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| 1 | A nationwide survey of psychological distress among Chinese people in the COVID-19 epidemic:implications and policy recommendations显示文摘The Coronavirus Disease 2019(COVID-19)epidemic emerged in Wuhan,China,spread nationwide and then onto half a dozen other countries between December 2019 and early 2020.The implementation of unprecedented strict quarantine measures in China has kept a large number of people in isolation and affected many aspects of people's lives.It has also triggered a wide variety of psychological problems,such as panic disorder,anxiety and depression.This study is the first nationwide largescale survey of psychological distress in the general population of China during the COVID-19 epidemic. | Jianyin Qiu Bin Shen Min Zhao Zhen Wang Bin Xie Yifeng Xu | 2020 | General Psychiatry2020，33，2： | 69 |
| 2 | A nationwide survey of psychological distress among Chinese people in the COVID-19 epidemic: implications and policy recommendations显示文摘The Coronavirus Disease 2019(COVID-19)epidemic emerged in Wuhan,China,spread nationwide and then onto half a dozen other countries between December 2019 and early 2020.The implementation of unprecedented strict quarantine measures in China has kept a large number of people in isolation and affected many aspects of people’s lives.It has also triggered a wide variety of psychological problems,such as panic disorder,anxiety and depression.This study is the first nationwide largescale survey of psychological distress in the general population of China during the COVID-19 epidemic. | Jianyin Qiu Bin Shen Min Zhao Zhen Wang Bin Xie Yifeng Xu | 2020 | General Psychiatry2020，33，1： | 26 |
| 3 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 4 | Proteomic characteristics of the liver and skeletal muscle in the Chinese tree shrew(Tupaia belangeri chinensis)显示文摘Valid animal models are useful for studying the pathophysiology of specific disorders,such as neural disease,diabetes and cancer.Previous molecular phylogeny studies indicate that the tree shrew is in the same order as(or a close sister to)primates,and thus may be an ideal model in which to study human disease.In this study,the proteome of liver and muscle tissue in tree the shrew was identified by combining peptide fractionation and LC-MS/MS identification.In total,2146 proteins were detected,including 1759 proteins in liver samples and 885 proteins in skeletal muscle samples from the tree shrew.Further sub-source analysis revealed that nearly half of the identified proteins(846 proteins and 418 proteins)were derived from human database.In this study,we are the first to describe the characteristics of the proteome from the liver and skeletal muscle of the tree shrew.Phylogenetic tree analysis based on these proteomic data showed that the tree shrew is closer to primates(human)than to glires(the mouse and rat). | Rongxia Li Wei Xu Zhen Wang Bin Liang Jia-Rui Wu Rong Zeng | 2012 | Protein & Cell2012，3，9： | 18 |
| 5 | Association of Estrogen Receptor I Genetic Polymorphisms with Recurrent Spontaneous Abortion Risk显示文摘 | Xun-Qiang Yin Hong-Mei Ju Qiang Guo Lin Zhao Xiao-Xiao Zhu Ran Wei Zhen Zhang Yun-Hong Zhang Bin Wang Xia Li | 2018 | Chinese Medical Journal2018，，15： | 18 |
