′,7′-dichlorofluorescin diacetate(DCFH-DA).JC-1 was used to analyze the mitochondrial membrane potential(mtΔΨ)and Annexin-V-FITC/PI staining was applied to assess apoptosis of H9c2 by flow cytometry.Moreover,the expression of B-cell lymphoma-2(Bcl-2),Bcl-2-associated X(Bax),caspase-3,caspase-9,cleaved-caspase-3 and cleaved-caspase-9 proteins was determined by western blot analysis.RESULTS:WF increased cell viability and decreased LDH leakage in H9c2 cells exposed to H2O2.WF treatment decreased ROS and MDA level,enhanced SOD and CAT activities,improved mtΔΨand inhibited apoptosis.Western blot analysis demonstrated that the ratio of Bcl-2/Bax was increased and the expression cleaved-caspase-3,caspase-3,cleaved-caspase-9 and caspase-9 were decreased in group treated with WF.CONCLUSION:WF protects H9c2 myocardial cells on H2O2-induced oxidative stress and apoptosis by scavenging ROS,improving antioxidant capacity,protecting mitochondrial and regulating the proteins expression related to apoptosis. | LIU Chunhua PAN Jie WANG Aimin LAN Yanyu LI Yongjun LU Yuan SUN Jia WANG Yonglin LIU Ting LU Dingyan YOU Jingrui | 2021 | Journal of Traditional Chinese Medicine2021，41，1： | 4 |
| 4 | Analysis of genetic alterations identifies the frequent mutation of GNAS in colorectal laterally spreading tumors显示文摘Dear Editor,Colorectal cancer(CRC)is among the most commonly diagnosed cancer and the leading cause of cancer-related death worldwide[1].Most CRCs develop from adenomas.Laterally spreading tumors(LSTs)are non-polypoid superficial colorectal neoplasms(CRNs)that are larger than 1 cm and typically extend laterally along the luminal wall.Based on surface morphology,it can be classified into a granular or nongranular type.The pathological morphology of LST manifests only as adenoma or with cancer.Recent studies have characterized 45-79%of LSTs as high-grade intraepithelial neoplasia(HGIN)or submucosal invasion;and the risk of submucosal invasion increases with lesion size[2].Hence,LST is considered a precancerous CRC lesion.Patients with LSTs are usually asymptomatic and diagnosis typically occurs during physical examinations or screening colonoscopy. | Lei Pan Junsheng Chen Chaojun Zhu Lu Han Aimin Li Side Liu | 2020 | Cancer Communications2020，40，11： | 3 |
| 5 | Sedimentary environment of the Dajin conglomerate in Tibet, age of foraminiferan assemblages and their tectonic significance显示文摘Dajin 集团企业,它在先是 Xigaze 的最重要的沉积继任之一在西藏的弧盆,中国,由忍受货币石, Assilina, Alveolina 和 Lock-hartia 的深浅的海洋的 tuffaceousturbidites 和棒麴霉素组成。这些石块很类似于有孔虫目动物一在里面在 Gangbaand Dingri 区域的 Jialazi 和 Maila 集团企业,和那些。他们发展了在始新世。由分析西藏高原和有孔虫目动物的 Eocenesedimentary 环境的空间变化一在里面 Dajin 集团企业,我们发现了那始新世沉积应该发生在 Yarlung Tsangpo 缝术的双方上,并且晚始新世的构造高举应该做在先弧盆从海水平暴露并且开始收到非海洋的存款。 | YAN Zhen FANG Aimin PAN Yusheng LI Jiliang LIU Xiaohan YU Liangjun ZHANG Binggao | 2005 | Progress in Natural Science:Materials International2005，15，11： | 2 |
| 6 | Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice显示文摘 | Zhuofeng Lin Fan Wu Shaoqiang Lin Xuebo Pan Leigang Jin Tingting Lu Lihua Shi Yu Wang Aimin Xu Xiaokun Li | 2014 | Journal of Hepatology2014，，： | 1 |
| 7 | Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride显示文摘 | Huating Li Qichen Fang Fei Gao Jia Fan Jian Zhou Xiaoying Wang Huizhen Zhang Xiaoping Pan Yuqian Bao Kunsan Xiang Aimin Xu Weiping Jia | 2010 | Journal of Hepatology2010，，5： | 1 |
