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| 1 | The Relationship between Glucose Excursion and Cognitive Function in Aged Type 2 Diabetes Patients显示文摘Objective Evidence suggests that type 2 diabetes (T2DM) is associated with an increased risk of dementia and that glucose variability is an independent risk factor for diabetic complications.This study investigated the relationship between glucose excursion and cognitive function in aged T2DM patients.Methods A total of 248 aged T2DM patients wore a continuous glucose monitoring system (CGMS) for 3 days in order to evaluate glucose excursion,including mean amplitude of glycemic excursions (MAGE) and mean of daily difference (MODD).All subjects were evaluated with a number of accepted cognitive function tests,including themini‐mental status examination (MMSE).The relationship between MAGE and MODD and performance on these cognitive tests was assessed.Results The MAGE and MMSE score were negatively correlated,likewise with the correlation between MODD and MMSE.Liner multivariate regression analysis showed that MAGE and MODD were also negatively related to MMSE independent of age,sex,glycemic control,hypertension,smoking,or coronary heart disease history.Conclusion Glucose excursion is related to cognitive function in aged T2DM patients.Elevated glucose excursion decreased the MMSE score,which reflects general cognitive function.Thus,therapy aimed at controlling glucose excursion may be beneficial for maintaining cognitive function in aged T2DM patients. | ZHONG Yuan ZHANG Xiao Yan MIAO Ya ZHU Jie Hua YAN Hong WANG Bei Yun JIN Jun HU Ting Jun JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 34 |
| 2 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 3 | Elevated nocturnal and morning blood pressure in patients with obstructive sleep apnea syndrome显示文摘 | HE Quan-ying FENG Jing ZHANG Xilong LIANG Zong-an HUANG Shao-guang KANG Jian WANG Guang-fa ZHANG Li-qiang MA Li-jun WANG Bei LIN Qi-chang ZHANG Jin-nong LIU Hui-guo LUO Yuan-ming LIU Jian-hong WANG Shi XIAO Gao-hui LU Gan ZHANG Jin FENG Xue-wei CHEN Bao-yuan | 2012 | Chinese Medical Journal2012，，10： | 15 |
| 4 | Entecavir add-on Peg-interferon therapy plays a positive role in reversing hepatic fibrosis in treatment-naive chronic hepatitis B patients: a prospective and randomized controlled trial显示文摘Background:The efficacy of entecavir(ETV)add-on peg-interferon therapy compared with ETV monotherapy in treatment-naive hepatitis B virus(HBV)patients remains controversial.We investigated whether adding peg-interferon to ongoing ETV treatment leads to a better curative effect or not.Methods:All patients have been recruited between August 2013 and January 2015 from the Shanghai Public Health Clinical Center and Zhongshan Hospital(China).Eligible HBV patients(n=144)were randomly divided(1:1)to receive either ETV monotherapy(n=70)or peg-interferon add-on therapy from week 26 to 52(«=74).Patients were followed-up for at least 2 years.Indexes including hepatitis B surface antigen(HBsAg)and hepatitis B e antigen(HBeAg)seroconversion rate,sustained virologic response,transient elastography value,and histological scores were evaluated every 3 months until the end of the study.The rate of patients with HBsAg loss was defined as the primary endpoint criteria.Results:At week 26,no patient achieved HBsAg seroconversion in either group.At week 52,one patient in the monotherapy