| 6 | Generation of a monkey with MECP2 mutations by TALEN-based gene targeting显示文摘Gene editing in model organisms has provided critical insights into brain development and diseases. Here, we report the generation of a cynomolgus monkey(Macaca fascicularis) carrying MECP2 mutations using transcription activator-like effector nucleases(TALENs)-mediated gene targeting. After injecting TALENs mRNA into monkey zygotes achieved by in vitro fertilization and embryo transplantation into surrogate monkeys, we obtained one male newborn monkey with an MECP2 deletion caused by frameshifting mutation in various tissues. The monkey carrying the MECP2 mutation failed to survive after birth, due to either the toxicity of TALENs or the critical requirement of MECP2 for neural development. The level of MeCP2 protein was essentially depleted in the monkey's brain. This study demonstrates the feasibility of introducing genetic mutations in non-human primates by site-specific gene-editing methods. | Zhen Liu Xue Zhou Ying Zhu Zhi-Fang Chen Bin Yu Yan Wang Chen-Chen Zhang Yan-Hong Nie Xiao Sang Yi-Jun Cai Yue-Fang Zhang Chen Zhang Wen-Hao Zhou Qiang Sun Zilong Qiu | 2014 | Neuroscience Bulletin2014，30，3： | 17 |
| 7 | Investigation of the prevalence of patients co-colonized or infected with methiclllin-resistant Staphylococcus aureus and vancomycin- resistant enterococci in China: a hospital-based study显示文摘methicillin 抵抗的葡萄球菌 aureus (MRSA ) 和万古霉素抵抗的 enterococci (VRE ) 引起的背景医院的感染能导致增加的病态和死亡。在 2006,自从第一 VRE 医院的感染, VRE 医院的传播在 2003 在我们的医院里成为了现实。很少在病人与 VRE 和 MRSA 对共存的流行被知道。学习的主要目的是在2年的经期期间在一样的病人与 MRSA 和 VRE 在我们的医院和共存的流行里识别流行 MRSA 克隆的分子的特征, 2006-2007 .Methods 临床的特征,实验室测试结果,并且 129 个盒子的治疗学的结果从2006年1月孤立 MRSAcollected 到2007年12月的人,回顾地被分析。聚合酶链反应(PCR ) 被用来决定 mecA-femB 类型和 staphylococcal 盒子染色体 mec (SCCmec ) 打字。所有参加者被屏蔽为临床并且与 129 MRSA 孤立的 MRSA.Results 识别 VRE 紧张的共存的 microbiological 数据在学习被包括:71 (55%) 从特别护理联合起来, 35 (27.2%) 从外科的病房并且 23 (17.8%) 从医药病房。MRSA 的隔离的最经常的来源是唾沫(76.7%) 。从七个病人,我们孤立 MRSA 和 VRE (E。faecium ) 同时在他们的住院病人停留期间。127 (127/129, 98.4%) MRSA 孤立 harboured SCCmec 类型, 2 仅仅 MRSA 紧张包含了 SCCmec 类型。所有 129 MRSA 孤立对万古霉素, teicoplanin 和 linezolid 仍然保持敏感。更高的敏感率以氯霉素 99.2% 闻名(128/129 ) 。(26/129 ) 仅仅, 20.2% MRSA 孤立对 rifampin 敏感。所有与高最小的禁止的集中(MIC ) 孤立介绍抵抗到多重抗菌剂代理人,包括:酮(青霉素,新青霉素, cefoxitin,和 cefazolin )(ciprofloxacin, levofloxacin,和 moxifloxacin ) ,四圜素,抗生素的一种, gentamicin,和 quinolones .Conclusions 在从 2006 ~ 2007 的北京 Chaoyang 医院的占优势的 MRSA 克隆有类型 SCCmec 元素。所有 MRSA 孤立是到抗菌剂代理人的 multiresistant。在一样的病人的 MRSA 和 VRE 的共存的出现不是稀罕的。医生们应该对源于 MRSA 和 VRE 的感染给予更多的注意。好攻击的感染控制措施应该被采取阻止 multidrug 抵抗有机体的传播。 | WANG Zhen CAO Bin LIU Ying-mei GU Li WANG Chen | 2009 | Chinese Medical Journal2009，，11： | 16 |
| 8 | WAVE-CURRENT INTERACTIONS WITH THREE-DIMENSIONAL FLOATING BODIES显示文摘A Time-domain Higher-Order Boundary Element Method(THOBEM) is developed for simulating wave-current interactions with 3-D floating bodies.Through a Taylor series expansion and a perturbation procedure,the model is formulated to the first-order in the wave steepness and in the current velocity,respectively.The boundary value problem is decomposed into a steady double-body flow problem and an unsteady wave problem.Higher-order boundary integral equation methods are then used to solve the proposed problems with a fourth-order Runge-Kutta method for the time marching.An artificial damping layer is adopted to dissipate the scattering waves.Different from the other time-domain numerical models,which are often focused on the wave-current interaction with restrained bodies,the present model deals with a floating hemisphere.The numerical results of wave forces,wave run-up and body response are all in a close agreement with those obtained by frequency-domain methods.The proposed numerical model is further applied to investigate wave-current interactions with a floating body of complicated geometry.In this work,the regular and focused wave combined with current interacting with a truss-spar platform is investigated. | LIU Zhen TENG Bin NING De-zhi GOU Ying | 2010 | Journal of Hydrodynamics2010，22，2： | 14 |
