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| 1 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 2 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 3 | Altered angiotensin-converting enzyme and its effects on the brain in a rat model of Alzheimer disease显示文摘背景 Alzheimer 疾病(广告)是与在场的 aging.At 有关的 neurodegenerative 疾病,它的病理学的机制 unclear.Family 留下高血压蛋白原酶血管收缩素系统(地岬)的成员祈祷在 neuronal 粘性的一个角色,以及学习和记忆的形成在这研究,我们探索改变的变换血管收缩素的酶(王牌)的效果,并且调查 perindopril 的可能的机制,一个王牌禁止者在在广告的一个老鼠模型的大脑结构和功能上。 | HOU De-ren WANG Yan ZHOU Lin CHEN Kun TIAN Yi SONG Zhi BAO Juan YANG Qi-dong | 2008 | Chinese Medical Journal2008，，22： | 11 |
| 4 | Genomic sequencing and analysis of the first imported Middle East Respiratory Syndrome Coronavirus(MERS CoV) in China显示文摘Dear Editors,Middle East Respiratory Syndrome(MERS)has spread to more than 23 countries since the first case of a MERS coronavirus(MERS Co V)infection was confirmed in Sep2012[1].Because MERS Co V has led to mortality as high as 40%,it has become one of the most important emerging pathogens threatening human health.Recently,the outbreak of MERS Co V,which resulted in 172 infections and | XIE Qian CAO YuJuan SU Juan WU XianBo WAN ChengSong KE ChangWen ZHAO Wei ZHANG Bao | 2015 | Science China(Life Sciences)2015，58，8： | 8 |
| 5 | Crystalline Silica Promotes Rat Fibrocyte Differentiation in Vitro,and Fibrocytes Participate in Silicosis in Vivo显示文摘Objective The aim of this study was to investigate the effects of Si O2 on fibrocytes and whether fibrocytes participate in silicosis in vivo. Methods A macrophagocyte(AM)/fibrocyte coculture system was established, and AMs were treated with 100 μg/mL SiO 2. Flow cytometry was used to detect the number of fibrocytes. Real‐time PCR was performed to measure the expression of collagen I, collagen III, and α‐SMA mR NA. The levels of collagen I, collagen III, and TGF‐β1 protein were determined by ELISA. Immunohistochemical staining was performed to measure α‐SMA protein expression. A rat silicosis model was induced by intratracheal instillation of SiO 2. Lung histopathological evaluation was conducted using HE and Masson's trichrome staining after 1 and 9 weeks. The number of fibrocytes in peripheral blood or lung tissue of rat was detected by flow cytometry. Double‐color immunofluorescence was applied to identify fibrocytes in the lung tissue. Results Peripheral blood monocytes were found to differentiate into fibrocytes in vitro in a time‐dependent manner, and exposure to crystalline silica might potentiate fibrocyte differentiation. In addition, fibrocytes were able to migrate from peripheral blood to the lung tissue, and the number of fibrocytes was increased after SiO 2 exposure. Conclusion Silica exposure potentiates fibrocyte differentiation, and fibrocytes may participate in silicosis in vivo. | LI Juan YAO Wu HOU Jian Yong Zhang Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao HAO Chang Fu | 2017 | Biomedical and Environmental Sciences2017，30，9： | 7 |
| 6 | Preparation and application of SBA-15-supported palladium catalyst for Heck reaction in supercritical carbon dioxide显示文摘为 SBA-15-supported 钯催化剂为的准备的一个新方法哎呀在 supercritical 二氧化碳的反应被介绍。最新形成的 SBA-15-supported 钯催化剂(Ph-SBA-15-PPh3-Pd ) 与甲基 acrylate 为 4-nitrobromobenzene 的 Heck 反应展出了高催化的活动。没有活动的损失,催化剂能若干次被再使用。 | Xiu Juan Feng Mei Yan Xin Zhang Ming Bao | 2011 | Chinese Chemical Letters2011，22，6： | 6 |