group was HBsAg-negative but there was none in the combination therapy group.The monotherapy group showed significantly better liver function recovery results than the combination therapy group.At week 78,one patient in the combination group had HBsAg seroconverted.At week 104,only three patients in the combination therapy group were HBsAg-negative compared with one patient in monotherapy.The mean alanine aminotransferase and aspartate aminotransferase levels and transient elastography values decreased significantly compared with baseline.Both groups showed a favorable decrease in alpha-fetoprotein(monotherapy:4.5[2.8,7.1]vs.2.2[1.8,3.1]ng/mL,P<0.001;combination therapy:5.7[3.0,18.8]vs.3.2[2.0,4.3]ng/mL,P<0.001)and an improved result of liver biopsy examination scores.The combination group showed a better improvement in histology compared with the monotherapy group(mean transient elastography value 6.6[4.9,9.8]vs.7.8[5.4,11.1]kPa,P=0.028).But there was no significant difference in HBsAg conversion rate(1.8%[1/56]i^s.4.1%[3/73],P=0.809)and HBeAg conversion rate(12.5%[7/56]i/s.11.0%[8/73],P=0.787),as well as HBV-DNA,sustained virologic response(93.2%vs.98.5%,P=0.150)between the two groups.Conclusions:Both therapies supported liver function recovery and histology improvement.Combination therapy did not show better anti-viral efficacy in HBsAg or HBeAg seroconversion compared with monotherapy.However,combination therapy played a more positive role in reversing hepatic fibrosis compared with monotherapy.Trial registration:ClinicalTrials.gov:NCT02849132;https://clinicaltrials.gov/ct2/show/NCT02849132. | Jing-Mao Yang Li-Ping Chen Ya-Jie Wang Bei Lyu Hong Zhao Zhi-Yin Shang Jun Li Zhen-Yu Fan Sheng-Di Wu Xiao Ming Xian Li Shao-Ping Huang Ji-Lin Cheng | 2020 | Chinese Medical Journal2020，，14： | 11 |
| 5 | 脑卒中后失能老人口腔健康状况相关生存质量研究进展显示文摘对脑卒中后失能老人口腔健康相关生存质量进行综述,分别从研究现状、相关危险因素、测评方面了解脑卒中后失能老人的口腔现状,从生理和心理两个方面了解到口腔问题对脑卒中后失能老人生存质量的影响,并从照顾者、护理、医疗、社会4个方面提出了相应的干预建议,旨在为我国脑卒中后失能老人的口腔护理提供科学的指导依据,提升病人的生存质量。 | 刘纪汝 李娟 Bei Wu Rong Xiao | 2019 | 护理研究2019，33，16： | 9 |
| 6 | Relationship of daytime blood pressure and severity of obstructive sleep apnea among Chinese: a multi-center investigation in China显示文摘背景流行病的研究显示出在妨碍的睡觉呼吸暂停(OSA ) 和高血压之间的一个独立、明确的协会。这研究试图在中国的大陆在中国人口定义在白天血压和 OSA 的严厉之间的协会。二十大学医院睡觉在中国的大陆集中的方法被中国医药协会(CMA ) 邀请参予这流行病的研究和 2297 个连续病人(年老的 18-85 年;1981 男性和 316 女性) 为在 2004 年 1 月之间的 OSA 的评估参考了这二十个睡觉中心, 2006 年 4 月有希望地被注册。夜的 polysomnography 在每个病人被执行,并且疾病严厉基于呼吸暂停呼吸过慢过浅索引(AHI ) 被估计。这些病人是进四个组的 classfied:non-apneic 控制(控制, n=257 ) 与 AHI 5 事件 / 小时;温和睡觉呼吸暂停(温和, n=402 ) 与 AHI > 5 和 15 个事件 / 小时;中等睡觉呼吸暂停(中等, n=460 ) 与 AHI > 15 和 30 个事件 / 小时和严重睡觉呼吸暂停(严重, n=1178 ) 与 AHI > 30 个事件 / 小时。白天血压大小在为得到平均价值参考睡觉中心的日子在办公室里在上午 10 点在每个病人在标准化条件下面被执行。所有病人被请求两个都在 assessing.Results 的日子前停止与血压有关的药三天收缩血压和心脏舒张的血压珍视的白天是显著地与 AHI 有关断然(r = 0.201 和 0.276 分别地;两 P 价值 < 0.001 ) 并且到天底夜的氧浸透否定地(r=-0.215 和 -0.277, 分别地;两 Pvalues < 0.001 ) ,它是 OSA 严厉的参数。在二个特殊设计吝啬的阴谋,收缩的白天和心脏舒张的血压的工具与增加 AHI 逐渐地增加了。在 61-65 的 AHI 以外,这个增加的趋势到达了结果显示出的 plateau.Conclusions 那 OSA 严厉与白天血压被联系直到 61-65 的 AHI,为早 OSA 管理提供证据,特别在有伴随物高血压的 OSA 病人。 | HE Quan-ying FENG Jing ZHANG Xi-long LIANG Zong-an HUANG Shao-guang KANG Jian WANG Guang-fa ZHANG Li-qiang MA Li-jun, WANG Bei, LIN Qi-chang, ZHANG Jing-nong, LIU Hui-guo, LUO Yuan-ming,LIU Jian-hong, WANG Shi, XIAO Gao-hui, LU Gan, ZHANG Jin, FENG Xue-wei and CHEN Bao-yuan MA Li-jun WANG Bei LIN Qi-chang ZHANG Jing-nong LIU Hui-guo LUO Yuan-ming LIU Jian-hong WANG Shi XIAO Gao-hui LU Gan ZHANG Jin FENG Xue-wei CHEN Bao-yuan | 2010 | Chinese Medical Journal2010，，1： | 9 |