| 9 | Expressions of chromogranin A and cathepsin D in human primary hepatocellular carcinoma显示文摘AIM To determine the expression and clinicalsignificance of chromogranin A and cathepsin Din hepatocellular carcinoma(HCC).METHODS Double immunofluorescence stain-ing techniques combined with laser confocalscanning microscopy(LSCM)was used toinvestigate chromogranin A and cathepsin Dexpressions in 85 HCC patients.RESULTS Cathepsin D was expressed in :3normal liver tissues,while in HCC the stainingshowed regional variation and the fraction ofstrongly stained cells increased as the tumorsbecame less differentiated and usually clinicallymore malignant.Cells which showed strongpositivity for cathepsin D were present in 71/85(83.5%)cases.Strong expression of cathepsinD in cancer cells was related tohistopathological features.They were morecommon in grade 3-4(26/28,92.9%)and grade2(46/53,86.8%)tumors than in grade 1 tumors(1/4,25.0%)(P<0.01).No significantcorrelation was found between age andcathepsin D expression.In patients with positivecathepsin D reaction,the mean age was 52.1±2.8 years(range 32-68 years)and in the groupwith negative reaction,the mean age was 51.3±4.5 years(range 28-71 years).No obvious relationship was observed between CgAexpression in cancer cells and thehistopathological features.The CgA positiverate was 75.0%(3/4)in grade 1,71.7%(38/53)in grade 2,and 71.4%(20/28)in grade 3-4(P>0.05)tumors.The coexpression of CgA andcathepsin D was found by double labeledimmunofluorescence staining techniques.Theprocessing of cathepsin D was disturbed in HCCcells and accumulated in the cells.Cathepsin Dhad proteolytic activity and autocrine mitogeniceffect,suggesting their functions in invasion.These findings demonstrated that the expressionof cathepsin D in HCC had prognostic value.CONCLUSION Chromogranin A and cathepsin Dare expressed in a high proportion of HCC andthe existence of cathepsin D in HCC might berelated to processing of CgA.This is clearly asubject for further studies because of itspotential clinical applications. | Xiao Feng Huang Chun Mei Wang Xiao Wen Dai Zhen Jiang Li Bo Rong Pan Li Bin Yu Bin Qian Li Fang | 2000 | World Journal of Gastroenterology2000，6，5： | 12 |
| 10 | Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome显示文摘PRKAG2 心脏的症候群正染色体的主导的继承疾病在编码 γ 的 PRKAG2 基因从变化被结果;激活安培的蛋白质 kinase 的 2 规章的子单元。影响病人通常开发室的 tachyarrhythmia 并且经历对医疗倔强并且要求心脏的移植的进步的心失败。在这研究,我们与家庭 Wolff-Parkinson-White 症候群从病人在 PRKAG2 识别一个 H530R 变化。由产生转基因的 H530R PRKAG2 和敲门在里面老鼠,我们证明两个模型包括心脏的肥大和肝糖存储概括人的症状,证实 H530R 变化是有原因地与 PRKAG2 有关心脏的症候群。我们进一步联合联系 adeno 的 virus-9 (AAV9 ) 和 CRISPR/Cas9 编辑基因的系统当让野类型的等位基因未经触动时,破坏编码 H530R 的变异的 PRKAG2 等位基因。在出生后的白天的 AAV9-Cas9/sgRNA 的单个全身的注射 4 或白天 42 实质地在转基因的 H530R PRKAG2 和敲门在里面鼠标恢复心的形态学和函数。一起,我们的工作建议在 vivo CRISPR/Cas9,染色体编辑由有选择地破坏引起疾病的变化是在 PRKAG2 心脏的症候群和另外的主导的继承心脏病的治疗的一个有效工具。 | Chang Xie Ya-Ping Zhang Lu Song Jie Luo Wei Qi Jialu Hu Danbo Lu Zhen Yang Jian Zhang Jian Xiao Bin Zhou Jiu-Lin Du Naihe Jing Yong Liu Yan Wang Bo-Liang Li Bao-Liang Song Yan Yan | 2016 | Cell Research2016，26，10： | 12 |
| 11 | Comparative Transcriptional Profiling and Preliminary Study on Heterosis Mechanism of Super-Hybrid Rice显示文摘杂种优势比也是从二父母表演的后代改善了的生物现象和优异性能生来的父母线。混合米饭是在利用杂种优势的庄稼的最成功的 apotheoses 之一。由基因表示(半自动地面防空系统)的连续分析 F1 超级混血儿的米饭 Liangyou-2186 和它的父母介绍的 Transcriptional 表明 1183 差别表示了基因( DG ),在哪个之中 DG 被发现显著地在象光合作用和碳固定那样的小径充实,并且大多数涉及碳固定小径的关键基因在 F1 混合米饭展出了起来调整的表示。而且,相应的酶的增加的分解代谢的活动和光合的效率也被检测,它联合了显示那碳固定可能在 F1 混血儿,和力量被提高在超级混血儿的米饭与收益活力和杂种优势被联系。由有收益相关的量的特点 loci (QTL ) 的相关 DG,在微分基因表示和 phenotypic 变化之间的一种潜在的关系也被发现。另外,当以前在 Arabidopsis 报导了,包含生理节奏节奏、轻的发信号的小径的一个规章的网络也被发现,它建议如此的一个网络可能也与在混合米饭的杂种优势是相关的。总的来说,现在的学习为理解在米饭位于杂种优势下面的分子的机制提供另一个看法。 | Gui-Sheng Song Hong-Li Zhai Yong-Gang Peng Lei Zhang Gang Wei Xiao- Ying Chen Yu-Guo Xiao Lili Wang Yue-Jun Chen Bin Wu Bin Chen Yu Zhang Hua Chen Xiu-Jing Feng Wan-Kui Gong Yao Liu Zhi-Jie Yin Feng Wang Guo-Zhen Liu Hong-Lin Xu Xiao-Li Wei Xiao-Ling Zhao Pieter B.F. Ouwerkerk Thomas Hankemeier Theo Reijmers Rob van der Heijden Cong-Ming Lu Mei Wang Jan van der Greef Zhen Zhu | 2010 | Molecular Plant2010，3，6： | 12 |