| 7 | Real-time pressure mapping smart insole system based on a controllable vertical pore dielectric layer显示文摘Real-time monitoring of plantar pressure has significant applications in wearable biosensors,sports injury detection,and early diagnostics.Herein,an all-in-one insole composed of 24 capacitive pressure sensors(CPSs)with vertical pores in an elastic dielectric layer is fabricated by laser cutting.Optimized CPSs with a hexagonal configuration and a pore size of 600μm possess good linearity over a wide detection range of 0–200 kPa with a sensitivity of 12×10^(–3) kPa−1.Then,a smart system including the all-in-one insole with the 24 CPS array,a data acquisition system with a wireless transmitter and a PC terminal with a wireless receiver is established for real-time monitoring to realize static and dynamic plantar pressure mapping.Based on this smart insole system,various standing and yoga postures can be distinguished,and variations in the center of gravity during walking can be recognized.This intelligent insole system provides great feasible supervision for health surveillance,injury prevention,and athlete training. | Juan Tao Ming Dong Li Li Chunfeng Wang Jing Li Yue Liu Rongrong Bao Caofeng Pan | 2020 | Microsystems & Nanoengineering2020，6，1： | 6 |
| 8 | Salidroside Protects Against 6-Hydroxydopamine-Induced Cytotoxicity by Attenuating ER Stress显示文摘Parkinson's disease(PD) is a neurodegenerative disease characterized by a persistent decline of dopaminergic(DA) neurons in the substantia nigra pars compacta. Despite its frequency, effective therapeutic strategies that halt the neurodegenerative processes are lacking, reinforcing the need to better understand the molecular drivers of this disease. Importantly, increasing evidence suggests that the endoplasmic reticulum(ER)stress-induced unfolded protein response is likely involved in DA neuronal death. Salidroside, a major compound isolated from Rhodiola rosea L., possesses potent antioxidative stress properties and protects against DA neuronal death. However, the underlying mechanisms are not well understood. In the present study, we demonstrate that salidroside prevents 6-hydroxydopamine(6-OHDA)-induced cytotoxicity by attenuating ER stress. Furthermore, treatment of a DA neuronal cell line(SN4741) and primary cortical neurons with salidroside significantly reduced neurotoxin-induced increases in cytoplasmic reactive oxygen species and calcium, both of which cause ER stress, and cleaved caspase-12, which is responsible for ER stress-induced cell death. Together, these results suggest that salidroside protects SN4741 cells and primary cortical neurons from 6-OHDA-induced neurotoxicity by attenuating ER stress. This provides a rationale for the investigation of salidroside as a potential therapeutic agent in animal models of PD. | Kai Tao Bao Wang Dayun Feng Wei Zhang Fangfang Lu Juan Lai Lu Huang Tiejian Nie Qian Yang | 2016 | Neuroscience Bulletin2016，32，1： | 5 |
| 9 | Facile synthesis of thiourea derivatives in ionic liquid显示文摘The synthesis of cinnamoyl thiourea derivatives from cinnamoyl isothiocyanate (CIT) with substituted aniline (RC6H4NH2) was investigated in the mostly used ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate, [Bmim][BF4]. Significant enhance-ments in reactivity, yield and reaction rate were achieved. The products could be recovered by simple filtration. [Bmim][BF4] couldbe recycled simply by removing water under vacuum and reused at least 9 times without significant decrease in activity. | Min Liang Xiao Feng Huang Chen Zhi Juan Chen Bao Shou Guo Xian Hai Lv Wen Ming Tang | 2007 | Chinese Chemical Letters2007，18，3： | 4 |
| 10 | Restrictive vs liberal transfusion for upper gastrointestinal bleeding:A meta-analysis of randomized controlled trials显示文摘AIM:To compare the outcome of upper gastrointestinal bleeding(UGIB) between patients receiving restrictive and liberal transfusion.METHODS:PubMed,EMBASE,and Cochrane Library databases were employed to identify all relevant randomized controlled trials regarding the outcome of UGIB after restrictive or liberal transfusion. Primary outcomes were death and rebleeding. Secondary outcomes were length of hospitalization,amount of blood transfused,and hematocrit and hemoglobin at discharge or after expansion.RESULTS:Overall,4 papers were included in this meta-analysis. The incidence of death was significantly lower in patients receiving restrictive