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| 1 | Enhanced biological phosphorus removal using thermal alkaline hydrolyzed municipal wastewater biosolids显示文摘This study reports the feasibility of using municipal wastewater biosolids as an alternative carbon source for biological phosphorus removal.The biosolids were treated by a lowtemperature,thermal alkaline hydrolysis process patented by Lystek International Inc.(Cambridge,ON,Canada)to produce short-chain volatile fatty acids and other readily biodegradable organics.Two sequencing batch reactors(SBRs)were operated with synthetic volatile fatty acids(Syn VFA)and readily biodegradable organics produced from the alkaline hydrolysis of municipal wastewater biosolids(Lystek)as the carbon source,respectively.Municipal wastewaters with different strengths and COD:N:P ratios were tested in the study.The reactors’performances were compared with respect to nitrogen and phosphorus removal.It was observed that phosphorus removal efficiencies were between 98%–99%and 90%–97%and nitrogen removal efficiencies were 78%–81%,and 67%for the Syn VFA and Lystek,respectively.However,the kinetics for phosphorus release and uptake during the anaerobic and aerobic stages with Lystek were observed to be significantly lower than Syn VFA due to the presence of higher order VFAs(C4 and above)and other fermentable organics in the Lystek. | Masuduz Zaman Mingu Kim George Nakhla Ajay Singh Fenghua Yang | 2019 | Journal of Environmental Sciences2019，31，12： | 4 |
| 2 | Analysis of equilibrium, kinetic, and thermodynamic parameters for biosorption of fluoride from water onto coconut(Cocos nucifera Linn.)root developed adsorbent显示文摘Drinking water with higher fluoride levels results in serious irremediable health problems that have attained a startle all over the world.Researches focused towards deflouridation through the application of biosorbents prepared from various plants are finding greater scope and significance.Present research is done on Cocos nucifera Linn.(coconut tree) one of the very commonly available plants throughout Kerala and around the globe.An adsorbent developed from the root portion of C.nucifera Linn.is used in the present study.Equilibrium study revealed that the fluoride uptake capacity is quite significant and linearly increases with initial adsorbate concentration.The adsorption data is analyzed for Langmuir, Freundlich, Temkin, and Dubinin–Radushkevich isotherm models at varying initial adsorbate concentrations(2–25 mg·L^(-1)).It is found that the adsorption of fluoride onto C.nucifera Linn.root adsorbent follows Langmuir isotherm.Langmuir isotherm constants 'a' and 'b' obtained are 2.037 mg·g^(-1) and 0.823 L·mg^(-1) at an adsorbent dose of 8 g·L^(-1) and temperature(26 ± 1) ℃.The mean free sorption energy, E obtained, is 9.13 kJ ·mol^(-1) which points out that the adsorption of fluoride onto C.nucifera Linn.root adsorbent is by chemisorption mechanism.The kinetic study also supports chemisorption with adsorption data fitting well with a pseudo-second-order kinetic model with an estimated rate constant K_2 of 0.2935 g·mg^(-1) min at an equilibrium contact time of 90 min.The thermodynamic study indicated the spontaneous and endothermic nature(ΔH =12.728 kJ·mol^(-1)) of fluoride adsorption onto the C.nucifera Linn.root adsorbent.Scanning Electron Microscopy(SEM), BET, FTIR, and EDX methods were used to analyze the surface morphology of adsorbent before and after fluoride adsorption process.Experiments on deflouridation using C.nucifera Linn.root adsorbent application on fluoride contaminated ground water samples from fields showed encouraging results. | Aju Mathew George Ajay R.Tembhurkar | 2019 | Chinese Journal of Chemical Engineering2019，27，1： | 2 |
| 3 | Prospective Study on Circulating MicroRNAs and Risk of Myocardial Infarction显示文摘 | Anna Zampetaki Peter Willeit Lindsey Tilling Ignat Drozdov Marianna Prokopi Jean-Marie Renard Agnes Mayr Siegfried Weger Georg Schett Ajay Shah Chantal M. Boulanger Johann Willeit Philip J. Chowienczyk Stefan Kiechl Manuel Mayr | 2012 | Journal of the American College of Cardiology2012，，： | 2 |