| 12 | Electroacupuncture regulates glucose-inhibited neurons in treatment of simple obesity显示文摘The glucose-inhibited neurons present in the lateral hypothalamic area are regarded as glucose detectors. This structure is involved in the regulation of food intake through extracellular blood glucose concentrations, and plays a crucial role in obesity onset. In the present study, obesity models established with high fat feeding were treated with electroacupuncture at Zusanli (ST36)/ Inner Court (ST44) on the left side and Tianshu (ST25) bilaterally. We found that electroacupuncture could effectively reduce body weight and the fat-weight ratio, and decrease serum leptin, resistin, tumor necrosis factor alpha, and neuropeptide Y levels, while increase serum adiponectin and cholecystokinin-8 levels. This treatment altered the electrical activity of glucose-inhibited neurons in the lateral hypothalamic area, with electroacupuncture at Zusanli/ Inner Court exerting an inhibitory effect, while electroacupuncture at bilateral Tianshu exerting an excitatory effect. These data suggest that electroacupuncture at the lower limbs and abdominal cavity is an effective means for regulating the activity of glucose-inhibited neurons in the lateral hypothalamic area and for improving the secretory function of adipose tissue. | Zhi Yu Youbing Xia Chuanhui Ju Qinghua Shao Zhen Mao Yun Gu Bin Xu | 2013 | Neural Regeneration Research2013，8，9： | 11 |
| 13 | Texture analysis on gadoxetic acid enhanced-MRI for predicting Ki-67 status in hepatocellular carcinoma: A prospective study显示文摘Objective: To investigate the value of whole-lesion texture analysis on preoperative gadoxetic acid enhanced magnetic resonance imaging(MRI) for predicting tumor Ki-67 status after curative resection in patients with hepatocellular carcinoma(HCC).Methods: This study consisted of 89 consecutive patients with surgically confirmed HCC. Texture features were extracted from multiparametric MRI based on whole-lesion regions of interest. The Ki-67 status was immunohistochemical determined and classified into low Ki-67(labeling index ≤15%) and high Ki-67(labeling index >15%) groups. Least absolute shrinkage and selection operator(LASSO) and multivariate logistic regression were applied for generating the texture signature, clinical nomogram and combined nomogram. The discrimination power, calibration and clinical usefulness of the three models were evaluated accordingly. Recurrence-free survival(RFS) rates after curative hepatectomy were also compared between groups.Results: A total of 13 texture features were selected to construct a texture signature for predicting Ki-67 status in HCC patients(C-index: 0.878, 95% confidence interval: 0.791-0.937). After incorporating texture signature to the clinical nomogram which included significant clinical variates(AFP, BCLC-stage, capsule integrity, tumor margin,enhancing capsule), the combined nomogram showed higher discrimination ability(C-index: 0.936 vs. 0.795,P<0.001), good calibration(P>0.05 in Hosmer-Lemeshow test) and higher clinical usefulness by decision curve analysis. RFS rate was significantly lower in the high Ki-67 group compared with the low Ki-67 group after curative surgery(63.27% vs. 85.00%, P<0.05).Conclusions: Texture analysis on gadoxetic acid enhanced MRI can serve as a noninvasive approach to preoperatively predict Ki-67 status of HCC after curative resection. The combination of texture signature and clinical factors demonstrated the potential to further improve the prediction performance. | Zheng Ye Hanyu Jiang Jie Chen Xijiao Liu Yi Wei Chunchao Xia Ting Duan Likun Cao Zhen Zhang Bin Song | 2019 | Chinese Journal of Cancer Research2019，31，5： | 11 |