| 7 | Vertically stacked holey graphene/polyaniline heterostructures with enhanced energy storage for on-chip micro-supercapacitors显示文摘平面 micro-supercapacitors (MSC ) 为 microelectronic 设备由于他们的唯一的结构的设计和尺寸相容性画了广泛的研究注意。Graphene 广泛地被用来改进 microscale 的表演电气化学的电容器。然而,为基于 graphene 的 microscale 设备的内在的电气化学的机制的调查仍然不是足够的。这里,有各种各样的典型体系结构的 micro-supercapacitors 作为模型被制作学习 graphene 效果,和他们的电气化学的表演也被评估。结果证明离子的可接近性和吸附极大地在有穴的 graphene 中介层的介绍以后被改进。这研究提供一条新线路理解内在的电气化学的行为并且为高度有效的在薄片上拥有令人激动的潜力微精力的存储。 | Xiaocong Tian Bei Xiao Xu Xu Lin Xu Zehua Liu Zhaoyang Wang Mengyu Yan Qiulong Wei Liqiang Mai | 2016 | Nano Research2016，9，4： | 7 |
| 8 | Characterization of aroma compounds of Pu-erh ripen tea using solvent assisted flavor evaporation coupled with gas chromatography-mass spectrometry and gas chromatography-olfactometry显示文摘Pu-erh ripen tea becomes popular worldwide owing to its unique taste and aroma.In the present study,volatile compounds from Pu-erh ripen tea were extracted using a solvent assisted flavor evaporation(SAFE)and analyzed with a gas chromatography-mass spectrometry(GC-MS)and a gas chromatography olfactometry(GC-O).Results demonstrated that 58 major volatile compounds and 24 aroma active substances of Pu-erh ripen tea were identified by GC-MS and GC-O analysis.Among volatile compounds identified,methoxyphenyl compounds were considered as the dominate compounds in the aroma of Pu-erh ripen tea.Further investigation showed that 6 methoxybenzenes were responsible for the aging aroma in Pu-erh ripen tea;α-ionone,3,4-dimethoxytoluene,1,3-dimethoxybenzene,etc.were responsible for the wood-like aroma.Linalool,α-terpineol,α-ionone,β-ionone,and benzeneacetaldehyde were responsible for the floral odor.Compared the odor detection threshold(ODT)among the 8 methoxyphenyl compounds in water,1,2,3-trimethoxybenzene showed the highest ODT,followed by 3,4-dimethoxyphenol.1,3-dimethoxybenzene(105μg/L)and 1,2,3-trimethoxy-5-methylbenzene(100μg/L)were present at relatively low odor threshold values.The result indicated that methoxyphenyl compounds play a vital role in the unique flavor of Pu-erh ripen tea. | Bei Wang Qing Meng Lin Xiao Ruili Li Chunhai Peng Xueli Liao Jingna Yan Honglin Liu Guanhua Xie Chi-Tang Ho Huarong Tong | 2022 | Food Science and Human Wellness2022，11，3： | 6 |
| 9 | Human fused NKG2D-IL-15 protein controls xenografted human gastric cancer through the recruitment and activation of NK cells显示文摘Interleukin (IL )-15 在生来的杀手(NK ) 和 CD8+T 房间增长和功能起一个重要作用并且是比为肿瘤免疫疗法的 IL-2 更有效的。由附近的房间的 IL-15 的 trans 演讲比它的可溶的 IL-15 为 NK 房间激活是更有效的。在这研究,熔化蛋白质 dsNKG2D-IL-15,由经由一个连接器联合到人的 IL-15 的人的 NKG2D 的二相同的细胞外的域组成了,在 Escherichia coli 被设计。DsNKG2D-IL-15 能高效地与二个 NKG2D 领域和 trans 礼品 IL-15 把人的肿瘤房间的链相关的蛋白质 A (云母) 绑在主要 histocompatibility 建筑群一级到 NK 或 CD8+ T 房间。我们移植了人的胃的癌症(SGC-7901 ) 房间进裸体老鼠和有进 C57BL/6 老鼠的云母(B16BL6 云母) 的宫外的表示的老鼠黑瘤房间。然后,我们学习了反肿瘤效果在二个 xenografted 肿瘤模特儿由 dsNKG2D-IL-15 调停了。人的 dsNKG2D-IL-15 在压制胃的癌症生长比 IL-15 展出了更高的效率。外长的人的 dsNKG2D-IL-15 集中地在老鼠肿瘤纸巾被散布基于在 vivo 实时成像。房间渗入了进跟随外部血 mononuclear 房间的注射进忍受人的胃的癌症的裸体老鼠的肿瘤纸巾的人的 CD56+ 的频率被人的 dsNKG2D-IL-15 治疗显著地增加。人的 dsNKG2D-IL-15 也由激活和招募的老鼠 NK 和 CD8+ T 房间推迟了移植黑瘤(B16BL6 云母) 的生长。在 C57BL/6 老鼠的人的 dsNKG2D-IL-15 的反黑瘤效果主要被减少由在里面老鼠 NK 房间的 vivo 弄空。这些数据热点为肿瘤的人的 dsNKG2D-IL-15 的潜在的使用治疗。 | Yan Chen Bei Chen Ti Yang Weiming Xiao Li Qian Yanbing Ding Mingchun Ji Xiaoqun Ge Weijuan Gong | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 10 | High-performance asymmetric electrodes photodiode based on Sb/WSe2 heterostructure显示文摘Two-dimensional (2D) van der Waals (vdWs) metal-semiconductor heterostructures with atomically sharp interface and matched work functions have recently attracted great attention due to their unique electronic and optoelectronic properties. Here we report the vapor phase epitaxial growth of large-scale vertical Sb/WSe2 metal-semiconductor vdWs heterostructures with uniform stacking orientation. Compared with the growth on S1O2/S1 substrate, the thick ness of Sb nan osheet on WSe2 can be reduced effectively to mono layer. We con struct Sb-WSe2-Au asymmetric electrodes photodiode based on the Sb/WSe2 heterostructures. Electrical transport measurements indicate that the photodiode show obvious rectifying effect. Optoelectronic characterizations show prominent photoresponse with a high photoresposivity of 364 mA/W, a fast response time of less than 8 ms, a large open-circuit voltage of 0.27 V and a maximum electrical power output of 0.11 nW. The direct growth of high-quality metal-semiconductor vdWs heterostructures may open up new realms in 2D functional electronics and optoelectronics. | Xiao Liu Guangzhuang Sun Peng Chen Junchi Liu Zhengwei Zhang Jia Li Huifang Ma Bei Zhao Ruixia Wu Weiqi Dang Xiangdong Yang Chen Dai Xuwan Tang Zhuojun Chen Lili Miao Xingqiang Liu Bo Li Yuan Liu Xidong Duan | 2019 | Nano Research2019，12，2： | 5 |
| 11 | Glacier extent changes and possible causes in the Hala Lake Basin of Qinghai-Tibet Plateau显示文摘Glacier is a common sensitivity indicator of environmental and global climate change.Examining the relationship between glacier area and climate change will help reveal glacier change mechanisms and future trends.Glacier changes are also of great significance to the regulation of regional water resources.This study selected the Hala Lake Basin in the northeastern Qinhai-Tibet Plateau as a study area,and examined the relationships between the temporal and spatial change of glaciers in the northeastern Qinghai-Tibet Plateau and climate change based on remote sensing imagery,climatological data,and topographic data during the past 30 years.Results showed that glacier area in the Hala Lake basin fluctuated and decreased from106.24 km2 in 1986 to 78.84 km2 in 2015,with a decreasing rate of 0.94 km2·yr-1.The number of glacier patches,mean patch area,and largest patch index all decreased from 1986 to 2015,while the splitting index increased from 1986 to 2015,indicating that the landscape fragmentation of glacier in the Hala Lake Basin was increasing significantly during the study period.Glacier area change was mainly concentrated in the slopes>25°with an altitude of 4500-5000 m,and the retreating rate of glacier of sunny slope was obviously higher than that of shady slope.Geometric center of glacier in the basin moved from southwest to northeast towards high altitude.Results of the response of glacier extent to climate change showed that temperature was the dominant factor affecting glacier area dynamic change in the Hala Lake Basin.It is predicted that in future several years,the glacier area will decrease and fragment continually as a result of global warming on the Tibetan Plateau. | LI Dong-Sheng CUI Bu-Li WANG Ying XIAO Bei JIANG Bao-Fu | 2019 | Journal of Mountain Science2019，16，7： | 5 |