| 8 | Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study显示文摘Background:Lipusu is the first commercialized liposomal formulation of pacli-taxel and has demonstrated promising efficacy against locally advanced lung squamous cell carcinoma(LSCC)in a small-scale study.Here,we conducted a multicenter,randomized,phase 3 study to compare the efficacy and safety of cis-platin plus Lipusu(LP)versus cisplatin plus gemcitabine(GP)as first-line treat-ment in locally advanced or metastatic LSCC.Methods:Patients enrolled were aged between 18 to 75 years,had locally advanced(clinical stage IIIB,ineligible for concurrent chemoradiation or surgery)or metastatic(Stage IV)LSCC,had no previous systemic chemother-apy and at least one measurable lesion as per the Response Evaluation Criteria in Solid Tumors(version 1.1)before administration of the trial drug.The primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),overall survival(OS),and safety profiles.To explore the possible predictive value of plasma cytokines for LP treatment,plasma samples were collected from the LP group at baseline and first efficacy evaluation time and were then subjected to analysis by 45-Plex ProcartaPlex Panel 1 to detect the presence of 45 cytokines using the Luminex xMAP technology.The correlation between treatment outcomes and dynamic changes in the levels of cytokines were evaluated in preliminary analyses.Results:The median duration of follow-up was 15.4 months.237 patients in the LP group and 253 patients in the GP group were included in the per protocol set(PPS).In the PPS,the median PFS was 5.2 months versus 5.5 months in the LP and GP group(hazard rtio[HR]:1.03,P=0.742)respectively.The median OS was 14.6 months versus 12.5 months in the LP and GP group(HR:0.83,P=0.215).The ORR(41.8%versus 45.9%,P=0.412)and DCR(90.3%versus 88.1%,P=0.443)were also similar between the LP and GP group.A significantly lower proportion of patients in the LP group experienced adverse events(AEs)leading to treatment interruptions(10.9%versus 26.4%,P<0.001)or treatment termination(14.3%versus 23.1%,P=0.011).The analysis of cytokine levels in the LP group showed that low baseline levels of 27 cytokines were associated with an increased ORR,and 15 cytokines were associated with improved PFS,with 14 cytokines,including TNF-a,IFN-y,IL-6,and IL-8,demonstrating an overlapping trend.Conclusion:The LP regimen demonstrated similar PFS,OS,ORR and DCR as the GP regimen for patients with locally advanced or metastatic LSCC but had more favorable toxicity profiles.The study also identified a spectrum of different cytokines that could be potentially associated with the clinical benefit in patients who received the LP regimen. | Jie Zhang Yueyin Pan Qin Shi Guojun Zhang Liyan Jiang Xiaorong Dong Kangsheng Gu Huijuan Wang Xiaochun Zhang Nong Yang Yuping Li Jianping Xiong Tienan Yi Min Peng Yong Song Yun Fan Jiuwei Cui Gongyan Chen Wei Tan Aimin Zang Qisen Guo Guangqiang Zhao Ziping Wang Jianxing He Wenxiu Yao Xiaohong Wu Kai Chen Xiaohua Hu Chunhong Hu Lu Yue Da Jiang Guangfa Wang Junfeng Liu Guohua Yu Junling Li Jianling Bai Wenmin Xie Weihong Zhao Lihong Wu Caicun Zhou | 2022 | Cancer Communications2022，42，1： | 1 |
| 9 | Design of a novel optically stimulatedluminescent dosimeter using alkaline earth sulfides doped with SrS:Eu,Sm materials显示文摘光学地刺激的光(OSL ) 是在暴露期间从照耀的绝缘体或半导体射出到光的光。OSL 紧张是样品吸收的放射的剂量的功能并且能因此被用作一个放射放射量测定方法的基础。与象 Ce, Sm 和 Eu 那样的稀土元素的元素做的碱的地球硫化物是与一个短时间常数有很高的敏感,和 OSL 的 OSL 量筒与刺激的光被分开。在这篇论文,一个新奇 OSL 量筒与 SrS 设计了: Eu, Sm 材料被描述。量筒利用套住材料 SrS 的充电的特征: Eu, Sm 那展览 OSL。量筒的测量范围从 0.01 到 100Gy。设备,在尺寸相对简单、小,为在空间探索和高剂量放射放射量测定的应用程序是有希望的。 | Yanping Liu Zhaoyang Chen Yanwei Fan Weizhen Ba Wu Lu Qi Guo Shilie Pan Aimin Chang Xinqiang Tang | 2008 | Progress in Natural Science:Materials International2008，18，10： | 1 |
| 10 | Adsorption of aromatic acids on an aminated hypercrosslinked macroporous polymer显示文摘 | Pan Bingcai Chen Jinlong Li Aimin | 2002 | Reactive and Functional Polymers2002，53，2： | 1 |