| 14 | Speciation and fractionation of heavy metals in soil experimentally contaminated with Pb, Cd, Cu and Zn together and effects on soil negative surface charge显示文摘Speciation and fractionation of heavy metals in soil subsamples experimentally loaded with Pb, Cd, Cu and Zn in orthogonal design was investigated by sequential extraction, and operationally defined as water soluble and exchangeable(SE), weakly specific adsorbed(WSA), Fe and Mn oxides bound(OX) and organic bound(ORG). The results showed that fractions of heavy metals in the soil subsamples depended on their speciation. About 90% of Cd and 75% of Zn existed in soil subsamples in the SE fraction. Lead and Cu existed in soil subsamples as SE, WSA and OX fractions simultaneously, although SE was still the major fraction. Organic bound heavy metals were not clearly apparent in all the soil subsamples. The concentration of some heavy metal fractions in soil subsamples showed the good correlation with ionic impulsion of soil, especially for the SE fraction. Continuous saturation of soil subsamples with 0.20 mol/L NH 4Cl, which is the first step for determination of the negative surface charge of soil by the ion retention method, resulted in desorption of certain heavy metals from the soil. It was found that the percentage desorption of heavy metals from soil subsamples depended greatly on pH, the composition and original heavy metal content of the soil subsamples. However, most of the heavy metals in the soil subsamples were still be retained after multiple saturation. Compared with the parent soil, the negative surface charge of soil subsamples loaded with heavy metals did not show difference significantly from that of the parent one by statistical analysis. Heavy metals existed in the soil subsamples mainly as exchangeable and precipitated simultaneously. | ZHOU Dong mei, HAO Xiu zhen, TU Cong, CHEN Huai man, SI You bin (Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China. ) | 2002 | Journal of Environmental Sciences2002，14，4： | 10 |
| 15 | Prognostic values of the integrated model incorporating the volume of metastatic regional cervical lymph node and pretreatment serum Epstein-Barr virus DNA copy number in predicting distant metastasis in patients with N1 nasopharyngeal carcinoma显示文摘Background: According to the 7 th edition of the American Joint Committee on Cancer(AJCC) staging system, over50% of patients with nasopharyngeal carcinoma(NPC) have N1 disease at initial diagnosis. However, patients with N1 NPC are relatively under-researched, and the metastasis risk of this group is not well-stratified. This study aimed to evaluate the prognostic values of gross tumor volume of metastatic regional lymph node(GTVnd) and pretreatment serum copy number of Epstein-Barr virus(EBV) DNA in predicting distant metastasis of patients with N1 NPC, and to develop an integrated prognostic model that incorporates GTVnd and EBV DNA copy number for this group of patients.Methods: The medical records of 787 newly diagnosed patients with nonmetastatic, histologically proven N1 NPC who were treated at Sun Yat-sen University Cancer Center between November 2009 and February 2012 were analyzed. Computed tomography-derived GTVnd was measured using the summation-of-area technique. Blood samples were collected before treatment to quantify plasma EBV DNA. The receiver operating characteristic(ROC) curve analysis was used to evaluate the cut-off point for GTVnd, and the area under the ROC curve was used to assess the predicted validity of GTVnd. The survival rates were assessed by Kaplan-Meier analysis, and the survival curves were compared using a log-rank test. Multivariate analysis was conducted using the Cox proportional hazard regression model.Results: The 5-year distant metastasis-free survival(DMFS) rates for patients with GTVnd > 18.9 vs.