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| 1 | GENERALIZED NEKRASOV MATRICES AND APPLICATIONS显示文摘In this paper,the concpet of generalized Nekrasov matrices in introduced,some prop-erties of these matrices are discussed,obtained equivalent representation of generalized diagonally dominant matrices. | Mingxian Pang Zhuxiang Li (Dept. of Math, of Normal college, Beihua University, Ji Lin 132013, China) | 2003 | Journal of Computational Mathematics2003，21，2： | 19 |
| 2 | Human trophoblast cells induced MDSCs from peripheral blood CD14+ myelomonocytic cells via elevated levels of CCL2显示文摘 | Yun Zhang Daiwei Qu Jintang Sun Lei Zhao Qingjie Wang Qianqian Shao Beihua Kong Xun Qu | 2016 | Cellular & Molecular Immunology2016，13，5： | 7 |
| 3 | Mechanisms of suppressing cup-burner flame with water vapor显示文摘The mechanisms of suppressing a laminar methane-air co-flow diffusion flame formed on a cup burner with water vapor have been studied experimentally and numerically. The methane burned in a steel cup surrounded by a glass chimney. A mist generator produced fine droplets delivered though the glass chimney with air. These droplets were heated into water vapor when they went though the diffuser. The extinguishing limit was obtained by gradually increasing the amount of water vapor to replace the air in the coflowing oxidizer stream. Results showed that the agent concentration required for extinguishment was constant over a wide range of the oxidizer velocity, i.e., a so-called 'plateau region'. The measured extinguishing mass fractions of the agents were: (16.7 ± 0.6)% for H2O, (15.9 ± 0.6)% for CO2, and (31.9 ± 0.6)% for N2. The computation used the Fire Dynamics Simulator (FDS) de- veloped by the NIST. The numerical simulations showed that the predicted water vapor extinguishing limits and the flickering frequency were in good agreements with the experimental observations and, more importantly, revealed that the sup- pression of cup-burner flames occurred via a partial extinction mechanism (in which the flame base drifts downstream and then blows off) rather than the global extinction mechanism of typical counter-flow diffusion flames. And the flame-base oscillation just before the blow-off was the key step for the non-premixed flame extinction in the cup burner. | CONG BeiHua LIAO GuangXuan | 2008 | Science China(Technological Sciences)2008，51，8： | 5 |
| 4 | Experimental studies on interaction of water mist with class K fires显示文摘Interaction of water mist with cooking oil fires is studied experimentally and theoretically. A LDV/APV system is used to measure the velocity and diameter of water mist at different pressures in the experiments,and the effect of water mist velocity and diameter on fire extinguishment efficiency is investi-gated. The experimental results show that water mist has excellent surface cooling effect; it can control and extinguish cooking oil fires quickly without re-ignition. The critical temperature (Tfo) is calculated by energy balance equation,and the fire plume momentum is calculated and compared with that of water mist in order to determine the critical velocity (νwy) of fire extinguishment. This paper provides references for cooking oil fires extinguishment with water mist. | FANG Yudong ZHANG Yongfeng LIN Lin LIAO Guangxuan HUANG Xin CONG Beihua | 2006 | Chinese Science Bulletin2006，51，24： | 4 |