| 4 | Heart failure in COVID-19 patients:Critical care experience显示文摘Patients with heart failure(HF)may be at a higher risk of coronavirus disease 2019(COVID-19)infection and may have a worse outcome due to their comorbid conditions and advanced age.In this narrative review,we aim to study the interaction between COVID-19 and HF from a critical care perspective.We performed a systematic search for studies that reported HF and critical carerelated outcomes in COVID-19 patients in the PubMed and Medline databases.From a total of 1050 papers,we identified 26 that satisfied the eligibility criteria for our review.Data such as patient demographics,HF,intensive care unit(ICU)admission,management,and outcome were extracted from these studies and analyzed.We reported outcomes in heart-transplant patients with COVID-19 separately.In hospitalized patients with COVID-19,the prevalence of HF varied between 4%and 21%.The requirement for ICU admission was between 8%and 33%.HF patients with COVID-19 had an overall mortality rate between 20%and 40%.We identified that HF is an independent predictor of mortality in hospitalized COVID-19 patients,and patients with HF were more likely to require ventilation,ICU admission and develop complications.Patients with HF with reduced ejection fraction did worse than those with HF with midrange ejection fraction,and HF with preserved ejection fraction.COVID-19 patients with HF should be identified early and managed aggressively in an attempt to improve outcomes in this cohort of patients. | Kevin John John Ajay K Mishra Chidambaram Ramasamy Anu A George Vijairam Selvaraj Amos Lal | 2022 | World Journal of Virology2022，11，1： | 1 |
| 5 | Gamma-glutamyl transferase and cardiovascular risk in nonalcoholic fatty liver disease:The Gut and Obesity Asia initiative显示文摘BACKGROUND Gamma-glutamyl transferase(GGT)is associated with the risk of cardiovascular disease(CVD)in the general population.AIM To identify the association of baseline GGT level and QRISK2 score among patients with biopsy-proven nonalcoholic fatty liver disease(NAFLD).METHODS This was a retrospective study involving 1535 biopsy-proven NAFLD patients from 10 Asian centers in 8 countries using data collected by the Gut and Obesity in Asia(referred to as“GO ASIA”)workgroup.All patients with available baseline GGT levels and all 16 variables for the QRISK2 calculation(QRISK2-2017;developed by researchers at the United Kingdom National Health Service;https://qrisk.org/2017/;10-year cardiovascular risk estimation)were included and compared to healthy controls with the same age,sex,and ethnicity.Relative risk was reported.QRISK2 score>10%was defined as the high-CVD-risk group.Fibrosis stages 3 and 4(F3 and F4)were considered advanced fibrosis.RESULTS A total of 1122 patients(73%)had complete data and were included in the final analysis;314(28%)had advanced fibrosis.The median age(interquartile range[IQR])of the study population was 53(44-60)years,532(47.4%)were females,and 492(43.9%)were of Chinese ethnicity.The median 10-year CVD risk(IQR)was 5.9%(2.6-10.9),and the median relative risk of CVD over 10 years(IQR)was 1.65(1.13-2.2)compared to healthy individuals with the same age,sex,and ethnicity.The high-CVD-risk group was significantly older than the low-risk group(median[IQR]:63[59-67]vs 49[41-55]years;P<0.001).Higher fibrosis stages in biopsy-proven NAFLD patients brought a significantly higher CVD risk(P<0.001).Median GGT level was not different between the two groups(GGT[U/L]:Median[IQR],high risk 60[37-113]vs low risk 66[38-103],P=0.56).There was no correlation between baseline GGT level and 10-year CVD risk based on the QRISK2 score(r=0.02).CONCLUSION The CVD risk of NAFLD patients is higher than that of healthy individuals.Baseline GGT level cannot predict CVD risk in NAFLD patients.However,advanced fibrosis is a predictor of a high CVD risk. | Panyavee Pitisuttithum Wah-Kheong Chan George Boon-Bee Goh Jian-Gao Fan Myeong Jun Song Phunchai Charatcharoenwitthaya Ajay Duseja Yock-Young Dan Kento Imajo Atsushi Nakajima Khek-Yu Ho Khean-Lee Goh Vincent Wai-Sun Wong Sombat Treeprasertsuk | 2020 | World Journal of Gastroenterology2020，26，19： | 1 |