| 12 | Simultaneous Determination of Bisphenols and Alkylphenols in Water by Solid Phase Extraction and Ultra Performance Liquid Chromatography-tandem Mass Spectrometry显示文摘To establish an analytical method for determination of four bisphenols(BPA,BPB,BPF,and BPS)and two alkylphenols(4-n-OP,4-n-NP)in water by ultra performance liquid chromatographytandem mass spectrometry(UPLC/MS/MS).The water samples were extracted and condensed with solid-phase extraction(SPE)using C18 cartridges and eluted by acetonitrile.Separation was carried out with Acquity BEH C8 column and detection were performed by UPLC/MS/MS.Quantification | SHAN Xiao Mei SHEN Deng Hui WANG Bing Shuang LU Bei Bei HUANG Fa Yuan | 2014 | Biomedical and Environmental Sciences2014，27，6： | 4 |
| 13 | Bioremediation of Hexavalent Chromium Pollution by Sporosarcina saromensis M52 Isolated from Offshore Sediments in Xiamen, China显示文摘Objective Cr(VI)removal from industrial effluents and sediments has attracted the attention of environmental researchers.In the present study,we aimed to isolate bacteria for Cr(VI)bioremediation from sediment samples and to optimize parameters of biodegradation.Methods Strains with the ability to tolerate Cr(VI)were obtained by serial dilution and spread plate methods and characterized by morphology,16S r DNA identification,and phylogenetic analysis.Cr(VI)was determined using the 1,5-diphenylcarbazide method,and the optimum p H and temperature for degradation were studied using a multiple-factor mixed experimental design.Statistical analysis methods were used to analyze the results.Results Fifty-five strains were obtained,and one strain(Sporosarcina saromensis M52;patent application number:201410819443.3)having the ability to tolerate 500 mg Cr(VI)/L was selected to optimize the degradation conditions.M52 was found be able to efficiently remove 50-200 mg Cr(VI)/L in24 h,achieving the highest removal efficiency at p H 7.0-8.5 and 35°C.Moreover,M52 could completely degrade 100 mg Cr(VI)/L at p H 8.0 and 35°C in 24 h.The mechanism involved in the reduction of Cr(VI)was considered to be bioreduction rather than absorption.Conclusion The strong degradation ability of S.saromensis M52 and its advantageous functional characteristics support the potential use of this organism for bioremediation of heavy metal pollution. | ZHAO Ran WANG Bi CAI Qing Tao LI Xiao Xia LIU Min HU Dong GUO Dong Bei WANG Juan FAN Chun | 2016 | Biomedical and Environmental Sciences2016，29，2： | 4 |
| 14 | 脑卒中住院患者口腔健康相关生活质量现状及影响因素分析显示文摘目的了解脑卒中住院患者口腔健康相关生活质量现状及影响因素。方法采用便利抽样法,于2019年8-12月在贵州省5所三级甲等综合医院选取符合纳入标准的脑卒中住院患者作为研究对象。采用一般资料调查表、口腔健康影响程度量表(OHIP-14)、口腔健康评估工具(OHAT)对403例脑卒中住院患者进行调查,以探索其口腔健康相关生活质量的影响因素。结果共发放问卷425份,回收有效问卷403份,有效回收率94.8%。脑卒中住院患者口腔健康相关生活质量得分为(10.32±6.32)分;多元线性回归分析显示,年龄、家庭人均月收入与口腔健康是脑卒中住院患者口腔健康相关生活质量的主要影响因素(P<0.05)。结论脑卒中住院患者口腔健康相关生活质量需引起重视,医护人员应重点关注年龄较大、家庭人均月收入较低以及口腔健康状况较差的脑卒中住院患者,并结合脑卒中患者的具体情况提供个性化的干预措施,从而提升脑卒中住院患者的口腔健康相关生活质量。 | 田芳 李娟 刘纪汝 Bei Wu Rong Xiao | 2021 | 护士进修杂志2021，36，7： | 4 |