| 11 | MouseVenue3D:A Markerless Three-Dimension Behavioral Tracking System for Matching Two-Photon Brain Imaging in Free-Moving Mice显示文摘Understanding the connection between brain and behavior in animals requires precise monitoring of their behaviors in three-dimensional(3-D)space.However,there is no available three-dimensional behavior capture system that focuses on rodents.Here,we present MouseVenue3D,an automated and low-cost system for the efficient capture of 3-D skeleton trajectories in markerless rodents.We improved the most time-consuming step in 3-D behavior capturing by developing an automatic calibration module.Then,we validated this process in behavior recognition tasks,and showed that 3-D behavioral data achieved higher accuracy than 2-D data.Subsequently,MouseVenue3D was combined with fast high-resolution miniature two-photon microscopy for synchronous neural recording and behavioral tracking in the freely-moving mouse.Finally,we successfully decoded spontaneous neuronal activity from the 3-D behavior of mice.Our findings reveal that subtle,spontaneous behavior modules are strongly correlated with spontaneous neuronal activity patterns. | Yaning Han Kang Huang Ke Chen Hongli Pan Furong Ju Yueyue Long Gao Gao Runlong Wu Aimin Wang Liping Wang Pengfei Wei | 2022 | Neuroscience Bulletin2022，38，3： | 0 |
| 12 | Environmental impact of energy imports:Natural resources income and natural gas production profitability in the Asia-Pacific Economic Cooperation Countries显示文摘Environmental degradation is a pressing global concern,with the energy sector being one of the major contributors to this issue.The environmental impact of energy imports,particularly regarding natural resources income and natural gas production profitability,cannot be ignored.Countries must assess the environmental consequences of their energy choices and take steps to minimize their impact.By transitioning to cleaner and more sustainable energy sources,countries can ensure a better future for the environment and their economies.This study examines the impact of energy imports and natural resources income on environmental degradation in the Asia-Pacific Economic Cooperation(APEC)countries from 1990 to 2020,using revenue minus the production cost of natural gas and electricity production from renewable sources as moderating variables.Long-run estimates are derived using the Generalized Method of Moments and robust least squares.Our findings elucidate that importing energy from countries specializing in renewable energy can help reduce reliance on fossil fuels.This diversification of energy sources decreases the overall carbon footprint and contributes to a cleaner environment.Natural gas production often involves infrastructure construction,such as drilling rigs and pipelines,which can disrupt natural habitats and wildlife corridors.This destruction of ecosystems can have long-term consequences on biodiversity and ecological balance.The environmental impact of energy imports,particularly related to natural resource income and natural gas production profitability,requires BRICS countries to take proactive measures.These nations can address the environmental challenges associated with their energy demands by implementing policies prioritizing sustainable resource management,carbon pricing,stringent regulation,and investment in research and development.By doing so,they can balance economic growth and environmental sustainability,ensuring a greener future for the BRICS countries. | Aimin Pan Si Xu Syed Anees Haider Zaidi | 2024 | Geoscience Frontiers2024，15，2： | 0 |
| 13 | 6-9 CW Beam Test of the Injector II RFQ for ADS Project显示文摘As one of the main components of the injector II of China ADS LINAC project, an RFQ working at 162.5 MHzis used to accelerate proton beams of 15 mA from 30 keV to 2.1 MeV. The four vane RFQ has been designed incollaboration with Lawrence Berkeley National Laboratory and built at the workshop of the Institute of ModernPhysics, Chinese Academy of Sciences (IMP, CAS). | Zhang Zhouli He Yuan Shi Aimin Sun Liepen Zhang Bin Jia Huan Wang Jing Pan Gang Shi Longbo Xu Xianbo Li Chenxing Wang Wenbin Wang Xianwu Wu Junxia Wu Qi Zhang Junhui Zhu Tieming Guo Yuhui Zhao Hongwei Liu Yong D. Li S. Virostek M. Hoff A. Lambert J. Staples | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 14 | Wind regime features and their impacts on the middle reaches of the Yarlung Zangbo River on the Tibetan