≤ 18.9 mL were82.2% vs. 93.2%(P < 0.001), and for patients with EBV DNA copy number > 4000 vs. < 4000 copies/mL were 83.5% vs.93.9%(P < 0.001). After adjusting for GTVnd, EBV DNA copy number, and T category in the Cox regression model, both GTVnd > 18.9 mL and EBV DNA copy number > 4000 copies/mL were significantly associated with poor prognosis(both P < 0.05). According to combination of GTVnd and EBV DNA copy number, all patients were divided into low-,moderate-, and high-risk groups, with the 5-year DMFS rates of 96.1,87.4, and 73.8%, respectively(P < 0.001). Multivariate analysis confirmed the prognostic value of this model for distant metastatic risk stratification(hazard ratio [HR],4.17; 95% confidence interval [CI] 2.34-7.59; P < 0.001).Conclusions: GTVnd and serum EBV DNA copy number are independent prognostic factors for predicting distant metastasis in NPC patients with N1 disease. The prognostic model incorporating GTVnd and EBV DNA copy number may improve metastatic risk stratification for this group of patients. | Ji‑Jin Yao Guan‑Qun Zhou Ya‑Qin Wang Si‑Yang Wang Wang‑Jian Zhang Ya‑Nan Jin Fan Zhang Li Li Li‑Zhi Liu Zhi‑Bin Cheng Jun Ma Zhen‑Yu Qi | 2017 | Chinese Journal of Cancer2017，36，12： | 9 |
| 16 | Banxia Xiexin Decoction(半夏泻心汤)Treats Diabetic Gastroparesis through PLC-IP3-Ca^2+/NO-cGMP-PKG Signal Pathway显示文摘Objective To test the effect of Banxia Xiexin Decoction(半夏泻心汤,BXD)on the contraction and relaxation of gastric smooth muscle(SM)in diabetic gastroparesis(DGP)model rats,and to explore the mechanism of BXD in the prevention and treatment of DGP through experiments of signal pathway both in vivo and in vitro.Methods Sixty Sprague-Dawley rats were divided into 6 groups according to a random number table:control group,model group,high-,medium-and low-dose BXD groups(9.2,4.6 and 1.8 g/(kg·d),respectively),and domperidone group(10 mg/(kg·d)),10 rats per group.DGP model was established initially by a single intraperitoneal injection of streptozotocin(STZ),and was confirmed by recording gastric emptying,intestinal transport velocity and gastric myoelectric activity of rats after 2 months.Each group was treated with a corresponding drug for 4 weeks.The mRNA and protein expressions of phospholipase C(PLC),inositol triphosphate(IP3),neuronal nitric oxide synthase(nNOS),and cyclic guanosine monophosphate(cGMP)dependent protein kinase G(PKG)were detected by reverse transcription-polymerase chain reaction and Western blot,respectively,while nitric oxide(NO)and cGMP expressions were detected by enzyme-linked immunosorbent assay.Gastric tissues were obtained from rats for primary cell culture preparation.Gastric SM cells were treated with 0.8µmol/L of STZ or STZ plus 1,000,500 and 200µg/mL of BXD or STZ plus 2.5µmol/mL of domperidone for 24,48,72 or 96 h,respectively.The length of gastric SM cells and intracellular Ca^2+concentration([Ca^2+]i)before and after BXD treatment was measured.Results Compared with the model group,high-and medium-dose BXD and domperidone significantly increased the expressions of PLC,IP3,NO,nNOS,cGMP and PKG in rat’s gastric tissue(P<0.01).Gastric SM cells treated with BXD showed a time-and dose-dependent increase in cell viability(P<0.01).The treatment with high-and medium-dose BXD and domperidone inhibited the increase in gastric SM cells length and increased[Ca^2+]i compared with the model cells(P<0.01).Conclusions Treatment with high-and medium-dose BXD significantly attenuated STZ-induced experimental DGP in rats.The therapeutic effect of BXD on DGP rats might be associated with the PLC-IP3-Ca^2+/NO-cGMP-PKG signal pathway. | WANG Bin ZENG Ke-wu HONG Zi-fu Tl Gui-xiang WANG Li-yun LU Pin LIU Zhen | 2020 | Chinese Journal of Integrative Medicine2020，26，11： | 8 |
