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| 1 | Evaluation on Spot Weld Models in Structural Dynamic Analysis of Automotive Body in White显示文摘Spot weld models are widely used in finite element analysis(FEA) of automotive body in white(BIW) to predict static,dynamic,durability and other characteristics of automotive BIW.However,few researches are done on evaluation of the validity of these spot weld models in structural dynamic analysis of BIW.To evaluate the validity and accuracy of spot weld models in structural dynamic analysis of BIW,two object functions,error function and deviation function,are introduced innovatively.Modal analysis of Two-panel and Double-hat structures,which are the dominated structures in BIW,is conducted,and the values of these two object functions are obtained.Based on the values of object functions,the validity of these spot weld models are evaluated.It is found that the area contact method(ACM2) and weld element connection(CWELD) can give more precise prediction in modal analysis of these two classical structures,thus are more applicable to structural dynamic analysis of automotive BIW.Modal analysis of a classical BIW is performed,which further confirms this evaluation.The error function and deviation function proposed in this research can give guidance on the adaptability of spot weld models in structural dynamic analysis of BIW.And this evaluation method can also be adopted in evaluation of other finite element models in static,dynamic and other kinds of analysis for automotive structures. | LIANG Jianyong LIANG Jun FANG Guodong PAN Zimin LI Wei | 2011 | Chinese Journal of Mechanical Engineering2011，24，1： | 9 |
| 2 | Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line treatment: a retrospective study of 251 cases显示文摘有在 2002 和 2008 之间治疗的上皮的卵巢的癌症(EOC ) 的 251 个病人的一个总数回顾地被分析调查长期的结果和这些病人的预示的因素,特别地,经历了主要 debulking 外科的那些由基于铂的化疗列在后面。包括没有前进的幸存(PFS ) 和全面幸存(OS ) , Clinicopathological 参数也被分析。从到 2010 年 6 月的起始的治疗的结束的中部的后续时期是 58 个月。三年的 PFS 率为妇科学和产科学(FIGO ) I-II 的国际联盟是 61.7% , 19.9% 为 FIGO III-IV,并且 33.9% 为所有阶段。由比较,五年的 PFS 率为 FIGO I-II 是 44.6% , 17.7% 为 FIGO III-IV,并且 28.3% 为所有阶段。三年的 OS 率为 FIGO I-II 是 67.9% , 41.7% 为 FIGO III-IV,并且 50.2% 为所有阶段。五年的 OS 率为 FIGO I-II 是 52.7% , 30.8% 为 FIGO III-IV,并且 39.2% 为所有阶段。Univariate 分析表明先进 FIGO 舞台,浆液 CA125,和非最优的 debulking 是影响 PFS 和 OS 的重要因素。在 multivariate 分析, PFS 被 FIGO 舞台和非最优的 debulking 显著地影响。然而, OS 被先进 FIGO 舞台显著地仅仅影响。我们的学习证实外科的功效为 EOC 由基于铂的化疗列在后面。FIGO 舞台与 EOC 被看作病人的预后的最可靠的预言者之一。 | Yunfeng Fu Xinyu Wang Zimin Pan Xing Xie | 2014 | Frontiers of Medicine2014，8，1： | 6 |
| 3 | Chemotherapy initiation with single-course methotrexate alone or combined with dactinomycin versus multi-course methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric randomized clinical trial显示文摘We aimed to evaluate the effectiveness and safety of single-course initial regimens in patients with low-risk gestational trophoblastic neoplasia(GTN).In this trial (NCT01823315),276 patients were analyzed.Patients were allocated to three initiated regimens:single-course methotrexate(MTX),single-course MTX+dactinomycin(ACTD),and multi-course MTX(control arm).The primary endpoint was the complete remission(CR)rate by initial drug(s).The primary CR rate was 64.4%with multi-course MTX in the control arm.For the single-course MTX arm,the CR rate was 35.8%by one course;it increased to 59.3%after subsequent multi-course MTX,with non-inferiority to the control(difference-5.1%,95%confidence interval(CI)-19.4%to 9.2%,P=0.014).After further treatment with multi-course ACTD,the CR rate(93.3%)was similar to that of the control(95.2%,P=0.577).For the single-course MTX+ACTD arm,the CR rate was 46.7%by one course,which increased to 89.1%after subsequent multi-course,with non-inferiority(difference 24.7%,95%CI 12.8%-36.6%,P<0.001)to the control.It was similar to the CR rate by MTX and further ACTD in the control arm(89.1%vs.95.2%,P=0.135).Four patients experienced recurrence,with no death,during the 2-year follow-up.We demonstrated that chemotherapy initiation with single-course MTX may be an alternative regimen for patients with low-risk GTN. | Lili Chen Ling Xi Jie Jiang Rutie Yin Pengpeng Qu Xiuqin Li Xiaoyun Wan Yaxia Chen Dongxiao Hu Yuyan Mao Zimin Pan Xiaodong Cheng Xinyu Wang Qingli Li Danhui Weng Xi Zhang Hong Zhang Quanhong Ping Xiaomei Liu Xing Xie Beihua Kong Ding Ma Weiguo Lu | 2022 | Frontiers of Medicine2022，16，2： | 2 |
| 4 | Faeile synthesized nanorod structured vanadium pentoxide for high-rate lithium batteries 显示文摘 | Pan Anqiang Zhang Jiguang Nie Zimin | 2010 | Joumal of Materials Chemistry2010，20，41： | 1 |
| 5 | Lentivirus-delivered short hairpin RNA targeting SNAIL inhibits HepG2cell growth显示文摘 | Jing Liu Gang Jiang Shihai Liu Zimin Liu Huazheng Pan Ruyong Yao Jun Liang | 2013 | Oncology Reports2013，，3： | 1 |