Plateau, China显示文摘The wide valley of the Yarlung Zangbo River is one of the most intense areas in terms of aeolian activity on the Tibetan Plateau,China.In the past,the evaluation of the intensity of aeolian activity in the Quxu–Sangri section of the Yarlung Zangbo River Valley was mainly based on data from the old meteorological stations,especially in non-sandy areas.In 2020,six new meteorological stations,which are closest to the new meteorological stations,were built in the wind erosion source regions(i.e.,sandy areas)in the Quxu–Sangri section.In this study,based on mathematical statistics and empirical orthogonal function(EOF)decomposition analysis,we compared the difference of the wind regime between new meteorological stations and old meteorological stations from December 2020 to November 2021,and discussed the reasons for the discrepancy.The results showed that sandy and non-sandy areas differed significantly regarding the mean velocity(8.3(±0.3)versus 7.7(±0.3)m/s,respectively),frequency(12.9%(±6.2%)versus 2.9%(±1.9%),respectively),and dominant direction(nearly east or west versus nearly north or south,respectively)of sand-driving winds,drift potential(168.1(±77.3)versus 24.0(±17.9)VU(where VU is the vector unit),respectively),resultant drift potential(92.3(±78.5)versus 8.7(±9.2)VU,respectively),and resultant drift direction(nearly westward or eastward versus nearly southward or northward,respectively).This indicated an obvious spatial variation in the wind regime between sandy and non-sandy areas and suggested that there exist problems when using wind velocity data from non-sandy areas to evaluate the wind regime in sandy areas.The wind regime between sandy and non-sandy areas differed due to the differences in topography,heat flows,and their coupling with underlying surface,thereby affecting the local atmospheric circulation.Affected by large-scale circulations(westerly jet and Indian monsoon systems),both sandy and non-sandy areas showed similar seasonal variations in their respective wind regime.These findings provide a credible reference for re-understanding the wind regime and scientific wind-sand control in the middle reaches of the Yarlung Zangbo River Valley. | ZHANG Yan ZHANG Zhengcai MA Pengfei PAN Kaijia ZHA Duo CHEN Dingmei SHEN Caisheng LIANG Aimin | 2023 | Journal of Arid Land2023，15，10： | 0 |
| 15 | Control strategies for disinfection byproducts by ion exchange resin,nanofiltration and their sequential combination显示文摘Disinfection byproducts (DBPs) are emerging pollutants in drinking water with high health risks. Precursor reduction before disinfection is an effective strategy to control the formation of DBPs. In this study, three types of anion exchange resins (AERs) and two types of nanofiltration (NF) membranes were tested for their control effects on DBP precursors, DBPs, and total organic halogen (TOX). The results showed that, for AER adsorption, the removal efficiencies of DBP precursors, DBPs, and TOX increased with the increase of resin dose, and the strong basic macroporous anion exchange resin (M500MB) had the highest removal efficiencies. For NF, the highest removal efficiencies were achieved at an operating pressure of 4 bar, and the membrane (NF90) with a smaller molecular weight cut-off, had a better control efficiency. However, AER adsorption was inefficient in removing dissolved organic carbon (DOC);NF was inefficient in removing Br− resulting in insufficient control of Br-DBPs. Accordingly, a sequential approach of AER (M500MB) adsorption followed by NF (NF90) was developed to enhance the control efficiency of DBPs. Compared with single AER adsorption and single NF, the sequential approach further increased the removal efficiencies of DOC by 19.4%–101.9%, coupled with the high Br− removal efficiency of 92%, and thus improved the reduction of cyclic DBPs and TOX by 3.5%–4.9%, and 2.4%–8.4%, respectively;the sequential approach also reduced the cytotoxicity of the water sample by 66.4%. | Yufeng Liao Mengmeng Tang Mengyuan Li Peng Shi Aimin Li Yangyang Zhang Yang Pan | 2023 | Frontiers of Environmental Science & Engineering2023，17，10： | 0 |