| 6 | An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease显示文摘Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly evident.In 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without MAFLD.However,to date,there is no appropriate guidance on CKD in individuals with MAFLD.Furthermore,there has been little attention paid to the link between MAFLD and CKD in the Nephrology community.Methods and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and CKD.Conclusions:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases. | Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 1 |
| 7 | Efficacy and safety of gemcitabine, carboplatin, dexamethasone, and rituximab in patients with relapsed/refractory lymphoma: a prospective multi-center phase II study by the Puget Sound Oncology Consortium显示文摘 | Ajay K. Gopal Oliver W. Press Andrei R. Shustov Stephen H. Petersdorf Ted A. Gooley Jasmine T. Daniels Mitchell A. Garrison George F. Gjerset Matthew Lonergan Anne E. Murphy Julie C. Smith John M. Pagel | 2010 | Leukemia & Lymphoma2010，，8： | 1 |
| 8 | A Risk Score to Predict Bleeding in Patients With Acute Coronary Syndromes显示文摘 | Roxana Mehran Stuart J. Pocock Eugenia Nikolsky Tim Clayton George D. Dangas Ajay J. Kirtane Helen Parise Martin Fahy Steven V. Manoukian Frederick Feit Magnus E. Ohman Bernard Witzenbichler Giulio Guagliumi Alexandra J. Lansky Gregg W. Stone | 2010 | Journal of the American College of Cardiology2010，，23： | 1 |
| 9 | The all-diode-pumped laser system POLARIS——an experimentalist's tool generating ultra-high contrast pulses with high energy显示文摘The development,the underlying technology and the current status of the fully diode-pumped solid-state laser system POLARIS is reviewed.Currently,the POLARIS system delivers 4 J energy,144 fs long laser pulses with an ultra-high temporal contrast of 5 × 1012 for the ASE,which is achieved using a so-called double chirped-pulse amplification scheme and cross-polarized wave generation pulse cleaning.By tightly focusing,the peak intensity exceeds 3.5 × 1020 W cm-2.These parameters predestine POLARIS as a scientific tool well suited for sophisticated experiments,as exemplified by presenting measurements of accelerated proton energies.Recently,an additional amplifier has been added to the laser chain.In the ramp-up phase,pulses from this amplifier are not yet compressed and have not yet reached the anticipated energy.Nevertheless,an output energy of 16.6 J has been achieved so far. | Marco Hornung Hartmut Liebetrau Andreas Seidel Sebastian Keppler Alexander Kessler Jrg Krner Marco Hellwing Frank Schorcht Diethard Klpfel Ajay K.Arunachalam Georg A.Becker Alexander Svert Jens Polz Joachim Hein Malte C.Kaluza | 2014 | High Power Laser Science and Engineering2014，2，3： | 1 |
| 10 | Food poisoning associated methemoglobinemia: Time to wake up显示文摘Dear editor,With interest we read the recent article on methemoglobinemia by Chan et al.[1]Through this letter,we would like to add few additional comments regarding methemoglobinemia and its relevance in medicine practice with regards to food poisoning.While Chan et al[1]successfully managed their patient of methemoglobinemia and could pinpoint choy sum as the responsible agent,we wonder if there were any more cases of choy sum related to methemoglobinemia detected at the same time in the community? | Kamal Kant Sahu Amos Lal Ajay Mishra Susan George | 2020 | World Journal of Emergency Medicine2020，11，2： | 1 |
| 11 | Nonylphenol, octylphenol, and bisphenol-A in the aquatic environment: A review on occurrence, fate, and treatment显示文摘 | Virender K. Sharma George A. K. Anquandah Ria A. Yngard Hynook Kim Jeno Fekete Karel Bouzek Ajay K. Ray Dmitriy Golovko | 2009 | Journal of Environmental Science and Health, Part A2009，，5： | 1 |
| 12 | A systematic review and recta-analysis of treatments for impetigo显示文摘 | Ajay George Greg Rubin | 2003 | British Journal of General Practice2003，，： | 1 |