| 5 | Evaluation of COC183B2 antibody targeting ovarian cancer by near-infrared fluorescence imaging显示文摘Objective: To evaluate the imaging potential of a novel near-infrared(NIR) probe conjugated to COC183 B2 monoclonal antibodies(MAb) in ovarian cancer(OC).Methods: The expression of OC183 B2 antigen in OC was determined by immunohistochemical(IHC) staining using tissue microarrays with the H-score system and immunofluorescence(IF) staining of tumor cell lines.Imaging probes with the NIR fluorescent dye cyanine 7(Cy7) conjugated to COC183 B2 Mab were chemically engineered. OC183 B2-positive human OC cells(SKOV3-Luc) were injected subcutaneously into BALB/c nude mice. Bioluminescent imaging(BLI) was performed to detect tumor location and growth. COC183 B2-Cy7 at 1.1,3.3, 10, or 30 μg were used for in vivo fluorescence imaging, and phosphate-buffered saline(PBS), free Cy7 dye and mouse isotype immunoglobulin G(IgG)-Cy7(delivered at the same doses as COC183 B2-Cy7) were used as controls.Results: The expression of OC183 B2 with a high H-score was more prevalent in OC tissue than fallopian tube(FT) tissue. Among 417 OC patients, the expression of OC183 B2 was significantly correlated with the histological subtype, histological grade, residual tumor size, relapse state and survival status. IF staining demonstrated that COC183 B2 specifically expressed in SKOV3 cells but not HeLa cells. In vivo NIR fluorescence imaging indicated that COC183 B2-Cy7 was mainly distributed in the xenograft and liver with optimal tumor-to-background(T/B)ratios in the xenograft at 30 μg dose. The highest fluorescent signals in the tumor were observed at 96 h postinjection(hpi). Ex vivo fluorescence imaging revealed the fluorescent signals mainly from the tumor and liver. IHC analysis confirmed that xenografts were OC183 B2 positive.Conclusions: COC183 B2 is a good candidate for NIR fluorescence imaging and imaging-guided surgery in OC. | Chen Zhang Xinyu Ling Yanxiu Guo Cunzhong Yuan Hongyan Cheng Xue Ye Ruiqiong Ma Yinli Zhang Yi Li Xiaohong Chang Beihua Kong Tao Liu Heng Cui | 2019 | Chinese Journal of Cancer Research2019，31，4： | 4 |
| 6 | Experimental Evaluation of Water Mist with Metal Chloride Additives for Suppressing CH_4 /Air Cup-Burner Flames显示文摘In order to investigate the fire suppression effectiveness of water mist with metal chloride additives, ultrafine water mists of these salts with diameters about 10μm were introduced into CH4 /air non-premixed flame in the cup burner. Results showed that these droplets hard to make itself to the flame front under the cup burner flow conditions functioned as a carrier of the vaporized solid particles or its decomposed materials. The metal chloride improved fire suppression efficacy of water mist which were affected by the type and concentration of metal chloride. On a mass basis, there is a fire suppression effectiveness relationship of MgCl2 | Jianghong Liu Beihua Cong | 2013 | Journal of Thermal Science2013，22，3： | 3 |
| 7 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
| 8 | Effects of Cerium on Microstructures and Mechanical Properties of Zn-22%Al Vibration Damping Alloy显示文摘Using natural aging and artificial aging treatment, the effects of cerium on microstructures and mechanical properties of Zn 22%Al vibration damping alloy were studied by optical microscope, transmission electron microscope and scanning electron microscope. The results show that cerium can refine the microstructure of Zn 22%Al alloy, slow the grain growth and retain the equiaxial degree during aging. The strength of Zn 22%Al (0 07%~0 20%)Ce alloy and Zn 22%Al alloy remains constant after aging below the hot rolling temperature of 80 ℃, and cerium can improve the strength and the stability of mechanical properties of Zn 22%Al alloy. | PANG Shao ping, SHI Yun bao, LI Jun, YANG Bin jiu, QUAN Mei hua, QIAO Yan hui, ZHANG Chi zhong (College of Mechanical Engineering, Beihua University, Jilin 132021, China) | 2000 | Journal of Rare Earths2000，18，4： | 3 |