transfusion than those receiving liberal transfusion(OR:0.52,95%CI:0.31-0.87,P = 0.01). The incidence of rebleeding was lower in patients receiving restrictive transfusion than those receiving liberal transfusion,but this difference did not reach any statistical significance(OR:0.26,95%CI:0.03-2.10,P = 0.21). Compared with those receiving liberal transfusion,patients receiving restrictive transfusion had a significantly shorter length of hospitalization(standard mean difference:-0.17,95%CI:-0.30--0.04,P = 0.009) and a significantly smaller amount of blood transfused(standard mean difference:-0.74,95%CI:-1.15--0.32,P = 0.0005) with a lower hematocrit and hemoglobin level at discharge or after expansion.CONCLUSION:Restrictive transfusion should be employed in patients with UGIB. | Juan Wang Yong-Xin Bao Ming Bai Yong-Guo Zhang Wen-Da Xu Xing-Shun Qi | 2013 | World Journal of Gastroenterology2013，19，40： | 4 |
| 11 | A New Sequential Systems of Linear Equations Algorithm of Feasible Descent for Inequality Constrained Optimization显示文摘Based on a new efficient identification technique of active constraints introduced in thispaper,a new sequential systems of linear equations (SSLE) algorithm generating feasible iterates isproposed for solving nonlinear optimization problems with inequality constraints.In this paper,we introducea new technique for constructing the system of linear equations,which recurs to a perturbationfor the gradients of the constraint functions.At each iteration of the new algorithm,a feasible descentdirection is obtained by solving only one system of linear equations without doing convex combination.To ensure the global convergence and avoid the Maratos effect,the algorithm needs to solve two additionalreduced systems of linear equations with the same coefficient matrix after finite iterations.Theproposed algorithm is proved to be globally and superlinearly convergent under some mild conditions.What distinguishes this algorithm from the previous feasible SSLE algorithms is that an improvingdirection is obtained easily and the computation cost of generating a new iterate is reduced.Finally,apreliminary implementation has been tested. | Jin Bao JIAN Dao Lan HAN Qing Juan XU | 2010 | Acta Mathematica Sinica,English Series2010，26，12： | 4 |
| 12 | Nitrogen‐Containing Microporous Conjugated Polymers via Carbazole‐Based Oxidative Coupling Polymerization: Preparation, Porosity, and Gas Uptake显示文摘 | Qi Chen De‐Peng Liu Min Luo Li‐Juan Feng Yan‐Chao Zhao Bao‐Hang Han | 2014 | Small2014，，2： | 3 |
| 13 | Impact of Enterprise Ownership and Size on Registered Hematotoxicity in Benzene-exposed Workers显示文摘Benzene is a classified as a human carcinogen that can cause myelodysplastic syndrome and acute myelogenous leukemia[1]. This compound is also a potent toxin suppressing the bone marrow. Accordingly, benzene causes serious hematological adverse effects, such as pancytopenia and aplastic anemia. In the 1920s, the carcinogenicity of benzene was identified in humans, in which it was shown to cause acute myelocytic leukemia (AML)[2]. The reports highlighting the first cases of hematopoietic disease associated with benzene appeared in China in the late 1950s[3]. Moreover, benzene exposure is likely to result in AML, having been identified as a Group Ⅰ carcinogen by the International Agency for Research on Cancer (1987)[4]. A meta-analysis has determined the links existing between childhood leukemia and the numbers of latent benzene exposure metrics[5]. | WANG Bo Shen HAN Lei YANG Dan Dan ZHANG Juan YIN Li Hong ZHANG Meng Ying XU Kai XING Cai Hong ZHU Bao Li PU Yue Pu | 2018 | Biomedical and Environmental Sciences2018，31，12： | 3 |