| 13 | Case-control analysis of venous thromboembolism risk in nonalcoholic steatohepatitis diagnosed by transient elastography显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is the most common cause of chronic liver disease worldwide.Studies have shown a strong association between nonalcoholic steatohepatitis(NASH)cirrhosis and portal vein thrombosis.Specifically,there is paucity of data on the association of NASH and venous thromboembolism(VTE),with one such study predicting a 2.5-fold increased risk for VTE compared to other liver diseases in hospitalized patients.The mechanism is believed to be a hepatocellular injury,which causes a chronic inflammatory state leading to the unregulated activation of procoagulant factors.There has been no prior analysis of the degree of steatosis and fibrosis(measured using transient elastography,commonly known as FibroScan)in NASH and its association with VTE.AIM To examine the association between the degree of hepatic steatosis and fibrosis,quantified by transient elastography,and the incidence of VTE in patients with NASH.METHODS In our case-control study,we included patients with a documented diagnosis of NASH.We excluded patients with inherited thrombophilia,hemoglobinopathy,malignancy,alcohol use disorder,autoimmune hepatitis,and primary biliary cirrhosis.The collected data included age,demographics,tobacco use,recreational drug use,medical history,and vibration controlled transient elastography scores.VTE-specific data included the location,type of anticoagulant,need for hospital stay,and history of VTE recurrence.Steatosis was categorized as S0-S1(mild)and S2-S3(moderate to severe)based on the controlled attenuation parameter score.Fibrosis was classified based on the kilopascal score and graded as F0-F1(Metavir stage),F2,F3,and F4(cirrhosis).χ^(2) and Mann-Whitney U tests were used for the qualitative and quantitative variable analyses,respectively.Furthermore,we performed a logistic regression using VTE as the dependent variable.RESULTS A total of 415 patients were analyzed,and 386 met the inclusion criteria.51 and 335 patients were included in the VTE and non-VTE groups,respectively.Patients with VTE had a mean age of 60.63 years compared to 55.22 years in the non-VTE group(P<0.014).Patients with VTE had a higher body mass index(31.14 kg/m²vs 29.30 kg/m²)and a higher prevalence of diabetes mellitus(29.4%vs 13.1%).The history of NASH was significantly higher in the VTE group(45.1%vs 30.4%,P<0.037).Furthermore,moderate-to-severe steatosis was significantly higher in the VTE group(66.7%vs 47.2%,P<0.009).Similarly,the F2-F4 fibrosis grade had a prevalence of 58.8%in the VTE group compared to 38.5%in the non-VTE group(P<0.006).On logistic regression,using VTE as a dependent variable,diabetes mellitus had an odds ratio(OR)=1.702(P<0.015),and F2-F4 fibrosis grade had an OR=1.5(P<0.033).CONCLUSION Our analysis shows that NASH is an independent risk factor for VTE,especially deep vein thrombosis.There was a statistically significant association between the incidence of VTE,moderate-to-severe steatosis,and fibrosis.All hospitalized patients should be considered for medical thromboprophylaxis,particularly those with NASH. | Mithil Gowda Suresh Maya Gogtay Yuvaraj Singh Lekha Yadukumar Ajay Kumar Mishra George M Abraham | 2023 | World Journal of Clinical Cases2023，11，34： | 0 |
| 14 | Effect of fuel additives on agricultural straw pellet quality显示文摘An investigation was conducted to determine the effect of addition of different levels of AK2,a fuel additive that reduces ash fusion for agricultural biomass,on the physico-chemical properties of biomass pellets.Three different biomass straws,barley,oat,and wheat were ground at two hammer mill screen sizes of 0.8 mm and 1.6 mm.Each ground biomass sample was mixed with three levels of AK2,0.05%,0.10%,and 0.15%by mass and also a blank(no AK2)was set aside for comparison.Pellets were made using single-pelleting unit at a pre-set load of 4400 N corresponding to a pressure of 138.9 MPa.Physical quality of pellets were determined by measuring pellet density,relaxed density,durability,and the specific energy required to make a pellet.Pellets having higher durability values(74%-88%)were obtained from ground straw at hammer screen size of 0.8 mm and AK2 level of 0.15%compared to other treatments.Carbon,hydrogen,nitrogen,and sulfur content of blank pellets and those with 0.15%AK2 at hammer screen size of 0.8 mm were determined.Pellets made with 0.15%AK2 at hammer screen size of 0.8 mm,manufactured by pilot-scale pellet mill,were gasified and the tar content was determined.The tar content of pellets with 0.15%AK2 was significantly lower than blank pellets. | Shahram Emami Lope G.Tabil Phani Adapa Elizabeth George Ashwini Tilay Ajay Dalai Mark Drisdelle Lily Ketabi | 2014 | International Journal of Agricultural and Biological Engineering2014，7，2： | 0 |