| 9 | Multi-regional input-output analysis for China's regional CH4 emissions显示文摘中国是在世界上的最大的 CH4 emitter。在温室气体排放库存给 CH4 的重要性,中国在不同规模的排出物该充分被理解的 CH4 的特征。在这介绍了纸是中国在 2007 的地区性的 CH4 排出物的 interprovincial 输入产量化身分析,基于最最近可得到的多地区性的输入产量表格,和相关 CH4 排出物数据。结果证明东方、中央、西方的区域分别地贡献 48.2% , 28.6% ,和 23.3% 国家全部的表达排出物。广东 30 个区域在所有之中有表达 CH4 排出物的高水平。农业部门在最后的需求生产大多数表达 CH4 排出物,由处理的构造,食物生产和烟草列在后面,并且另外的服务活动部门。表达 CH4 排放流动的重要的网转移经由 interregional 贸易从中央、西方的区域被识别到东方区域。山西是表达 CH4 排出物的最大的 interregional 出口商。相反,广东是最大的 interregional 进口商。精力活动,农业活动,和浪费管理分别地在 interregional 贸易包括 65.6% , 30.7% ,和 3.7% 全部的表达 CH4 排出物。由使用大多数的基于消费的财务原则,排放大小,人均的排出物,和排放紧张,东方区域显著地增加,当那些大部分一些中央、西方的区域减少时。完成地区性的 CH4 排放缓解,全面缓解措施应该在排放责任的地区性的转移的考虑下面被设计[出版摘要] | Bo ZHANG Jiashuo LI Beihua PENG | 2014 | Frontiers of Earth Science2014，8，1： | 3 |
| 10 | Experimental study on inhibition of low pressure premixed flat methane-oxygen flames by trifluoromethane显示文摘This paper presents measurements of combus- tion species of low pressure laminar premixed flat meth- ane-oxygen flames inhibited by trifluoromethane (CF3H) using synchrotron radiation-molecular beam mass spec- trometry (SR-MBMS). Fire suppression chemistry of CF3H is investigated by selective detection of combustion radicals and intermediates. Results show that SR-MBMS offers a powerful tool for studying fire suppression chemistry of ha- lon replacements, which may extensively detect combustion species in the inhibited flames, especially radicals and inter- mediates. The suppressant CF3H is completely consumed in the preheat zone of premixed flames and produces fluori- nated radicals such as CF3 and CF2. CF3 is the main radical participating in flame inhibition cycles in the reactive zone. Unlike HBr, HF produced by CF3H is very stable and will not act as a radical scavenger because the bond energy of H-F is much higher than that of H-Br, which is responsible for less effectiveness than conventional bromine-based sup- pressants. | CONG Beihua QI Fei LIAO Guangxuan KUANG Kaiqiang ZHOU Xiaomeng | 2005 | Chinese Science Bulletin2005，50，14： | 2 |
| 11 | Osteopontin splice variants expressed by breast tumors regulate monocyte activation via MCP-1 and TGF-β1显示文摘Osteopontin (OPN ) ,多功能的 glycoprotein,有在 vitro 在肿瘤有不同角色的三个抄本。OPN 抄本是否在 vivo 在肿瘤进程有不同函数,是不清楚的。有免疫力的导出房间的 OPN 能支持肿瘤形成,这被报导了。我们建议导出肿瘤的 OPN 可以便于的一个假设由影响有免疫力的房间区别和功能的肿瘤免疫者逃跑。在这研究,我们构造了 OPN 抄本和 transfected 的 lentiviral 表示向量他们进 MCF-7 房间线。有 OPN 抄本的 MCF-7 房间 transfected 被注入裸体老鼠的腋窝,并且肿瘤生长被监视。结果证明所有 OPN 抄本支持了本地肿瘤形成,而是那在抄本之中没有重要差别。我们也调查了 coculturing 单核白血球肿瘤房间与肿瘤上层清液在单核白血球区别上表示的 OPN 的效果。我们与 OPN 相比发现 OPN-c upregulated CD163 层次 --and OPN-b;然而,任何一个都没抄本影响 HLA 医生和 CD206 层次。所有 OPN 抄本显著地禁止了 TNF-α并且由单核白血球提高了 IL-10 生产。而且,我们发现了 OPN 抄本的 overexpression 显著地 upregulated TGF-β 1 并且由肿瘤房间的 MCP-1 生产。用抵销抗体和 recombinant cytokines,我们发现由肿瘤房间的 OPN overexpressed 调整 TNF-α 的生产;并且由单核白血球的 IL-10 部分经由 MCP-1 和 TGF-β 1 分别地。一起,我们的结果证明 OPN 抄本没在 vivo 在乳癌形成有不同角色。我们也证明 OPN 经由 TGF-β 调整单核白血球的其他的激活; 1 并且 MCP-1,它可以为肿瘤代表另外的机制免疫者逃跑。 | Jintang Sun Alei Feng Songyu Chen Yun Zhang Qi Xie Meixiang Yang Qianqian Shao Jia Liu Qifeng Yang Beihua Kong Xun Qu | 2013 | Cellular & Molecular Immunology2013，10，2： | 2 |
