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| 1 | Understanding the genetic and epigenetic architecture in complex network of rice flowering pathways显示文摘尽管 flowering 时间控制的分子的基础很好在长天(LD ) 内被把,种 Arabidopsis,它在短天(SD ) 内大部分仍然是未知的植物米饭。瑞斯 flowering 时间(标题日期) 是为季节改编和谷物产量的一个重要农学的特点,它被基因、环境的因素影响。在最后十年期间,作为被识别的、著名进步在探索上被取得了的成花素的性质,成花素基因表示怎么样,遗传上控制。然而,在象 FLOWERING 那样的某些关键 flowering 综合者的 Arabidopsis 表示,地点 C (FLC ) 和 FLOWERING 地点 T (英尺) 被各种各样的染色质修正 epigenetically 也调整几乎不在这个方面上在米饭被知道直到很最近。这评论在米饭 flowering 时间控制总结了基因网络和染色质修正的进展,试图给一个完全的看法基因并且在米饭 flowering 小径的复杂网络的 epigenetic 建筑学。 | Changhui Sun Dan Chen Jun Fang Pingrong Wang Xiaojian Deng Chengcai Chu | 2014 | Protein & Cell2014，5，12： | 19 |
| 2 | Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer显示文摘 | Xin Tian Baofa Sun Chuanyuan Chen Chunchun Gao Ji Zhang XingYu Lu Linchen Wang Xiangnan Li Yurong Xing Ruijuan Liu Xiao Han Zheng Qi Xiaojian Zhang Chuan He Dali Han Yun-Gui Yang Quancheng Kan | 2018 | Cell Research2018，28，5： | 12 |
| 3 | A proposed surface resistance model for the Penman-Monteith formula to estimate evapotranspiration in a solar greenhouse显示文摘Greenhousing is a technique to bridge season gap in vegetable production and has been widely used worldwide. Calculation of water requirement of crops grown in greenhouse and determination of their irrigation schedules in arid and semi-arid regions are essential for greenhouse maintenance and have thus attracted increased attention over the past decades. The most common method used in the literature to estimate crop evapotranspiration(ET) is the Penman-Monteith(PM) formula. When applied to greenhouse, however, it often uses canopy resistance instead of surface resistance. It is understood that the surface resistance in greenhouse is the result of a combined effect of canopy restriction and soil-surface restriction to water vapor flow, and the relative dominance of one restriction over another depends on crop canopy. In this paper, we developed a surface resistance model in a way similar to two parallel resistances in an electrical circuit to account for both restrictions. Also, considering that wind speed in greenhouse is normally rather small, we compared three methods available in the literature to calculate the aerodynamic resistance, which are the r_a^1 method proposed by Perrier(1975a, b), the r_a^2 method proposed by Thom and Oliver(1977), and the r_a^3 method proposed by Zhang and Lemeu(1992). We validated the model against ET of tomatoes in a greenhouse measured from sap flow system combined with micro-lysimeter in 2015 and with weighing lysimeter in 2016. The results showed that the proposed surface resistance model improved the accuracy of the PM model, especially when the leaf area index was low and the greenhouse was being irrigated. We also found that the aerodynamic resistance calculated from the r_a^1 and r_a^3 methods is applicable to the greenhouse although the latter is slightly more accurate than the former. The proposed surface resistance model, together with the r_a^3 method for aerodynamic resistance, offers an improved approach to estimate ET in greenhouse using the PM formula. | GONG Xuewen LIU Hao SUN Jingsheng GAO Yang ZHANG Xiaoxian Shiva K JHA ZHANG Hao MA Xiaojian WANG Wanning | 2017 | Journal of Arid Land2017，9，4： | 12 |
| 4 | TAOK1 negatively regulates IL-17-mediated signaling and inflammation显示文摘Interleukin 17(IL-17)is an important cytokine that can induce tissue inflammation and is involved in the pathogenesis of numerous autoimmune diseases.However,the regulation of its signaling transduction has not been well described.In this study,we report that thousand and one kinase 1(TAOK1)functions as a negative regulator of IL-17-mediated signal transduction and inflammation.TAOK1 knockdown promotes IL-17-induced cytokine and chemokine expression and the activation of mitogen-activated protein kinases and nuclear factor-κB.We further demonstrate that TAOK1 interacts with IL-17 receptor A(IL-17RA)independent of its kinase activity,and TAOK1 dose-dependently prevents the formation of the IL-17R-Act1(nuclear factor activator 1,also known as tumor necrosis factor receptor-associated factor 3 interacting protein 2)complex.Consistent with this,TAOK1 deficiency exacerbates colitis in the 2,4,6-trinitrobenzenesulfonic acid-induced experimental model of inflammatory bowel disease,likely by its promotion of the IL-17-mediated signaling pathway.TAOK1 expression is decreased in the colons of ulcerative colitis patients.In conclusion,these findings suggest that TAOK1 is involved in the development of IL-17-related autoimmune disorders. | Zhaoru Zhang Zhen Tang Xianwei Ma Kai Sun Liping Fan Jie Fang Jianping Pan Xiaojian Wang Huazhang An Jun Zhou | 2018 | Cellular & Molecular Immunology2018，15，8： | 10 |