| 15 | Impact of Living Donor Liver Transplantation on COVID-19 Clinical Outcomes from a Quaternary Care Centre in Delhi显示文摘Background and Aims:The anticipated fear of serious out-comes in coronavirus infected liver transplant recipients led to disruption of transplant services globally.The aim of our study was to analyze COVID-19 severity in transplant recipients and to compare the difference of COVID-19 clinical outcomes in early(<1 year)vs.late(>1 year)post-transplant period.Methods:41 post-living donor liver transplant recipients with COVID-19 infection were studied retrospectively from 1st April 2020 to 28th February 2021.Results:The median age was 49.00 years with a male preponderance(80.49%).Fif-teen patients had infection within 1 year of transplant and 26 were infected after 1 year of transplant.The overall median interval between transplantation and COVID-19 diagnosis was 816.00 days.Fever and malaise were the common presenting symptoms.The most common associated comorbidities were diabetes mellitus(65.85%)and hypertension(46.34%).The severity of illness was mild in 28(68.29%),moderate in 4(9.76%),severe in 6(14.63%)and critical in 3(7.32%).To identify associated risk factors,we divided our patients into less severe and more severe groups.Except for lymphopenia,there was no worsening of total bilirubin,transaminases,al-kaline phosphatase,and gamma-glutamyl transferase in the more severe group.Eight(19.51%)patients required inten-sive care unit admission and three(7.32%)died,while none suffered graft rejection.In recipients with early vs.late post-transplant COVID-19 infection,there were similar outcomes in terms of severity of COVID-19 illness,intensive care unit care need,requirement of respiratory support,and death.Conclusion:Living donor liver transplantation can be per-formed during the COVID-19 pandemic without the fear of poor recipient outcome in cases of unfortunate contraction of severe acute respiratory syndrome coronavirus-2. | Imtiakum Jamir Niteen Kumar Gaurav Sood Ashish George Pankaj Lohia Samba Siva Rao Pasupuleti Amrish Sahney Manav Wadhawan Ajay Kumar Abhideep Chaudhary | 2022 | Journal of Clinical and Translational Hepatology2022，10，4： | 0 |
| 16 | Takotsubo cardiomyopathy following envenomation:An updated review显示文摘BACKGROUND Takotsubo cardiomyopathy(TTC)can be diagnosed in patients presenting with clinical features of acute coronary syndrome(ACS)by using Mayo clinic criteria.Multiple precipitators have been attributed to causing TTC.Rarely it has been reported to occur following an acute envenomation.AIM This review describes the various patterns,mechanisms,and outcomes of envenomation induced TTC.METHODS In this review,we included all studies on“TTC”and“envenomation”published in the various databases before June 2022.To be included in the review articles had to have a distinct diagnosis of TTC and an envenomation RESULTS A total of 20 patients with envenomation induced TTC were identified.Most episodes of envenomation induced TTC were reported following a bee sting,scorpion sting,and snake envenomation.Fear and anxiety related to the sting,direct catecholamine toxicity and administration of exogenous beta-adrenergic agents have been commonly postulated to precipitate TTC in these patients.95%of these patients presented with a clinical picture of ACS.Most of these patients also fulfill at least 3 out of 4 criteria of Mayo clinic criteria for TTC.Echocardiographic evidence of Apical TTC was noted in 72%of patients.94%of these patients had clinical improvement following optimal management and 35%of these patients were treated with guideline directed medications for heart failure.CONCLUSION Envenomation following multiple insect stings and reptile bites can precipitate TTC.Most reported envenomation related TTC has been due to bee stings and scorpion bites.Common mechanisms causing TTC were fear,anxiety,and stress of envenomation.Most of these patients present with clinical presentation of ACS,ST elevation,and elevated troponin.The most common type of TTC in these patients is Apical,which improved following medical management. | Ajay K Mishra Anu A George Kevin John John Pramukh Arun Kumar Mahati Dasari Mohammed Afraz Pasha Michelle Hadley | 2023 | World Journal of Cardiology2023，15，1： | 0 |
