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| 1 | SARS-CoV-2 infects human neural progenitor cells and brain organoids显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)1 has resulted in over 13 million confirmed cases and more than 580,045 deaths across 218 countries and geographical regions as of July 16,2020.This novel coronavirus primarily causes respiratory illness with clinical manifestations largely resembling those of SARS.However,neurological symptoms including headache,anosmia,ageusia,confusion,seizure,and encephalopathy have also been frequently reported in COVID-19 patients. | Bao-Zhong Zhang Hin Chu Shuo Han Huiping Shuai Jian Deng Ye-fan Hu Hua-rui Gong Andrew Chak-Yiu Lee Zijiao Zou Thomas Yau Wutian Wu Ivan Fan-Ngai Hung Jasper Fuk-Woo Chan Kwok-Yung Yuen Jian-Dong Huang | 2020 | Cell Research2020，30，10： | 8 |
| 2 | A Subpopulation of CD26 + Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer显示文摘 | Roberta Pang Wai Lun Law Andrew C.Y. Chu Jensen T. Poon Colin S.C. Lam Ariel K.M. Chow Lui Ng Leonard W.H. Cheung Xiao R. Lan Hui Y. Lan Victoria P.Y. Tan Thomas C. Yau Ronnie T. Poon Benjamin C.Y. Wong | 2010 | Cell Stem Cell2010，，6： | 4 |
| 3 | Unit root tests in panel data: asymptotic and finite-sample properties显示文摘 | Andrew Levin Chien-Fu Lin Chia-Shang James Chu | 2002 | Journal of Econometrics2002，，1： | 4 |
| 4 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 5 | Safety of endovascular therapy for symptomatic intracranial artery stenosis:a national prospective registry显示文摘Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment. | Yabing Wang Tao Wang Adam Andrew Dmytriw Kun Yang Liqun Jiao Huaizhang Shi Jie Lu Tianxiao Li Yujie Huang Zhenwei Zhao Wei Wu Jieqing Wan Qinjian Sun Bo Hong Yongli Li Liyong Zhang Jianfeng Chu Qiong Cheng Yiling Cai Pengfei Wang Qi Luo Hua Yang Baijing Dong Yang Zhang Jun Zhao Zuoquan Chen Wei Li Xiaoxin Bai Weiwen He Xueli Cai Maimai Ti Osama O Zaidat | 2022 | Stroke & Vascular Neurology2022，7，2： | 3 |
| 6 | Aflibercept for diabetic macular oedema: a Meta-analysis of randomized controlled trials显示文摘AIM: To evaluate the relative efficacy and safety of aflibercept for treatment of diabetic macular oedema(DMO).METHODS: A comprehensive search in MEDLINE, CENTRAL and EMBASE was undertaken for randomized controlled trials(RCTs) comparing intravitreal antivascular endothelial growth factor(anti-VEGF) versus another treatment. Primary outcome measures were proportion of patients with at least 15 letters of gain or loss on a log MAR visual acuity chart, and change in best corrected visual acuity(BCVA) and central macular thickness(CMT) from baseline. Safety outcomes were rates of death, thromboembolic events and any systemic or ocular serious adverse events. The final search was performed on November 2017.RESULTS: Four RCTs were included. Only one trial compared efficacy and safety of aflibercept with bevacizumab and ranibizumab over 1 or 2 y. Three trials were included for Meta-analysis comprising 661 patients(331 in the aflibercept, and 330 in the photocoagulation group). Aflibercept was more efficacious compared to photocoagulation in the proportion of patients with at least 15 letters of improvement and worsening, and in improvement of BCVA and reduction in CMT at 1 or 2 y. The safety estimates at 1 or 2 y did not differ statistically.CONCLUSION: Aflibercept offers superior benefits over photocoagulation in improving and preserving vision, with no differences in safety. Further comparative effectiveness trials between aflibercept and other anti-VEGF agents will aid ophthalmologists in treatment decisions. | Chu Luan Nguyen Andrew Lindsay Eugene Wong Michael Chilov | 2018 | International Journal of Ophthalmology(English edition)2018，11，6： | 2 |