| 16 | Augmented reality-based visual-haptic modeling for thoracoscopic surgery training systems显示文摘Background Compared with traditional thoracotomy,video-assisted thoracoscopic surgery(VATS)has less minor trauma,faster recovery,higher patient compliance,but higher requirements for surgeons.Virtual surgery training simulation systems are important and have been widely used in Europe and America.Augmented reality(AR)in surgical training simulation systems significantly improve the training effect of virtual surgical training,although AR technology is still in its initial stage.Mixed reality has gained increased attention in technology-driven modern medicine but has yet to be used in everyday practice.Methods This study proposed an immersive AR lobectomy within a thoracoscope surgery training system,using visual and haptic modeling to study the potential benefits of this critical technology.The content included immersive AR visual rendering,based on the cluster-based extended position-based dynamics algorithm of soft tissue physical modeling.Furthermore,we designed an AR haptic rendering systems,whose model architecture consisted of multi-touch interaction points,including kinesthetic and pressure-sensitive points.Finally,based on the above theoretical research,we developed an AR interactive VATS surgical training platform.Results Twenty-four volunteers were recruited from the First People's Hospital of Yunnan Province to evaluate the VATS training system.Face,content,and construct validation methods were used to assess the tactile sense,visual sense,scene authenticity,and simulator performance.Conclusions The results of our construction validation demonstrate that the simulator is useful in improving novice and surgical skills that can be retained after a certain period of time.The video-assisted thoracoscopic system based on AR developed in this study is effective and can be used as a training device to assist in the development of thoracoscopic skills for novices. | Yonghang TAI Junsheng SHI Junjun PAN Aimin HAO Victor CHANG | 2021 | Virtual Reality & Intelligent Hardware2021，3，4： | 0 |
| 17 | Control of upper limb rehabilitation robot based on active disturbance rejection control显示文摘The upper limb rehabilitation robot technology integrates rehabilitation medicine,human anatomy,mechanics,computer science,robotics,and many other disciplines.Its main function is to drive the affected limb to carry out rehabilitation training to restore the condition of patients with upper limb dyskinesia,which plays a great role in improving the quality of life.In this study,to resolve the problems of slow convergence speed and poor tracking accuracy due to the interference of patient spasms with the trajectory-tracking control of the upper limb rehabilitation robot,a novel algorithm based on active disturbance rejection control(ADRC)is adopted,and the convergence of its main structure is proved by the time-domain analysis method.First,this ADRC algorithm can obtain better trajectory-tracking performance due to its non-linear extended observer and non-linear feedback mechanism,even if the model suffers a strong disturbance or receives inaccurate information.Second,the non-linear tracking differentiator can guarantee to gain quick convergence speed.To validate this algorithm,a model of three degrees of freedom upper limb rehabilitation robot is established using MATLAB R2019b and three situations including strong spasm and weak spasm are carried out to prove the effectiveness and reliability of the control algorithm designed. | Junchen Li Wenzhao Zhang Yu Zheng Aimin An Wenda Pan | 2021 | IET Cyber-Systems and Robotics2021，3，4： | 0 |
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