| 6 | Biochar mitigates the biotoxicity of heavy metals in livestock manure during composting显示文摘The addition of biochar could mitigate the bioavailability of heavy metals during livestock manure composting.However,the main action mechanism of biochar,such as how it worked,was ambiguous.Therefore,in this study,materials(biochar,alkali modified biochar,pretreated cotton ball)were added by embedding with nylon mesh bags to explore the adsorption performance of added materials and its influence on the composting process.The results showed that embedded materials promoted the formation of humic acid and reduced the distribution proportion of bioavailable fraction of heavy metals during composting(Cu:at least 15.72%;Zn:at least 33.44%).The surface of biochar extracted from composting contained attachments,however,the attachment of heavy metal was not detected and functional groups on the materials did no change significantly.This indicated that the addition of biochar did not directly adsorb heavy metals.Most notably,the microbial network changed after embedding materials,and the succession of microbial community promoted the formation of humic acid.Ultimately,structural equation models verified that embedded materials promoted the formation of humic acid through stable microbial groups,thereby accelerating the passivation of heavy metals during composting.This study provides theoretical and technical supports for mitigating the biotoxicity of heavy metals by biochar during composting. | Xiaomeng Chen Zhuang Du Dan Liu Liqin Wang Chaonan Pan Zimin Wei Liming Jia Ran Zhao | 2022 | Biochar2022，4，1： | 1 |
| 7 | Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer:a randomized,non-inferiority,multicenter trial显示文摘We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB–IIA) cervical cancer having risk factors after surgery. The condition was assessed in terms of prognosis, adverse effects, and quality of life. This randomized trial involved nine centers across China. Eligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery. The primary end-point was progression-free survival (PFS). From December 2012 to December 2014, 337 patients were subjected to randomization. Final analysis included 329 patients, including 165 in the adjuvant chemotherapy group and 164 in the adjuvant CCRT group. The median follow-up was 72.1 months. The three-year PFS rates were both 91.9%, and the five-year OS was 90.6% versus 90.0% in adjuvant chemotherapy and CCRT groups, respectively. No significant differences were observed in the PFS or OS between groups. The adjusted HR for PFS was 0.854 (95% confidence interval 0.415–1.757;P = 0.667) favoring adjuvant chemotherapy, excluding the predefined non-inferiority boundary of 1.9. The chemotherapy group showed a tendency toward good quality of life. In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervical cancer having pathological risk factors. Adjuvant chemotherapy alone is a favorable alternative post-operative treatment. | Danhui Weng Huihua Xiong Changkun Zhu Xiaoyun Wan Yaxia Chen Xinyu Wang Youzhong Zhang Jie Jiang Xi Zhang Qinglei Gao Gang Chen Hui Xing Changyu Wang Kezhen Li Yaheng Chen Yuyan Mao Dongxiao Hu Zimin Pan Qingqin Chen Baoxia Cui Kun Song Cunjian Yi Guangcai Peng Xiaobing Han Ruifang An Liangsheng Fan Wei Wang Tingchuan Xiong Yile Chen Zhenzi Tang Lin Li Xingsheng Yang Xiaodong Cheng Weiguo Lu Hui Wang Beihua Kong Xing Xie Ding Ma | 2023 | Frontiers of Medicine2023，17，1： | 0 |
| 8 | CD19-targeted chimeric antigen receptor-modified T cells induce remission in patients with relapsed acute B lymphoblastic leukemia after umbilical cord blood transplantation显示文摘To the Editor:Umbilical cord blood transplant(UCBT)serves as an alternative option for treating patients with B cell acute lymphoblastic leukemia(ALL),in the absence of a compatible donor.However,disease recurrence presents a difficult challenge.Chimeric antigen receptor(CAR)-T cell therapy is a promising approach for treating patients with relapsed/refractory ALL.Among the intensive investigations of infusion of CAR-T cells after transplant,few focus on patients who were administered CAR-T therapy after they relapsed subsequently to UCBT.Here,we report the response rate,toxicity,and survival of CD19 CAR-T cells administered to 10 children and young adults with relapsed acute B lymphoblastic leukemia(B-ALL)after UCBT.Between April 2018 and September 2019,11 patients with relapsed B-ALL after UCBT were enrolled,including three females and eight males,the median age was 10 years(range 7-22 years)and median weight was 35.0 kg(range 21.0-72.0 kg).Patient 10 was excluded because of unsuccessful cell culture. | Qianwen Xu Hui Xu Lei Xue Min Wang Guiwang Pan Xuhan Zhang Kaidi Song Wen Yao Xiang Wan Juan Tong Huilan Liu Hanying Xu Xin Liu Xiaoyu Zhu Zimin Sun Lin Yang Xingbing Wang | 2022 | Chinese Medical Journal2022，，1： | 0 |
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