| 12 | Study on Bamboo Treatment Technology with CuAz Preservative显示文摘In order to research the effect of preservative penetrability, CuAz (copper azole) was used for the preservative, and pieces of Moso bamboo (Phyllostachys pubescens) were used for the experimental materials in this study. The vacuum pressure process was used to treat bamboo pieces. The results showed as follows: 1) Main treatment factors were preservative concentration and applied pressure; 2) In the same technology, both the retention and the weight proportion gain of the samples without node were less than those of ones with node, due to special structure of bamboo node; 3) For the samples without node, a good result could be gotten when the preservative concentration was from 1% to 2%, treatment pressure was 0.6 MPa, and treatment time was 30 min. And for the bamboo samples with node, a good result can be gotten when the concentration was 2%, treatment pressure was 0.4 MPa, and treatment time was 30 min. This study demonstrates that the interaction between preservative and bamboo can be improved by adjusting the parameters. | QIN Shaoshan 1, 2 LIU Yanlong 1 LIU Junliang 1 1.College of Transportation and Civil Engineering, Beihua University, Jilin132013, P.R.China 2. Research Institute of Wood Industry, Chinese Academy of Forestry, Beijing 100091, P.R.China | 2008 | Chinese Forestry Science and Technology2008，7，3： | 2 |
| 13 | Taurine Inhibits Myocardial Fibrosis via PKC-ERK1/2 Signaling Pathways显示文摘Previous studies have demonstrated the important role of taurine in inhibiting proliferation of myofibrob lasts(myoFb) and myocardial fibrosis. However, the underlying mechanisms are unclear. The present study was de signed to shed light on this issue through exploring the signal pathways via in vitro experiments. Angiotension II (AngII) treatment significantly increased myoFb proliferation and the levels of collagens I and III(P<0.05), whereas taurine, PKCα(PKC: protein kinase C) specific inhibitor L-threo-dihydro-sphingosine(D4681), ERK1/2 inhibitor (PD98095) abrogated myoFb proliferation and collagen levels(P<0.05, P<0.01, respectively), and increased the G0/G1 phase rate and decreased S phase rate. Immunocytochemistry, confocal fluorescence staining and image analy sis showed that taurine could inhibit the translocation and expression of p-PKCαin membrane, and then inhibit nuc lear translocation and expression of p-ERK1/2. These results have statistically significant differences compared with those of AngII group(P<0.01). Western blot results also show that taurine could inhibit the protein expression of p-PKCα and p-ERK1/2. We used p-PKCα specific inhibitor D4681 in order to elucidate the relationship between p-PKCα and p-ERK1/2 in signal transduction pathways. Finally, the results show that the protein expression of p-ERK1/2 and nuclear translocation were suppressed in D4681 group. | WANG Li-ying1,2, LI Hong1 and YANG Shi-jie1 1. Department of Pharmacology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, P. R. China 2. Department of Physiology, Basic Medicine College, Beihua University, Jilin 132013, P. R. China | 2012 | Chemical Research in Chinese Universities2012，28，1： | 2 |
| 14 | Chemotherapy initiation with single-course methotrexate alone or combined with dactinomycin versus multi-course methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric randomized clinical trial显示文摘We aimed to evaluate the effectiveness and safety of single-course initial regimens in patients with low-risk gestational trophoblastic neoplasia(GTN).In this trial (NCT01823315),276 patients were analyzed.Patients were allocated to three initiated regimens:single-course methotrexate(MTX),single-course MTX+dactinomycin(ACTD),and multi-course MTX(control arm).The primary endpoint was the complete remission(CR)rate by initial drug(s).The primary CR rate was 64.4%with multi-course MTX in the control arm.For the single-course MTX arm,the CR rate was 35.8%by one course;it increased to 59.3%after subsequent multi-course MTX,with non-inferiority to the control(difference-5.1%,95%confidence interval(CI)-19.4%to 9.2%,P=0.014).After further treatment with multi-course ACTD,the CR rate(93.3%)was similar to that of the