| 7 | Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice显示文摘The mammalian epididymis not only plays a fun dame ntal role in the maturati on of spermatozoa,but also provides protecti on agai nst various stressors.The foremost among these is the threat posed by oxidative stress,which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids,proteins,and nucleic acids.In mice,the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5(GPX5)as a major luminal scavenger in the proximal caput epididymidal segment.Accordingly,the loss of GPX5^-/-mediated protection leads to impaired DNA integrity in the spermatozoa of aged Gpx57 mice.To explore the underlying mechanism,we have conducted transcriptomic analysis of caput epididymidal epithelial cells from aged(13 months old)Gpx5^-/-m mice.This analysis revealed the dysregulation of several thousand epididymal mRNA transcripts,in eluding the downregulation of a subgroup of piRNA pathway gen es,in aged Gpx5^-/-mice.In agreeme nt with these fin dings,we also observed the loss of piRNAs,which potentially bind to the P-element-induced wimpy testis(PlWI)-like proteins PIWIL1 and PIWIL2.The absence of these piRNAs was correlated with the elevated mRNA levels of their putative gene targets in the caput epididymidis of Gpx5^-/-mice.Importantly,the oxidative stress response genes tend to have more targeting piRNAs,and many of them were among the top increased genes upon the loss of GPX5^-/-.Taken together,our findings suggest the existence of a previously uncharacterized somatic piRNA pathway in the mammalian epididymis and its possible invoIvement in the aging and oxidative stress-mediated responses. | Chen Chu Lu Yu Joelle Henry-Berger Yan-Fei Ru Ayhan Kocer Alexandre Champroux Zhi-Tong Li Miao He Sheng-Song Xie Wu-Bin Ma Min-Jie Ni Zi-Mei Ni Yun-Li Guo Zhao-Liang Fei Lan-Tao Gou Qiang Liu Samanta Sharma Yu Zhou Mo-Fang Liu Charlie Degui Chen Andrew L Eamens Brett Nixon Yu-Chuan Zhou Joel R Drevet Yong-Lian Zhang | 2020 | Asian Journal of Andrology2020，22，6： | 2 |
| 8 | Biomechanical design of the Berkeley lower Extremity Exoskeleton (BLEEX) 显示文摘 | ZOSS A B KAZEROONI H CHU Andrew | 2006 | IEEE/ASME Trans on Mechatronics2006，11，2： | 1 |
| 9 | Derivatives of eigenval- ues and eigenvectors of matrix functions 显示文摘 | Andrew A L Chu K W E Lancaster P | 1993 | SIAM journal on matrix analysis and applications1993，14，4： | 1 |
| 10 | Bent-Beam Electrothermal Actuators-part Ⅱ:Linear and Rotary Microengines显示文摘 | Jae-sung Park Larry Chu Andrew D Oliver | 2001 | Journal of MicroElectroMechanical Systems2001，10，2： | 1 |
| 11 | Enhanced Myocyte Contractility and Ca Handling in a Calcineurin Transgenic Model of Heart Failure显示文摘 | GUOXIANG CHU ANDREW N CARR KAREN B YOUNG | 2002 | Cardiovas Res2002，54，： | 1 |
| 12 | Unit root tests in panel data: asymptotic and finite-sample properties显示文摘 | Andrew Levin Chien-Fu Lin Chia-Shang James Chu | 2002 | Journal of Econometrics2002，，1： | 1 |
| 13 | Unit Root Tests in Panel Data: Asymptotic and Finite Sample Properties 显示文摘 | Andrew Levin Chien-Fu Lin Chia-Shang James Chu | 2002 | Journal of Econometrics2002，，108： | 1 |
| 14 | Unit Root Tests in Panel Data: Asymptotic and Finite-sample Properties 显示文摘 | Levin Andrew Lin Chien-Fu and Chu Chia-Shang James | 2002 | Journal of Econometrics2002，，108： | 1 |
| 15 | Biomechanical design of the berkeley lower extremity exoskeleton (BLEEX) 显示文摘 | Adam B Zoss H Kazerooni and Andrew Chu | 2006 | IEEE/ASME Transactions on Mechatronics April2006，11，2： | 1 |
| 16 | Biomechanical designof the berkeley lower extremity exoskeleton(BLEEX)显示文摘 | ZOSS Adam B KAZEROONI H CHU Andrew | 2006 | IEEE/ASMETransactions on Mechatronics2006，2，： | 1 |
| 17 | Unit Root Tests in Panel Data: Asymptotic and Finite-sample Properties显示文摘 | Andrew Levin Chien-Fu Lin Chia-Shang James Chu | 2002 | Journal of Econometrics2002，108，： | 1 |
| 18 | Atrial overdrive pacing to prevent atrial fibrillation: Insights from ASSERT显示文摘 | Stefan H. Hohnloser Jeff S. Healey Michael R. Gold Carsten W. Israel Sean Yang Isabelle van Gelder Alessandro Capucci Chu P. Lau Eric Fain Carlos A. Morillo Andrew Ha Mark Carlson Stuart J. Connolly | 2012 | Heart Rhythm2012，，10： | 1 |
| 19 | Comparison of commercial supercapacitors and high-power lithium-ion batteries for power-assist applications in hybrid electric vehicles 显示文摘 | Andrew Chu Paul Braatz | 2002 | J of Power Sources2002，112，2： | 1 |
| 20 | Derivatives of eigenvalues and eigenvectors of matrix functions显示文摘 | Andrew A L Chu K W Lancaster P | 1993 | SIAM J Matrix Anal Appl1993，14，4： | 1 |
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