| 17 | Tolerance analysis of multiple-element linear retrodirective cross-eye jamming显示文摘Tolerance sensitivity limits the practical application of the cross-eye jammer.Previous literature has demonstrated that retrodirective cross-eye jamming with multiple antenna elements possesses the advantage of loose tolerance requirements compared to traditional cross-eye jamming.However,the previous analysis was limited,because there are still some factors affecting the parameter tolerance of the multiple-element retrodirective cross-eye jamming(MRCJ)system and they have not been investigated completely,such as the loop difference,the baseline ratio and the jammer-to-signal ratio.This paper performs a comprehensive tolerance analysis of the MRCJ system with a nonuniformspacing linear array.Simulation results demonstrate the tolerance effects of the above influence factors and give reasonable advice for easing tolerance sensitivity. | LIU Tianpeng WEI Xizhang PENG Bo LIU Zhen SUN Bin GUAN Zhiqiang | 2020 | Journal of Systems Engineering and Electronics2020，31，3： | 7 |
| 18 | Speech Signal Processing on Graphs: Graph Topology, Graph Frequency Analysis and Denoising显示文摘The paper investiga tes the hidden relationships among speech samples by applying graph tools.Specifically,we first estimate an applicable graph topology for unstructured speech signals,which can map speech signals into the ver tex domain successfully and cons true t as Speech graph signals(SGSs).On the basis,we define a new graph Fourier transfbrm for SGSs,which can investigate its related graph Fourier analysis.Moreover,we propose a new Graph st ruc ture spec tral sub traction(GSSS)method for speech enhancement under different noisy environments.Simulation results show that the performance of the GSSS method can be significantly improved than the classical Basic spectral subtraction(BSS)method in terms of the average Segmentai signal-tonoise ratio(SSNR),Perceptual evaluation of speech quality(PESQ)and the computational complexity. | WANG Tingting GUO Haiyan LYU Bin YANG Zhen | 2020 | Chinese Journal of Electronics2020，29，5： | 7 |
| 19 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 20 | Toxicity of Graphene Quantum Dots in Zebrafish Embryo显示文摘Objective To evaluate the bio-safety of graphene quantum dots(GQDs), we studied its effects on the embryonic development of zebrafish. Methods In vivo, biodistribution and the developmental toxicity of GQDs were investigated in embryonic zebrafish at exposure concentrations ranging from 12.5-200 μg/m L for 4-96 h post-fertilization(hpf). The mortality, hatch rate, malformation, heart rate, GQDs uptake, spontaneous movement, and larval behavior were examined. Results The fluorescence of GQDs was mainly localized in the intestines and heart. As the exposure concentration increased, the hatch and heart rate decreased, accompanied by an increase in mortality. Exposure to a high level of GQDs(200 μg/mL) resulted in various embryonic malformations including pericardial edema, vitelline cyst, bent spine, and bent tail. The spontaneous movement significantly decreased after exposure to GQDs at concentrations of 50, 100, and 200 μg/mL. The larval behavior testing(visible light test) showed that the total swimming distance and speed decreased dose-dependently. Embryos exposed to 12.5 μg/mL showed hyperactivity while exposure to higher concentrations(25, 50, 100, and 200 μg/mL) caused remarkable hypoactivity in the light-dark test. Conclusion Low concentrations of GQDs were relatively non-toxic. However, GQDs disrupt the progression of embryonic development at concentrations exceeding 50 μg/mL. | WANG Zhen Guo ZHOU Rong JIANG Dan SONG Jing E XU Qian SI Jing CHEN Yun Ping ZHOU Xin GAN Lu LI Jian Zhen ZHANG Hong LIU Bin | 2015 | Biomedical and Environmental Sciences2015，28，5： | 6 |
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