| 14 | Acute Pesticide Poisoning in Jiangsu Province, China, from 2006 to 2015显示文摘This study aimed to investigate the characteristics of pesticide poisoning in Jiangsu Province, China, and to provide a scientific basis for developing effective interventional measures and preventive strategies. From 2006 to 2015, a total of 35,308 cases of pesticide poisoning were reported in Jiangsu Province. Non‐occupational poisoning accounted for 73.79% of all poisoning cases. A comparison of the data collected before(2006) and after(2015) this study showed a decrease in non‐occupational pesticide poisoning. Pesticide poisoning showed an age central tendency of 30 to 44 years, area central tendency for northern Jiangsu, and seasonal central tendency of occupational pesticide poisoning in autumn. Pesticide poisoning remains a major health concern in China. Government agencies together with scientists should focus their efforts on the prevention of potential threats to vulnerable groups such as the elderly, women, and children. | WANG Bo Shen CHEN Lin LI Xiu Ting XU Ming ZHU Bao Li ZHANG Juan | 2017 | Biomedical and Environmental Sciences2017，30，9： | 3 |
| 15 | Anti-cancer Effect of 20(S)-Ginsenoside-Rh2 on Oral Squamous Cell Carcinoma Cells via the Decrease in ROS and Downregulation of MMP-2 and VEGF显示文摘Squamous cell carcinoma(SCC) is the most common in oral and maxillofacial regions and occupy more than 90% of the malignant lesions in the oral cavity[1]. The complex anatomy of the head and neck region gives rise to intricate patterns of local invasion and regional spread, which makes primary tumors more difficult to eradicate. | ZHANG Bao Ping LI Bo CHENG Jing Yang CAO Rui GAO Shu Ting HUANG Chun Juan LI Rui Ping NING Jing LIU Bin LI Zhi Ge | 2020 | Biomedical and Environmental Sciences2020，33，9： | 3 |
| 16 | A review and research on comprehensive characterization of microscopic shale gas reservoir space显示文摘In this paper,substantial domestic and foreign research results of microscopic shale reservoir space were systemically reviewed,the research history consisting of simple observation and qualitative classification,quantitative research,the combination of qualitative and quantitative research successively as well as the characteristics of each research stage were summarized.In addition,the current problems existing in the characterization methods of shale reservoir space were also analyzed.Furthermore,based on massive actual detection of typical core samples obtained from more than 50 global shale gas wells and relevant practical experience,a comprehensive characterization method of combining qualitative with the semiquantitative characterization was put forward.In detail,the indicators of the qualitative characterization include pore combination type and organic-matter microscopic morphology type,while the core elements of the semi-quantitative characterization include the percentage of the organic-matter area and the plane porosity of the pores of different types.Based on the reference of the naming and classification of rocks,the three-end-member diagram method was used to characterize microscopic shale reservoir space.This is achieved by plotting the three end-member diagram of 3 kinds of first-order critical reservoir spaces,i.e.,organic-matter pores,matrix pores,and micro-fractures,in order to intuitively present the features of the microscopic pore combination.Meanwhile,statistic histograms of organic-matter microscopic morphology type and the plane porosity of different types of pores were adopted to characterize the development degree of second-order pores quantitatively.By this comprehensive characterization method,the importance of both pore combination and the microscopic morphology of organic matter were emphasized,revealing the control of organic-matter microscopic morphology over the organic-matter pores.What is more,high-resolution FE-SEM was adopted to obtain semi-quantitative statistics results.In this way,the features of pore development and pore combination were quantified,not only reflecting the types and storage capacity of the microscopic shale reservoir space,but also presenting the hydrocarbongenerating potential of organic matter in shale.Therefore,the results of this research are capable of providing in-depth microscopic information for the assessment and exploration and development of shale gas resources. | Yu-ru Yang Xiao-chen Liu Hui Zhang Gang-yi Zhai Jiao-dong Zhang Zhi-fang Hu Shu-jing Bao Cong Zhang Xiang-hua Wang Xiao Yang Zheng-zhuang Liu Ting Xie Juan Chen Liyu Fang Li-juan Qin | 2019 | China Geology2019，2，4： | 3 |