| 5 | 5-Hydroxymethylome in Circulating Cell-free DNA as A Potential Biomarker for Non-small-cell Lung Cancer显示文摘Non-small-cell lung cancer(NSCLC), the most common type of lung cancer accounting for 85% of the cases, is often diagnosed at advanced stages owing to the lack of efficient early diagnostic tools. 5-Hydroxymethylcytosine(5 hmC) signatures in circulating cell-free DNA(cfDNA) that carries the cancer-specific epigenetic patterns may represent the valuable biomarkers for discriminating tumor and healthy individuals, and thus could be potentially useful for NSCLC diagnosis. Here,we employed a sensitive and reliable method to map genome-wide 5 hmC in the cfDNA of Chinese NSCLC patients and detected a significant 5 hmC gain in both the gene bodies and promoter regions in the blood samples from tumor patients compared with healthy controls. Specifically, we identified six potential biomarkers from 66 patients and 67 healthy controls(mean decrease accuracy>3.2, P < 3.68E-19) using machine-learning-based tumor classifiers with high accuracy. Thus,the unique signature of 5 hmC in tumor patient's cfDNA identified in our study may provide valuable information in facilitating the development of new diagnostic and therapeutic modalities for NSCLC. | Ji Zhang Xiao Han Chunchun Gao Yurong Xing Zheng Qi Ruijuan Liu Yueqin Wang Xiaojian Zhang Yun-Gui Yang Xiangnan Li Baofa Sun Xin Tian | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 7 |
| 6 | Theoretical and numerical research of wire array Z-pinch and dynamic hohlraum at IAPCM显示文摘Dense Z-pinch plasmas are powerful and energy-efficient laboratory sources of X-rays,and show the possibility to drive inertial confinement fusion(ICF).Recent advances in wire-array Z-pinch and Z-pinch dynamic hohlraum(ZPDH)researches at the Institute of Applied Physics and Computational Mathematics are presented in this paper.Models are setup to study different physical processes.A full circuit model(FCM)was used to study the coupling between Z-pinch implosion and generator discharge.A mass injection model with azimuthal modulation was setup to simulate the wire-array plasma initiation,and the two-dimensional MHD code MARED was developed to investigate the Z-pinch implosion,MRT instability,stagnation and radiation.Implosions of nested and quasi-spherical wire arrays were also investigated theoretically and numerically.Key processes of ZPDH,such as the arrayefoam interaction,formation of the hohlraum radiation,as well as the following capsule ablation and implosion,were analyzed with different radiation magneto-hydrodynamics(RMHD)codes.An integrated 2D RMHD simulation of dynamic hohlraum driven capsule implosion provides us the physical insights of wire-array plasma acceleration,shock generation and propagation,hohlraum formation,radiation ablation,and fuel compression. | Ning Ding Yang Zhang Delong Xiao Jiming Wu Zihuan Dai Li Yin Zhiming Gao Shunkai Sun Chuang Xue Cheng Ning Xiaojian Shu Jianguo Wang | 2016 | Matter and Radiation at Extremes2016，1，3： | 7 |
| 7 | Seed dormancy and germination characteristics of two Rheum species in the Himalaya-Hengduan Mountains显示文摘Seed dormancy and germination characteristics are important factors determining plant reproductive success, and may be expected to have a major influence on plant distribution. In this study, we aimed to explore the characteristics of seed dormancy and germination in two endemic Rheum species(Rheum nobile and Rheum alexandrae) in the Himalaya-Hengduan Mountains. To determine the type of dormancy,fresh seeds of the two species(one population each) were incubated in light at 25/15 and 15/5℃, and then dry after-ripening(DAR) seeds were incubated on water agar substrate with or without GA_3. To determine the effect of temperature and light on germination, DAR seeds of the two species(two populations each) were incubated both in the light and in the dark at several temperatures, including constant and alternating temperatures. Base temperature(T_b) and thermal times for 50% germination(θ_(50)) were calculated. DAR released physiological dormancy(PD), increasing final germination at 15/5℃ and widening the range of germination temperatures from