| 17 | 婴儿急性淋巴细胞白血病治疗方案(Interfant-99):一项多中心随机临床试验及观察研究显示文摘背景急性淋巴细胞白血病(ALL)极少见于1岁以内的婴儿,一旦患病其预后将比年长幼儿更差。本项国际研究旨在观察一种新的兼具ALL与急性髓系白血病(AML)治疗要素的混合治疗方案的应用效果,并确定可能影响婴儿预后的因素。本研究同时还进行了一项随机临床试验,以确定晚期强化治疗的,临床价值。
方法本研究包括来自22个国家的17个研究组,分别于1999-2005年选取年龄为0~12个月的ALL婴儿。根据前期泼尼松治疗7d后外周血的反应,对患儿进行风险分层,然后给予以ALL标准疗法为基础的混合治疗,该疗法亦包含某些AML治疗要素。在维持期之前,将完全缓解的一组患儿随机分为标准治疗组和应用高剂量阿糖胞苷及甲氨蝶呤的高强度化疗组。主要结局指标为初选治疗组的无事件生存率(EFS)与随机治疗组的无病存活率(DFS)。数据处理以意向治疗分析为基础。该试验在ClinicalTrials.gov网站上的注册号为NCT 00015873,在controlled—trials.com网站上注册号为ISRCTN24251487。
结果共计482例患婴接受混合治疗,其中260例(58%)完全缓解,中位随访期为38个月(极差1~78),4年EFS达47.0%(si=2.6,95%CI41.9%~52.1%)。诱导治疗5周后445例获完全缓解,入选随机分组191例,其中晚期强化治疗组95例,对照组96例。在中位数为42个月(极差1~73)的随访期后,治疗组无病存活60例,对照组57例。2组间4年DFS无显著差异[治疗组为60.9%(sx^-=5.2)VS对照组为57.0%;P=0.81]。在强化治疗期,71例随机治疗组患婴反馈有毒性统计数据,其中感染35例(49%)、黏膜炎21例(30%)、肝脏毒性反应22例(33%)、神经毒性2例(3%)。反映预后不佳的独立因素包括:各种M比(混合系白血病)基因重排、极高的白细胞计数、年龄〈6个月、前期泼尼松治疗反应差。
结论与多数报道相比,ALL婴儿(特别是那些对泼尼松反应差的患儿)接受混合治疗后可获得较好的EFS。但晚期强化化疗的效果并不明显。 | Rob Pieters Martin Schrappe Paola De Lorenzo lan Hann Giulio De Rossi Maria Felice Liisa Houi Thierry LeBlanc Tomasz Szczepanski Alice Ferster Gritta Janka Jeffrey Rubnitz Lewis Silverman Jan Story Myriam Campbell Chi-Kong Li Georg Mann Ram Suppiah Andrea Biondi Ajay Vora Maria Grazia Valsecchi 王顺涛(译) | 2008 | 世界临床医学2008，2，1： | 0 |
| 18 | Improved lifestyle is associated with improved depression,anxiety and wellbeing over time in UK healthcare professionals during the COVID-19 pandemic:insights from the CoPE-HCP cohort study显示文摘Background One potential modifiable factor to improve the mental health of healthcare professionals(HCPs)during the pandemic is lifestyle.Aims This study aimed to assess whether an improved lifestyle during the pandemic is associated with improved mental health symptoms and mental well-being in HCPs over time.Methods This was a cohort study involving an online survey distributed at two separate time points during the pandemic(baseline(July–September 2020)and follow-up(December 2020–March 2021))to HCPs working in primary or secondary care in the UK.Both surveys assessed for major depressive disorder(MDD)(Patient Health Questionnaire-9(PHQ-9)),generalised anxiety disorder(GAD)(Generalised Anxiety Disorder-7(GAD-7)),mental well-being(Short Warwick-Edinburgh Mental Well-being Score(SWEMWBS))and self-reported lifestyle change(compared with the start of the pandemic)on multiple domains.Cumulative scores were calculated to estimate overall lifestyle change compared with that before the pandemic(at both baseline and follow-up).At each time point,separate logistic regression models were constructed to relate the lifestyle change score with the presence of MDD,GAD and low mental well-being.Linear regression models were also developed relating the change in lifestyle scores from baseline to follow-up to changes in PHQ-9,GAD-7 and SWEMWBS scores.Results 613 HCPs completed both baseline assessment and follow-up assessment.Consistent significant cross-sectional associations between increased lifestyle change scores and a reduced risk of MDD,GAD and low mental well-being were observed at both baseline and follow-up.Over the study period,a whole unit increase in the change in novel scores(ie,improved overall lifestyle)over 4 months was inversely associated with changes in PHQ-9(adjusted coefficient:−0.51,95%confidence interval(CI):−0.73 to−0.30,p<0.001)and GAD-7 scores(adjusted coefficient:−0.32,95%CI:−0.53 to−0.10,p=0.004)and positively associated with the change in SWEMWBS scores(adjusted coefficient:0.37,95%CI:0.18 to 0.55,p<0.001).Conclusions Improved lifestyle over time is associated with improved mental health and mental well-being in HCPs during the pandemic.Improving lifestyle could be a recommended intervention for HCPs to help mitigate the mental health impact during the current and future pandemics. | Mohammed Y Khanji George Collett Thomas Godec Carmela Maniero Sher May Ng Imrana Siddiqui Jaya Gupta Vikas Kapil Ajay Gupta | 2023 | General Psychiatry2023，36，1： | 0 |