| 17 | CS1003, a novel human and mouse cross-reactive PD-1 monoclonal antibody for cancer therapy显示文摘The programmed cell death protein 1(PD-1)is an immune-checkpoint that negatively regulates the immune system and a key mechanism that tumors utilize to escape from immune surveillance.PD-1 antibodies can block the interaction of PD-1 with its ligands(PD-L1 and PD-L2),restore T cells activation,and elicit antitumor activity.In this paper,we reported a novel PD-1 monoclonal antibody(mAb)CS1003,which is a humanized IgG4 PD-1 mAb generated by conventional hybridoma technology,and currently being developed in multiple clinical trials as monotherapy or in combination with other anticancer agents.We showed that CS1003 bound to recombinant human,cynomolgus monkey,and mouse PD-1 with EC50 values of 0.1757,0.2459,and 0.3664 nM,respectively.CS1003 blocked PD-1 interaction with its ligands,dose-dependently enhanced T cell proliferation and secretion of cytokines(IL-2 and IFN-γ)to the levels comparable to the reference antibody pembrolizumab.Intraperitoneal administration of CS1003(0.1,0.5,2.5 mg/kg,once every 3 days)dose-dependently suppressed the growth of MC38-hPD-L1 colon cancer in hPD-1 knock-in mice.Pharmacokinetics(PK)study revealed a linear PK profile within the dose range of 2–18 mg/kg following single intravenous administration in cynomolgus monkey.These data provide a comprehensive preclinical characterization of CS1003 that supports its clinical development for cancer immunotherapy. | Fu Li Jingrong Li Ke Yin Juan Zhang Zhen-hu Li Liang Lu Yuan-wu Bao Zhen Qin Yong Zheng Bao-tian Yang Jing Li Xinzhong Wang | 2021 | Acta Pharmacologica Sinica2021，42，1： | 2 |
| 18 | Preparation of new hybrid organic/inorganic polymeric chiral stationary phases for ligand-exchange chromatography显示文摘三新混合器官 / 无机的聚合 ligand 交换 chiral 静止阶段被激进的链转移反应和表面 grafting 在硅石胶化上开发,并且成功地为 dl 氨基的酸和 dl 氢氧根酸的 enantioseparations 使用了。决定被使用包含 2.0 ×的水完成 10 ? 是的 CuAc2 的 4 mol/L 一个活动阶段, 40 ° C 的列温度, 1.0 mL/min 和察觉在的流动率紫外 254 nm。在 l 异构体前的 d 异构体的 elution 顺序为除了 dl 职业人员,解决的所有 dl 氨基的酸被观察。 | Rui Juan Song Yu Fu Na Yao Yuan De Long Tian Bao Huang | 2007 | Chinese Chemical Letters2007，18，10： | 2 |
| 19 | The clinical application of guided bone regeneration technique the dental implant restoration of traumatic dentition defect显示文摘 | XU Liang - peng JIA Bao - jun HUANG Zheng - nan WANG Juan YANG Hai - qing | 2014 | 医学美学美容(中旬刊)2014，23，4： | 2 |
| 20 | Three Super Active Regions in the Descending Phase of Solar Cycle 23显示文摘We analyze the magnetic configurations of three super active regions,NOAA 10484, 10486 and 10488, observed by the Huairou Multi-Channel Solar Telescope (MCST) from 2003 October 18 to November 4. Many energetic phenomena,such as flares (including a X-28 flare) and coronal mass ejections (CMEs), occurred during this period. We think that strong shear and fast emergence of magnetic flux are the main causes of these events. The question is also of great interest why these dramatic eruptions occurred so close together in the descending phase of the solar cycle. | Hong-Qi Zhang, Xing-Ming Bao, Yin Zhang, Ji-Hong Liu, Shu-Dong Bao, Yuan-Yong Deng, Wei Li, Jie Chen, Jin-Ping Dun, Jiang-Tao Su, Juan Guo, Xiao-Fan Wang, Ke-Liang Hu, Gang-Hua Lin and Dong-Guang WangNational Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 | 2003 | Chinese Journal of Astronomy and Astrophysics2003，3，6： | 2 |
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