higher to lower, indicative of type 2 non-deep PD for the two Rheum species. Light had no significant effect on germination of seeds from the two species(two populations each). Seeds of the two species germinated significantly better(>80%) at medium temperatures(10-25℃) than at extreme low(5℃) or high(35℃) temperatures. Alternating temperatures(25/15 and 15/5℃) did not significantly increase the final germination of the two species either in the light and in the dark, but it promoted seed germination more quickly than corresponding constant temperatures in the light in both Rh. alexandrae populations, especially at 15/5℃. Germination in response to temperature was well described by the thermal-time model at suboptimal temperatures. The estimated Tbvalues were 1 and 0.9℃, respectively, in two Rh. nobile populations; 4 and 4.1℃,respectively, in two Rh. alexandrae populations; θ_(50)(thermal time) were 100 and 125℃d, respectively in two Rh. nobile populations; 76.92 and 83.33℃d, respectively in two Rh. alexandrae populations. The dormancy type, and germination responses to temperature and light condition does not explain why the two Rheum species are distributed in contrasting habitats. However, these findings reflect an advantageous germination strategy of these two Rheum species to adapt to the same alpine environments. | Deli Peng Zhe Chen Xiaojian Hu Zhimin Li Bo Song Hang Sun | 2017 | Plant Diversity2017，39，4： | 4 |
| 8 | Nonlinear relationship between enteric-coated mycophenolate sodium dose and mycophenolic acid exposure in Han kidney transplantation recipients显示文摘The aim of the research was to investigate the pharmacokinetics(PK) of enteric-coated mycophenolate sodium(EC-MPS) by quantification of the active metabolite of mycophenolic acid(MPA)after multiple escalating oral doses in Han kidney transplant recipients. A total of 28 Han postoperative kidney transplant recipients were given a multiple-dose of 540, 720 or 900 mg of EC-MPS two times a day in combination with tacrolimus for 6 days. Blood specimens were collected at each time point from0 to 12 h after EC-MPS administration. MPA plasma concentrations were measured by UPLC–UV. The relationship between the EC-MPS dose and its PK parameters was assessed. In the range from 540 to900 mg, C_(max) and AUC_(0–12h) did not increase with dose escalation. The AUC_(0–12h), C_(max), C_0 and T_(max) for the 540 720 and 900 mg doses were not significantly different, respectively(P 40.05). AUC_0–12 h and C_(max) were increased less than proportionally with increasing EC-MPS dose levels. Inter-individual variability in AUC_(0–12h), C_(max) and C_0 were considerable. Nonlinear PK relationships were found from the doses of 540–900 mg of EC-MPS. | Jun Zhang Mengmeng Jia Lihua Zuo Na Li Yonggang Luo Zhi Sun Xiaojian Zhang Zhenfeng Zhu | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 3 |
| 9 | Disassemblability Modeling Technology of Configurable Product Based on Disassembly Constraint Relation Weighted Design Structure Matrix(DSM)显示文摘The current research of configurable product disassemblability focuses on disassemblability evaluation and disassembly sequence planning.Little work has been done on quantitative analysis of configurable product disassemblability.The disassemblability modeling technology for configurable product based on disassembly constraint relation weighted design structure matrix(DSM)is proposed.Major factors affecting the disassemblability of configurable product are analyzed,and the disassembling degrees between components in configurable product are obtained by calculating disassembly entropies such as joint type,joint quantity,disassembly path,disassembly accessibility and material compatibility.The disassembly constraint relation weighted DSM of configurable product is constructed and configuration modules are formed by matrix decomposition and tearing operations.The disassembly constraint relation in configuration modules is strong coupling,and the disassembly constraint relation between modules is weak coupling,and the disassemblability configuration model is constructed based on configuration module.Finally,taking a hydraulic forging press as an example,the decomposed weak coupling components are used as configuration modules alone,components with a strong coupling are aggregated into configuration modules,and the disassembly sequence of components inside configuration modules is optimized by tearing operation.A disassemblability configuration model of the hydraulic forging press is constructed.By researching the disassemblability modeling technology of product configuration design based on disassembly constraint relation weighted DSM,the disassembly property in maintenance,recycling and reuse of configurable product are optimized. | QIU Lemiao LIU Xiaojian ZHANG Shuyou SUN Liangfeng | 2014 | Chinese Journal of Mechanical Engineering2014，27，3： | 3 |