| 19 | Clinical Efficacy of Inhaled Nitric Oxide in Preventing the Progression of Moderate to Severe COVID-19 and Its Correlation to Viral Clearance:Results of a Pilot Study显示文摘Hypoxic patients with coronavirus disease 2019(COVID-19)are at high risk of adverse outcomes.Inhaled nitric oxide(iNO)has shown anti-viral and immunomodulatory effects in vitro.However,in vivo evidence of efficacy in hypoxic COVID-19 is sparse.This open label feasibility study was conducted at a single referral center in South India and evaluated the effectiveness of repurposed iNO in improving clinical outcomes in COVID-19 and its correlation with viral clearance.We recruited hypoxemic COVID-19 patients and allocated them into treatment(iNO)and control groups(1:1).Viral clearance on day 5 favored the treatment group(100%vs 72%,P<0.01).The speed of viral clearance as adjudged by normalized longitudinal cycle threshold(Ct)values was positively impacted in the treatment group.The proportion of patients who attained clinical improvement,defined as a≥2-point change on the World Health Organization ordinal scale,was higher in the iNO cohort(n=11,79%)as compared to the control group(n=4,36%)(odds ratio 6.42,95%confidence interval 1.09–37.73,P=0.032).The proportion of patients progressing to mechanical ventilation in the control group(4/11)was significantly higher than in the treatment group(0/14).The all-cause 28-day mortality was significantly different among the study arms,with 36%(4/11)of the patients dying in the control group while none died in the treatment group.The numbers needed to treat to prevent an additional poor outcome of death was estimated to be 2.8.Our study demonstrates the putative role of repurposed iNO in hypoxemic COVID-19 patients and calls for extended validation. | Merlin Moni Thushara Madathil Dipu T.Sathyapalan Veena Menon Georg Gutjahr Fabia Edathadathil Deepthi Sureshkumar Preetha Prasanna Soumya Jose Roshni Jerome Ajai Krishnan Indulekha C.L.Pillai Geetha Kumar Bipin Nair Victor Nizet Aveek Jayant | 2022 | Infectious Microbes & Diseases2022，4，1： | 0 |
| 20 | Cardiovascular complications following medical termination of pregnancy: An updated review显示文摘BACKGROUND Around 1 million cases of medical termination of pregnancy(MTP)take place yearly in the United States of America with around 2 percent of this population developing complications.The cardiovascular(CVD)complications occurring post MTP or after stillbirth is not very well described.AIM To help the reader better understand,prepare,and manage these complications by reviewing various cardiac comorbidities seen after MTP.METHODS We performed a literature search in PubMed,Medline,RCA,and google scholar,using the search terms“abortions”or“medical/legal termination of pregnancy”and“cardiac complications”or“cardiovascular complications”.RESULTS The most common complications described in the literature following MTP were infective endocarditis(IE)(n=16),takotsubo cardiomyopathy(TTC)(n=7),arrhythmias(n=5),and sudden coronary artery dissection(SCAD)(n=4).The most common valve involved in IE was the tricuspid valve in 69%(n=10).The most observed causative organism was group B Streptococcus in 81%(n=12).The most common type of TTC was apical type in 57%(n=4).Out of five patients de veloping arrhythmia,bradycardia was the most common and was seen in 60%(3/5)of the patients.All four cases of SCAD-P type presented as acute coronary syndrome 10-14 d post termination of pregnancy with predominant involvement of the right coronary artery.Mortality was only reported following IE in 6.25%.Clinical recovery was reported consistently after optimal medical management following all these complications.CONCLUSION In conclusion,the occurrence of CVD complications following pregnancy termination is infrequently documented in the existing literature.In this review,the most common CVD complication following MTP was noted to be IE and TTC. | Tejveer Singh Ajay K Mishra Nikhil Vojjala Kevin John John Anu A George Anil Jha Michelle Hadley | 2023 | World Journal of Cardiology2023，15，10： | 0 |
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