| 15 | Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N^(6)-Methyladenosine-Modified Yap Expression显示文摘Circular RNAs take crucial roles in several pathophysiological processes.The regulatory role and its underlying mechanisms of circ-ZNF609 in the heart remains largely unknown.Here,we report that circ-ZNF609 is upregulated during myocardial ischemia/reperfusion(I/R)remodeling.Knockdown of circ-ZNF609 protects against acute I/R injury and attenuates left ventricle dysfunction after I/R remodeling in vivo.In vitro,circ-ZNF609 regulates cardiomyocyte survival and proliferation via modulating the crosstalk between Hippo-YAP and Akt signaling.Mechanically,N6-methyladenosine-modification is involved in the regulatory role of circ-ZNF609 on YAP.An in-depth study indicates that knockdown of circ-ZNF609 decreases the expression of YTHDF3 and further fine-tuned the accessibility of Yap mRNA to YTHDF1 and YTHDF2 to regulate YAP expression.circ-ZNF609 knockdown represents a promising therapeutic strategy to combat the pathological process of myocardial I/R injury. | Lijun Wang Pujiao Yu Jiaqi Wang Guie Xu Tianhui Wang Jingyi Feng Yihua Bei Jiahong Xu Hongbao Wang Saumya Das Junjie Xiao | 2022 | Research2022，，3： | 3 |
| 16 | 美国护士在医院门诊中的角色显示文摘本文阐述了美国门诊医疗体系、医院门诊部概况及护士在医院门诊中的角色,包括护士在医院门诊中的工作内容、任务、分工及护士诊室的特点,以期为我国门诊护士的工作提供参考。 | 李娟 Rong Xiao Bei Wu | 2019 | 中国护理管理2019，19，1： | 3 |
| 17 | Pharmacokinetic interactions between 20(S)- ginsenoside Rh2 and the HIV protease inhibitor ritonavir in vitro and in vivo显示文摘 | Jian SHI Bei CAO Wei-bin ZHA Xiao-lan WU Lin-sheng LIU Wen-jing XIAO Rong-rong GU Run-bin SUN Xiao-y YU Tian ZHENG Meng-jie LI Xin-wen WANG Jun ZHOU Yong MAO Chun GE Ting MA Wen-juan XIA Ji-ye AA Guang-ji WANG Chang-xiao LIU | 2013 | Acta Pharmacologica Sinica2013，34，10： | 3 |
| 18 | New players in ABA signaling: identification of PUB12/13 involved in degradation of ABA co-receptor ABI1显示文摘Abscisic acid(ABA)was originally identified in the early1960s,and was thought to be involved in fruit and leaf abscission.Over the past 50 years,ABA was intensely studied and has become one of the vital plant hormones implicated in seed dormancy,seed germination,stomatal regulation,flowering,senescence and environmental stress responses. | MA Xuan MO Bei Xin CAO Xiao Feng | 2015 | Science China(Life Sciences)2015，58，11： | 3 |
| 19 | Drug Resistance to HIV-1 Integrase Inhibitors among Treatment-naive Patients in Jiangsu, China显示文摘Integrase strand transfer inhibitors (In STIs) have been widely used in recent years because of their high genetic barrier to resistance.The World Health Organization (WHO) has recommended dolutegravir(DTG)-containing regimens as the preferred first-and second-line antiretroviral therapy (ART) regimens for people living with human immunodeficiency virus(HIV)[1]. | YIN Yue Qi LU Jing ZHOU Ying SHI Ling En YUAN De Fu CHEN Jian Shuang XU AN Yan HU Hai Yang ZHANG Zhi XU Xiao Qin FU Geng Feng WANG Bei | 2021 | Biomedical and Environmental Sciences2021，34，5： | 2 |
| 20 | Characterization of DNA damage response deficiency in pancreatic cancer patients from China显示文摘To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-apy have been confirmed in pancreatic cancer.Recently,it was substantiated that pancreatic cancer patients carry-ing deleterious mutations of the DNA damage response(DDR)genes are more likely to benefit from platinum-based chemotherapy[2]and poly(adenosine diphosphate-ribose)polymerase(PARP)inhibitor[3]. | Xiaofei Zhang Tiebo Mao Bei Zhang Haiyan Xu Jiujie Cui Feng Jiao Dongqin Chen Yu Wang Jiong Hu Qing Xia Shumin Li Ming Yue Jingyu Ma Jiayu Yao Yongchao Wang Xiao Zhang Shiqing Chen Yuezong Bai Yuexiang Wang Xuebin Zhang Qiang Liu Yongwei Sun Deliang Fu Yingbin Liu Lei Xiong Liwei Wang | 2022 | Cancer Communications2022，42，1： | 2 |
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