| 10 | A novel entry point for pedicle screw placement in the thoracic spine显示文摘This study was aimed to introduce a novel entry point for pedicle screw fixation in the thoracic spine and compare it with the traditional entry point. A novel entry point was found with the aim of improving accuracy, safety and stability of pedicle screw technique based on anatomical structures of the spine. A total of 76 pieces of normal thoracic CT images at the transverse plane and the thoracic pedicle anatomy of 6 cadaveric specimens were recruited.Transverse pedicle angle(TPA), screw length, screw placement accuracy rate and axial pullout strength of the two different entry point groups were compared. There were significant differences in the TPA, screw length, and the screw placement accuracy rate between the two groups(P<0.05). The maximum axial pullout strength of the novel entry point group was slightly larger than that of the traditional group. However, the difference was not significant(P > 0.05). The novel entry point significantly improved the accuracy, stability and safety of pedicle screw placement.With reference to the advantages above, the new entry point can be used for spinal internal fixations in the thoracic spine. | Zhifeng Sun Kaixiang Yang Hongtao Chen Tao Sui Lei Yang Dawei Ge Jian Tang Xiaojian Cao | 2018 | The Journal of Biomedical Research2018，32，2： | 3 |
| 11 | Cytoplasmic and nuclear genome variations of rice hybrids and their parents inform the trajectory and strategy of hybrid rice breeding显示文摘The male sterility(MS)line is a prerequisite for efficient production of hybrid seeds in rice,a self-pollinating species.MS line breeding is pivotal for hybrid rice improvement.Understanding the historical breeding tra-jectory will help to improve hybrid rice breeding strategies.Maternally inherited cytoplasm is an appro-priate tool for phylogenetic reconstruction and pedigree tracing in rice hybrids.In this study,we analyzed the cytoplasmic genomes of 1495 elite hybrid rice varieties and identified five major types of cytoplasm,which correspond to different hybrid production systems.As the cytoplasm donors for hybrids,461 MS lines were also divided into five major types based on cytoplasmic and nuclear genomic architecture.Spe-cific core accessions cooperating with different fertility-associated genes drove the sequence divergence of MS lines.Dozens to hundreds of convergent and divergent selective sweeps spanning several agro-nomic trait-associated genes were identified among different types of MS lines.We further analyzed the cross patterns between different types of MS lines and their corresponding restorers.This study system-atically analyzed the cytoplasmic genomes of rice hybrids revealed their relationships with nuclear ge-nomes of MS lines,and illustrated the trajectory of hybrid rice breeding and the strategies for breeding different types of MS lines providing new insights for future improvement of hybrid rice. | Zhoulin Gu Zhou Zhu Zhen Li Qilin Zhan Qi Feng Congcong Zhou Qiang Zhao Yan Zhao Xiaojian Peng Bingxin Dai Rongrong Sun Yan Li Hengyun Lu Lei Zhang Tao Huang Junyi Gong Danfeng Lv Xuehui Huang Bin Han | 2021 | Molecular Plant2021，14，12： | 2 |
| 12 | Low complexity Chase-2 decoding of concatenated codes显示文摘The concatenated codes are widely used in current communication systems, such as satellite communication systems and WiMAX system. The objective of this study was to present a low complexity iterative soft decoding algorithm for concatenated codes. The concatenation was between a Reed-Solomon (RS) code and recursive systematic convolutional (RSC) code. The reduction in computational complexity was achieved by simplifying the Chase-2 decoder for RS codes with limited usage of test patterns. The processing of soft information between inner and outer decoders was also discussed. Simulation results showed that the proposed algorithm could achieve a good trade-off between complexity and performance. | LIU XiaoJian ZHAO ChunMing SUN XiaoJun | 2010 | Chinese Science Bulletin2010，55，26： | 2 |