control(95.2%,P=0.577).For the single-course MTX+ACTD arm,the CR rate was 46.7%by one course,which increased to 89.1%after subsequent multi-course,with non-inferiority(difference 24.7%,95%CI 12.8%-36.6%,P<0.001)to the control.It was similar to the CR rate by MTX and further ACTD in the control arm(89.1%vs.95.2%,P=0.135).Four patients experienced recurrence,with no death,during the 2-year follow-up.We demonstrated that chemotherapy initiation with single-course MTX may be an alternative regimen for patients with low-risk GTN. | Lili Chen Ling Xi Jie Jiang Rutie Yin Pengpeng Qu Xiuqin Li Xiaoyun Wan Yaxia Chen Dongxiao Hu Yuyan Mao Zimin Pan Xiaodong Cheng Xinyu Wang Qingli Li Danhui Weng Xi Zhang Hong Zhang Quanhong Ping Xiaomei Liu Xing Xie Beihua Kong Ding Ma Weiguo Lu | 2022 | Frontiers of Medicine2022，16，2： | 2 |
| 15 | Snail family proteins in cervical squamous carcinoma:Expression and signicance显示文摘 | Wei DZ Ying Z Beihua K | 2013 | Clin Invest Med2013，36，4： | 1 |
| 16 | Distribution of Th17 cells and Foxp3-expressing T cells in tumor-infiltrating lymphocytes in patients with uterine cervical cancer显示文摘 | Fei Hou Zhen Li Daoxin Ma Wenjing Zhang Youzhong Zhang Tingguo Zhang Beihua Kong Baoxia Cui | 2012 | 2012 (23-2)2012，，23： | 1 |
| 17 | TLRs, macrophages, andNK cells: Our understandings of their fimctions in uterus and ovary 显示文摘 | Ziyan Yang Beihua Kong David M | 2011 | International Immunopharmacology2011，11，10： | 1 |
| 18 | Dendritic ceils transduced with Rsf-1/HBXAP gene generate specific cytotoxic T lymphocytes a- gainst ovarian cancer in vitro 显示文摘 | Li Sun Beihua Kong Xiugui Sheng | 2010 | Biochemical and Biophysical Research Communications2010，394，3： | 1 |
| 19 | Cloning and characterization of the Na+/H+antiport genes fromTriti-cum aestivum显示文摘 | WANG Zining ZHANG Jinsong GUO Beihua | 2002 | Acta Botanica Sincia2002，44，10： | 1 |
| 20 | Glutamate drives local Ca^(2+)release'in cardiac pacemaker cells显示文摘The sinoatrial node(SAN)is the origin of the electrical signals for rhythmic heartbeats in mammals.The spontaneous fring of SAN pacemaker cells(SANPCS)triggers cardiac contraction.'Local Ca^(2+)release'(LCR),a unique cellular activity,acts as the'engine'of the spontaneous fring of SANPCs.However,the mechanism of LCR initiation remains unclear.Here,we report that endogenous glutamate drives LCRs in SANPCs.Using a glutamate sensor,we unraveled a tight correlation between glutamate accumulation and LCR occurrence,indicating a potential relationship between glutamate and LCRs.Intracellular application of glutamate significantly enhanced the LCRs in both intact and permeabilized SANPCs.Mechanitically,we revealed that mitochondrial excitatory amino acid transporter 1(EAAT 1)-dependent mitochondrial glutamate import promoted ROS generation,which in turn led to the oxidation of Ca^(2+)-handling proteins,ultimately resulting in enhanced LCRs.Importantly,EAAT1 depletion reduced both the spontaneous fring rates of isolated SANPCs and the heart rate in vitro and in vivo,suggesting the central role of EAAT1 as a glutamate transporter in the regulation of cardiac autonomic rhythm.In conclusion,our results indicate that glutamate serves as an LCR igniter in SANPCs,adding a potentially important element to the coupled clock theory that explains the origin of spontaneous firing.These findings shed new light on the future prevention and treatment of cardiac pacemaker cell-related arrhythmias. | Duanyang Xie Ke Xiong Xuling Su Guanghua Wang Qicheng Zou Luxin Wang Caihong Zhang Yuting Cao Beihua Shao Yixin Zhang Peidong Zhang Dandan Liang Yi Liu Yi-Han Chen | 2022 | Cell Research2022，32，9： | 0 |
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