| 13 | Development of a Soil Stabilizer for Road Subgrade Based on Original Phosphogypsum显示文摘The research used industrial by-products original phosphogypsum(PG)as the main raw material,slag(SG)and Portland cement(PC)as auxiliary materials,and the optimal additive amount was determined according to the compressive strength value of the sample.Comprehensively evaluate the water resistance and volume stability of the samples,and determine the best formula for new roadbed stabilized materials.The results showed that when the weight ratio of PG,slag and cement was OPG:SG:PC=6:3:1,and mixed with 5%micro silica fume(MSF)and 3‰hydroxypropyl methyl cellulose(HPMC),the sample’s comprehensive performance was the best,specifically,the sample’s compressive strength in 60 days reached 28.8 MPa,the softening coefficient reached 0.9,and the expansion rate was stable at about−0.2%.In addition,the mechanism of action of enhancers MSF and HPMC was analyzed according to use Vicat device,X-ray diffractometer and scanning electron microscope.The best formula SP3GH3 has the best curing effect on soil.The 28-day unconfined compressive strength(UCS)of the sample reached 2.4 MPa,the expansion rate was less than 0.09%,and the water stability coefficient was above 0.79,which was higher than that of the samples cured by traditional cement and lime during the same period. | Zenghuan Gu Aiguo Fang Sudong Hua Qingzhou Zhao Lidong Sun Fan Xia Liying Qian Xiaojian Ren | 2021 | Journal of Renewable Materials2021，9，2： | 2 |
| 14 | Cyclooxygenase-2 (COX-2) G-765C is a protective factor for coronary artery disease but not for ischemic stroke: A meta-analysis显示文摘 | Wenlong Li Jing Xu Xiaojian Wang Jingzhou Chen Channa Zhang Kai Sun Rutai Hui | 2009 | Atherosclerosis2009，，2： | 1 |
| 15 | Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal cells显示文摘 | Hongying Sun Nan Li Xiaojian Wang Taoyong Chen Liyun Shi Lihuang Zhang Jianli Wang Tao Wan Xuetao Cao | 2005 | Molecular and Cellular Biochemistry2005，，1： | 1 |
| 16 | The impact of quality of work life on job embeddedness and affective commitment and their co‐effect on turnover intention of nurses显示文摘 | XiaoWen Zhao Tao Sun QiuRu Cao Ce Li XiaoJian Duan LiHua Fan Yan Liu | 2012 | Journal of Clinical Nursing2012，，5： | 1 |
| 17 | Boolean evaluation for interactive genetic algorithms and its fatigue-re- duction effects in product optimization task 显示文摘 | Sun Yan Liu Xiaojian He Xiaodong | 2012 | International Review on Computers and Software2012，7，1： | 1 |
| 18 | An experimental study on the user evaluation accuracy of interactive genetic algorithms 显示文摘 | Sun Yan Liu Xiaojian Wang Wanliang | 2012 | Journal of Convergence Information Technology2012，7，1： | 1 |
| 19 | Effects of leptin on femoral fracture in rats显示文摘In this study, our objective was to evaluate effects of leptin on fracture healing in rats. Seventy two male SpragueDawley(SD) rats were randomized into 3 groups. Standardized femoral fractures were created in all the rats. Group A was treated with 1 mL normal saline(NS), group B with 0.3μg/kg leptin in 1 mL NS, and group C with 0.5μg/kg leptin in 1 mL NS for 2 weeks intraperitoneally. Each group was divided into three subgroups including 8 rats for evaluation at 2, 4 and 8 weeks. Radiological evaluation showed that callus formation of group B and C was all significantly higher than group A at 8 weeks(P=0.04 and P = 0.013, respectively). There was no statistically significant difference in fracture healing between group B and group C at 8 weeks(P = 0.197). Histological evaluation revealed fracture healing of group B and C was better than group A at 4 weeks(P=0.01 and P= 0.002,respectively) and 8 weeks(P = 0.008 and P= 0.003, respectively). Micro-computed tomography(Micro-CT) analysis demonstrated that greater amounts of bony callus and evidence of bone fusion were observed in group B and C at 4 weeks(P = 0.02 and P = 0.04, respectively) and 8 weeks(P= 0.005 and P = 0.001, respectively) compared to group A. Group C also had better fracture healing than group B at 8 weeks(P = 0.01). In conclusion, leptin has a positive effect on rat femoral fracture healing. | Lei Wang Sixin Sun Lei Yang Chun Lu Xiaojian Cao | 2018 | The Journal of Biomedical Research2018，32，2： | 1 |
| 20 | Muhi-compo- nent Simulation and Kinetics Model for Co-combustion of Huadian Oil Shale Retorting Residue and Comstalks显示文摘 | LIU Hongpeng SUN Xiaojian WANG Xudong | 2015 | Oil Shale2015，32，2： | 1 |
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